Robert Benedikt Höh, Jan Lukas Hohenhorst, Mike Wenzel, Clara Julia Humke, Felix Martin Preißer, Clarissa Wittler, Marie Brand, Jens Köllermann, Thomas Steuber, Markus Graefen, Derya Tilki, Pierre I. Karakiewicz, Andreas Becker, Luis Kluth, Felix Chun, Philipp Mandel
- The objective of the study was to test the impact of implementing standard full functional-length urethral sphincter (FFLU) and neurovascular bundle preservation (NVBP) with intraoperative frozen section technique (IFT) on long-term urinary continence in patients undergoing robotic-assisted radical prostatectomy (RARP). We relied on an institutional tertiary-care database to identify patients who underwent RARP between 01/2014 and 09/2019. Until 10/2017, FFLU was not performed and decision for NVBP was taken without IFT. From 11/2017, FFLU and IFT-guided NVBP was routinely performed in all patients undergoing RARP. Long-term continence (≥ 12 months) was defined as the usage of no or one safety- pad. Uni- and multivariable logistic regression models tested the correlation between surgical approach (standard vs FFLU + NVBP) and long-term continence. Covariates consisted of age, body mass index, prostate volume and extraprostatic extension of tumor. The study cohort consisted of 142 patients, with equally sized groups for standard vs FFLU + NVBP RARP (68 vs 74 patients). Routine FFLU + NVBP implementation resulted in a long-term continence rate of 91%, compared to 63% in standard RARP (p < 0.001). Following FFLU + NVBP RARP, 5% needed 1–2, 4% 3–5 pads/24 h and no patient (0%) suffered severe long-term incontinence (> 5 pads/24 h). No significant differences in patient or tumor characteristics were recorded between both groups. In multivariable logistic regression models, FFLU + NVBP was a robust predictor for continence (Odds ratio [OR]: 7.62; 95% CI 2.51–27.36; p < 0.001). Implementation of FFLU and NVBP in patients undergoing RARP results in improved long-term continence rates of 91%.
MetadatenAuthor: | Robert Benedikt HöhORCiDGND, Jan Lukas HohenhorstORCiD, Mike WenzelORCiDGND, Clara Julia HumkeGND, Felix Martin PreißerORCiDGND, Clarissa WittlerGND, Marie Brand, Jens KöllermannORCiDGND, Thomas SteuberGND, Markus GraefenORCiDGND, Derya TilkiORCiDGND, Pierre I. Karakiewicz, Andreas BeckerGND, Luis KluthORCiDGND, Felix ChunORCiDGND, Philipp MandelORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-694960 |
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DOI: | https://doi.org/10.1007/s11701-022-01408-7 |
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ISSN: | 1863-2491 |
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Parent Title (English): | Journal of robotic surgery |
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Publisher: | Springer |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/04/22 |
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Date of first Publication: | 2022/04/22 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/05/11 |
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Tag: | FFLU; Functional outcomes; NVBP; Radical prostatectomy; Urinary continence; Urinary incontinence |
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Volume: | 17 |
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Issue: | 1 |
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Page Number: | 8 |
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First Page: | 177 |
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Last Page: | 184 |
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Note: | Open Access funding enabled and organized by Projekt DEAL. |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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