Unveiling ubiquitinome rearrangements induced by salmonella infection

  • Ubiquitination plays a critical role in the activation of host immune responses to infection and serves as a signal for pathogen delivery to phagophores along the xenophagy pathway. We recently performed systematic ubiquitination site profiling of epithelial cells infected with Salmonella Typhimurium. Our findings specifically highlight components of the NFKB, membrane trafficking pathways and RHO GTPase systems as ubiquitination hubs during infection. In addition, a broad spectrum of bacterial effectors and several outer membrane proteins are ubiquitinated in infected cells. This comprehensive resource of ubiquitinome dynamics during Salmonella infection enables further understanding of the complex host-pathogen interplay and may reveal novel targets for the inhibition of Salmonella invasion and inflammation.

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Author:Tihana Bionda, Christian Behrends
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/27467224
Parent Title (English):Autophagy
Publisher:Taylor & Francis
Place of publication:Abingdon, Oxon
Document Type:Article
Date of Publication (online):2016/12/01
Date of first Publication:2016/07/28
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2016/12/01
Tag:Salmonella infection; immune response; ubiquitin coat; ubiquitination; xenophagy
Page Number:3
First Page:1683
Last Page:1684
© 2016 Tihana Bionda and Christian Behrends. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0