Biochemie und Chemie
Refine
Year of publication
Document Type
- Article (1112)
- Doctoral Thesis (729)
- Book (46)
- Preprint (32)
- Contribution to a Periodical (14)
- Conference Proceeding (11)
- Report (11)
- Review (9)
- diplomthesis (3)
- Part of a Book (2)
Has Fulltext
- yes (1975)
Is part of the Bibliography
- no (1975)
Keywords
- crystal structure (37)
- Crystal Structure (25)
- Synthesis (15)
- ESR Spectra (14)
- RNA (14)
- NMR-Spektroskopie (12)
- hydrogen bonding (11)
- IR Spectra (10)
- NMR spectroscopy (10)
- RNS (9)
- Membranproteine (8)
- PE Spectra (8)
- Paracoccus denitrificans (8)
- NMR (7)
- Phase Diagrams (7)
- X-Ray (7)
- X-Ray Structure Analysis (7)
- structural biology (7)
- Addition Compounds (6)
- Biochemistry (6)
- Cytochromoxidase (6)
- Electron Transfer (6)
- Optogenetics (6)
- Ubihydrochinon-Cytochrom-c-Reductase (6)
- X-ray crystallography (6)
- p63 (6)
- rna (6)
- ABC-Transporter (5)
- Bioenergetics (5)
- Cyclic Voltammetry (5)
- ESR/ENDOR Spectra (5)
- Gentherapie (5)
- HIV (5)
- Ligand <Biochemie> (5)
- MNDO Calculations (5)
- Membrane proteins (5)
- Organische Synthese (5)
- PELDOR (5)
- Pyridine (5)
- Research article (5)
- Silicon (5)
- Streptomyces hydrogenans (5)
- Super-resolution microscopy (5)
- membrane protein (5)
- mitochondria (5)
- Biochemie (4)
- Biophysical chemistry (4)
- Cell biology (4)
- Chemiluminescence (4)
- Chemische Synthese (4)
- Cryoelectron microscopy (4)
- Elektronenspinresonanz (4)
- Elektronentransfer (4)
- Kinases (4)
- Kinetics (4)
- Kristallographie (4)
- MHC (4)
- MO Calculations (4)
- Molekulardynamik (4)
- Nitroxylradikal (4)
- Phosphorylation (4)
- Photosynthese (4)
- Silicium (4)
- Single Crystal Structure (4)
- Single Crystal Structures (4)
- Solution-state NMR (4)
- TATD (4)
- antibiotic resistance (4)
- atomic volume (4)
- biophysics (4)
- dynamics (4)
- environmental tobacco smoke (4)
- inflammation (4)
- kinetics (4)
- membrane proteins (4)
- nuclear magnetic resonance (NMR) (4)
- particulate matter (4)
- protein-protein interaction (4)
- quality control (4)
- ABC Transporter (3)
- ATPases (3)
- Acridine Orange (3)
- Alzheimer-Krankheit (3)
- Antigen Processing (3)
- Antisense-Oligonucleotide (3)
- Apoptosis (3)
- Atomic force microscopy (3)
- Bacterial Chromosome (3)
- Biophysik (3)
- C. elegans (3)
- CRISPR/Cas9 (3)
- Caenorhabditis elegans (3)
- Channelrhodopsin (3)
- Contact Ion Pairs (3)
- Crystallography (3)
- Cyclic Compounds (3)
- Cyclovoltammetry (3)
- DNA (3)
- DNS (3)
- DNS-Synthese (3)
- Electron transfer (3)
- Elektronenspinresonanzspektroskopie (3)
- Entzündung (3)
- Enzyme Induction (3)
- Enzyme mechanisms (3)
- FT-IR-Spektroskopie (3)
- Gaschromatographie (3)
- Gentransfer (3)
- Heterologe Genexpression (3)
- Immunologie (3)
- Konformationsänderung (3)
- Kraftmikroskopie (3)
- LILBID (3)
- Licht-Sammel-Komplex (3)
- Lichtsammelkomplexe (3)
- Ligand (3)
- Lutidine (3)
- Membrane protein (3)
- Mitophagy (3)
- Molekülstruktur (3)
- Naturstoff (3)
- Nucleinsäuren (3)
- Ortspezifische Mutagenese (3)
- Peptide (3)
- Phase Diagram (3)
- Phosphorus (3)
- Photoelectron Spectra (3)
- Photosynthesis (3)
- Protein folding (3)
- Proteine (3)
- Proteinfaltung (3)
- Proteorhodopsin (3)
- Protonentransfer (3)
- Pyrazine (3)
- Quinones (3)
- Radical Complexes (3)
- Schiff bases (3)
- Strukturaufklärung (3)
- Substituent Effects (3)
- Tin (3)
- Totalreflexionsröntgenfluoreszenzanalyse (3)
- UV/VIS Spectra (3)
- Virtual Screening (3)
- X-ray (3)
- X-ray powder diffraction (3)
- allostery (3)
- apoptosis (3)
- base pairing (3)
- benzoxazines (3)
- co-crystalline adducts (3)
- cryo-EM (3)
- cytokine receptor (3)
- cytotoxicity (3)
- gene therapy (3)
- high pressure (3)
- hydrogen bond (3)
- membrane transport (3)
- molecular dynamics (3)
- packing density (3)
- peptides (3)
- phenolic resins (3)
- photolabile Schutzgruppe (3)
- polymorphism (3)
- protein folding (3)
- signal transduction (3)
- solid-state NMR (3)
- type I interferon receptor (3)
- ubiquitin (3)
- 2-aminobenzimidazole (2)
- 20β-Hydroxysteroid Dehydrogenase (2)
- 5-lipoxygenase (2)
- ABC transporter (2)
- ABC transporters (2)
- ADC (2)
- AEC syndrome (2)
- APM (2)
- Acetonitrile Adduct (2)
- Addition Compound (2)
- Affinity Labeling (2)
- Aluminium Chloride (2)
- Amyloid (2)
- Analysis (2)
- Anorganische Synthese (2)
- Atmungskette (2)
- Aufreinigung (2)
- Authentizität (2)
- Azobenzol (2)
- Biocatalysis (2)
- Biophysics and structural biology (2)
- Blutgefäßsystem (2)
- Brownian dynamics simulation (2)
- Carotinoide (2)
- Carrier-Proteine (2)
- Cell membranes (2)
- Chemie und Pharmazie (2)
- Chemieunterricht (2)
- Chemische Analyse (2)
- Chlorophyll (2)
- Complex Formation (2)
- Computational chemistry (2)
- Cycles (2)
- Cytochrom c (2)
- Cytochrom c Oxidase (2)
- Cytochrome Oxidase (2)
- Cytochrome c Oxidase (2)
- DEER (2)
- Dehydrogenases (2)
- Diabetes mellitus (2)
- Dimethyldichlorosilane (2)
- Docking (2)
- Drug Design (2)
- Dynamik (2)
- E. coli (2)
- EGFR (2)
- EPR (2)
- EPR spectroscopy (2)
- ESR (2)
- Einzelpartikelelektronenmikroskopie (2)
- Endothelin (2)
- Epoxides (2)
- Escherichia coli (2)
- Esters (2)
- Excess Volumes (2)
- Fluoreszenzspektroskopie (2)
- Fluoro Compounds (2)
- Fluororganische Verbindungen (2)
- Frankfurt <Main> / Universität / Fachbereich Biochemie (2)
- G protein-coupled receptors (2)
- G-Protein gekoppelte Rezeptoren (2)
- G-quadruplexes (2)
- Green chemistry (2)
- HIV-1 (2)
- HLA class I (2)
- Halbleiteroberfläche (2)
- Heme (2)
- IAPs (2)
- Immunology (2)
- Iodine (2)
- Ion Pair Formation (2)
- Ion transport (2)
- Kinetik (2)
- Kombinatorische Synthese (2)
- Kontamination (2)
- Kristallisation (2)
- LILBID-MS (2)
- Lactate Dehydrogenase (2)
- Lentiviren (2)
- Ligand (Biochemie) (2)
- Luciferase (2)
- Lutidines (2)
- Lysozyme (2)
- MET receptor (2)
- MHC Klasse I (2)
- Magnetische Kernresonanz (2)
- Makromolekül (2)
- Massenspektrometrie (2)
- Membrane (2)
- Membrane biophysics (2)
- Membrane potential (2)
- Membranprotein (2)
- Membrantransport (2)
- Metabolic engineering (2)
- Metal Organic Derivatives (2)
- Methanbakterien (2)
- Methylchlorosilanes (2)
- Methylhalogenosilanes (2)
- Mitochondrium (2)
- Modifizierung (2)
- Molecular biology (2)
- Molecular conformation (2)
- Molecular dynamics simulation (2)
- Monoklonaler Antikörper (2)
- Monoschicht (2)
- Mycobacterium tuberculosis (2)
- NADH-Dehydrogenase <Ubichinon> (2)
- NHC (2)
- NMR Spectra (2)
- NMR Spectroscopy (2)
- NMR-spectroscopy (2)
- Nanodisc (2)
- Nanoscale biophysics (2)
- NhaA (2)
- Niob (2)
- Nitrid (2)
- Nitrogen (2)
- Oberflächenchemie (2)
- Oligomerisation (2)
- Optische Spektroskopie (2)
- Organic electrochemistry (2)
- Organisches Pigment (2)
- Organocatalysis (2)
- Organokatalyse (2)
- Organosilicon Compounds (2)
- Oxidation (2)
- PROTAC (2)
- Peptides (2)
- Permeasen (2)
- Permeation and transport (2)
- Photodynamic Effect (2)
- Photoelectron (2)
- Photooxidation (2)
- Photoreduction (2)
- Photosystem II (2)
- Pichia pastoris (2)
- Preseniline (2)
- Prionprotein (2)
- Protein-Protein Interaktion (2)
- Proteinexpression (2)
- Proteintransduktion (2)
- Proteomanalyse (2)
- Proteomics (2)
- Pump-Probe-Technik (2)
- Purification (2)
- Pyridiniumbromide (2)
- Pyrrolimidazolalkaloide (2)
- Quantenchemie (2)
- RNA interference (2)
- RNS-Interferenz (2)
- RNS-Synthese (2)
- Rapid Thermal Processing (2)
- Rapid thermal processing (2)
- Reaction Kinetics (2)
- Reaktionskinetik (2)
- Reduction (2)
- Reduction to Radical Anions (2)
- Regenerative Energie / Wasserstoff / Halbmetall / Dezentrale Energieversorgung (2)
- Retinal (2)
- Ribosome (2)
- Röntgenkristallographie (2)
- Saccharomyces cerevisiae (2)
- Schwefel (2)
- Screening (2)
- Semiempirical Calculations (2)
- Semiquinone (2)
- Sensorrhodopsin (2)
- Sequenzierung durch Synthese (2)
- Signaltransduktion (2)
- Silanide (2)
- Simulation (2)
- Single molecule force spectroscopy (2)
- Single-molecule biophysics (2)
- Singlet Oxygen (2)
- Solid Supported Membrane (2)
- Solid-state NMR (2)
- Spectra (2)
- Spectroscopy (2)
- Stereochemistry (2)
- Stofftransport <Biologie> (2)
- Sumoylation (2)
- Supersilyl (2)
- Tandem-Massenspektrometrie (2)
- Target validation (2)
- Tin Organic Compounds (2)
- Transport (2)
- Transporter (2)
- Trifluoromethylation (2)
- Trimethylbromosilane (2)
- Tumor (2)
- Typ I Interferon Rezeptor (2)
- USP28 (2)
- Ubiquitin (2)
- Vanadium (2)
- Wirkstoff-Rezeptor-Bindung (2)
- X-ray diffraction (2)
- XIAP (2)
- Yarrowia lipolytica (2)
- Yeast (2)
- Zellzyklus (2)
- Zytokinrezeptor (2)
- additives (2)
- adenine (2)
- aminal structure (2)
- amino acids (2)
- antibiotics (2)
- antigen presentation (2)
- asymmetric catalysis (2)
- automation (2)
- autophagy (2)
- biochemistry (2)
- bioenergetics (2)
- blood coagulation (2)
- caging (2)
- co-crystalline adduct (2)
- cytochrome c oxidase (2)
- deubiquitinase (DUB) (2)
- electron cryo-microscopy (2)
- electrophysiology (2)
- guanidine analogs (2)
- halogen bonding (2)
- helix (snails) (2)
- hydrogen bonds (2)
- internalin B (2)
- intrinsically disordered protein (2)
- lentiviral vectors (2)
- leukotriene (2)
- ligand binding (2)
- macrophage (2)
- mass spectrometry (2)
- membrane protein complex (2)
- metabolism (2)
- metallic elements (2)
- microbial rhodopsin (2)
- molecular structure (2)
- multienzyme (2)
- nuclear magnetic resonance spectroscopy (2)
- oligonucleotides (2)
- organic synthesis (2)
- peptide-loading complex (2)
- phage display (2)
- photopharmacology (2)
- pore-forming toxin (2)
- prostaglandins (2)
- protein denaturation (2)
- proteins (2)
- proteorhodopsin (2)
- proton transfer (2)
- pseudosymmetry (2)
- radiation-induced nanostructures (2)
- reactive oxygen species (2)
- respiratory chain (2)
- retrovirus (2)
- secondary transport (2)
- short contacts (2)
- silicon (2)
- simulation (2)
- single particle electron microscopy (2)
- solvate (2)
- spectroscopy (2)
- stereoselective synthesis (2)
- structure determination (2)
- structure elucidation (2)
- subtomogram averaging (2)
- sumoylation (2)
- temperature (2)
- time-resolved spectroscopy (2)
- transcription (2)
- transcriptional regulation (2)
- transient absorption (2)
- transiente Absorption (2)
- tryptophan (2)
- von Willebrand factor (2)
- yeast (2)
- Übergangsmetall (2)
- (2-hydroxynaphthalen-1-yl)methyl (1)
- (Hydroxymethyl)diphenyl(piperidinoalkyl)silanes (1)
- (novel) brominated flame retardants ((N)BFR) (1)
- 1,1-dichloro-3,5-diphenyl-4-H-1,2,4,6-λ4-selenatriazine (1)
- 1,2,3 triazole (1)
- 1,2,3-Triazoles (1)
- 1,2,3-bis-triazoles (1)
- 1,2,3-triazole-acyclonucleosides (1)
- 1,2,4,5-Tetracyanobenzene (1)
- 1,2,4-thiadiazoles (1)
- 1,2-D ioxetanes (1)
- 1,2-Dimesitoylbenzene (1)
- 1,3-Diamine (1)
- 1,3-bis(2,6-di-methylphenyl)imidazol-2-ylidene (1)
- 1,3-diazinane (1)
- 1,3-dipolar cycloaddition (1)
- 1-(3-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)thiourea (1)
- 1-octanol (1)
- 1.10-Phenanthrolin-5,6-dione (1)
- 13C NMR Spectra (1)
- 14C-Labeled Terpenoids (1)
- 15d-PGJ2 (1)
- 19F NM R Spectra (1)
- 1H NMR Spectra (1)
- 1H NMR; Conformational Properties (1)
- 1H and 13C NMR Spectroscopy (1)
- 2,5-Bis(trimethylsilyl)-p-quinone and -hydroquinone-monosodium Salt (1)
- 2-(2′-Pyridyl)indole Derivatives (1)
- 2-2-Dichloropropane (1)
- 20 β-Activity (1)
- 2H-Azirine (1)
- 3,17 β-Hydroxysteroid Dehydrogenase (1)
- 3,30′-ethane-1,2-diyl-bis-1,3,5-triazabicyclo[3.2.1]octane (1)
- 3,4-Benzopyrene (1)
- 3,4-Dimethylpyridine (1)
- 3-hydroxypropionaldehyde (1)
- 31P-NMR (1)
- 3D EM (1)
- 3D reconstruction and image processing (1)
- 3´-5´ phosphodiesterases (1)
- 4,4’-Disubstituted 2,2’-Bipyridines (1)
- 4-hydroxycyclophosphamide (1)
- 5-Hydroxyaloin A (1)
- 7,7,8,8-Tetracyano-p-quinodimethane (1)
- 7-Dehydrocholesterol (1)
- 9-aminoacridine (1)
- ABC proteins (1)
- ABC-transporter (1)
- ACPM (1)
- ADAR (1)
- AM1 Calculations (1)
- AML – acute myeloid leukemia (1)
- AMPK, nuclear receptors, PPAR, LXR, fatty acid oxidation, ABCA1, human macrophages (1)
- API (1)
- APOBEC3G (1)
- ATP synthase (1)
- ATP-Binding Cassette Transporter (ABC) (1)
- ATP-citrate lyase (1)
- ATPase (1)
- AVA (1)
- Ab-initio-Rechnungen (1)
- Absorptionsspektroskopie (1)
- Abstandsmessung (1)
- Acetylcholin-Bindeprotein (1)
- Acidic Amino Acids (1)
- Acinetobacter baumannii (1)
- Acute Promyelocytic Leukemia (1)
- Acylimin Sulfonylimin (1)
- Addition compounds (1)
- Adenin (1)
- Adenocarcinoma (1)
- Adenom (1)
- Adenosintriphosphatasen (1)
- Adenylate Kinase (1)
- Adherens junctions (1)
- Adhesion (1)
- Adolf von (1)
- Adrenodoxine (1)
- Affenimmundefizienzvirus (1)
- Affinity Chromatography (1)
- Agelas (1)
- Aiolochroia crassa (1)
- Aktivitätsmuster (1)
- Alcohols (1)
- Aldehydes (1)
- Algebraisch Diagrammatische Konstrution (1)
- AlignMe (1)
- Alignment (1)
- Alkali Metal Reduction (1)
- Alkaline and Alkaline Earth Metals (1)
- Alkaloide (1)
- Alkylating Agents (1)
- Alkylating NAD-Analogs (1)
- Alltag (1)
- Aloe (1)
- Altern (1)
- Aluminium (1)
- Aluminium Bromide (1)
- Aluminium bromide (1)
- Aluminium chloride (1)
- Aluminiumbromide (1)
- Alveolar macrophages (1)
- Alzheimer's disease (1)
- Amidiniumsalze (1)
- Aminoboranes (1)
- Aminosäuren (1)
- Aminosäurensequenz (1)
- Ammonium Chloride (1)
- Amyloid proteins (1)
- Amyloidkern (1)
- Androst-4-en-3,17-dione (1)
- Angeborene Immunität (1)
- Angeregter Zustand (1)
- Angiogenese (1)
- Anion Radicals (1)
- Anion and Zwitterion Transport (1)
- Anionic boranes (1)
- Anisotropy (1)
- Anodic oxidation (1)
- Anthracen (1)
- Antibiotic Resistance (1)
- Antigenprozessierung (1)
- Antigens (1)
- Antigens/Peptides/Epitopes (1)
- Antimony Methyl Halides (1)
- Antiporter (1)
- Antisense-Nucleinsäuren (1)
- Antiviral activity (1)
- Apoptose (1)
- Applied microbiology (1)
- Aprotic Conditions (1)
- Aprotic Solution (1)
- Aptamere (1)
- Aquaporin (1)
- Arboran-/Fernanderivate (1)
- Archaea (1)
- Archaebacterial Lipids (1)
- Archaebakterien (1)
- Archebacterial Lipids (1)
- Arduengo-type carbene (1)
- Aromastoff (1)
- Aromatic Nitro Compounds (1)
- Arsenic (1)
- Artifizielle Ribonucleasen (1)
- Arzneimittel (1)
- Arzneimitteldesign (1)
- Ascidien (1)
- Asphodelaceae (1)
- Association (1)
- Asymmetric Catalysis (1)
- Asymmetrische Analyse (1)
- Asymmetrische Synthese (1)
- Atemwege (1)
- Atmosphärenchemie (1)
- Atomic volume (1)
- Attenuated Total Reflection (1)
- Ausgangsmaterial (1)
- Austrittsarbeit (1)
- Autophagy (1)
- Autoxidation (1)
- Azide (1)
- Azidoacetonitrile Trimethylenetetrazole and Tetrazolo[1,5-a]pyridine (1)
- Azo Compounds (1)
- Azobenzene (1)
- Azobenzolderivate (1)
- Azodicarbonitrile (1)
- B-factor (1)
- B. subtilis (1)
- BET inhibitor (1)
- BET inhibitors (1)
- BN Addition Compounds (1)
- BN-PAGE (1)
- BPTI (1)
- BRAF (1)
- Bacteria (1)
- Bacterial Protein Kinases (1)
- Bacterial Protein Phosphatases (1)
- Bacterial genomics (1)
- Bacterial structural biology (1)
- Bacteriophages (1)
- Baeyer (1)
- Bakteriorhodopsin (1)
- Base Catalysis (1)
- Beer (1)
- Benzolsensor (1)
- Benzoquinone Radical Anion (1)
- Berlin <Region>; Luftverschmutzung (1)
- Biacore (1)
- Bildungswahrscheinlichkeit (1)
- Bindestelle (1)
- Bindungsaffinität (1)
- Bioassay-guided fractionation (1)
- Biochemische Analyse (1)
- Biochemistry and chemical biology (1)
- Bioenergetik (1)
- Biofuel (1)
- Bioinformatik (1)
- Biomarker (1)
- Biomolekül (1)
- Biopolymers in vivo (1)
- Biosensorik (1)
- Biotin (1)
- Biphasisch (1)
- Biradicals (1)
- Bis(N,N-diethyl-N′-benzoylselenoureato)lead(II) (1)
- Bis(η-cyclopentadienyl)titana(TiIV)cyclohexaselenane (1)
- Bis-azido-NAD+ Analog (1)
- Bisaboloids (1)
- Bisamidines (1)
- Bismut (1)
- Bivalentes Ion (1)
- Black Lipid Membrane (1)
- Blitzlicht (1)
- Blitzlicht-Photolyse (1)
- Blutgefäß (1)
- Blutgerinnung (1)
- Blutstammzelle (1)
- Blutstammzelle ; Nabelschnur ; Antigen CD34 ; Zellkultur (1)
- Bolhmann bands (1)
- Bond Order (1)
- Bororganische Verbindungen (1)
- Borrelia burgdorferi (1)
- Bovines Herpesvirus 1 (1)
- Bradyrhizobium (1)
- Breast Cancer (1)
- Bronchopneumonie (1)
- Brustkarzinom (1)
- Brustkrebs (1)
- Brønsted Acid (1)
- Brønsted base (1)
- Buparlisib (1)
- Butylmethylether <tertiär-> (1)
- C peptide (1)
- C-H...Br hydrogen bond (1)
- C-H...O interactions (1)
- C-H...O interactions (1)
- C-H...[pi] interactions (1)
- C-H...[pi] interactions (1)
- C-Peptid (1)
- C-mannosylation (1)
- CCR5 (1)
- CD34+ Zellen (1)
- CD34+ cells (1)
- CD4 binding site (1)
- CD44s (1)
- CD44v6 (1)
- CDC-42 (1)
- CEP-1 (1)
- CEP68 (1)
- CIDNP (1)
- CLC (1)
- CNN (1)
- CRASP-Proteine (1)
- CUE domain (1)
- CV9202 (1)
- CXCR4 (1)
- CaChR1 (1)
- Caged Compound (1)
- Caged Verbindungen (1)
- Calcium activated potassium channels (1)
- Calcium-aktivierte (1)
- Calycotome villosa (Poiret) Link Subsp. Intermedia (1)
- Cancer epidemiology (1)
- Candida albicans ; Antimykotikum (1)
- Caprylic acid (1)
- Carbene (1)
- Carbene Complexes (1)
- Carbene Transfer (1)
- Carbonates (1)
- Carbonyl Complexes (1)
- Carbonyl Compounds (1)
- Carboxylic acid reductase (1)
- Carcinogenese (1)
- Cardiolipin (1)
- Cas9 inhibitor (1)
- Caspase-3 (1)
- Cation Proton Antiporter (1)
- Cation coupled symporters (1)
- Cation/proton antiport (1)
- Cell Death Program (1)
- Cell Motility (1)
- Cell Surface Receptor (1)
- Cell signalling (1)
- Cell-free synthetic biology (1)
- Cellular Immune Response (1)
- Central Nervous System (1)
- Ceramide (1)
- Cesium (1)
- Cezanne (1)
- Chalcogen-Liganden (1)
- Chalydomonas (1)
- Charakterisierung (1)
- CheF (1)
- CheY (1)
- Chelate-Capped Hydrogen Bridges (1)
- Chelated Pentacoordinated Silicon (1)
- Chemical Force Microscopy (1)
- Chemical synthesis (1)
- Chemiedidaktik (1)
- Chemiepraktikum (1)
- Chemieunterricht; Experimentiermaterial; Low-Cost (1)
- Chemische Ökologie (1)
- Chemisches Element (1)
- Chemistry (1)
- Chemometry (1)
- Chemotaxonomy (1)
- Chinoloxidase ba3 (1)
- Chinoxalinderivate (1)
- Chiralität (1)
- Chlamydomonas (1)
- Chloridkanal (1)
- Chloromethylsilanes (1)
- Chlorophyll-a (1)
- Chromatin (1)
- Chromatin and Epigenetics (1)
- Chromium (1)
- ClC-7 (1)
- Cocain ; Pyrolyseprodukt ; Biochemische Analyse ; Metabolismus (1)
- Coenzyme Analogue (1)
- Coenzyme Binding (1)
- Coenzyme analogues (1)
- Cofactors (biochemistry) (1)
- Collagen (1)
- Compound Database (1)
- Computation (1)
- Computational Biology (1)
- Computational biology and bioinformatics (1)
- Computational models (1)
- Computersimulation (1)
- Conformational Dynamics (1)
- Conformational State (1)
- Conformational trapping (1)
- Conformers (1)
- Constrained posture (1)
- Contact Ion Pair [Ag⊕(PR3)2(R2H2C6O2·⊖)] (1)
- Contact Ion Pairs and Triples (1)
- Coordination Compounds (1)
- Coordinative Bonding (1)
- Copper decoration (1)
- Copper(I) Chloride Adducts of Phosphoranimines (1)
- Cordaiten (1)
- Core-Hole-Clock Methode (1)
- Cornea (1)
- Correlative electron and light microscopy (1)
- Corynebakterium efficiens (1)
- Coxsackievirus B3 (1)
- Cristallization (1)
- Cross-linking (1)
- Cryo-EM (1)
- Cryo-electron microscopy (1)
- Crystal Structure Analysis (1)
- Crystal Structure Dinuclear Ti-S and Ti-Se Complexes (1)
- Crystal Structure of [(η3-C4H7)6Pd6Se3] (1)
- Crystal Structure of [Co8Se8(PPh3)6]n (n = 0; 1+) (1)
- Crystal Structure of [Fe4Se4Br4]2--Cluster (1)
- Crystal Structures (1)
- Crystal and Molecular Structure (1)
- Cuela (1)
- Cyanine Distortion (1)
- Cyanine Distortion of C6-Rings (1)
- Cyanobacteria (1)
- Cyanogen Azide (1)
- Cyclic Organosulfides (1)
- Cyclic S-N-Compounds (1)
- Cyclic Sulfonyl Derivatives (1)
- Cyclopentadienyl Complexes (1)
- Cyclopenten (1)
- Cyclopentenone (1)
- Cyclophilin (1)
- Cyclophosphamide (1)
- Cystein-Scanning Mutagenese (1)
- Cytochrom-bc1-Komplex (1)
- Cytochrome bc1 complex (1)
- Cytochrome c oxidase (1)
- Cytological techniques (1)
- Cytostatic Agents (1)
- C— H interactions (1)
- C— HCl contacts (1)
- C—H...π interactions (1)
- C—H⋯Br and C—H⋯O hydrogen bonds (1)
- C—H⋯Cl hydrogen bonds (1)
- C—H⋯O hydrogen bonds (1)
- C—H⋯π interactions (1)
- C−H···F (1)
- DASPMI (1)
- DFT (1)
- DFWM (1)
- DIPSHIFT (1)
- DNA Leitfähigkeit (1)
- DNA damage (1)
- DNA nanopores (1)
- DNA nanostructures (1)
- DNA- Spaltung (1)
- DNA-Analytik (1)
- DNA-LNA mixmers (1)
- DNA-PAINT (1)
- DNA-ligand complexes (1)
- DNA/LNA mixmers (1)
- DNS analytics (1)
- DNS-Sequenz (1)
- DNS-Sonde (1)
- DNS-abhängige-DNS-Polymerasen (1)
- DNS; Sequenzanalyse <Chemie>; Abbruchreaktion; Nucleotide; Chemische Synthese; DNS; Sequenzanalyse <Chemie>; Abbruchreaktion; Nucleotide; Chemische Synthese (1)
- DSC-Curves (1)
- Data processing (1)
- Datenbank (1)
- Decalin (1)
- Dehydrogenase (1)
- Dehydrogenase Cofactors (1)
- Dekalin (1)
- Delayed Infectivity Panning (1)
- Delayed Light Emission (1)
- Dendrobates (1)
- Dendrobatides (1)
- Density Functional Theory (1)
- Dentist (1)
- Deoxyribonuclease Digestion (1)
- Depolarization (1)
- Dermatitis (1)
- Deskriptor (1)
- Desoxyribonucleotide ; Fluoreszenzfarbstoff ; Markierung <Chemie> ; DNS-Sequenz (1)
- Detergents (1)
- Detergenz (1)
- Deubiquitination (1)
- DgkA (1)
- Diabetes (1)
- Dialkylamino Substituted π Systems (1)
- Dialkylamino-substituted π-Systems (1)
- Diastereomeric Camphanoates (1)
- Dibenzophosphole (1)
- Dicer (1)
- Dichtefunktionaltheorie mit Dispersionskorrektur (1)
- Dictyostelium (1)
- Diels- Alder reaction (1)
- Diels-Alder-Reaktion (1)
- Diels-Alder-reaction (1)
- Different Forms (1)
- Differential Thermoanalysis (1)
- Differential equations (1)
- Diffraktometrie (1)
- Diffusion (1)
- Dihydroquinolin-4-ones (1)
- Diisobutylaluminum Hydride (1)
- Diisopropylfluorophosphatase (1)
- Dimerization (1)
- Dimethyl maleic anhydride (1)
- Dioxetanes (1)
- Dipolmoment (1)
- Direct carbon (1)
- Direktsynthese (1)
- Disease burden (1)
- Dissipation (1)
- Distance averaging (1)
- Disturbancies and mistakes (1)
- Dolastatinderivate ; Konformationsanalyse ; Tubuline ; Proteinbindung ; NMR-Spektroskopie ; Hammerkopf-Ribozym ; Übergangszustand ; Phospholamban (1)
- Donor/Acceptor-Complexes (1)
- Doorway-Window-Formalismus (1)
- Doorway-window-formalism (1)
- Dreidimensionale NMR-Spektroskopie (1)
- Drift correction (1)
- Drug Resistance (1)
- Dynamic covalent chemistry (1)
- Dynamic networks (1)
- Dynamische Kernpolarisation (1)
- E. colo (1)
- E3 ligase (1)
- EAAC1 (1)
- EAAT3 (1)
- EAAT4 (1)
- EDTA (1)
- EEC syndrome (1)
- EGF-Rezeptor (1)
- EGFR vIII (1)
- EIGER detector (1)
- ENDOR (Special; General Triple) Spectra (1)
- ENDOR Couplings (1)
- ENDOR Spectra (1)
- ENDOR and Triple Spectra (1)
- EPR of Copper (II) Complexes with Membrane Proteins (1)
- ERAD (1)
- ESIPT (1)
- ESR Spectroscopy (1)
- ESR-spectra (1)
- ESR/ENDOR Measurements (1)
- EcNhaA (1)
- Echtzeit-NMR-Spektroskopie (1)
- Effect of Copper (II) (1)
- Ein-Topf-Reaktionen (1)
- Eintrittsinhibitor (1)
- Einzelmolekülanalyse (1)
- Eisenmangel (1)
- Electrochemistry (1)
- Electron Pair Interaction (1)
- Electron Paramagnetic Resonance (EPR) (1)
- Electron tomography (1)
- Electronic Structure (1)
- Electronic Structures (1)
- Electrophysiology (1)
- Elektronenmikroskopie (1)
- Elektronensprayionisations-Massenspektrometrie (1)
- Elektrophorese (1)
- Elektrophysiologie (1)
- Elektrospray-Ionisation (1)
- Elimination (1)
- Empfindlichkeitsverstärkung (1)
- Enantiospecific GC-Analysis (1)
- Endogene Carcinogenesis (1)
- Endogene Retroviren (1)
- Endogene Retroviren ; Schwein ; Heterotransplantation ; Wirt (1)
- Endogene Retroviren; Mensch; Schwein; Genregulation; Wirtsspezifität; Heterotransplantation (1)
- Endogenous RNA-Polymerase (1)
- Endogenous RNA-Polymerase Activity (1)
- Endoplasmic reticulum (1)
- Endothel (1)
- Endothelin B Rezeptor (1)
- Endothelin Receptor B (1)
- Endothelin-Rezeptor (1)
- Endothelzelle (1)
- Ene Reaction (1)
- Energieübertragung (1)
- Enthalpie (1)
- Enzym (1)
- Enzymatic Behaviour (1)
- Enzymatic DNA Methylation (1)
- Enzymatic Methylation (1)
- Enzymatic decomposition (1)
- Enzymatische Regulation (1)
- Enzyme (1)
- Enzyme Preparation (1)
- Enzyme-linked immunoassays (1)
- Enzymes (1)
- Enzymes and Biomimetic Systems (1)
- Eph receptors (1)
- Ephrin ligand (1)
- Epidermal growth factor receptor (1)
- Epidermaler Wachstumsfaktor Rezeptor (1)
- ErbB2; Single-chain Fv Antikörper (1)
- Etching (1)
- Ethene (1)
- Ethenoxidation (1)
- Etherisches Öl (1)
- Ethyne (1)
- Eukaryota (1)
- Evaluation (1)
- Evolution (1)
- Evolution/Protein (1)
- Evolutionärer Algorithmus (1)
- Exchange PAINT (1)
- Experiment (1)
- Eyes (1)
- FF-ATP synthase dimer (1)
- FGFR (1)
- FHL-1 (1)
- FIH1 (1)
- FRAM <Informatik> (1)
- FRET (1)
- FT-IR-spectroscopy (1)
- FT-Raman-Spektroskopie (1)
- Faktor H (1)
- Farbstoffsolarzelle (1)
- Farnsamer (1)
- Faserverbundwerkstoff (1)
- Fatty Acid Synthase (1)
- Fatty Acids (1)
- Fatty acid synthase (1)
- Fatty alcohol (1)
- Femtosekundenspektroskopie (1)
- Fermats letzter Satz (1)
- Ferrocenderivate (1)
- Ferroelektrikum (1)
- Fester Zustand (1)
- Festkörper-DNP (1)
- Festkörperunterstützte Membran (1)
- Festkörperunterstützte Membranen (1)
- Festphasenmikroextraktion (1)
- Fettsäuresynthase (1)
- Fettsäuresynthase Typ I (1)
- Fibrillen (1)
- Fibrils (1)
- Fibrose (1)
- Flavin (1)
- Flavin-binding Protein (1)
- Flavoproteins (1)
- Flightless-I (1)
- Flow chemistry (1)
- Flugzeitmassenspektrometer (1)
- Flugzeitmassenspektrometrie (1)
- Fluorbenzolderivate ; Nucleosidderivate ; Chemische Synthese ; Fluorbenzimidazolderivate ; RNS ; Doppelhelix ; Stabilität (1)
- Fluorescence (1)
- Fluorescence Lifetime (1)
- Fluorescence correlation spectroscopy (1)
- Fluorescence labelling (1)
- Fluoreszenz (1)
- Fluoreszenz <Motiv> (1)
- Fluoreszenz-Resonanz-Energie-Transfer (1)
- Fluoreszenzmarkierung (1)
- Fluoreszenzspektrometer (1)
- Fluorid cleavable linker (1)
- Fluorid spaltbarer Linker (1)
- Fluorierung (1)
- Fluorig (1)
- Fluorine-Sulfur-Nitrogen Compounds (1)
- Fluorous (1)
- Fluorwasserstoff (1)
- Fmoc solid phase peptide synthesis (1)
- Force Field Development (1)
- Formaldehyde (1)
- Frankfurt <Main> / Max-Planck-Institut für Biophysik (1)
- Freie Energie (1)
- Friedel-Crafts Reaction (1)
- Friedel-Crafts-Reaktion (1)
- Frösche <Familie> (1)
- Fucoxanthin-Chlorophyll-Protein (1)
- Funding (1)
- Funktionelle Gruppe (1)
- Further Training (1)
- G protein-coupled receptor (GPCR) (1)
- G quadruplex helicase RHAU (1)
- G-protein coupled receptor (1)
- GC-Aktivität (1)
- GCN (1)
- GIXRF (1)
- GTPase (1)
- Gallensäurederivate (1)
- Gallium (1)
- Gas Phase Conformation (1)
- Gas Phase Dehydrochlorination (1)
- Gas Phase Pyrolysis (1)
- Gas Phase Thermolysis (1)
- Gasphase (1)
- Gasphase Pyrolyses (1)
- Gassensor (1)
- Gating (1)
- Gaussian Process (1)
- Gefrierpunkt (1)
- Gelchro (1)
- Gemeinschwämme (1)
- Gemischtvalente Verbindungen (1)
- Genanalyse (1)
- Gene Regulation (1)
- Gene therapy (1)
- Genetischer Fingerabdruck (1)
- Genregulation (1)
- Gephyrin (1)
- Geranylgeranyl Pyrophosphate (1)
- Germane (1)
- Germanium (1)
- Germoxane (1)
- Get Pathway (1)
- Gewürzvanille (1)
- Ginseng (1)
- Ginsenoside (1)
- Glatter Krallenfrosch (1)
- Glucose tolerance test (1)
- Glucosetoleranztest (1)
- Glutamattransport (1)
- Glyceraldehyde-3 Phosphate Dehydrogenase (1)
- Glyceraldehyde-3-phosphate Dehydrogenase (1)
- Glycinrezeptor (1)
- Glykoproteine5550 !085487139!{{Chemische Synthese}}; Enzymkatalyse (1)
- Gold (1)
- Graetzelzelle (1)
- Gramicidin A (1)
- Gram‐negative (1)
- Granzym B (1)
- Grenz- und Oberflächenmodifizierung (1)
- Grignard Reagents (1)
- Grignard reagent (1)
- Group II Aryls (1)
- Group III Alkyls (1)
- Grundwasserverschmutzung (1)
- Grüne Chemie (1)
- Grüne Meerkatze ; Immundefekt ; Virusinfektion ; Resistenz (1)
- Guanine nucleotide exchange factors (1)
- Guanosine triphosphatase (1)
- Guanylatcyclase ; Phosphorylierung ; Protein-Tyrosin-Kinasen (1)
- H3 receptor (1)
- HCMV-Retinitis (1)
- HCV (1)
- HDAC inhibitor (1)
- HER2 (1)
- HGF (1)
- HIV ; Genetische Variabilität ; Immunoassay (1)
- HIV-Infektion (1)
- HOX gene (1)
- HPLC (1)
- HPLC-MS (1)
- HRAS 28 Gefitinib (1)
- Haarnadelschleife (1)
- Habituation (1)
- Hairpins (1)
- Halbleiter (1)
- Halbleiterreinigung (1)
- Halbleitersilicium-Oberflächen (1)
- Halbleiterspeicher (1)
- Half-of-the-Sites Reactivity (1)
- Halobacillus halophilus (1)
- Halogenation (1)
- Halogenobenzimidazoles (1)
- Halophile (1)
- Halophile Bakterien (1)
- Halve-wave-potentials (1)
- Harnstoff (1)
- Harnstoffderivate (1)
- Hauptkomponentenanalyse (1)
- Helicobacter pylori (1)
- Hepatitis-C-Virus (1)
- Herpesvirus (1)
- Heterogene Katalyse (1)
- Heterogeneous Catalysis (1)
- Heterozyklen (1)
- High Pressure Stability (1)
- High pressure (1)
- High throughput screening (1)
- High-k-Dielektrikum (1)
- High-throughput screening (1)
- Hirnforschung (1)
- Histrionicotoxin (1)
- Hitlers Atombombe (1)
- Hochschuldidaktik (1)
- Hofmeister Effekten (1)
- Hofmeister effects (1)
- Hohes Magnetfeld (1)
- Homogene Katalyse (1)
- Homologe <Chemie> (1)
- Huisgen cycloaddition (1)
- Human (1)
- Hybrid Formation (1)
- Hydrogen Addition (1)
- Hydrogenasen (1)
- Hydrolasen (1)
- Hydrolysis (1)
- Hydroquinone (1)
- Hydroxybenzaldehyde (1)
- Hydroxylation (1)
- Hyperconjugation (1)
- Hypersensitive Reaction (1)
- Häm a Synthase (1)
- Häm-Redox-Status (1)
- I50 Value (1)
- IGF-1R (1)
- IMAC (1)
- IN-VIVO (1)
- IR (1)
- IR Spektroskopie (1)
- IR-spectra (1)
- IR/fsMPI (1)
- ISR (1)
- Identical Topology (1)
- Imido Complex of Tantalum (1)
- Iminophosphoranes (1)
- Immundiffusion (1)
- Immunkomplex (1)
- Immunodiffusion (1)
- Immunoprecipitation (1)
- Immuntherapie (1)
- Impfung (1)
- In silico-Methode (1)
- In vitro selection (1)
- Incidence (1)
- Indikator (1)
- Indol (1)
- Induced pluripotent stem cells (1)
- Induzierte Mutation (1)
- Infrared Raman (1)
- Infrared Spectra (1)
- Infrarotspektroskopie (1)
- Inhibition (1)
- Inhibition of Photosynthetic Electron Transport (1)
- Inhibitor (1)
- Inhibitor-binding (1)
- Injektionsschicht (1)
- Insertion Reactions (1)
- Integrale Membranproteine (1)
- Interaktion (1)
- Interferon (1)
- Interferon <alpha-> (1)
- Interferon response (1)
- Interferonrezeptor (1)
- Intermetallische Phasen (1)
- Internal motion (1)
- Internal ribosome entry site (1)
- Intrabody (1)
- Intracellular Trafficking (1)
- Inverted DNA Repeats (1)
- Ion source (1)
- Ionenkanal (1)
- Ionentransport ; Anion ; Sarkoplasmatisches Retikulum (1)
- Ionic radii (1)
- Ionization State (1)
- Iron (1)
- Isocyanates (1)
- Isolierung <Chemie> (1)
- Isomerie (1)
- Isomerisierungsreaktion (1)
- Isosterism (1)
- Isotopenhäufigkeit (1)
- Isoxazoline Alkaloids (1)
- J coupling constants (1)
- Kabachnik–Fields reaction (1)
- Kaiser-Wilhelm-Gesellschaft (1)
- Kalium Kanäle (1)
- Kalmar <Art> ; Diisopropylfluorophosphatase (1)
- Katalyse (1)
- Katalytische Oxidation (1)
- Kation ; Organische Verbindungen ; Elektrophysiologie (1)
- Kaurene (1)
- Kelvin Sonde (1)
- Keramischer Werkstoff (1)
- Kernhülle ; Hitzeschock-Proteine ; Proteine ; Wechselwirkung (1)
- Ketene Imine (1)
- Kinase (1)
- Kinematic analysis (1)
- Kinetics of the Back Reaction (1)
- Kohlenstoffisotop (1)
- Kohlenstoffisotopie (1)
- Kohlenwasserstoffe (1)
- Kollagen (1)
- Kolloider Halbleiter (1)
- Komplexbildnerstabilität (1)
- Konformation (1)
- Konformationsanalyse (1)
- Koniferen (1)
- Kopplungskonstante (1)
- Kopplungskonstanten (1)
- Korrektur (1)
- Kosten-Nutzen-Bewertung (1)
- Kraftfeld (1)
- Kraftfeld-Rechnung (1)
- Kraftfeldmethoden (1)
- Krebs (Medizin) (1)
- Krebstherapie (1)
- Kristallkeimbildung (1)
- Kristallografie (1)
- Kristallstruktur (1)
- Kristallstrukturanalyse (1)
- Kristallzüchtung (1)
- Kryo-Elektronenkristallographie (1)
- Kryoelektronenmikroskopie (1)
- Kryokonservierung (1)
- Kupfer(II)terephthalat-Koordinationspolymere (1)
- Kupfer-ATPase (1)
- Kurzzeit (1)
- Künstliche Ribonucleasen (1)
- LAMTOR1 (1)
- LCMV (1)
- LHC-II (1)
- LIR interaction, (1)
- LOCKED NUCLEIC-ACID (1)
- LYR motif (1)
- LYR proteins (1)
- LYRM (1)
- Lactalbumin (1)
- Ladungstransfer (1)
- Langlois reagent (1)
- Larvae (1)
- Laser mass spectrometry (1)
- Laserin (1)
- Laserinduzierte Massenspektrometrie (1)
- Lateral Force Microscopy (1)
- Lead Structure (1)
- Lehrerfortbildung (1)
- Leigh Syndrom (1)
- Lentivirale Vektoren (1)
- Lewis Acid Base Interactions (1)
- Lewis acids (1)
- Library screening (1)
- Lichtreaktion (1)
- Ligand-gated ion channel (1)
- Ligandenbindung (1)
- Light (1)
- Light pulses (1)
- Light-Harvesting Complex (1)
- Linker (1)
- Lipid Organization (1)
- Lipopolysaccharide (1)
- Liposomes (1)
- Lipoxygenase (1)
- Lise Meitner (1)
- Lithium (1)
- Lithium-uranate(VI) (1)
- Lithographie <Halbleitertechnologie> (1)
- Lone Pair Electrons (1)
- Low Molecular Weight PTP (1)
- Luminescence (1)
- Luminescence Spectra Flash Photolysis (1)
- Lymphozyt (1)
- Lymphozytäre Choriomeningitis (1)
- Lysosomal storage disease (1)
- Lysosomale Speicherkrankheit (1)
- Lysozym (1)
- MALDI (1)
- MALDI-TOF-Massenspektrometrie (1)
- MALDI-TOF-Massenspektrometrie ; Abtragen ; Ionisation (1)
- MAMMALIAN-CELLS (1)
- MD (1)
- MD Simulation (1)
- MD simulations (1)
- MD-Simulation (1)
- MET (1)
- MIR-Spektroskopie (1)
- MLL1/2 (1)
- MO Interpretation (1)
- MO Models (1)
- MODIFIED OLIGONUCLEOTIDES (1)
- MTBE (1)
- MYC (1)
- Magnesium (1)
- Major Histocompatibility Complex (MHC) (1)
- Makromolekulare (1)
- Makromolekulare Chemie (1)
- Malaria (1)
- Malate Dehydrogenases (1)
- Manganese (1)
- Manganese Binding Sites (1)
- Mannheimia (1)
- Mannich-type bases (1)
- Manteltiere (1)
- Mass spectrometry (1)
- Mathematikgeschichte <Fach> (1)
- Matricaria chamomilla L (1)
- Matricaria chamomilla L; (1)
- Matricine (1)
- Maus ; Recombinasen (1)
- Maus-Leukämie-Virus (1)
- Md simulations (1)
- MdfA (1)
- Medizin (1)
- Mehrdimensionale NMR-Spektroskopie (1)
- Mehrstoffsystem (1)
- Melting Point (1)
- Melting Point Diagrams (1)
- Membran (1)
- Membrane Potential (1)
- Membrane Protein (1)
- Membrane Protein Alignments (1)
- Membrane Proteins (1)
- Membrane Transport (1)
- Membrane protein complex (1)
- Membrane transport (1)
- Membrane-Phloretin Interaction (1)
- Membrane-Proteine (1)
- Membrane/Proteins (1)
- Membranproteine ; Multiproteinkomplex ; Nachweis ; Massenspektrometrie ; Gelelektrophorese (1)
- Membrantopologie (1)
- Mensch (1)
- Merocyanin (1)
- Mesangium (1)
- Mesenchymal stem cells (1)
- Messenger-RNS (1)
- Messenger-RNS ; Translokation ; Peptide ; Wechselwirkung ; Leukämie (1)
- Messung (1)
- Met (1)
- Metabolite Transport (1)
- Metal Organic Derivates (1)
- Metal-Metal Multiple Bonds (1)
- Metall-organische Gerüstverbindungen (MOFs) (1)
- Metallfreie Ribonucleasen (1)
- Metallic radii (1)
- Metallic valence (1)
- Metallion (1)
- Metalloenzymes (1)
- Metalloproteins (1)
- Metallorganische Polymere (1)
- Methanogen (1)
- Methanogenesis (1)
- Methyleneaminoacetonitrile Monomer and Trimer (1)
- Methylmercury Containing Inactivator (1)
- Microbielle rhodopsine (1)
- Mikroelektronik (1)
- Mikroelektronik-Technologie (1)
- Mikroreaktor (1)
- Mikroskopie (1)
- Mikrowelle (1)
- Milchdrüse ; Entwicklung ; Genregulation (1)
- Millisecond Luminescence of Chloroplasts (1)
- Minigramicidin (1)
- Mitochondria (1)
- Mitochondrial and Cytoplasmic Malate Dehydrogenase (1)
- Mitochondrial protein import (1)
- Mitochondrial proteins (1)
- Mixed Lipid Phases (1)
- Mixed Valence Nb-Se Complexes (1)
- Mixed-S tack Donor/Acceptor Complexes (1)
- MjNhaP1 (1)
- Mn(III)-Chlorin (1)
- Modellierung von Fehlordnungen (1)
- Modified nucleosides (1)
- Molecular Complexes (1)
- Molecular Conformation (1)
- Molecular Dynamics (1)
- Molecular Orbitals (1)
- Molecular Physiology of the Cell Membrane (1)
- Molecular Weight (1)
- Molecular chaperones (1)
- Molecular dynamics simulations (1)
- Molecular modelling (1)
- Molecular neuroscience (1)
- Molecular structure (1)
- Molecules with S·̱·̱̱·̱·̱·̱̱·̱N Bonds (1)
- Molekulardesign (1)
- Molekulare Maschinerien (1)
- Molekulare Virologie (1)
- Molekularer Schalter (1)
- Molekül (1)
- Molekülcluster (1)
- Moleküldynamik (1)
- Molekülkomplex (1)
- Molekülparameter (1)
- Molybdenum Bronce (1)
- Molybdenumnitridetrichloride-2.3.3-trichloroacrylnitrile (1)
- Monoclonal Antibodies (1)
- Monolagen (1)
- Monomers (1)
- Monomolecular Films (1)
- Monozyt (1)
- Motor neurons (1)
- MptpA (1)
- Mucopolysaccharidoses (1)
- Mullit (1)
- Multidrug Transporters (1)
- Multikatalytische Proteasen (1)
- Multikomponentenreaktion (1)
- Multiple Kernel (1)
- Multiple Transport Systems (1)
- Multiproteinkomplex (1)
- Multivariate Analysis (1)
- Muscarinic Antagonists (1)
- Muscarinic Receptors (1)
- Muscle contraction (1)
- Muscle electrophysiology (1)
- Muscle fibers (1)
- Musculoskeletal disorder (1)
- Musik (1)
- Musikverarbeitung (1)
- Mutagenese (1)
- Mutante (1)
- MySQL (1)
- Mädchen ; Unterrichtsbeteiligung ; Lernmotivation ; Chemieunterricht ; Sekundarstufe 1 (1)
- Müller’s hydrocarbons (1)
- N,N'-Bis(trimethylsilyl)benzamidinato Complexes (1)
- N,O Ligands (1)
- N-Chloro-Nitrene-Molybdenum Tetrafluoride (1)
- N-Chloro-Nitrene-Tungsten Tetrachloride (1)
- N-Heterocycles (1)
- N-Sulfonylamide (1)
- N-Triflyl Phosphoramide (1)
- N-Trimethylsilyl-iminotriphenylphosphorane Copper(II) Chloride (1)
- N5 -methyl-tetrahydromethanopterin: coenzyme M methyltransferase (1)
- NACI (1)
- NAD + Analogues (1)
- NAD Analogs (1)
- NAD+-Analogs (1)
- NADH:ubiquinone oxidoreductase (1)
- NADP+ Analogues (1)
- NADPH oxidase (1)
- NADPH-Oxidase (1)
- NAD⊕-Isomer (1)
- NAFLD (1)
- NASH (1)
- NBO analysis (1)
- NEXAFS (1)
- NF-kappaB (1)
- NMDA-Rezeptor (1)
- NMR -spectra (1)
- NMR crystallography (1)
- NMR spectrum (1)
- NMR structure determination (1)
- NMR-Spectroscopy (1)
- NO-Sensitivität (1)
- NOE (1)
- NOTCH (1)
- Na+ transport (1)
- Nachweis (1)
- Naja naja atra (1)
- Nanobiotechnologie (1)
- Nanobiotechnology (1)
- Nanobody (1)
- Nanomedicine (1)
- Nanometer Abstandsmessung (1)
- Nanometer Distance Measurements (1)
- Nanotechnologie (1)
- Nascent RNA (1)
- Native mass spectrometry (1)
- Natrium-Kalium-Pumpe (1)
- Natriumglutamat <Natrium-L-glutamat> (1)
- Natural Quinones (1)
- Nekrose (1)
- Nerolidol (1)
- Nerve fibers (1)
- Nervensystem (1)
- Neural pathways (1)
- Neuronales Netz (1)
- Neurospora crassa (1)
- Neurowissenschaft (1)
- Neurowissenschaften (1)
- Niere (1)
- Niobium (1)
- Nitric oxide (1)
- Nitride (1)
- Nitro Compounds (1)
- Nitromethane (1)
- Nitrosative Stress (1)
- Nitroso Compounds (1)
- Nitroxid-Spin-Label (1)
- Non-covalent mass spectrometry (1)
- Non-negative matrix factorization (1)
- Normalkoordinatenanalyse (1)
- Nuclear Overhauser effect (1)
- Nuclear magnetic resonance (1)
- Nucleosidderivate (1)
- Nucleoside (1)
- Nucleoside Triphosphates (1)
- Nucleotide (1)
- Nucleotide Triphosphate Analogue (1)
- N—H⋯O hydrogen bonds (1)
- O-H...[pi] interactions (1)
- OD approach (1)
- OFET (1)
- OH Radical (1)
- OTU domain-containing protein 7B (OTUD7B) (1)
- OXPHOS complexes (1)
- Oberfläche (1)
- Oberflächenanalytik (1)
- Oberflächengewässer (1)
- Octanoic acid (1)
- Olefins (1)
- Olfactoric Properties (1)
- Oligodesoxynucleotide (1)
- Oligomeric State (1)
- Oligomers (1)
- Oligonucleotide (1)
- Oligonukleotide (1)
- One-Electron Oxidation (1)
- One-Electron Reduction of 9,9′-Bianthryl (1)
- One-Electron Reduction of Diphenoquinones (1)
- Oozyten von Xenopus laevis (1)
- Opacity (1)
- Ophthalmology (1)
- Optical Spectroscopy (1)
- Optical electrophysiology (1)
- Optical lenses (1)
- Optical tweezers (1)
- Optimally Solvated Sodium Cation (1)
- Optimierung (1)
- Optogenetik (1)
- Organelle (1)
- Organische Chemie (1)
- Organoboranes (1)
- Organophosphorus Compounds (1)
- Organosulfur Radical Cations (1)
- Osmoregulation (1)
- Ostm1 (1)
- Otto Hahn (1)
- Overhauser-Effekt (1)
- Oxidation States (1)
- Oxidoreductases (1)
- Oxo-and Alkylamino-Substituted p-Benzoquinone Derivatives (1)
- Oxocarboxylic Acids (1)
- Oxoferrylzustand (1)
- Oxynitrid (1)
- Oxynitride (1)
- Ozon (1)
- P4 (1)
- PABP (1)
- PALM (1)
- PAM-complex (1)
- PAR complex (1)
- PASSENGER-STRAND (1)
- PDZ domain (1)
- PE Assignment (1)
- PELDOR/DEER (1)
- PGE2 Cancer Tumorigenesis (1)
- PIDDosome (1)
- PIK3CA (1)
- PPAR (Peroxisome proliferator-activated receptors) (1)
- PPARγ (1)
- PSGP (1)
- Paarverteilungsfunktion (1)
- Packing density (1)
- Pairwise Sequence Alignment (1)
- Palladium (1)
- Palladium-Katalyse (1)
- Palladiumorganische Verbindungen (1)
- Paracoccus denitrificans ; Cytochrom c1 (1)
- Paracoccus denitrificans ; Cytochromoxidase ; Protonentransfer ; Elektronentransport (1)
- Parametrisierung (1)
- Parasite immune evasion (1)
- Parasitic infection (1)
- Parkinson disease (1)
- Pasteurella (1)
- Patch-Clamp-Methode (1)
- Paul-Ehrlich-Institut (1)
- Peak overlap (1)
- Peak picking (1)
- Pentafluorophenyl Derivatives (1)
- Peptid-Aptamer (1)
- Peptidantibiotikum ; NMR-Spektroskopie ; Glycerinderivate ; Quantencomputer (1)
- Peptidbeladungskomplex (1)
- Peptide Loading Complex (PLC) (1)
- Peptidomics (1)
- Perfluoranthracen (1)
- Perfluoromethanimine (1)
- Perizyten (1)
- Personalisierte Medizin (1)
- Pfeilgift (1)
- Pflanzeninhaltsstoff (1)
- Phage Display (1)
- Phage display (1)
- Pharmacodynamics (1)
- Phase diagrams (1)
- Phenazinderivate (1)
- Phenols (1)
- Phospholipide (1)
- Phosphonium Salts (1)
- Phosphor (1)
- Phosphoramide mustard (1)
- Phosphorsäureester (1)
- Photoaffinity Labeling (1)
- Photobiology (1)
- Photodecom position (1)
- Photodynamics (1)
- Photoelectron Spectroscopy (1)
- Photofragmentations (1)
- Photoisomerisierungen (1)
- Photoisomerizations (1)
- Photolabiler Quencher (1)
- Photoreaktion (1)
- Photoreceptor (1)
- Photoresist (1)
- Phvtoene Desaturase (1)
- Phvtofluene (1)
- Phylobates (1)
- Phytoene (1)
- Pias1 (1)
- Pigment (1)
- Pigment Yellow 181 (1)
- Plasmamembran ; Calcium-ATPasen ; Calmodulin ; Peptide ; Wechselwirkung ; Dreidimensionale NMR-Spektroskopie (1)
- Plasmid mapping (1)
- Platelet physiology (1)
- Polarography (1)
- Polyacrylamid-Gel (1)
- Polyamides (1)
- Polyaromatic Hydrocarbons (1)
- Polycyclic Hydrocarbons (1)
- Polycyclic aromatic hydrocarbons (1)
- Polyene (1)
- Polymere (1)
- Polymere Chemie (1)
- Polymerization (Polymers) (1)
- Polymorphie (1)
- Polymorphs (1)
- Polypharmacology (1)
- Polyphenole (1)
- Polyunsaturated fatty acid mediators (1)
- Porphyrine (1)
- Potassium channels (1)
- Potassium transport (1)
- PrP27-30 (1)
- Preparation (1)
- Primary hemostasis (1)
- Primary metabolites (1)
- Primär aktive Transporter (1)
- Prion (1)
- Prion Protein (1)
- Programme Cell Death (1)
- Propen (1)
- Prostaglandin (1)
- Prostaglandine (1)
- Proteases (1)
- Proteasome (1)
- Protein (1)
- Protein Domains (1)
- Protein Dynamics (1)
- Protein Expression (1)
- Protein Structure (1)
- Protein Structure and Dynamics (1)
- Protein design (1)
- Protein structure (1)
- Protein translation (1)
- Protein-Tyrosin-Kinase (1)
- Protein-Tyrosin-Phosphatase (1)
- Protein/Sorting (1)
- Protein/Targeting (1)
- Protein/Translocation (1)
- Proteinchips (1)
- Proteindegradation (1)
- Proteine ; Ligand <Biochemie> ; Wechselwirkung ; NMR-Spektroskopie (1)
- Proteine ; Struktur-Aktivitäts-Beziehung ; NMR-Spektroskopie (1)
- Proteine; Posttranslationale Änderung; Elektrospray-Ionisation; Massenspektrometrie (1)
- Proteinregulation (1)
- Proteins (1)
- Proteinsekretion (1)
- Proteintransport (1)
- Proteintyrosinphosphatase (1)
- Proteolyse (1)
- Proteolysis (1)
- Proteostasis (1)
- Proton Transfer (1)
- Proton Transfer Kinetics (1)
- Proton Transport (1)
- Proton pumping (1)
- Proton transfer (1)
- Protonenpumpe (1)
- Pseudo Jahn-Teller-Effect (1)
- Pseudorotation (1)
- Pseudotypisierung (1)
- Psoriasis (1)
- PtkA (1)
- Pulmonale Hypertonie (1)
- Pulsed epr (1)
- Pumiliotoxin (1)
- Pump-probe (1)
- Pump-probe-spectroscopy (1)
- Punktmutation (1)
- Purin (1)
- Purinnucleoside (1)
- Purpurbakterien (1)
- Pyrazolderivate (1)
- Pyrazole (1)
- Pyridazine (1)
- Pyridinium Bromide (1)
- Pyridinium Iodide (1)
- Pyridinium chloride (1)
- Pyrolyse-Gaschromatographie (1)
- Pyrrolidin (1)
- Pyruvate Kinase (1)
- Pythagoreische Tripel (1)
- Python (1)
- Python <Programmiersprache> (1)
- Q cycle (1)
- Qo site (1)
- Quality (1)
- Quality Management (1)
- Qualität (1)
- Qualitätsmanagement (1)
- Quantum Chemical Calculations (1)
- Quantum chemistry (1)
- Quasiklassisches Modell (1)
- Quinhydrone (1)
- Quinon-Fumarat-Reduktase (1)
- R peptide (1)
- R-Peptid (1)
- RDCs (1)
- RNA editing (1)
- RNA hairpin (1)
- RNA in zebrafish brain (1)
- RNA induced silencing complex (1)
- RNA jepit rambut (1)
- RNA processing (1)
- RNA recognition (1)
- RNA recognition motif (1)
- RNA sequencing (RNA-Seq) (1)
- RNA stability (1)
- RNA stem-loop structure (1)
- RNA synthesis (1)
- RNA-DNA-Hybridization (1)
- RNA-Liganden (1)
- RNA-Polymerase Binding (1)
- RNA-folding (1)
- RNA-ligands (1)
- RNA-protein complex (RNP) (1)
- RNASolution-state NMR (1)
- RNActive (1)
- RND (1)
- RNP dynamics (1)
- RNS-Edierung (1)
- RRM domain (1)
- RXRα (1)
- Rab7 (1)
- Rac1 (1)
- Radical Anion Sodium Salt (1)
- Radical Anions (1)
- Radical Cation (1)
- Radical Cations (1)
- Radical Contact Ion Pairs (1)
- Radical Ions (1)
- Radicals (1)
- Radikal <Chemie> (1)
- Radioliganden (1)
- Ragulator complex (1)
- Raman Spectroscopy (1)
- Raman-spectra (1)
- Rap1 (1)
- Rasterkraftmikroskopie (1)
- Rastersondenmikroskopie (1)
- Rastertunnelmikroskopie (1)
- Ratte (1)
- RbfA (1)
- Reaction products (1)
- Reaktionsbeschleunigung (1)
- Reaktionsdynamik (1)
- Reaktionsführung (1)
- Reaktionsgeschwindigkeit (1)
- Reaktionszentrum (1)
- Reassociation Kinetics (1)
- Receptor Tyrosine Kinase (1)
- Reconstitution (1)
- Reconstitution of Membrane Transporters (1)
- Redfield-Theorie (1)
- Redfield-Theory (1)
- Redox-linked Proton Pump (1)
- Redoxactive Ligands (1)
- Reduction by R4N®BH4e (1)
- Reduction of 1-Sila-2,5-diazacyclopentane-3,4-dithione and of Tetrakis(isopropylthio)-p-benzoquinone (1)
- Registration (1)
- Reinheit (1)
- Reinigung (1)
- Rekombinantes Fusionsprotein (1)
- Rekonstitution (1)
- Research trends (1)
- Resonance Raman spectroscopy (1)
- Resonance assignment (1)
- Reticulon (1)
- Retinalproteine (1)
- Retroviren (1)
- Retroviren ; Matrixproteine (1)
- Retrovirus (1)
- Reversible Terminatoren (1)
- Rezeptor-Tyrosin-Kinase (1)
- Rezeptor-Tyrosinkinasen (1)
- Rheb (1)
- Rhenium(VII) (1)
- RhoA (1)
- RhoGTPases (1)
- Rhodopsin (1)
- Ribonucleasen (1)
- Ribonucleic Acids (1)
- Ribonucleosides (1)
- Ribosom (1)
- Ribosome display (1)
- Riboswitch, RNA, translation, NMR, smFRET (1)
- Ribozym (1)
- Rieske domains (1)
- Rind (1)
- Rind ; Herz ; Fettsäuren ; Bindeproteine ; Mehrdimensionale NMR-Spektroskopie ; Molekulardynamik (1)
- Rpo4/7 (1)
- Rtn3 (1)
- Ruthenium (1)
- Ruthenium Complexes (1)
- Ruthenium-Laserflash-Spektroskopie (1)
- Rydberg transitions (1)
- Röntgen-Photoelektronenspektroskopie (1)
- Röntgenfluoreszenzspektroskopie (1)
- Röntgenstrukturanalyse (1)
- Rückzugsreflex (1)
- S. Cerevisiae (1)
- SAM (1)
- SAP domain (1)
- SAXS (1)
- SEC-MALS (1)
- SELEX (1)
- SF3b145 (1)
- SF3b49 (1)
- SILAC-based proteomics (1)
- SIMPrint (1)
- SMALL INTERFERING RNA (1)
- SNARE-Komplex (1)
- SSM (1)
- SSR128129E (1)
- STED superresolution (1)
- STRUCTURAL BASIS (1)
- SUMOylation (1)
- Salicylic Acid (1)
- Salmonella Typhimurium (1)
- Salmonella typhimurium (1)
- Salmonella-induced filaments (1)
- Saphir (1)
- Sauerstoff (1)
- Sauerstoffradikal; Fluoreszenzlöschung; Sauerstoffradikal; Fluoreszenzlöschung (1)
- Scanning Probe Microscopy (1)
- Schichten (1)
- Schmelzpunktalternanz (1)
- Schnee (1)
- Schwein (1)
- Scribble (1)
- SecYEG (1)
- Secondary metabolites (1)
- Sekretion (1)
- Sekundärmetabolite (1)
- Selbstkompartimentierung (1)
- Selective autophagy (1)
- Selenium Compounds (1)
- Selenium Organic Compounds (1)
- Seleniumphosphoryl-compounds (1)
- Self-Assembled Monolayer (1)
- Semiconductor (1)
- Sensorik (1)
- Separation of ADP-Binding Enzymes (1)
- Septische Granulomatose (1)
- Sequenzanalyse <Chemie> (1)
- Shift-Reagents (1)
- Shine-Dalgarno (1)
- Short-chain fatty acids (1)
- Short-lived Intermediates (1)
- SiN Double Bond (1)
- Signal Transduction (1)
- Signal processing (1)
- Signal transduction (1)
- Sila-difenidol (1)
- Sila-pridinol (1)
- Silanimine (1)
- Silatran (1)
- Silber (1)
- Silicium-Reinigungschemie (1)
- Siliciumbauelement (1)
- Silikon (1)
- Silver (1)
- Silyl Amine (1)
- Silylamide (1)
- Single chain Antikörper (1)
- Single-molecule localization microscopy (1)
- Single-molecule photobleaching (1)
- Single-particle (1)
- Sinorhizobium fredii (1)
- Small Rings (1)
- Small molecules (1)
- Soap Solutions (1)
- Sodium (1)
- Sodium -15-crown-5-pentafluoro-N-chloronitreno-tungstate(VI) (1)
- Sodium Metal Reduction (1)
- Sodium Proton Exchange (1)
- Sodium-15-crown-5-pentafluoro-N-chloronitreno-molybdate(VI) (1)
- Solid supported membrane (1)
- Soluble epoxide hydrolase (1)
- Soluble gp140 Env (1)
- Soluble proteins (1)
- Solvation Effects (1)
- Solvent-Separated Radical Ion Pair (1)
- Solvents (1)
- Sonogashira-Kreuz-Kupplung (1)
- Sonogashira-cross-coupling (1)
- Soybean (1)
- Specific Synthesis (1)
- Spektroskopie (1)
- Sphingolipide (1)
- Sphingosine-1-Phosphate (1)
- Spin Trap (1)
- Spin-Spin-Kopplungskonstante (1)
- Spiro Compounds (1)
- Sponges (1)
- Spontaneous Reduction of Mn(IV)-chlorin (1)
- Squalene (1)
- Sr2CO4 (1)
- SseJ (1)
- Stabilität (1)
- Stammzellen (1)
- Ste2p (1)
- Stem-cell differentiation (1)
- Stereoselektive Synthese (1)
- Sterically Overcrowded Organosilicon Molecules (1)
- Sterols (1)
- Stilbene (1)
- Stoffwechsel (1)
- Stress response (1)
- Structural Changes (1)
- Structural and Conformational Changes (1)
- Structural biology (1)
- Structural biology and molecular biophysics (1)
- Structure Elucidation (1)
- Struktur (1)
- Struktur-Aktivitäts-Beziehung (1)
- Strukturanalyse (1)
- Strukturbiologie (1)
- Strychnin (1)
- Störmöglichkeiten und Fehlermöglichkeiten (1)
- Subcellular Organelles (1)
- Substanzbibliothek (1)
- Substituents (1)
- Substitution of Ribose (1)
- Subvalent Main Group Metals (1)
- Subvalent compounds (1)
- Sulfhydryl Groups (1)
- Sulfolobus solfataricus (1)
- Sulfur (1)
- Sulfur Dioxide (1)
- Sulfur-nitrogen Ring Systems (1)
- Sumoylierung (1)
- Superkomplex (1)
- Support Vector Regression (1)
- Support Vector Regression Model (1)
- Supramolekulare Struktur (1)
- Surf1 (1)
- Surface (1)
- Surface Chemistry (1)
- Surface Coverage (1)
- Symmetry Properties (1)
- Synthese (1)
- Syntheses (1)
- Synthesis of oligodeoxynucleotides (1)
- Synthetic methods (1)
- Säure-Base-Katalyse (1)
- TAP (1)
- TAP Transporter (1)
- TAPL (1)
- TAR-RNA (1)
- TATU (1)
- TBMP (1)
- TDDFT (1)
- TEMPO (1)
- TLS refinement (1)
- TSC2 (1)
- TSE (1)
- Taddol (1)
- Tail-anchored Proteins (1)
- Targeted drug delivery (1)
- Taschenoberfläche (1)
- Tat-TAR-Interaktion (1)
- Tat-TAR-Komplex (1)
- Tat-TAR-complex (1)
- Tau-Protein (1)
- Teachers (1)
- Tellurates (1)
- Tellurium Organic Compounds (1)
- Temperatur (1)
- Temperaturabhängigkeit (1)
- Temperature Dependence (1)
- Testosterone (1)
- TetR family (1)
- Tetra(2'-pyridyl)pyrazine (1)
- Tetra(methylthio)thiophene (1)
- Tetrabenzoato-tetrachloro-dimolybdate (1)
- Tetraederstruktur (1)
- Tetraether Lipids (1)
- Tetraketone Radical Anion (1)
- Tetranuclear Ti Cluster (1)
- Tetraphenyl-p-benzoquinone Reduction (1)
- Tetraphenyl-p-quinodimethane Dianion (1)
- Tetraphenylbutatriene Radical Anion and Dianion Salts (1)
- Tetrastigma voinierianum (1)
- Tetrodotoxin (1)
- Thalassiosira Pseudonana (1)
- Thermal Retrotrimerization (1)
- Thermal motion (1)
- Thermodynamic Excess Functions (1)
- Thermodynamic excess functions (1)
- Thermophile (1)
- Thermophile Bakterien (1)
- Thermoplasma acidophilum Membranes (1)
- Thermoplasma acidophilum Membranes; Tetraetherlipids (1)
- Thermowaage (1)
- Thermus thermophilus (1)
- Thienylidene Complexes (1)
- Thiocarbonates (1)
- Thiolate Ligands (1)
- Thionitrosyl Complexes (1)
- Thiosulfat Sulfurtransferase (1)
- Tierphysiologie (1)
- Time-resolved Absorption Spectroscopy (1)
- Time-resolved Fluorescence (1)
- Titandioxid (1)
- Titanium (1)
- TolC (1)
- Tolbutamide-test (1)
- Tolbutamidtest (1)
- Tools and resources (1)
- Tools and ressources (1)
- Topology (1)
- Torsionswinkel (1)
- Totalreflexions-Röntgenfluoreszenz-Spektrometrie (1)
- Toxin (1)
- Transcriptional Control (1)
- Transcriptional activity (1)
- Transcriptomics (1)
- Transduktion B Zellen (1)
- Transition Metals (1)
- Transkription (1)
- Translation initiation (1)
- Transporter associated with antigen processing (TAP) (1)
- Transporter assoziiert mit Antigen-Prozessierung (1)
- Transporters (1)
- Transportprozess (1)
- Triazene (1)
- Tricyanomethane Derivatives (1)
- Tricycloheptane (1)
- Tridentate Ligands (1)
- Triel (1)
- Trifluoromethoxy groups (1)
- Trifluoromethyl Derivatives (1)
- Trifluoromethylazide (1)
- Trigonal Prismatic Pd-Se Cluster (1)
- Trimethylchloromethane (1)
- Trimethylchlorosilane (1)
- Trimethyltin Chloride (1)
- Trinkwasser (1)
- Tripeptide (1)
- Triphenylmethylphosphonium Nitrite and Formate (1)
- Triphenylphosphane (1)
- Triplett-Triplett-Energieübertragung (1)
- Tubastrin (1)
- Tuberculosis (1)
- Tumorsuppressor-Gen (1)
- Tumortherapie (1)
- Typ I Interferone (1)
- Tyrosin (1)
- U V /V IS Spectra (1)
- U2 snRNP (1)
- U4/U6 (1)
- UBA domain (1)
- UBA5 (1)
- UFC1 (1)
- UFM1 (1)
- UL49.5 (1)
- USIR (1)
- USP32 (1)
- UUUU (1)
- UV spectra (1)
- UV-VIS-Spektroskopie (1)
- Ubihydroquinon-cytochrom-c-reductase (1)
- Ubiquinon-Cytochrome c-Reductase (1)
- Ubiquitin-Protein-Ligase (1)
- Ubiquitination (1)
- Ultrafast Spectroscopy (1)
- Ultrakurzzeitspektroskopie (1)
- Ultraviolettspektroskop (1)
- Umpolung (1)
- Umweltbilanz (1)
- Universität (1)
- Untereinheit (1)
- V3 loop (1)
- VEGF (1)
- VSV (1)
- Valence (1)
- Valence State (1)
- Vanillin (1)
- Varicellovirus (1)
- Varizellen-Virus (1)
- Vektor <Genetik> (1)
- Vemurafenib (1)
- Ventricular tachycardia (1)
- Verpackung (1)
- Verzögerte Fluoreszenz (1)
- Vesicles (1)
- Vibronic Coupling (1)
- Vinyl Azide (1)
- Viral Immunology (1)
- Viral Infection (1)
- Virologie (1)
- Virtual drug screening (1)
- Virus-ähnliche Partikel (1)
- Virusinfektion (1)
- Visual acuity (1)
- Visual impairments (1)
- Vitriole ; Pyrolyse ; Schwefelsäure ; Entdeckung ; Geschichte (1)
- Vitriole ; Pyrolyse ; Schwefelsäureherstellung (1)
- Volmer–Weber growth (1)
- Voltage Clamp (1)
- Voltage Imaging (1)
- WL110547 (1)
- Wang resin (1)
- Wasserstoff (1)
- Wasserstoffbrückenbindung (1)
- Wasserstoffionenkonzentration (1)
- Wasserstoffperoxid (1)
- Wasserstoffperoxid; Chemische Reaktion; Phosphoreszenzspektroskopie (1)
- Weihrauch (1)
- Western blot (1)
- Wilson Disease Protein (1)
- Wnt (1)
- X-Ray Crystal Structures of Co- and Mn-Clusters (1)
- X-Ray Crystallography (1)
- X-Ray Structure (1)
- X-ray Crystallography (1)
- X-ray crystal structure determination (1)
- X-ray detectors (1)
- XRPD (1)
- X‐ray diffraction (1)
- Y10B (1)
- Yarrowia lipolytica F1Fo-ATP synthase (1)
- Yeast Two-Hybrid (1)
- YidC (1)
- Zeitauflösung (1)
- Zellaufnahme (1)
- Zelle (1)
- Zellfreies System (1)
- Zellskelett (1)
- Zellstudien (1)
- Zelltod (1)
- Zentralnervensystem (1)
- Zersetzungsreaktion (1)
- Zinc (1)
- Zirconium (1)
- Zweiphotonen (1)
- Zytomegalievirus (1)
- [pi]-[pi] interaction (1)
- a-proteobacteria (1)
- abnormality detection (1)
- absolute configuration (1)
- accessory subunit (1)
- acetyl-CoA (1)
- acetylcholine binding protein (1)
- acridine orange (1)
- actomyosin (1)
- acyl carrier protein, polyketide synthases, Curacin cluster (1)
- adaptive immunity (1)
- affinities (1)
- aggregation (1)
- aggregopathy (1)
- air pollution (1)
- airborne bacteria (1)
- alanylphenylalanyl derivative (1)
- algebraic diagrammatic construction (1)
- alkali and alkaline earth metal salts (1)
- alkaloids (1)
- alkylation (1)
- all-optical electrophysiology (1)
- allergy (1)
- allosteric coupling (1)
- alpha toxin (1)
- amidiniumsalts (1)
- amoeboid (1)
- amorphous stability (1)
- amphipols (1)
- anaerobic energy metabolism (1)
- analysis (1)
- anthrone (1)
- antibacterial activities (1)
- antibiotic transporters (1)
- antibody Fv fragment (1)
- anticoagulants (1)
- anticonvulsant activity (1)
- antigen processing (1)
- antigen processing and presentation (1)
- aptamers (1)
- archaellum (1)
- argonaute protein (1)
- aromatics (1)
- artificial ribonuclease (1)
- artificial ribonucleases (1)
- asthma (1)
- asymmetrische Katalyse (1)
- asymmetry (1)
- atopy (1)
- auto-inhibition (1)
- automatic environmental tobacco smoke emitter (1)
- aza-Michael Addition (1)
- azo compounds (1)
- azobenzene (1)
- bacterial resistance mechanisms (1)
- bc1-complex (1)
- bcr-abl (1)
- beam-induced movement (1)
- benzoxazine (1)
- biased signaling (1)
- binding affinity (1)
- binding sites (1)
- bioinformatics (1)
- biological chemistry (1)
- biological macromolecules (1)
- biological models (1)
- biophysical investigation (1)
- biophysics and structural biology (1)
- biosenors (1)
- biotin (1)
- biphasic (1)
- black lipid membrane (1)
- borane (1)
- bovine pneumonia (1)
- bromodomain (1)
- c-JUN (1)
- c-MYC (1)
- cGMP (1)
- cIAP1 (1)
- cIAP1 BIR (1)
- caged ATP (1)
- caged compound (1)
- caged compounds (1)
- caged diacylglycerol (1)
- caged nucleosides (1)
- cancer (1)
- cancer immunotherapy (1)
- car indoor (1)
- carbenium ions (1)
- carbodiimide (1)
- carbon and proton assignments (1)
- carbon oxides (COx) (1)
- carcinogenesis (1)
- cardiolipin (1)
- carotenoid radical cation (1)
- caspase-2 (1)
- catabolism (1)
- cell biology (1)
- cell cycle (1)
- cell death (1)
- cell migration (1)
- cell proliferation (1)
- cell studies (1)
- cell targeting (1)
- cell uptake (1)
- cell-free (1)
- cell-free expression (1)
- cellular rosette (1)
- cellular self-organization (1)
- centrosome (1)
- centrosome linker (1)
- chalcogen ligands (1)
- channelrhodopsin (1)
- characterisation (1)
- charge-transfer (1)
- chelator lipid (1)
- chemical bonding (1)
- chemical signaling (1)
- chemical synthesis (1)
- chemical vapor deposition (1)
- chemical vapour deposition (1)
- chemical-induced proximity (1)
- chemische Charakterisierung (1)
- chemotaxis (1)
- chirality (1)
- chlorophyll triplets (1)
- chloroplast membrane proteins (1)
- chlorosilane (1)
- cholesterol-dependent cytolysin (cdc) (1)
- chromatin (1)
- chromatin remodeling (1)
- chronic myeloid leukemia (1)
- chymotrypsin inhibitor (1)
- cigaret smoke (1)
- cigarette strength (1)
- circular dichroism (1)
- cis`-Phytoene (1)
- citrate transport (1)
- clathrin heavy chains (1)
- cleavage of DNS (1)
- cleavage of large RNA molecules (1)
- cleavage site selection (1)
- click azide-alkyne (1)
- co-crystal (1)
- coagulation process (1)
- cocrystalline adducts (1)
- cocrystals (1)
- cofactor recruitment (1)
- collagen (1)
- collagen VI (1)
- colon cancer (1)
- colorectal cancer (1)
- colorimetric signals (1)
- combinatorial biosynthesis (1)
- combined therapy (1)
- compatible solutes (1)
- complex III2 (1)
- complex structure (1)
- complexing agent stability (1)
- complexity (1)
- computational chemistry (1)
- computational modeling (1)
- conformation (1)
- conformation analysis (1)
- conformational changes (1)
- conformational dynamics (1)
- conformational flexibility (1)
- conformational heterogeneity (1)
- conformational space (1)
- cooperativity (1)
- correlated dynamics (1)
- correlations (1)
- cortical flow (1)
- costimulation (1)
- coumarin-4-ylmethyl (1)
- cryo-electron microscopy (1)
- cryo-electron tomography (1)
- cryo-eletron crystallography (1)
- cryoEM (1)
- cryoelectron microscopy (1)
- cryoem (1)
- cryoet (1)
- crystal engineering (1)
- crystal structure determination (1)
- cupriavidus necator (1)
- cyclic compounds (1)
- cyclization (1)
- cycloaddition (1)
- cyclophilin (1)
- cytarabin (1)
- cytochromes (1)
- dNTP hydrolysis (1)
- dNTP pool sanitizing enzymes (1)
- dNTPase inhibitor (1)
- dPCA (1)
- dSTORM (1)
- data-collection strategy (1)
- decachlorocyclopentasilanes (1)
- decomposition reaction (1)
- dehydrogenases (1)
- denisovite (1)
- density functional calculations (1)
- designed multitarget ligands (1)
- detection (1)
- detergent (1)
- deubiquitylation (deubiquitination) (1)
- development (1)
- devitrification (1)
- diMannich base (1)
- diagnostic radiologic examination (1)
- difference spectra (1)
- diffusion barrier (1)
- diffusion dynamics (1)
- digital twin (1)
- dihedral angles (1)
- dipolare Schicht (1)
- disorder (1)
- dispersion-corrected density functional theory (1)
- disulfide bond isomerization (1)
- dithiourea (1)
- divalent metal ions (1)
- dna (1)
- docking domains (1)
- domino reactions (1)
- doppelt angeregte Zustände (1)
- doubly excited states (1)
- drinking water (1)
- drug design (1)
- drug target (1)
- dsRNA (1)
- dual BET/HDAC inhibitor (1)
- dual nucleic acid binding (1)
- dye labeling (1)
- dynein (1)
- efflux pumps (1)
- eicosanoid (1)
- electrochemical CO2 reduction (1)
- electrochromic FRET (1)
- electron cryo-microscopy (cryoem) (1)
- electron cryo-tomography (cryoet) (1)
- electron cryomicroscopy (1)
- electron cryotomography (1)
- electron crystallography (1)
- electron diffraction tomography (1)
- electron microscopy (1)
- electron tomography (1)
- electron transfer (1)
- electron transfer chain (1)
- electron-beam lithography (1)
- embryologic development (1)
- enamides (1)
- enantioselektive Katalyse (1)
- enantioselektive Synthese (1)
- endocytosis (1)
- endophilin (1)
- endosomal tubulation (1)
- endothelial cell (1)
- endothelin receptor (1)
- enhancer (1)
- entropy (1)
- entry inhibitor (1)
- envelope membrane proteome approach comparison (1)
- enzymatically cleavable Linker (1)
- enzymatisch spaltbarer Linker (1)
- enzymes (1)
- eph receptor tyrosin kinase family (1)
- ephrins (1)
- epidermis (1)
- epigenetic (1)
- evolutionary algorithm (1)
- exact NOE (1)
- excitation transport (1)
- excited molecules (1)
- excited states (1)
- excited states dipole moment (1)
- experiment (1)
- f-MLF (1)
- fatty acid synthases (1)
- fatty acid synthesis (1)
- fatty-acid synthase (1)
- fatty-acid synthesis (1)
- fertility (1)
- fibrous materials (1)
- field-effect transistor (1)
- fluorescence (1)
- fluorescence dye (1)
- fluorescent proteins (1)
- fluorinated compounds (1)
- folding (1)
- force field (1)
- formate (1)
- formylation (1)
- framework-structured solids (1)
- free energy landscape (1)
- fucoxanthin-chlorophyll-protein (1)
- functional (1)
- fungi (1)
- funktionelle Materialien (1)
- fusion (1)
- gait adaptation (1)
- gastric cancer (1)
- gastrulation (1)
- gelfiltration (1)
- gene expression regulation (1)
- generation probability (1)
- genetic analysis (1)
- genetic predisposition (1)
- genetransfer (1)
- genome editing (1)
- glass forming ability (1)
- glatte Gefäßmuskelzellen (1)
- glattmuskulär (1)
- glutaconyl-CoA decarboxylase (1)
- glutamate transport (1)
- glutamate transporter (1)
- glutamine synthetase (1)
- glycine receptor (1)
- glycoproteins (1)
- gold (1)
- graetzel cell (1)
- graphene (1)
- green chemistry (1)
- groundwater (1)
- guanosine (1)
- hairpins (1)
- halogenierte Kohlenwasserstoffe (1)
- halophile (1)
- heart (1)
- hen egg white lysozyme (1)
- herpesvirus (1)
- heterocycles (1)
- heterodimer (1)
- heterologous expression (1)
- heteronuclear detection (1)
- hexahydropyrimidine (1)
- hexahydropyrimidine (1)
- high molecular weight plasticizer (1)
- histamine (1)
- histone acetylation (1)
- hochfluorierte Aromaten (1)
- homodimer (1)
- homogeneous time-resolved FRET (HTRF) (1)
- homologe Reihe (1)
- hotmelt extrusion (1)
- hotochromism (1)
- humectant agents (1)
- hydrate (1)
- hydrazide (1)
- hydroxylation (1)
- hydroxynaphthoquinone (1)
- hyperconjugation (1)
- hyperconjugative interaction (1)
- imadazolidine (1)
- imidazole (1)
- imidazolidine (1)
- immunity (1)
- immunology (1)
- in vitro Assay (1)
- in vivo Assay (1)
- in-cabin exposure (1)
- in-vitro Assay (1)
- infrared spectroscopy (1)
- inhibition (1)
- inhibitor (1)
- inhibitor design (1)
- inhibitors (1)
- inner membrane morphology (1)
- inorganic materials (1)
- inorganic synthesis (1)
- inositol (1)
- insulin resistance (1)
- integral membrane proteins (1)
- interaction network (1)
- interdomain signal transmission (1)
- interferon receptor (1)
- intramolecular hydrogen bond (1)
- intramolecular hydrogen bond (1)
- inverse-sandwich complex (1)
- iodine (1)
- ion translocation (1)
- ion treatment (1)
- ions (1)
- iron-sulfur proteins (1)
- irradiation-promoted exchange reaction (1)
- irrigation (1)
- isilane cleavage (1)
- isocyanate (1)
- isomere Reihe (1)
- isomeric antagonists (1)
- isomerization mechanisms (1)
- isothermal titration calorimetry (ITC) (1)
- isothiocyanate (1)
- isotope labeling (1)
- jumping crystals (1)
- katalytischer Zyklus (1)
- kinesin (1)
- kinetic resolution (1)
- kinetically trapped state (1)
- knockout (1)
- kolorektale Tumorzellen (1)
- kuzwirksame Insulinanaloga (1)
- lactose permease (1)
- lantibiotic (1)
- large functional RNAs (1)
- layer-by-layer (LbL) (1)
- leaf patch clamp pressure (1)
- lentiviral vector (1)
- lentivirale Vektoren (1)
- lentivrale Vektoren (1)
- leukocyte-endothelial cell interaction (1)
- liana (1)
- lichtaktivierbare Nukleinsäure (1)
- ligand (1)
- ligand interactions (1)
- ligands (1)
- light harvesting complexes (1)
- light harvesting networks (1)
- light-gated ion channel (1)
- light-harvesting complexes (1)
- lightactivatable nucleic acids (1)
- light–energy conversion (1)
- lipase (1)
- lipoic acid (6,8-dithio-octanoic acid) (1)
- lipoprotein (1)
- lipoproteins (1)
- lithium chloride (1)
- lithium hydride (1)
- live-cell imaging (1)
- local radiotherapy (1)
- locked nucleic acids (1)
- locomotion (1)
- lung cancer (1)
- lysozyme (1)
- mPGES-1 (1)
- mPGES-2 (1)
- mRNA (1)
- mRNA translation (1)
- mRNA vaccine (1)
- mTOR (1)
- mTORC1 (1)
- machine learning (1)
- macromolecular complexes (1)
- macromolecular crystallography (1)
- macrophage polarization (1)
- macrophages (1)
- magic angle spinning (1)
- magic-angle spinning (1)
- magnetic measurements (1)
- magnetic properties (1)
- major facilitator superfamily (1)
- mammals (1)
- maternal tobacco smoke (1)
- matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (1)
- md simulations (1)
- mechanochemical synthesis (1)
- mechanochemistry (1)
- megasynthases (1)
- melibiose permease (1)
- melting point (1)
- membrane curvature (1)
- membrane pore (1)
- membrane proteome (1)
- menthol (1)
- merocyanine (1)
- mesenchymal (1)
- mesopore (1)
- mesoporous silica (1)
- messenger (1)
- meta-stable structures (1)
- metabolic enzyme engineering (1)
- metabolic reprogramming (1)
- metabotropic glutamate receptor (1)
- metal organic derivatives (1)
- metal-free ribonucleases (1)
- metal-ion translocation (1)
- metals (1)
- metal–organic frameworks (1)
- metastases (1)
- methylene derivatives (1)
- miRNA (1)
- miRNS (1)
- mice (1)
- microRNA (1)
- microRNA-17-92 cluster (1)
- microbial electrosynthesis (1)
- microbiology and infectious disease (1)
- microcontact printing (1)
- microenvironment (1)
- microwave-assisted synthesis (1)
- migration (1)
- minerals (1)
- mitochondrial acyl-carrier protein (1)
- mitochondrial fatty acid synthesis type II (1)
- mitogenic effects (1)
- mobile air quality study (1)
- modeling (1)
- modified oligodeoxynucleotides (1)
- modularity (1)
- modularity of megasynthases (1)
- molecular beacons (1)
- molecular conformation (1)
- molecular machines (1)
- molecular motors (1)
- molecular switch (1)
- molecular tug-of-war (1)
- molecular co-crystal (1)
- monocytes (1)
- monosilanes (1)
- morphogenesis (1)
- mouse (1)
- mouse model (1)
- multi-drug-resistant pathogens (1)
- multi-network (1)
- multidimensional nmr spectroscopy (1)
- multidomain protein (1)
- multidrug resistance (1)
- multidrug transport (1)
- multiple sclerosis (1)
- multiplexing (1)
- muscle activity (1)
- muscular dystrophies (1)
- musculoskeletal radiographs (1)
- mutants (1)
- mycolic acid (1)
- n-Ionizations (1)
- nESI (1)
- nRNA Complexity (1)
- nanocrystalline materials (1)
- nanoparticle (1)
- nanoscience (1)
- nanostructure (1)
- native Peptide (1)
- negative-stain electron microscopy (1)
- neuromuscular (1)
- neuronal RNA (1)
- neuronal synapse (1)
- neurons (1)
- newly synthesized RNA (1)
- nicht-kovalente Komplexe (1)
- nicht-native Proteine (1)
- nichtklassisch (1)
- nicotinic acetylcholine receptor (1)
- nikotinischer Acetylcholinrezeptor (1)
- niobium (1)
- niobium oxynitrides (1)
- niobium pentoxide (1)
- nisin binding (1)
- nitrogen oxides (NOx) (1)
- non-alcoholic steatohepatitis (1)
- non-classical (1)
- non-conventional hydrogen bonds (1)
- non-covalent complexes (1)
- non-native proteins (1)
- non-photochemical quenching (1)
- non-ribosomal peptide synthetases (1)
- non-small cell lung cancer (1)
- non-uniform sampling 2 (1)
- noncovalent interactions (1)
- nor-N-mustard (1)
- nuclear magnetic resonance (1)
- nuclear matrix (1)
- nuclear receptor (1)
- nucleic acids (1)
- nucleotides (1)
- oligonucleotide (1)
- oligosilanes (1)
- oocyte death (1)
- oocytes (1)
- open quantum systems (1)
- open structure (1)
- open-cube cluster (1)
- open-shell (1)
- optical spectroscopy (1)
- optogenetic stimulation (1)
- organic pigment (1)
- organic thin films (1)
- organische Pigmente (1)
- organische Verbindungen (1)
- organophosphate flame retardants (OFR) (1)
- orthocarbonates (1)
- osmoregulation (1)
- over-expression (1)
- overview (1)
- oxazine (1)
- oxidases (1)
- oxidative phosphorylation (1)
- oxylipin (1)
- ozone (1)
- p-hydroxyphenacyl (1)
- p53 family (1)
- p73 (1)
- pH Indicator Dye (1)
- pH Regulation (1)
- pH-indicator dye (1)
- packaging (1)
- pancreatic ductal adenocarcinoma (1)
- paramagnetic effects (1)
- parameterization (1)
- particle size distribution (1)
- particulate matter (PM) (1)
- passive smoke (1)
- patch-clamp technique (1)
- patterning (1)
- pcr (1)
- pearling transition (1)
- peptide editing (1)
- peptidyl-prolyl isomarase (1)
- perlakuan ion (1)
- personalized medicine (1)
- phagocytosis (1)
- phase transitions (1)
- phase-shift (1)
- phenylsilane (1)
- phosphate homeostasis (1)
- phosphate translocation mechanism (1)
- phosphate transport regulation (1)
- phosphate transporter (1)
- phosphorus (1)
- phosphorus organic compounds; (1)
- phosphorus-fluoro compounds (1)
- phosphorylation (1)
- photlabile protecting group (1)
- photo reaction (1)
- photoacid generator (1)
- photoaktivierbar (1)
- photochromism (1)
- photodynamic effect (1)
- photoelectron spectra (1)
- photolabile protection (1)
- photolysis (1)
- photooxidation (1)
- photoswitchable organic fluorophores (1)
- photoswitches (1)
- photosynthesis (1)
- phylogeny (1)
- planar polarity (1)
- plant proteomics (1)
- plant symbioses (1)
- plasmid copy number (1)
- plasticity (1)
- pocket surface (1)
- polyenes (1)
- polyhydroxy (1)
- polyketide synthase (1)
- polyketide synthases (1)
- polynaphthoxazine materials (1)
- polysilane (1)
- polytypism (1)
- portable electronic nose (1)
- postsynthetical modification (1)
- postsynthetische Modifikation (1)
- posttranslational modification (PTM) (1)
- pre-steady state (1)
- precision (1)
- preparative cell-free expression (1)
- primary active transporters (1)
- prion (1)
- prion protein (1)
- prostacyclin (1)
- prostaglandin (1)
- protein aggregation (1)
- protein assembly (1)
- protein design (1)
- protein dynamics (1)
- protein engineering (1)
- protein evolution (1)
- protein expression (1)
- protein flexibilty (1)
- protein phosphorylation (1)
- protein structure (1)
- protein structure determination 1 (1)
- protein tyrosine kinase (1)
- protein-protein interactions (1)
- protein–protein interaction (1)
- proteomics (1)
- protons (1)
- pseudotyping (1)
- pull-down (1)
- pulmonary hypertension (1)
- pump-probe spectroscopy (1)
- pyrazoles (1)
- quantum transport (1)
- quinazoline ribonucleosides (1)
- quinazolinone alkylation (1)
- quorum sensing (QS) (1)
- rRNA (1)
- radiation-induced nanostructure (1)
- radioligand (1)
- rapid thermal processing (RTP) (1)
- ratiometric (1)
- real-time NMR spectroscopy (1)
- receptor tyrosine kinase (1)
- receptor tyrosine kinase activation (1)
- receptor tyrosine kinases (1)
- recycling pathway (1)
- reductases (1)
- reflectance spectra (1)
- regioisomers (1)
- rekombinante Proteintherapeutika (1)
- relapsing-remitting (1)
- remote Carbenes (1)
- remote control (1)
- residual dipolar couplings (1)
- resist characterisation (1)
- resist stripping (1)
- resistance–nodulation–cell division (RND) (1)
- resolution (1)
- respirasomes (1)
- respiratory chain supercomplexes (1)
- respiratory complex I (1)
- respiratory complex IV (1)
- response patterns (1)
- response regulator (1)
- retinal proteins (1)
- retrograde transport (1)
- reversible Terminatoren (1)
- reversible terminator (1)
- reversible terminators (1)
- rezeptor glutamat (1)
- ribonucleases (1)
- ribosomal binding site (1)
- ribosome (1)
- ribosome quality control (1)
- riboswitches (1)
- rna recognition motif (1)
- roentgen rays (1)
- rootletin (1)
- rotary ATPase mechanism (1)
- rotational coherence spectroscopy (1)
- rotator phase (1)
- rotaxane shuttling (1)
- sORF (1)
- salmonella (1)
- scaffold attachment factor proteins (1)
- second-hand smoke (1)
- secondary chemical shifts (1)
- secondary transporter (1)
- secretion (1)
- selbstanordnende Monolagen (SAMs) (1)
- selective autophagy receptor (1)
- selective isotopic labeling (1)
- selenolates (1)
- self-assembled monolayer (1)
- self-assembled monolayers (1)
- semi-thin brain tissue sections (1)
- semiconductors (1)
- sequence alignment (1)
- sequencing by synthesis (1)
- sequencing-by-synthesis (1)
- short linear motifs (SLiMs) (1)
- siRNA (1)
- silane (1)
- silatranes (1)
- silica (1)
- silicon chips (1)
- silicon cleaning chemistry (1)
- silicon derivatives (1)
- silicon nanowires (1)
- silver salt (1)
- simulasi DM (1)
- single molecule (1)
- single particle (1)
- single particle analysis (1)
- single-crystal X-ray diffraction (1)
- single-molecule FRET (1)
- single-molecule analyses (1)
- single-molecule förster resonance energy transfer (smFRET) spectroscopy (1)
- single-molecule localization microscopy (1)
- single-particle averaging (1)
- single-particle cryo-EM (1)
- single-particle tracking (1)
- single-particle tracking with photoactivated-localization microscopy (1)
- singlet oxygen (1)
- singlet oxygen (1Δg) chemiluminescence (1)
- single‐molecule tracking (1)
- site-directed mutagenesis (1)
- site-directed spinlabeling (1)
- size of cigarettes (1)
- skalare Kopplungskonstanten (1)
- skeletal muscle (1)
- skin (1)
- small angle x-ray scattering (1)
- small gene (1)
- small protein (1)
- smoking in pregnancy (1)
- smooth muscle cell (1)
- snake venom (1)
- snow (1)
- sodium-proton exchange (1)
- solid supported lipid bilayer (1)
- solid supported membrane (1)
- solid-state NMR spectroscopy (1)
- solid-state nanopores (1)
- solid-supported membrane (1)
- soluble epoxide hydrolase (1)
- solvents (1)
- specialized pro-resolving mediator (1)
- specific interactions (1)
- specificity of cleavage (1)
- spectrum (1)
- spectrum analysis (1)
- spectrum reconstruction 3 (1)
- spermidine (1)
- spezifische Wechselwirkungen (1)
- spliceosome (1)
- spring-loaded activation (1)
- squamous cell carcinoma (1)
- ssFLYA (1)
- stability (1)
- stacking (1)
- stem cells (1)
- stereoselectivity (1)
- steroid (1)
- stratified epithelial tissues (1)
- structural biolog (1)
- structural biology and molecular biophysics (1)
- structural calculation 4 (1)
- structural investigations (1)
- structure calculation (1)
- structure ensemble (1)
- structure-property relationship (1)
- structure/function analysis (1)
- strychnin (1)
- substrate-binding site (1)
- substrate-bound state (1)
- sumo-1 (1)
- super-resolution (1)
- super-resolution microscopy (1)
- super-structure (1)
- superbugs (1)
- superresolution microscopy (1)
- supersaturation (1)
- support vector machine (1)
- supramolecular chain (1)
- supramolecular chemistry (1)
- surface chemistry (1)
- surface water (1)
- surface-attached metal–organic framework (1)
- surface-mounted metal–organic frameworks (SURMOFs) (1)
- syn conformation (1)
- synaptic vesicles (1)
- synaptische Vesikel (1)
- synthetic riboswitches (1)
- taddol (1)
- tapasin (1)
- targeted cell entry (1)
- tau protein (1)
- telomerase (1)
- tetracycline (1)
- tetracycline aptamer (1)
- tetracycline transporter (1)
- tetrahydroisoquinoline (1)
- tetrahydropyrans (1)
- tetramerization (1)
- thermometers (1)
- thin films (1)
- thiolates (1)
- thiophenylazobenzene (1)
- thiostrepton (1)
- thrombin (1)
- thromboxane (1)
- tigecycline (1)
- time-dependent density functional theory (1)
- time-resolved absorption spectroscopy (1)
- time-resolved fluorescence (1)
- tissue imaging (1)
- titanium dioxide (1)
- titration method (1)
- traffic emissions (1)
- trans-Hexafluoroazomethane (1)
- transacylation (1)
- transcription repressor (1)
- transcriptional activity (1)
- transduction B cells (1)
- transfer function (1)
- transition metal (1)
- translation initiation region (1)
- triaminodihydropyrimidinone (1)
- tripartite efflux pumps (1)
- triphenylmethyl ions (1)
- triptycene (1)
- tropism (1)
- tuberculosis (1)
- tumor angiogenesis (1)
- tumor hypoxia (1)
- tumor perfusion (1)
- tumour (1)
- turgor pressure (1)
- turgor pressure probe (1)
- twinning (1)
- type I interferon (1)
- tyrosine kinase inhibitors (1)
- tyrosine kinase inhibitors. (1)
- tyrosine kinase signaling (1)
- tyrosine radical (1)
- ubiquitin chain conformation (1)
- ubiquitin conjugating enzyme9 (1)
- ubiquitination (1)
- ultrafast (1)
- umweltfreundliche Chemie (1)
- unfolded proteins (1)
- uridine (1)
- urotropine (1)
- v-ATPase (1)
- vaccination (1)
- valence (1)
- valences (1)
- vapor-liquid-solid mechanism (1)
- vapor–liquid–solid mechanism (1)
- varicellovirus (1)
- ventilation modes (1)
- virology (1)
- virus-like particle (1)
- visualization of RNA (1)
- volatile organic compounds (VOC) (1)
- voltage imaging (1)
- water solubility (1)
- wheezing (1)
- wine (1)
- x-ray crystallography (1)
- xCGD (1)
- xefoampeptides (1)
- yeast two-hybrid (1)
- zeitabhängige Dichtefunktional-Theorie (1)
- zeitaufgelöste Fluoreszenz (1)
- zeitaufgelöste IR-Spektroskopie (1)
- zellfrei (1)
- zellfreie Expression (1)
- zielgerichteter Zelleintritt (1)
- Ätzen (1)
- Überbrückte Verbindungen (1)
- Überexpression (1)
- ΔNp63 (1)
- α-Aminophosphonates (1)
- α-Iminoketones (1)
- β -Diketiminate (1)
- β-Chloroethyl Azide (1)
- β-ᴅ-2′-Deoxyribosides (1)
- ζ-Carotene (1)
- μ-Nitrido Complexes of Tungsten(V) (1)
- π Conjugation (1)
- π Perturbation (1)
- π-Interactions (1)
- π-clamp (1)
- π–π stacking (1)
Institute
- Biochemie und Chemie (1975)
- Medizin (83)
- Exzellenzcluster Makromolekulare Komplexe (68)
- Biowissenschaften (64)
- Präsidium (64)
- Zentrum für Biomolekulare Magnetische Resonanz (BMRZ) (63)
- Pharmazie (52)
- MPI für Biophysik (49)
- Sonderforschungsbereiche / Forschungskollegs (48)
- Georg-Speyer-Haus (22)
In the present work, the photo-protection mechanisms in plants and purple bacteria were investigated experimentally at the molecular level. For this purpose, several spectroscopic methods were combined and applied to elucidate the function of carotenoids, pigments of the photosynthetic apparatus, in photo-protection. The experiments were focused on the mechanisms involved in quenching of singlet and triplet states of the electronically excited (bacterio)chlorophylls. This photosynthetic reaction events occur on an ultrafast time-scale. Measuring such short-lived events, and understanding the underlying principles, demand some of the most precise experiments and exact measurement technologies currently available. This implies certain requirements for the light source used: a suitable wavelength within the absorption band of the sample, sufficient power, and, most importantly, a pulse duration short compared to the studied reaction. Nowadays, we can achieve all this requirements using femtosecond-spectroscopic systems, which produce laser pulses shorter than 100 femtoseconds (fs). Transient absorption spectroscopy provides important information on molecular dynamics interrogating electronic transitions. The technique is based on photochemical generation of transient species with femtoseconds pump pulses and measuring transient absorption changes of the sample using a second, time delayed probe pulse which in this case is a spectrally broad white-light pulse.
This work presents a contribution to the literature on methods in search of lowdimensional models that yield insight into the equilibrium and kinetic behavior of peptides and small proteins. A deep understanding of various methods for projecting the sampled configurations of molecular dynamics simulations to obtain a low-dimensional free energy landscape is acquired. Furthermore low-dimensional dynamic models for the conformational dynamics of biomolecules in reduced dimensionality are presented. As exemplary systems, mainly short alanine chains are studied. Due to their size they allow for performing long simulations. They are simple, yet nontrivial systems, as due to their flexibility they are rapidly interconverting conformers. Understanding these polypeptide chains in great detail is of considerable interest for getting insight in the process of protein folding. For example, K. Dill et al. conclude in their review [28] about the protein folding problem that "the once intractable Levinthal puzzle now seems to have a very simple answer: a protein can fold quickly and solve its large global optimization puzzle simply through piecewise solutions of smaller component puzzles".
Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1
(2011)
The respiratory chain in the inner mitochondrial membrane contains three large multi-enzyme complexes that together establish the proton gradient for ATP synthesis, and assemble into a supercomplex. A 19-Å 3D map of the 1.7-MDa amphipol-solubilized supercomplex I1III2IV1 from bovine heart obtained by single-particle electron cryo-microscopy reveals an amphipol belt replacing the membrane lipid bilayer. A precise fit of the X-ray structures of complex I, the complex III dimer, and monomeric complex IV indicates distances of 13 nm between the ubiquinol-binding sites of complexes I and III, and of 10–11 nm between the cytochrome c binding sites of complexes III and IV. The arrangement of respiratory chain complexes suggests two possible pathways for efficient electron transfer through the supercomplex, of which the shorter branch through the complex III monomer proximal to complex I may be preferred.
Die Atmungskette in der inneren Membran der Mitochondrien besteht aus fünf großen Enzymkomplexen. Die NADH-Dehydrogenase (I), Succinat-Dehydrogenase (II, indirekt), Cytochrom c-Reduktase (III) und Cytochrom c-Oxidase (IV) nutzen die Energie aus Elektronentransfers zum Aufbau eines Protonengradienten über die innere Mitochondrienmembran. Dieser wird anschließend von der FOF1-ATP-Synthase (V) als Energiequelle zur Phospho-rylierung von ADP verwendet. Für lange Zeit bestand eine Kontroverse, wie diese Proteine in der Membran organisiert sind. Nach dem „random collision“-Modell diffundieren sie frei als Einzelmoleküle und treffen sich nur zufällig, während sie nach dem „solid state“-Modell größere funktionelle Einheiten bilden. In den letzten Jahren gab es vermehrt Hinweise darauf, dass das letztere Modell das zutreffendere ist, da tatsächlich sogenannte Superkomplexe der Atmungskette in aktiver Form isoliert werden konnten. Schließlich konnte 2007 die erste drei-dimensionale Rekonstruktion eines Superkomplexes, bestehend aus Komplex I, dimerem Komplex III und Komplex IV publiziert werden. Aufgrund der Einschränkungen der verwendeten Negativkontrasttechnik hatte dieses Modell allerdings nur eine niedrige Auflösung und repräsentierte durch die Dehydrierung keinen nativen Zustand. Dadurch ließen sich die Strukturen der einzelnen Komplexe nur ungenau einpassen. Um diese Probleme zu umgehen, sollte eine Struktur unter Kryo-Bedingungen rekonstruiert werden. Um die für Kryo-EM benötigte größere Ausbeute und höhere Konzentration zu erzielen, wurde ein neues Reinigungsprotokoll für die Superkomplexe etabliert. Die wesentlichen Punkte darin sind der Austausch des für die Solubilisierung verwendeten Digitonins durch Amphipol A8-35 mittels ?-Cyclodextrin und eine anschließende Dichtegradienten-Ultrazentrifugation. Im BN-PAGE zeigten die auf diese Art gereinigten Superkomplexe das gleiche Banden- und Aktivitätsmuster wie Proben in Digitonin. Auch bei einer Einzelpartikelanalyse nach Negativ-kontrastfärbung konnten keine Unterschiede festgestellt werden und die Partikel zeigten ähnliche Orientierungen wie in der vorherigen Studie. Einige neue Ansichten ließen sich jedoch nicht zuordnen und stellten eventuell eine Verunreinigung mit größeren Superkomplexen dar. Da auch bei der Reinigung mit Amphipol die Proteinkonzentration letztlich nicht wesentlich erhöht werden konnte und sich die Superkomplexe nicht wie für Kryo-EM erforderlich in einen löchrigen Kohlefilm einlagerten, wurden die Proteine auf einem durchgehenden Kohlefilm in einer dünnen Pufferschicht vitrifiziert. Die dabei zu beobachtenden bevorzugten Orientierungen, sollten auch die Unterscheidung von verschiedenen Populationen von Superkomplexen erleichtern. Eine erste 3D-Rekonstruktion wurde mit Hilfe der „random conical tilt“-Methode errechnet. Dieses Modell wurde durch „projection matching“ bis zu einer Auflösung von 19 Å verfeinert, womit die Auflösung fast doppelt so hoch ist, wie bei der Rekonstruktion aus Negativ-kontrastfärbung (36 Å). Die Struktur repräsentiert einen natürlichen Zustand des Proteins und zeigt Details wie einzelne Domänen, Spalten zwischen Domänen und eine starke Krümmung des Membranarms von Komplex I, die zuvor nicht erkenn-bar waren. Die Amphipole bilden einen Gürtel um den Transmembranbereich. Die Röntgenstrukturen von Komplex I, III2 und IV konnten mit großer Präzision in die Dichtekarte eingepasst werden. Die wenigen kleinen Unterschiede zwischen Röntgenstrukturen und EM-Dichtekarte sind auf leichte Konformations-änderungen zurückzuführen. Die Kryo-EM-Rekonstruktion ist erheblich größer als die Rekonstruktion aus Negativfärbung, wodurch die enthaltenen Komplexe nur noch wenige punktuelle Kontakte haben. In den Zwischenräumen könnte eine spezielle Lipidumgebung die kleinen Elektronenüberträger Ubichinon und Cytochrom c in den Superkomplex integrieren. Ihre Bindestellen sind jeweils zueinander orientiert und die geringen Abstände, die zum ersten Mal bestimmt werden konnten, stützen die Hypothese eines gerichteten Substrattransfers über kurze Entfernungen. Von den möglichen Übertragungswegen scheint der kürzere mit weniger Transferreaktionen bevorzugt zu werden. Während der Entwicklung des neuen Reinigungsprotokolls für die Superkomplexe konnte zusätzlich eine neue Methode zur Rekonstitution von Membranproteinen entwickelt werden. Die solubilisierten Proteine werden dabei in Dichtegradienten mit steigenden Konzentrationen von ansolubilisierten Liposomen und Cyclodextrin zentrifugiert, wodurch ihnen langsam das Detergens entzogen und durch Lipid ersetzt wird. Proteoliposomen werden gleichzeitig von überschüssigem Lipid und Cyclodextrin-Detergens-Komplexen getrennt.
Current metabolomics approaches utilize cellular metabolite extracts, are destructive, and require high cell numbers. We introduce here an approach that enables the monitoring of cellular metabolism at lower cell numbers by observing the consumption/production of different metabolites over several kinetic data points of up to 48 hours. Our approach does not influence cellular viability, as we optimized the cellular matrix in comparison to other materials used in a variety of in‐cell NMR spectroscopy experiments. We are able to monitor real‐time metabolism of primary patient cells, which are extremely sensitive to external stress. Measurements are set up in an interleaved manner with short acquisition times (approximately 7 minutes per sample), which allows the monitoring of up to 15 patient samples simultaneously. Further, we implemented our approach for performing tracer‐based assays. Our approach will be important not only in the metabolomics fields, but also in individualized diagnostics.
Current metabolomics approaches utilize cellular metabolite extracts, are destructive, and require high cell numbers. We introduce here an approach that enables the monitoring of cellular metabolism at lower cell numbers by observing the consumption/production of different metabolites over several kinetic data points of up to 48 hours. Our approach does not influence cellular viability, as we optimized the cellular matrix in comparison to other materials used in a variety of in‐cell NMR spectroscopy experiments. We are able to monitor real‐time metabolism of primary patient cells, which are extremely sensitive to external stress. Measurements are set up in an interleaved manner with short acquisition times (approximately 7 minutes per sample), which allows the monitoring of up to 15 patient samples simultaneously. Further, we implemented our approach for performing tracer‐based assays. Our approach will be important not only in the metabolomics fields, but also in individualized diagnostics.
pH and Na+ homeostasis in all cells requires Na+/H+ antiporters. The crystal structure, obtained at pH 4, of NhaA, the main antiporter of Escherichia coli, has provided general insights into an antiporter mechanism and its unique pH regulation. Here, we describe a general method to select various NhaA mutants from a library of randomly mutagenized NhaA. The selected mutants, A167P and F267C are described in detail. Both mutants are expressed in Escherichia coli EP432 cells at 70–95% of the wild type but grow on selective medium only at neutral pH, A167P on Li+ (0.1 M) and F267C on Na+ (0.6 M). Surprising for an electrogenic secondary transporter, and opposed to wild type NhaA, the rates of A167P and F267C are almost indifferent to membrane potential. Detailed kinetic analysis reveals that in both mutants the rate limiting step of the cation exchange cycle is changed from an electrogenic to an electroneutral reaction.
Die Messung von heteronuklearen 15N-Relaxationszeiten (Longitudinale, transversale sowie heteronukleare NOE) bei verschiedenen Magnetfeldstärken (500, 600 und 800 MHz 1H Larmorfrequenz) ergeben Informationen über interne dynamische Prozesse in Biomolekülen. Diese verschiedenen Relaxationsraten sind voneinander abhängig und über die spektrale Leistungsdichtefunktion miteinander gekoppelt. Die mikrodynamischen Parameter des NH-Peptidrückgratvektors (der Ordnungsparameter S2 und die effektive interne Korrelationszeit te) sowie der Beitrag des konformationellen Austausches zur transversalen Relaxationsrate der Austauschparameter Rex wurden für einige Proteine errechnet und angepaßt. Das Human ILBP gehört zur Familie der intrazellulären Lipidbindungsproteine (LBP), die in der Lage sind, Fett- und Gallensäuren spezifisch zu binden und in Cytosol zu transportieren. Viele verschiedene Typen von LBPs sind bis heute identifiziert worden. Diese Proteine enthalten 127 - 135 Aminosäurereste und werden nach dem Gewebe benannt, aus dem sie isoliert wurden. Human-ILBP enthält 127 Aminosäurereste und besteht haupsächlich aus 10 antiparallelen beta-Faltblattsträngen, die eine beta-Fassstruktur mit einer großen Bindungstasche bilden, und zwei alpha-Helices. ILBP hat die Tendenz, Gallensäuren oder Fettsäuren zu binden. Diese geringe Tendenz zur liganden Spezifität ist entweder in der Struktur oder in seiner Dynamik begründet. Aus diesem Grund kann die Untersuchung der Dynamik des Human ILBP (apo- und holo-Form) in zwei Zeitfenstern zum besseren Verständnis der Funktion führen. Für die nicht-terminalen Peptidrückgratgruppen wurde ein S2-Parameter> 0,8 mit einen Durchschnitt von 0,88 beobachtet, was auf eine niedrige Mobilität im ganzen Protein in einem Nano- zu Picosekunden-Zeitfenster deutet, wobei eine Korrelationszeit von tc = 6.25 ns für ILBP (apo-form) und tc = 6.10 ns für ILBP (holo-Form) beobachtet wurde. Apo- und holo-Form (mit Taurocholat als Ligand) zeigen eine ähnliche Dynamik in diesem Zeitfenster. Überdurchschnittliche S2-Werte der alpha-Helix I deuten eine geringe Flexibilität des Peptidrückgrats an, während alpha-Helix II als Teil der Portalregion eine höhere Beweglichkeit zeigt. Austauschparameter Rex wurden hauptsächlich in den Regionen der Ligandenbindung nachgewiesen. Die hier beschriebenen Eigenschaften unterscheiden sich von denen des H-FABP und des E-FABP. Offensichtlich unterscheiden sich verschiedene Mitglieder der LBP-Familie wie ILBP (Human oder Schwein), H-FABP und E-FABP in der Funktion und Dynamik des Peptidrückgrats. In der vorliegenden Arbeit wurden die transversalen 15N CSA/DD-kreuzkorrelierten Kreuzrelaxationsraten bestimmt. Für die Bestimmung der Anisotropie des chemischen Verschiebungstensors wurde des Verhältnis zwischen den Auto- und Kreuzrelaxationsraten in Abhängigkeit von der magnetischen Feldstärke genutzt, wobei es möglich war, die Orientierung und Größe des CSA-Tensors einzelner Aminosäurereste zu bestimmen. Bei dieser Methode (wie auch in vielen anderen Studien gezeigt) wurde keine Korrelation zwischen der Sekundärstruktur des Proteins und den 15N CSA-Werten festgestellt. Zum Vergleich der CSA-Konstanten der ILBP-Spezies wurden die entsprechenden Parameter der RNaseT1 gemessen. Alle Daten wurden im Hinblick auf strukturelle Details kritisch diskutiert.
Long non-coding RNAs are a very versatile class of molecules that can have important roles in regulating a cells function, including regulating other genes on the transcriptional level. One of these mechanisms is that RNA can directly interact with DNA thereby recruiting additional components such as proteins to these sites via an RNA:dsDNA triplex formation. We genetically deleted the triplex forming sequence (FendrrBox) from the lncRNA Fendrr in mice and found that this FendrrBox is partially required for Fendrr function in vivo. We found that the loss of the triplex forming site in developing lungs causes a dysregulation of gene programs associated with lung fibrosis. A set of these genes contain a triplex site directly at their promoter and are expressed in lung fibroblasts. We biophysically confirmed the formation of an RNA:dsDNA triplex with target promoters in vitro. We found that Fendrr with the Wnt signalling pathway regulates these genes, implicating that Fendrr synergizes with Wnt signalling in lung fibrosis.
Large crystals of the methyl ester of the N-a-benzyloxycarbonyl protected Ala-Phe dipeptide (Z-AF-OMe) were obtained after the very slow evaporation of a solution of the corresponding carboxylic acid (Z-AF-OH) in methanol containing an excess of HCl. The structure was confirmed by single crystal X-ray diffraction data. It crystallizes in the orthorhombic space group P212121 with unit cell dimensions a = 5.0655(6) Å, b = 8.4614(8) Å, c = 46.856(5) Å, V = 2008.3(4) Å3, Z = 4. In the crystal, the molecules form hydrogen bonded chains running along the a axis of the unit cell. Other secondary interactions are also discussed.