Tumor-associated immune cell infiltrate density in penile squamous cell carcinomas
- Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapted to the individual patient. Fifty-five therapy naïve squamous cell carcinomas, age range between 41 and 85 years with known clinicopathological data, were investigated with the use of tissue microarrays (TMA) regarding the tumor-associated immune cell infiltrate density (ICID). Slides were stained with antibodies against CD3, CD8 and CD20. An image analysis software was applied for evaluation. Data were correlated with clinicopathological characteristics and overall survival. There was a significant increase of ICID in squamous cell carcinomas of the penis in relation to tumor adjacent physiological tissue. Higher CD3-positive ICID was significantly associated with lower tumor stage in our cohort. The ICID was not associated with overall survival. Our data sharpens the view on tumor-associated immune cell infiltrate in penile squamous cell carcinomas with an unbiased digital and automated cell count. Further investigations on the immune cell infiltrate and its prognostic and possible therapeutic impact are needed.
Author: | Luca Hladek, Katrin BankovORCiDGND, Jens Müller-von der GrünORCiDGND, Sonja Natalie FilmannGND, Melanie Christin DemesGND, Stefan ValloGND, Peter Johannes WildORCiDGND, Anne Ria WinkelmannORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-696192 |
DOI: | https://doi.org/10.1007/s00428-022-03271-1 |
ISSN: | 1432-2307 |
Parent Title (English): | Virchows Archiv |
Publisher: | Springer |
Place of publication: | Berlin ; Heidelberg |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/01/13 |
Date of first Publication: | 2022/01/13 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/11/06 |
Tag: | Antibodies; Penile carcinomas; Tissue microarray; Tumor microenvironment |
Volume: | 480 |
Issue: | 6 |
Page Number: | 11 |
First Page: | 1159 |
Last Page: | 1169 |
Note: | Open Access funding enabled and organized by Projekt DEAL. |
HeBIS-PPN: | 515679755 |
Institutes: | Medizin |
Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS) | |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |