Hemmung der steroidabhängigen Enzyminduktion bei Pseudomonas testosteroni mit Alkaloiden
- Induction of the enzyme Δ5-3-ketosteroid isomerase in Pseudomonas testosteroni was found to be strongly inhibited by reserpine and by the alkaloids of Vinca and Ergot. Morphine, colchicine and papaverine caused weaker inhibition whilst a series of other alkaloids were almost ineffective. Ergot alkaloids were inhibitory towards all steroids tested, androgens, oestrogens and progestagens, and a similar effect was shown with the other inducible enzymes, 3α- and 3β.17β-hydroxysteroid-dehydrogenase. Experiments with cell-free protein synthesis indicate that reserpine inhibits the induction of messenger RNA.
Author: | M. Maturová, Helga Beckmann, Adolf WackerGND |
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URN: | urn:nbn:de:hebis:30:3-748758 |
DOI: | https://doi.org/10.1515/znb-1967-0611 |
ISSN: | 1865-7117 |
ISSN: | 0932-0776 |
Parent Title (German): | Zeitschrift für Naturforschung, B |
Publisher: | Verlag der Zeitschrift für Naturforschung |
Place of publication: | Tübingen |
Document Type: | Article |
Language: | German |
Date of Publication (online): | 2014/06/02 |
Year of first Publication: | 1967 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/02/07 |
Volume: | 22.1967 |
Issue: | 6 |
Page Number: | 6 |
First Page: | 621 |
Last Page: | 626 |
Institutes: | Biochemie, Chemie und Pharmazie / Biochemie und Chemie |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
Sammlungen: | Universitätspublikationen |
Licence (German): | ![]() |