Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity and emerges early during adult neurogenesis

  • Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large ones. We analysed the impact of synaptic activity and plasticity on the spine size distribution in adult-born hippocampal granule cells from rats with induced homo- and heterosynaptic long-term plasticity in vivo and CA1 pyramidal cells from Munc-13-1-Munc13-2 knockout mice with completely blocked synaptic transmission. Neither induction of extrinsic synaptic plasticity nor the blockage of presynaptic activity degrades the lognormal-like distribution but changes its mean, variance and skewness. The skewed distribution develops early in the life of the neuron. Our findings and their computational modelling support the idea that intrinsic synaptic plasticity is sufficient for the generation, while a combination of intrinsic and extrinsic synaptic plasticity maintains lognormal like distribution of spines.

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Author:Nina RößlerORCiD, Tassilo JungenitzORCiDGND, Albrecht SiglerGND, Alexander D BirdORCiD, Martin MittagORCiD, Jeong Seop RheeORCiD, Thomas DellerORCiDGND, Hermann CuntzORCiDGND, Nils BroseGND, Stephan SchwarzacherORCiDGND, Peter JedličkaORCiDGND
Parent Title (English):bioRxiv
Document Type:Preprint
Date of Publication (online):2023/03/15
Date of first Publication:2023/03/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/03/24
Page Number:49
Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International