Mike Wenzel, Christoph Würnschimmel, Francesco Chierigo, Zhe Tian, Shahrokh F. Shariat, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Séverine Banek, Luis Kluth, Philipp Mandel, Felix Chun, Pierre I. Karakiewicz
- Background: To analyze postoperative, in-hospital, complication rates in patients with organ transplantation before radical prostatectomy (RP). Methods: From National Inpatient Sample (NIS) database (2000–2015) prostate cancer patients treated with RP were abstracted and stratified according to prior organ transplant versus nontransplant. Multivariable logistic regression models predicted in-hospital complications. Results: Of all eligible 202,419 RP patients, 216 (0.1%) underwent RP after prior organ transplantation. Transplant RP patients exhibited higher proportions of Charlson comorbidity index ≥2 (13.0% vs. 3.0%), obesity (9.3% vs. 5.6%, both p < 0.05), versus to nontransplant RP. Of transplant RP patients, 96 underwent kidney (44.4%), 44 heart (20.4%), 40 liver (18.5%), 30 (13.9%) bone marrow, <11 lung (<5%), and <11 pancreatic (<5%) transplantation before RP. Within transplant RP patients, rates of lymph node dissection ranged from 37.5% (kidney transplant) to 60.0% (bone marrow transplant, p < 0.01) versus 51% in nontransplant patients. Regarding in-hospital complications, transplant patients more frequently exhibited, diabetic (31.5% vs. 11.6%, p < 0.001), major (7.9% vs. 2.9%) cardiac complications (3.2% vs. 1.2%, p = 0.01), and acute kidney failure (5.1% vs. 0.9%, p < 0.001), versus nontransplant RP. In multivariable logistic regression models, transplant RP patients were at higher risk of acute kidney failure (odds ratio [OR]: 4.83), diabetic (OR: 2.81), major (OR: 2.39), intraoperative (OR: 2.38), cardiac (OR: 2.16), transfusion (OR: 1.37), and overall complications (1.36, all p < 0.001). No in-hospital mortalities were recorded in transplant patients after RP. Conclusions: Of all transplants before RP, kidney ranks first. RP patients with prior transplantation have an increased risk of in-hospital complications. The highest risk, relative to nontransplant RP patients appears to acute kidney failure.
MetadatenAuthor: | Mike WenzelORCiDGND, Christoph WürnschimmelORCiDGND, Francesco ChierigoORCiD, Zhe Tian, Shahrokh F. ShariatORCiDGND, Carlo TerroneORCiDGND, Fred SaadORCiDGND, Derya TilkiORCiDGND, Markus GraefenORCiDGND, Séverine BanekGND, Luis KluthORCiDGND, Philipp MandelORCiDGND, Felix ChunORCiDGND, Pierre I. Karakiewicz |
---|
URN: | urn:nbn:de:hebis:30:3-644110 |
---|
DOI: | https://doi.org/10.1002/pros.24224 |
---|
ISSN: | 1097-0045 |
---|
Parent Title (English): | The prostate |
---|
Publisher: | Wiley-Liss |
---|
Place of publication: | New York, NY |
---|
Document Type: | Article |
---|
Language: | English |
---|
Date of Publication (online): | 2021/09/13 |
---|
Date of first Publication: | 2021/09/13 |
---|
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
---|
Release Date: | 2022/01/13 |
---|
Tag: | bone barrow; heart; kidney; liver; surgical complications |
---|
Volume: | 81 |
---|
Issue: | 16 |
---|
Page Number: | 9 |
---|
First Page: | 1294 |
---|
Last Page: | 1302 |
---|
Note: | The research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Open Access funding enabled and organized by Projekt DEAL. |
---|
HeBIS-PPN: | 490811981 |
---|
Institutes: | Medizin |
---|
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
---|
Sammlungen: | Universitätspublikationen |
---|
Licence (English): | Creative Commons - Namensnennung-Nicht kommerziell 4.0 |
---|