Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications
- Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes. What was once regarded as a mere signal for protein degradation has turned out to be a major regulator of molecular signalling networks. Deregulation of ubiquitin signalling is closely associated with various human pathologies. Here, we summarize the current knowledge of ubiquitin signalling in immune deficiencies and cancer as well as the available therapeutic strategies targeting the ubiquitin system in combating these pathogenic conditions.
| Author: | Simone FuldaORCiDGND, Krishnaraj RajalingamORCiDGND, Ivan ĐikićORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-287713 |
| DOI: | https://doi.org/10.1002/emmm.20110070 |
| ISSN: | 1715-4684 |
| ISSN: | 1757-4676 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/22730341 |
| Parent Title (English): | EMBO molecular medicine |
| Publisher: | Wiley-VCH |
| Place of publication: | Weinheim |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2012/06/25 |
| Date of first Publication: | 2012/06/25 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/02/07 |
| Tag: | NF-κB; apoptosis; cell death; inflammation; ubiquitin |
| Volume: | 4 |
| Issue: | 7 |
| Page Number: | 12 |
| First Page: | 545 |
| Last Page: | 556 |
| Note: | Copyright © 2012 EMBO Molecular Medicine. This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| HeBIS-PPN: | 328084433 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell 3.0 |
