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cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood

  • Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in the somatosensory system. Accumulating evidence suggests that cGMP regulates different cellular processes from embryonic development through to adulthood. During embryonic development, a cGMP-dependent signalling cascade in the trunk sensory system is essential for axon bifurcation, a specific form of branching of somatosensory axons. In adulthood, various cGMP signalling pathways in distinct cell populations of sensory neurons and dorsal horn neurons in the spinal cord play an important role in the processing of pain and itch. Some of the involved enzymes might serve as a target for future therapies. In this review, we summarise the knowledge regarding cGMP-dependent signalling pathways in dorsal root ganglia and the spinal cord during embryonic development and adulthood, and the potential of targeting these pathways. LINKED ARTICLES This article is part of a themed issue on cGMP Signalling in Cell Growth and Survival. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.11/issuetoc

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Author:Hannes Schmidt, Alexandra Böttcher, Tilman GroßGND, Achim SchmidtkoORCiDGND
URN:urn:nbn:de:hebis:30:3-723333
DOI:https://doi.org/10.1111/bph.15514
ISSN:1476-5381
Parent Title (English):British journal of pharmacology
Publisher:Wiley
Place of publication:Malden, MA
Document Type:Article
Language:English
Date of Publication (online):2021/05/03
Date of first Publication:2021/05/03
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/04/25
Tag:axon bifurcation; axon branching; cGMP signalling; dorsal root ganglia; itch; pain; somatosensory system; spinal cord
Volume:179
Issue:11
Page Number:17
First Page:2361
Last Page:2377
Note:
The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) with Research Unit FOR 2060 project SCHM 2371/1 to Hannes Schmidt, project 335549539/GRK2381 to Alexandra Böttcher and Hannes Schmidt and Research Unit FOR 2060 project SCHM 2629/3-1 and project SCHM 2629/4-1 to Achim Schmidtko. This article is based in part upon work from the DFG-funded Research Unit FOR 2060.
HeBIS-PPN:508586313
Institutes:Biochemie, Chemie und Pharmazie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0

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