Pavol Mikolas, Kyra Bröckel, Christoph Vogelbacher, Dirk K. Müller, Michael Marxen, Christina Berndt, Cathrin Sauer, Stine Jung, Juliane Hilde Fröhner, Andreas J. Fallgatter, Thomas Ethofer, Anne Katrin Rau, Tilo Kircher, Dania Irina Falkenberg, Martin Lambert, Vivien Kraft, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Thomas Stamm, Felix Bermpohl, Jana Fiebig, Georg Juckel, Vera Flasbeck, Christoph U. Correll, Philipp Stefan Ritter, Michael Bauer, Andreas Jansen, Andrea Pfennig
- In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used magnetic resonance imaging (MRI) data from a multicenter study to assess structural gray matter alterations in N = 263 help-seeking individuals from seven study sites. We defined the risk using the EPIbipolar assessment tool as no-risk, low-risk, and high-risk and used a region-of-interest approach (ROI) based on the results of two large-scale multicenter studies of bipolar disorder by the ENIGMA working group. We detected significant differences in the thickness of the left pars opercularis (Cohen’s d = 0.47, p = 0.024) between groups. The cortex was significantly thinner in high-risk individuals compared to those in the no-risk group (p = 0.011). We detected no differences in the hippocampal volume. Exploratory analyses revealed no significant differences in other cortical or subcortical regions. The thinner cortex in help-seeking individuals at risk of bipolar disorder is in line with previous findings in patients with the established disorder and corresponds to the region of the highest effect size in the ENIGMA study of cortical alterations. Structural alterations in prefrontal cortex might be a trait marker of bipolar risk. This is the largest structural MRI study of help-seeking individuals at increased risk of bipolar disorder.
MetadatenAuthor: | Pavol MikolasORCiD, Kyra Bröckel, Christoph VogelbacherORCiDGND, Dirk K. Müller, Michael MarxenORCiD, Christina Berndt, Cathrin Sauer, Stine Jung, Juliane Hilde FröhnerORCiD, Andreas J. FallgatterORCiD, Thomas Ethofer, Anne Katrin Rau, Tilo KircherORCiDGND, Dania Irina FalkenbergORCiDGND, Martin Lambert, Vivien KraftORCiD, Karolina Leopold, Andreas BechdolfGND, Andreas ReifORCiDGND, Silke MaturaORCiDGND, Thomas Stamm, Felix BermpohlORCiD, Jana Fiebig, Georg Juckel, Vera FlasbeckORCiDGND, Christoph U. Correll, Philipp Stefan RitterORCiDGND, Michael BauerORCiD, Andreas JansenORCiDGND, Andrea PfennigORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-645614 |
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DOI: | https://doi.org/10.1038/s41398-021-01598-y |
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ISSN: | 2158-3188 |
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Parent Title (English): | Translational Psychiatry |
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Publisher: | Nature Publishing Group |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/09/20 |
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Date of first Publication: | 2021/09/20 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2022/04/11 |
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Tag: | Bipolar disorder; Diagnostic markers |
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Volume: | 11 |
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Issue: | art. 485 |
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Page Number: | 8 |
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First Page: | 1 |
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Last Page: | 8 |
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Note: | Early-BipoLife is funded by the Federal Ministry of Education and Research (BMBF, grant numbers: 01EE1404A, 01EE1404E, and 01EE1404F). M.M. was supported by the Deutsche Forschungsgemeinschaft (DFG grant Nos. 178833530 [SFB 940] and 402170461 [TRR 265]. |
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HeBIS-PPN: | 494894601 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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