Robert Benedikt Höh, Jan L. Hohenhorst, Rocco Simone Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F. Shariat, Luis Kluth, Andreas Becker, Felix Chun, Pierre I. Karakiewicz
- Purpose: To test for differences in cancer-specific mortality (CSM) rates in Hispanic/Latino prostate cancer patients according to treatment type, radical prostatectomy (RP) vs external beam radiotherapy (EBRT).
Methods: Within the Surveillance, Epidemiology, and End Results database (2010–2016), we identified 2290 NCCN (National Comprehensive Cancer Network) high-risk (HR) Hispanic/Latino prostate cancer patients. Of those, 893 (39.0%) were treated with RP vs 1397 (61.0%) with EBRT. First, cumulative incidence plots and competing risks regression models tested for CSM differences after adjustment for other cause mortality (OCM). Second, cumulative incidence plots and competing risks regression models were refitted after 1:1 propensity score matching (according to age, PSA, biopsy Gleason score, cT-stage, cN-stage).
Results: In NCCN HR patients, 5-year CSM rates for RP vs EBRT were 2.4 vs 4.7%, yielding a multivariable hazard ratio of 0.37 (95% CI 0.19–0.73, p = 0.004) favoring RP. However, after propensity score matching, the hazard ratio of 0.54 was no longer statistically significant (95% CI 0.21–1.39, p = 0.2).
Conclusion: Without the use of strictest adjustment for population differences, NCCN high-risk Hispanic/Latino prostate cancer patients appear to benefit more of RP than EBRT. However, after strictest adjustment for baseline patient and tumor characteristics between RP and EBRT cohorts, the apparent CSM benefit of RP is no longer statistically significant. In consequence, in Hispanic/Latino NCCN high-risk patients, either treatment modality results in similar CSM outcome.
MetadatenAuthor: | Robert Benedikt HöhORCiDGND, Jan L. HohenhorstORCiD, Rocco Simone FlammiaORCiD, Benedikt Horlemann, Gabriele SorceORCiD, Francesco ChierigoORCiD, Zhe Tian, Fred SaadORCiDGND, Markus GraefenORCiDGND, Michele GallucciORCiD, Alberto BrigantiORCiD, Carlo TerroneORCiDGND, Shahrokh F. ShariatORCiDGND, Luis KluthORCiDGND, Andreas BeckerGND, Felix ChunORCiDGND, Pierre I. Karakiewicz |
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URN: | urn:nbn:de:hebis:30:3-695528 |
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DOI: | https://doi.org/10.1007/s11255-021-03055-7 |
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ISSN: | 1573-2584 |
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Parent Title (English): | International urology and nephrology |
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Publisher: | Springer Science + Business Media B.V. |
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Place of publication: | Dordrecht [u.a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/11/16 |
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Date of first Publication: | 2021/11/16 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/08/17 |
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Tag: | Cancer-specific survival; External beam radiotherapy; High-risk prostate cancer; Hispanic–Latino race/ethnicity; Radical prostatectomy |
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Volume: | 54 |
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Issue: | 1 |
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Page Number: | 7 |
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First Page: | 81 |
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Last Page: | 87 |
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Note: | Open Access funding enabled and organized by Projekt DEAL. |
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Note: | All data generated for this analysis were from the SEER database. The code for the analyses will be made available upon request. |
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HeBIS-PPN: | 512572585 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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