Tineke Grent-'t-Jong, Joachim Groß, Jozien Goense, Michael Wibral, Ruchika Gajwani, Andrew I. Gumley, Stephen M. Lawrie, Matthias Schwannauer, Frauke Schultze-Lutter, Tobias Navarro Schröder, Dagmar Köthe, F. Markus Leweke, Wolf Singer, Peter J. Uhlhaas
- We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.
MetadatenAuthor: | Tineke Grent-'t-JongORCiDGND, Joachim GroßORCiD, Jozien Goense, Michael WibralORCiDGND, Ruchika Gajwani, Andrew I. Gumley, Stephen M. LawrieORCiDGND, Matthias SchwannauerORCiD, Frauke Schultze-LutterORCiDGND, Tobias Navarro Schröder, Dagmar KötheORCiDGND, F. Markus LewekeORCiDGND, Wolf SingerORCiDGND, Peter J. UhlhaasORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-476915 |
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DOI: | https://doi.org/10.7554/eLife.37799 |
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ISSN: | 2050-084X |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30260771 |
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Parent Title (English): | eLife |
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Publisher: | eLife Sciences Publications |
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Place of publication: | Cambridge |
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Contributor(s): | Richard B. Ivry |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2018 |
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Date of first Publication: | 2018/09/27 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2018/10/16 |
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Tag: | E/I-Balance; Gamma-Band Activity; Neuroscience; Research Article; Schizophrenia; human |
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Volume: | 7 |
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Issue: | e37799 |
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Page Number: | 19 |
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First Page: | 1 |
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Last Page: | 19 |
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Note: | Copyright Grent-’t-Jong et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
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HeBIS-PPN: | 439213126 |
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Institutes: | Medizin / Medizin |
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| Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS) |
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| Angeschlossene und kooperierende Institutionen / MPI für Hirnforschung |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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