PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

  • A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.

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Author:Antonius A. de WaardORCiD, Tamara VerkerkORCiD, Marlieke L. M. JongsmaORCiD, Kelly Hoefakker, Sunesh SethumadhavanORCiDGND, Carolin GerkeGND, Sophie Bliss, Xiangrui Kong, George M. C. JanssenORCiD, Arnoud H. de Ru, Frans H. J. ClaasORCiDGND, Arend MulderORCiD, Robert TampéORCiDGND, Peter A. van VeelenORCiD, Anne HaleniusORCiDGND, Robbert M. SpaapenORCiD
URN:urn:nbn:de:hebis:30:3-732869
DOI:https://doi.org/https://doi.org/10.1002/eji.202048599
Parent Title (English):European Journal of Immunology
Publisher:Wiley-VCH
Place of publication:Weinheim
Document Type:Article
Language:English
Year of Completion:2021
Year of first Publication:2021
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/03/18
Tag:APM; CRISPR/Cas9; HLA class I; MHC; antigen presentation
Volume:51
Issue:3
Page Number:4
First Page:734
Last Page:737
HeBIS-PPN:508737184
Institutes:Biochemie, Chemie und Pharmazie / Biochemie und Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International

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