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Darstellung und Eigenschaften von 5-Acetyl-4-methyl-1-(β -D-ribofuranosyl)-imidazol-5′-di- und -triphosphat
Synthesis and properties of 5-acetyl-4-methyl-1-(β-D-ribofuranosyl)-imidazole-5′ di- and -triphosphate
- 5-Acetyl-4-methyl-1-(β-D-ribofuranosyl) -imidazole-5′-phosphate reacts with diphenylphospho chloridate forming the asymmetrical pyrophosphate ester. This in turn reacts with tri-n-butylammonium phosphate yielding 5-acetyl-4-methyl-imidazole-riboside-5′-diphosphate and with tri-rcbutylammonium pyrophosphate to give the nucleotide triphosphate. 5-Acetyl-4-methyl-imidazole-riboside-5′-pyrophosphate shows in the test with pyruvate kinase a reaction rate three times slower than that of ADP; but the same Km as that of ADP. The ATP analogue is only about 10% as effective as ATP itself in the test with hexokinase, 3-phosphoglycerate kinase and gluconate kinase. Adenylate kinase and NAD+ kinase show no activity when ATP is replaced by the nucleotide-triphosphate-analogue. In presence of ATP the analogue strongly inhibits the reaction of adenylate kinase.
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| Author: | Gerd Johnscher, Jürgen BerghäuserGND, Christoph Woenckhaus |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-722278 |
| DOI: | https://doi.org/10.1515/znc-1975-1-206 |
| ISSN: | 0939-5075 |
| ISSN: | 1865-7125 |
| Parent Title (German): | Zeitschrift für Naturforschung, C |
| Publisher: | Verlag der Zeitschrift für Naturforschung |
| Place of publication: | Tübingen |
| Document Type: | Article |
| Language: | German |
| Date of Publication (online): | 2014/06/02 |
| Year of first Publication: | 1975 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2024/02/05 |
| Tag: | Enzymatic Behaviour; Kinases; Nucleotide Triphosphate Analogue |
| Volume: | 30.1975 |
| Issue: | 1-2 |
| Page Number: | 4 |
| First Page: | 25 |
| Last Page: | 28 |
| Institutes: | Medizin |
| Biochemie, Chemie und Pharmazie / Biochemie und Chemie | |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
