Daniel Dubinski, Sae-Yeon Won, Bedjan Behmanesh, Maximilian Dosch, Viktoria Schneider, Peter Baumgarten, Joshua D. Bernstock, Martin Voß, Patrick Schuß, Jürgen Konczalla, Marcus Alexander Czabanka, Thomas Michael Freiman, Florian Geßler
- Background: Glioblastoma (GBM) patients are at particularly high risk for thrombotic complications. In the event of a postoperative pulmonary embolism, therapeutic anticoagulation (tAC) is indispensable. The impact of therapeutic anticoagulation on recurrence pattern in GBM is currently unknown. Methods: We conducted a matched-pair cohort analysis of 57 GBM patients with or without tAC that were matched for age, sex, gross total resection and MGMT methylation status in a ratio of 1:2. Patients’ characteristics and clinical course were evaluated using medical charts. MRI characteristics were evaluated by two independent authors blinded to the AC status. Results: The morphologic MRI appearance in first GBM recurrence showed a significantly higher presence of multifocal, midline crossing and sharp demarcated GBM recurrence patterns in patients with therapeutic tAC compared to the matched control group. Although statistically non-significant, the therapeutic tAC cohort showed increased survival. Conclusion: Therapeutic anticoagulation induced significant morphologic changes in GBM recurrences. The underlying pathophysiology is discussed in this article but remains to be further elucidated.
Metadaten| Author: | Daniel DubinskiORCiDGND, Sae-Yeon WonORCiDGND, Bedjan BehmaneshORCiDGND, Maximilian DoschGND, Viktoria SchneiderGND, Peter BaumgartenORCiDGND, Joshua D. BernstockORCiD, Martin VoßORCiDGND, Patrick SchußORCiDGND, Jürgen KonczallaORCiDGND, Marcus Alexander CzabankaORCiDGND, Thomas Michael FreimanORCiDGND, Florian GeßlerORCiDGND |
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| URN: | urn:nbn:de:hebis:30:3-800339 |
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| DOI: | https://doi.org/10.3390/jcm11020422 |
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| ISSN: | 2077-0383 |
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| Parent Title (English): | Journal of Clinical Medicine |
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| Publisher: | MDPI |
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| Place of publication: | Basel |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2022/01/14 |
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| Date of first Publication: | 2022/01/14 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2023/12/06 |
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| Tag: | glioblastoma survival; pulmonary embolism; recurrence pattern; therapeutic anticoagulation |
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| Volume: | 11 |
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| Issue: | 2, art. 422 |
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| Article Number: | 422 |
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| Page Number: | 8 |
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| First Page: | 1 |
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| Last Page: | 8 |
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| HeBIS-PPN: | 516555138 |
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| Institutes: | Medizin |
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| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
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