Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development
- Different molecular pathways involved in maintaining mitochondrial function are of fundamental importance to control cellular homeostasis. Mitochondrial i-AAA protease is part of such a surveillance system, and PaIAP is the putative ortholog in the fungal aging model Podospora anserina. Here, we investigate the role of PaIAP in aging and development. Deletion of the gene encoding PaIAP resulted in a specific phenotype. When incubated at 27°C, spore germination and fruiting body formation are not different from that of the corresponding wild-type strain. Unexpectedly, the lifespan of the deletion strain is strongly increased. In contrast, cultivation at an elevated temperature of 37°C leads to impairments in spore germination and fruiting body formation and to a reduced lifespan. The higher PaIAP abundance in wild-type strains of the fungus grown at elevated temperature and the phenotype of the deletion strain unmasks a temperature-related role of the protein. The protease appears to be part of a molecular system that has evolved to allow survival under changing temperatures, as they characteristically occur in nature.
Verfasserangaben: | Andrea Weil, Karin Luce, Stefan DröseORCiDGND, Ilka WittigORCiD, Ulrich BrandtORCiDGND, Heinz D. OsiewaczORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-314958 |
DOI: | https://doi.org/10.4161/cc.10.24.18560 |
ISSN: | 1551-4005 |
ISSN: | 1538-4101 |
Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/22134244 |
Titel des übergeordneten Werkes (Englisch): | Cell cycle |
Verlag: | Landes Bioscience |
Verlagsort: | Georgetown, Tex. |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Datum der Veröffentlichung (online): | 06.09.2013 |
Jahr der Erstveröffentlichung: | 2011 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 06.09.2013 |
Freies Schlagwort / Tag: | Podospora anserina; aging; i-AAA protease; mitochondria; protein quality control; temperature |
Jahrgang: | 10 |
Ausgabe / Heft: | 24 |
Seitenzahl: | 11 |
Erste Seite: | 4280 |
Letzte Seite: | 4290 |
Bemerkung: | © 2011 Landes Bioscience |
HeBIS-PPN: | 353136352 |
Institute: | Biowissenschaften / Biowissenschaften |
Medizin / Medizin | |
DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Sammlungen: | Universitätspublikationen |
Sammlung Biologie / Sondersammelgebiets-Volltexte | |
Lizenz (Deutsch): | Deutsches Urheberrecht |