Yonatan Sanz Perl, Carla Pallavicini, Ignacio Pérez Ipiña, Athena Demertzi, Vincent Bonhomme, Charlotte Martial, Rajanikant Panda, Jitka Annen, Agustín Ibáñez, Morten L. Kringelbach, Gustavo Deco, Helmut Laufs, Jacobo Sitt, Steven Laureys, Enzo Tagliazucchi
- Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.
MetadatenAuthor: | Yonatan Sanz PerlORCiD, Carla PallaviciniORCiD, Ignacio Pérez IpiñaORCiD, Athena DemertziORCiD, Vincent BonhommeORCiD, Charlotte MartialORCiD, Rajanikant PandaORCiD, Jitka AnnenORCiD, Agustín IbáñezORCiDGND, Morten L. KringelbachORCiDGND, Gustavo DecoORCiDGND, Helmut LaufsORCiDGND, Jacobo SittORCiD, Steven LaureysGND, Enzo TagliazucchiORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-628266 |
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DOI: | https://doi.org/10.1371/journal.pcbi.1009139 |
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ISSN: | 1553-7358 |
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Parent Title (English): | PLoS Computational Biology |
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Publisher: | Public Library of Science |
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Place of publication: | San Francisco, Calif. |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/07/27 |
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Date of first Publication: | 2021/07/27 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/04/26 |
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Volume: | 17 |
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Issue: | 7, art. e1009139 |
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Article Number: | e1009139 |
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Page Number: | 24 |
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First Page: | 1 |
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Last Page: | 24 |
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Note: | All code written in support of this publication and the Sleep data set is publicly available at https://github.com/yonisanzperl/Perturbation_in_dynamical_models
Data of disorders of Consciousness and anesthesia cannot be shared publicly because contains data and information from a clinical population of patients, and are not publicly available due to constraints imposed by the currently approved ethics protocol, but are available upon request to Comité d'Éthique Hospitalo-Facultaire Universitaire de Liège (https://www.chuliege.be/jcms/c2_16986309/fr/comite-d-ethique-hospitalo-facultaire-universitaire-de-liege/accueil): ethique@chuliege.be |
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HeBIS-PPN: | 508618681 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik |
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| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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