Quercetin-induced lifespan extension in podospora anserina requires methylation of the flavonoid by the O-methyltransferase PaMTH1

  • Quercetin is a flavonoid that is ubiquitously found in vegetables and fruits. Like other flavonoids, it is active in balancing cellular reactive oxygen species (ROS) levels and has a cyto-protective function. Previously, a link between ROS balancing, aging, and the activity of O-methyltransferases was reported in different organisms including the aging model Podospora anserina. Here we describe a role of the S-adenosylmethionine-dependent O-methyltransferase PaMTH1 in quercetin-induced lifespan extension. We found that effects of quercetin treatment depend on the methylation state of the flavonoid. Specifically, we observed that quercetin treatment increases the lifespan of the wild type but not of the PaMth1 deletion mutant. The lifespan increasing effect is not associated with effects of quercetin on mitochondrial respiration or ROS levels but linked to the induction of the PaMth1 gene. Overall, our data demonstrate a novel role of O-methyltransferase in quercetin-induced longevity and identify the underlying pathway as part of a network of longevity assurance pathways with the perspective to intervene into mechanisms of biological aging.
Author:Verena WarnsmannORCiDGND, Saskia Hainbuch, Heinz D. OsiewaczORCiDGND
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29780405
Parent Title (English):Frontiers in genetics
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):S. Michal Jazwinsk
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/05/04
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/05/29
Tag:Podospora anserina; isorhamnetin; lifespan; methyltransferase; quercetin
Issue:Art. 160
Page Number:14
First Page:1
Last Page:14
Copyright: © 2018 Warnsmann, Hainbuch and Osiewacz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Institutes:Biowissenschaften / Biowissenschaften
Exzellenzcluster / Exzellenzcluster Makromolekulare Komplexe
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 4.0