Photodynamic effects on the template activity of nucleic acids
- The photodynamic inactivation of nucleic acids with pyronin, methylene blue, thiopyronin and furocoumarines has been studied. The template efficiency of DNA in RNA-Polymerase reaction was found to be decreased after the treatment of DNA with these compounds. However, the magnitude of their inhibiting capacity varied from one compound to the other. Psoralen and thiopyronin were found to be the most active inhibitors followed by xanthotoxin and methylene blue respectively. At a lower temperature the inhibiting capacity of thiopyronin was considerably decreased but that of psoralen remained nearly unaffected. We have also tried to show evidence for a complimentary code in t-RNA through a specific destruction of guanine with thiopyronin.
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| Author: | Prakash ChandraGND, Adolf WackerGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-714030 |
| DOI: | https://doi.org/10.1515/znb-1966-0712 |
| ISSN: | 1865-7117 |
| ISSN: | 0932-0776 |
| Parent Title (German): | Zeitschrift für Naturforschung, B |
| Publisher: | Verlag der Zeitschrift für Naturforschung |
| Place of publication: | Tübingen |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2014/06/02 |
| Year of first Publication: | 1966 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/07/17 |
| Volume: | 21 |
| Issue: | 7 |
| Page Number: | 4 |
| First Page: | 663 |
| Last Page: | 666 |
| HeBIS-PPN: | 512575622 |
| Institutes: | Biochemie, Chemie und Pharmazie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
