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Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in complex I are involved in a wide range of degenerative disorders. Recent progress in the X-ray structural analysis of prokaryotic and eukaryotic complex I confirmed that the redox reactions are confined entirely to the hydrophilic peripheral arm of the L-shaped molecule and take place at a remarkable distance from the membrane domain. While this clearly implies that the proton pumping within the membrane arm of complex I is driven indirectly via long-range conformational coupling, the molecular mechanism and the number, identity, and localization of the pump-sites remains unclear. Here, we report that upon deletion of the gene for a small accessory subunit of the Yarrowia complex I, a stable subcomplex (nb8m delta) is formed that lacks the distal part of the membrane domain as revealed by single particle analysis. The analysis of the subunit composition of holo and subcomplex by three complementary proteomic approaches revealed that two (ND4 and ND5) of the three subunits with homology to bacterial Mrp-type Na+/H+ antiporters that have been discussed as prime candidates for harbouring the proton pumps were missing in nb8m delta. Nevertheless, nb8m delta still pumps protons at half the stoichiometry of the complete enzyme. Our results provide evidence that the membrane arm of complex I harbours two functionally distinct pump modules that are connected in series by the long helical transmission element recently identified by X-ray structural analysis.
An optimized design of a stellarator-type storage ring for low energy ion beams was numerically investigated. The magnetic field variation along the circumference and therefore magnetic heating is suppressed by using simple circular correction coils. Particle-in-Cell (PIC) simulations in a magnetic flux coordinate system show the ability of high current ion beam accumulation in such a configuration with unique features for clockwise and anticlockwise moving beams. Additionally scaled down experiments with two 30 degree room temperature toroidal segments were performed to demonstrate toroidal transport and to develop optical beam diagnostics. Properties of multi-component beams, redistribution of transversal momenta in the non-adiabatic part of the experimental configuration and investigation of strongly confined beam induced electron clouds will be addressed.
This paper presents a preliminary survey of the positions and prosodies associated with Wh-questions in two Bantu languages spoken in Malawi. The paper shows that the two languages are similar in requiring focused subjects to be clefted. Both also require 'which' questions and 'because of what' questions to be clefted or fronted. However, for other non-subjects Tumbuka rather uniformly imposes an IAV (immediately after the verb) requirement, while Chewa does not. In both languages, we found a strong tendency for there to be a prosodic phrase break following the Wh-word. In Tumbuka, this break follows from the general phrasing algorithm of the language, while in Chewa, I propose that the break can be best understood as following from the inherent prominence of Wh-words.
Introduction
(2011)
In spite of this long history, most work to date on the phonology-syntax interface in Bantu languages suffers from limitations, due to the range of expertise required: intonation, phonology, syntax. Quite generally, intonational studies on African languages are extremely rare. Most of the existing data has not been the subject of careful phonetic analysis, whether of the prosody of neutral sentences or of questions or other focus structures. There are important gaps in our knowledge of Bantu syntax which in turn limit our understanding of the phonology-syntax interface. Recent developments in syntactic theory have provided a new way of thinking about the type of syntactic information that phonology can refer to and have raised new questions: Do only syntactic constituent edges condition prosodic phrasing? Do larger domains such as syntactic phases, or even other factors, like argument and adjunct distinctions, play a role? Further, earlier studies looked at a limited range of syntactic constructions. Little research exists on the phonology of focus or of sentences with non-canonical word order in Bantu languages. Both the prosody and the syntax of complex sentences, questions and dislocations are understudied for Bantu languages. Our project aims to remedy these gaps in our knowledge by bringing together a research team with all the necessary expertise. Further, by undertaking the intonational, phonological and syntactic analysis of several languages we can investigate whether there is any correlation among differences in morphosyntactic and prosodic properties that might also explain differences in phrasing and intonation. It will also allow us to investigate whether there are cross-linguistically common prosodic patterns for particular morpho-syntactic structure.
Der Roman Morenga, der erstmals 1978 beim Verlag Autoren-Edition veröffentlicht wurde, zählt zu den deutschsprachigen Romanen, die Göttsche als „neue Historische Afrika-Roman[e]“ bezeichnet. Laut Göttsche werfen die AutorInnen solcher Romane einen unvoreingenommenen Blick auf Afrika, anerkennen die kulturellen Realitäten Afrikas und stellen sie im Vergleich zu denen ihrer Gesellschaft als gleichwertig dar. […] Bei den literaturwissenschaftlichen Studien zum postkolonialen Diskurs unterscheidet Lützeler zwei dominante Aspekte: Einen deskriptiven und einen programmatischen Aspekt. Für ihn hebt der deskriptive Aspekt die ungleichberechtigte Beziehung zwischen den ehemaligen kolonisierenden und kolonisierten Ländern hervor. Durch den programmatischen Aspekt aber setzt man sich zum Ziel, dieses Machtherrschaftsverhältnis zu überwinden, damit eine gleichberechtigte Beziehung zwischen „Erster und Dritter Welt bzw. Nord und Süd“ möglich wird. Die Überwindung der Machtherrschaftsverhältnisse in den Beziehungen zwischen Afrika und Europa, hier im kulturellen Bereich, ist meines Erachtens eine notwendige Voraussetzung für die gegenseitige Bereicherung. Für Hofmann soll der postkoloniale Umgang der Europäer mit den außereuropäischen Kulturen nicht mehr der einer kulturellen Bevormundung sein, sondern einen Dialog zulassen, in den beide Seiten ihr jeweils Bestes einbringen5. Wie wird der postkoloniale Umgang der Europäer mit der afrikanischen Kultur im Roman Morenga inszeniert? Dies ist die Ausgangsfrage, die ich in Mittelpunkt dieses Aufsatzes stelle.
Background: We assessed the hemodynamic performance of various prostheses and the clinical outcomes after aortic valve replacement, in different age groups.
Methods: One-hundred-and-twenty patients with isolated aortic valve stenosis were included in this prospective randomized randomised trial and allocated in three age-groups to receive either pulmonary autograft (PA, n = 20) or mechanical prosthesis (MP, Edwards Mira n = 20) in group 1 (age < 55 years), either stentless bioprosthesis (CE Prima Plus n = 20) or MP (Edwards Mira n = 20) in group 2 (age 55-75 years) and either stentless (CE Prima Plus n = 20) or stented bioprosthesis (CE Perimount n = 20) in group 3 (age > 75). Clinical outcomes and hemodynamic performance were evaluated at discharge, six months and one year.
Results: In group 1, patients with PA had significantly lower mean gradients than the MP (2.6 vs. 10.9 mmHg, p = 0.0005) with comparable left ventricular mass regression (LVMR). Morbidity included 1 stroke in the PA population and 1 gastrointestinal bleeding in the MP subgroup. In group 2, mean gradients did not differ significantly between both populations (7.0 vs. 8.9 mmHg, p = 0.81). The rate of LVMR and EF were comparable at 12 months; each group with one mortality. Morbidity included 1 stroke and 1 gastrointestinal bleeding in the stentless and 3 bleeding complications in the MP group. In group 3, mean gradients did not differ significantly (7.8 vs 6.5 mmHg, p = 0.06). Postoperative EF and LVMR were comparable. There were 3 deaths in the stented group and no mortality in the stentless group. Morbidity included 1 endocarditis and 1 stroke in the stentless compared to 1 endocarditis, 1 stroke and one pulmonary embolism in the stented group.
Conclusions: Clinical outcomes justify valve replacement with either valve substitute in the respective age groups. The PA hemodynamically outperformed the MPs. Stentless valves however, did not demonstrate significantly superior hemodynamics or outcomes in comparison to stented bioprosthesis or MPs.
Parece estranho à primeira vista tratarmos do tema da ausência, tão caro à antropologia, à semiótica e às artes. Para tanto, procederemos inicialmente a uma breve conceituação do termo, para depois passarmos a um curto panorama da produção cinematográfica dos últimos 20 anos na Alemanha, que geralmente acompanha tendências semelhantes na literatura. Verificaremos em que medida podem ser detectados elementos de ausência no cinema pós-muro na Alemanha. Em seguida, procederemos a uma análise de planos fílmicos de três filmes nos quais se evidencia a questão da ausência. Para este trabalho, utilizaremos como base teórica considerações de Lehmann/Weibel, Bernhard Waldenfels, Gilles Deleuze e Michel Chion.
This article provides an overview of valence lexicography and focuses especially on the Spanish-German case. Based on valence dictionaries and ongoing projects that describe the languages mentioned, this paper addresses the question of equivalence considering both quantitative and qualitative parameters and the various diffi culties found out through the process of description. A central role is ascribed to the problems surrounding the selection and description of equivalence in non-standard cases. Discussion of new theoretical and practical proposals is also included.