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DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer
(2011)
TAp63a, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. Remarkably, already undamaged oocytes express high levels of the protein, suggesting that TAp63a’s activity is under tight control of an inhibitory mechanism. Biochemical studies have proposed that inhibition requires the C-terminal transactivation inhibitory domain. However, the structural mechanism of TAp63a inhibition remains unknown. Here, we show that TAp63a is kept in an inactive dimeric state. We reveal that relief of inhibition leads to tetramer formation with ~20-fold higher DNA affinity. In vivo, phosphorylation-triggered tetramerization of TAp63a is not reversible by dephosphorylation. Furthermore, we show that a helix in the oligomerization domain of p63 is crucial for tetramer stabilization and competes with the transactivation domain for the same binding site. Our results demonstrate how TAp63a is inhibited by complex domain-domain interactions that provide the basis for regulating quality control in oocytes.
This paper studies the impact of the concentration of control, the type of controlling shareholder and the dividend tax preference of the controlling shareholder on dividend policy for a panel of 220 German firms over 1984-2005. While the concentration of control does not have an effect on the dividend payout, there is strong evidence that the type of controlling shareholder matters as family controlled firms have high dividend payouts whereas bank controlled firms have low dividend payouts. However, there is no evidence that the dividend preference of the large shareholder has an impact on the dividend decision. JEL Classification: G32, G35 Keywords: Dividend Policy, Payout Policy, Lintner Dividend Model, Tax Clientele Effects, Corporate Governance
Reproductive isolation among locally adapted populations may arise when immigrants from foreign habitats are selected against via natural or (inter-)sexual selection (female mate choice). We asked whether also intrasexual selection through male-male competition could promote reproductive isolation among populations of poeciliid fishes that are locally adapted to extreme environmental conditions [i.e., darkness in caves and/or toxic hydrogen sulphide (H(2)S)]. We found strongly reduced aggressiveness in extremophile P. oecilia mexicana, and darkness was the best predictor for the evolutionary reduction of aggressiveness, especially when combined with presence of H(2)S. We demonstrate that reduced aggression directly translates into migrant males being inferior when paired with males from non-sulphidic surface habitats. By contrast, the phylogenetically old sulphur endemic P. sulphuraria from another sulphide spring area showed no overall reduced aggressiveness, possibly indicating evolved mechanisms to better cope with H(2)S.
The southern Appalachian millipeds Boraria stricta (Brölemann, 1896) and B. infesta (Chamberlin, 1918) (Diplopoda: Polydesmida: Xystodesmidae) have become established in Westchester Co., New York, and Hartford Co., Connecticut, respectively. Only three individuals are available for the latter, but B. stricta has established a reproducing population in southern New York state. This species is also recorded from Bland Co., Virginia, in the Ridge and Valley Physiographic Province. Boraria profuga (Causey, 1955) comprises two allopatric populations, one in Montgomery Co., Arkansas, and the other in Ouachita Parish, Louisiana. Distributional records and gonopod drawings are presented for these species plus B. deturkiana (Causey, 1942).
Solving the problem of consciousness remains one of the biggest challenges in modern science. One key step towards understanding consciousness is to empirically narrow down neural processes associated with the subjective experience of a particular content. To unravel these neural correlates of consciousness (NCC) a common scientific strategy is to compare perceptual conditions in which consciousness of a particular content is present with those in which it is absent, and to determine differences in measures of brain activity (the so called "contrastive analysis"). However, this comparison appears not to reveal exclusively the NCC, as the NCC proper can be confounded with prerequisites for and consequences of conscious processing of the particular content. This implies that previous results cannot be unequivocally interpreted as reflecting the neural correlates of conscious experience. Here we review evidence supporting this conjecture and suggest experimental strategies to untangle the NCC from the prerequisites and consequences of conscious experience in order to further develop the otherwise valid and valuable contrastive methodology.
Diskus : Nr. 1.11
(2011)
Es ist bekannt, daß sich der theoretische Dissens zwischen Michel Foucault und Jacques Derrida, wie er seit den sechziger Jahren, seit Foucaults Buch "Wahnsinn und Gesellschaft", in den Texten beider Autoren seinen Niederschlag gefunden hat, anhand von Fragen entzündet hat, die die Problematik der Lektüre einiger Passagen der "Meditationes de Prima Philosophia" von René Descartes betreffen. Diese durchaus von polemischer Schärfe getragene Auseinandersetzung, deren z.T. unversöhnbar scheinende Rhetorik angesichts einer strategischen Nähe, die man prima facie zwischen den theoretischen Projekten beider vermuten könnte, verwundern mag, findet ihren Ausgangspunkt in Foucaults frühem Projekt einer Rekonstruktion des für die klassische und moderne Epoche angeblich konstitutiven Ausschlusses des Wahnsinns aus der Vernunft. [...]
Im folgenden werde ich zunächst die Position Foucaults in Bezug auf den Zusammenhang des Ausschlusses der wahnsinnigen Sprache aus der Vernunft und der Entstehung einer spezifischen Literatur erläutern. Die Erläuterung der Beziehung von Wahnsinn, Sprache, Vernunft und Literatur macht es notwendig, weitere Texte Foucaults heranzuziehen, trotz eines gewissen Vorbehalts bezüglich der Zulässigkeit einer Art der Rekonstruktion der Thesen Foucaults, die über verschiedene Texte hinweg zeitlich divergierende Stadien seiner Theorie als eine einheitliche und kohärente Theorie behandelt. Der dritte Teil widmet sich einer Rekonstruktion der theoretischen Verschiebung, die Derrida an Foucaults Projekt vornimmt. Schließlich folgt im letzten Teil eine Rekonstruktion der gegenseitig erhobenen Einwände im Rahmen eines Vergleichs beider Positionen und ein Aufriß der Strategie und Methodik.
The aim of this paper is to examine what has been the role of information provision to the market throughout the crisis. We consider two main sources of information to the market, financial statements and information provided by credit rating agencies. We examine how these sources of information work and the effectiveness of their disclosure process during the crisis. Contrary to the commonly held view, fair value accounting did not have a major impact on the crisis development and severity. However, the structure and lack of accountability of credit rating agencies had a profound impact on their incentives, which may have jeopardized the accuracy of the whole rating process. We claim that the crisis experience has changed the way we think about information as well as market discipline and discuss policy implications and proposals for regulation. JEL Classification: G01, G24, G28, M41, M48
Disability, Society and Theology: Voices from Africa is the result of a workshop which brought together African theologians, persons with disabilities and disability expertise in the Region to prepare resource materials to enrich the disability study process in the context of the Africa region. The book is in six parts and includes contributions from scholars across the continent. The parts are: Disability Theology: Issue to Debate; The Able Disabled and the Disabled Church: The Church's Response to Disability; Disability and Society; Disability Theology: Some Interfaces; Disability and Caregiving; and Disability in the African Experience.
STAR's measurements of directed flow (v1) around midrapidity for π±, K±, K0S, p and p¯ in Au + Au collisions at $\sqrtsNN = 200$ GeV are presented. A negative v1(y) slope is observed for most of produced particles (π±, K±, K0S and p¯). The proton v1(y) slope is found to be much closer to zero compared to antiprotons. A sizable difference is seen between v1 of protons and antiprotons in 5-30% central collisions. The v1 excitation function is presented. Comparisons to model calculations (RQMD, UrQMD, AMPT, QGSM with parton recombination, and a hydrodynamics model with a tilted source) are made. Anti-flow alone cannot explain the centrality dependence of the difference between the v1(y) slopes of protons and antiprotons.