Influence of ridge preservation procedures on extraction socket healing under antiresorptive therapy: An experimental study in rabbits
- Background: To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy. Material and Methods: A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino‐bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZa]) (n = 5). At 6 months, the mandibular and maxillary molars were extracted and the four experimental sites randomly allocated to the following subgroups: (a) socket grafting using a collagen‐coated natural bone mineral (BOC) + primary wound closure, (b) coronectomy (CO), or (c) spontaneous healing + primary wound closure (SP). Za medication was continued for another 4 months. Histomorphometrical analyses considered, for example, crestal hard tissue closure of the extraction site (C) and mineralized tissue (MT) formation. Results: Za‐SP was associated with an incomplete median C (31.76% vs 100% in nZa‐SP) and signs of bone arrosion along the confines of the socket. BOC had no major effects on increases in C and MT values in the Za group. CO commonly resulted in an encapsulation and partial replacement resorption of residual roots by MT without any histological signs of osteonecrosis. Conclusions: (a) Za‐SP was commonly associated with a compromised socket healing and signs of osteonecrosis, (b) BOC had no major effect on socket healing in the Za group, and (c) CO at noninfected teeth might be a feasible measure for the prevention of a Za‐related osteonecrosis of the jaw.
Author: | Frank SchwarzORCiDGND, Gordon JohnORCiDGND, Jürgen Becker, Knut Achim Grötz, Robert Alexander SaderORCiDGND, Ilja MihatovicGND |
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URN: | urn:nbn:de:hebis:30:3-564673 |
DOI: | https://doi.org/10.1111/cid.12916 |
ISSN: | 1708-8208 |
ISSN: | 1523-0899 |
Parent Title (English): | Clinical implant dentistry and related research |
Publisher: | Wiley-Blackwell |
Place of publication: | Oxford [u.a.] |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2020/06/15 |
Date of first Publication: | 2020/06/15 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2020/11/11 |
Tag: | animal experiment; antiresorptive agents; extraction socket healing; histological technic; ridge preservation |
Volume: | 22 |
Issue: | 4 |
Page Number: | 9 |
First Page: | 477 |
Last Page: | 485 |
HeBIS-PPN: | 477035248 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (English): | Creative Commons - Namensnennung-Nicht kommerziell 4.0 |