Clinical assessment of W-band spectroscopy for non-invasive detection and monitoring of sustained hyperglycemia
- HbA1c is the gold standard test for monitoring medium/long term glycemia conditions in diabetes care, which is a critical factor in reducing the risk of chronic diabetes complications. Current technologies for measuring HbA1c concentration are invasive and adequate assays are still limited to laboratory-based methods that are not widely available worldwide. The development of a non-invasive diagnostic tool for HbA1c concentration can lead to the decrease of the rate of undiagnosed cases and facilitate early detection in diabetes care. We present a preliminary validation diagnostic study of W-band spectroscopy for detection and monitoring of sustained hyperglycemia, using the HbA1c concentration as reference. A group of 20 patients with type 1 diabetes mellitus and 10 healthy subjects were non-invasively assessed at three different visits over a period of 7 months by a millimeter-wave spectrometer (transmission mode) operating across the full W-band. The relationship between the W-band spectral profile and the HbA1c concentration is studied using longitudinal and non-longitudinal functional data analysis methods. A potential blind discrimination between patients with or without diabetes is obtained, and more importantly, an excellent relation (R-squared = 0.97) between the non-invasive assessment and the HbA1c measure is achieved. Such results support that W-band spectroscopy has great potential for developing a non-invasive diagnostic tool for in-vivo HbA1c concentration monitoring in humans.
Author: | Aldo Moreno-OyervidesORCiD, M. Carmen Aguilera-Morillo, María José de la Cruz Fernández, Edurne Lecumberri Pascual, Lucía Llanos Jiménez, Viktor KrozerORCiDGND, Pablo AcedoORCiD |
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URN: | urn:nbn:de:hebis:30:3-630853 |
DOI: | https://doi.org/10.1364/BOE.428524 |
ISSN: | 2156-7085 |
Parent Title (English): | Biomedical optics express |
Publisher: | Optica |
Place of publication: | Washington, DC |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/07/19 |
Date of first Publication: | 2021/07/19 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2022/06/15 |
Volume: | 12.2021 |
Issue: | 8 |
Page Number: | 15 |
First Page: | 5008 |
Last Page: | 5022 |
Note: | Instituto de Salud Carlos III (DTS17/00135). Aldo Moreno-Oyervides thanks the Consejo Nacional de Ciencia y Tecnología de México (CONACYT) for financially supporting his doctoral education (PhD. Grant) associated to this work. This work has been supported by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with UC3M in the line of Excellence of University Professors (EPUC3M26), and in the context of the V PRICIT (Regional Programme of Research and Technological Innovation). |
HeBIS-PPN: | 497224259 |
Institutes: | Physik |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 51 Mathematik / 510 Mathematik |
5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik | |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Sammlungen: | Universitätspublikationen |
Licence (German): | Deutsches Urheberrecht |