Aktivierung von Steroidsystemen zu alkylierenden Agenzien
Activation of steroid systems to alkylating agents
- 7-Dehydrocholesterol and ergosterol are oxidised by iodine and FeCl3 under "physiologically similar" conditions to highly reactive alkylating species. These can be trapped by nucleophiles, such as 1-methylimidazole. The oxidation of the sterols to those alkylating species is discussed as a model-reaction for the first step in chemical carcinogenesis by endogene substrates.
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| Author: | Manfred Wilk, Karlheinz SchmittGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-698603 |
| DOI: | https://doi.org/10.1515/znb-1981-0222 |
| ISSN: | 1865-7117 |
| ISSN: | 0932-0776 |
| Parent Title (German): | Zeitschrift für Naturforschung, B |
| Publisher: | Verlag der Zeitschrift für Naturforschung |
| Place of publication: | Tübingen |
| Document Type: | Article |
| Language: | German |
| Date of Publication (online): | 2014/06/02 |
| Year of first Publication: | 1981 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/07/05 |
| Tag: | 7-Dehydrocholesterol; Endogene Carcinogenesis; Oxidation |
| Volume: | 36 |
| Issue: | 2 |
| Page Number: | 4 |
| First Page: | 248 |
| Last Page: | 251 |
| HeBIS-PPN: | 511914806 |
| Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
