Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding

  • Vampire bats are the only mammals that feed exclusively on blood. To uncover genomic changes associated with this dietary adaptation, we generated a haplotype-resolved genome of the common vampire bat and screened 27 bat species for genes that were specifically lost in the vampire bat lineage. We found previously unknown gene losses that relate to reduced insulin secretion (FFAR1 and SLC30A8), limited glycogen stores (PPP1R3E), and a unique gastric physiology (CTSE). Other gene losses likely reflect the biased nutrient composition (ERN2 and CTRL) and distinct pathogen diversity of blood (RNASE7) and predict the complete lack of cone-based vision in these strictly nocturnal bats (PDE6H and PDE6C). Notably, REP15 loss likely helped vampire bats adapt to high dietary iron levels by enhancing iron excretion, and the loss of CYP39A1 could have contributed to their exceptional cognitive abilities. These findings enhance our understanding of vampire bat biology and the genomic underpinnings of adaptations to blood feeding.

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Author:Moritz BlumerORCiD, Thomas BrownORCiD, Mariella Bontempo FreitasORCiD, Ana Luiza DestroORCiD, Juraci A. OliveiraORCiD, Ariadna E. MoralesORCiD, Tilman SchellORCiDGND, Carola GreveORCiDGND, Martin PippelORCiDGND, David Jebb, Nikolai HeckerORCiD, Alexis-Walid Ahmed, Bogdan M. KirilenkoORCiDGND, Maddy FooteORCiD, Axel JankeORCiD, Burton K. LimORCiD, Michael HillerORCiDGND
Parent Title (English):Science Advances
Publisher:American Association for the Advancement of Science
Place of publication:Washington, DC [u.a.]
Document Type:Article
Date of Publication (online):2022/03/25
Date of first Publication:2022/03/25
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/07/10
Issue:12, eabm6494
Page Number:16
Biowissenschaften / Institut für Ökologie, Evolution und Diversität
Fachübergreifende Einrichtungen / Biodiversität und Klima Forschungszentrum (BiK-F)
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0