Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction
- Class I ventral posterior dendritic arborisation (c1vpda) proprioceptive sensory neurons respond to contractions in the Drosophila larval body wall during crawling. Their dendritic branches run along the direction of contraction, possibly a functional requirement to maximise membrane curvature during crawling contractions. Although the molecular machinery of dendritic patterning in c1vpda has been extensively studied, the process leading to the precise elaboration of their comb-like shapes remains elusive. Here, to link dendrite shape with its proprioceptive role, we performed long-term, non-invasive, in vivo time-lapse imaging of c1vpda embryonic and larval morphogenesis to reveal a sequence of differentiation stages. We combined computer models and dendritic branch dynamics tracking to propose that distinct sequential phases of stochastic growth and retraction achieve efficient dendritic trees both in terms of wire and function. Our study shows how dendrite growth balances structure–function requirements, shedding new light on general principles of self-organisation in functionally specialised dendrites.
Author: | André Ferreira CastroORCiDGND, Lothar Gunnar BaltruschatGND, Tomke StürnerORCiDGND, Amirhoushang BahramiGND, Peter JedličkaORCiDGND, Gaia TavosanisORCiDGND, Hermann CuntzORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-733942 |
DOI: | https://doi.org/10.7554/eLife.60920 |
ISSN: | 2050-084X |
Parent Title (German): | eLife |
Publisher: | eLife Sciences Publications |
Place of publication: | Cambridge |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2020/11/26 |
Date of first Publication: | 2020/11/26 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/03/24 |
Volume: | 9 |
Issue: | e60920 |
Page Number: | 30 |
HeBIS-PPN: | 508322189 |
Institutes: | Medizin |
Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS) | |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |