Unveiling ubiquitinome rearrangements induced by salmonella infection
- Ubiquitination plays a critical role in the activation of host immune responses to infection and serves as a signal for pathogen delivery to phagophores along the xenophagy pathway. We recently performed systematic ubiquitination site profiling of epithelial cells infected with Salmonella Typhimurium. Our findings specifically highlight components of the NFKB, membrane trafficking pathways and RHO GTPase systems as ubiquitination hubs during infection. In addition, a broad spectrum of bacterial effectors and several outer membrane proteins are ubiquitinated in infected cells. This comprehensive resource of ubiquitinome dynamics during Salmonella infection enables further understanding of the complex host-pathogen interplay and may reveal novel targets for the inhibition of Salmonella invasion and inflammation.
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| Author: | Tihana Bionda, Christian Behrends |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-422627 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082772 |
| DOI: | https://doi.org/10.1080/15548627.2016.1203490 |
| ISSN: | 1554-8627 |
| ISSN: | 1554-8635 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27467224 |
| Parent Title (English): | Autophagy |
| Publisher: | Taylor & Francis |
| Place of publication: | Abingdon, Oxon |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2016/12/01 |
| Date of first Publication: | 2016/07/28 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2016/12/01 |
| Tag: | Salmonella infection; immune response; ubiquitin coat; ubiquitination; xenophagy |
| Volume: | 12 |
| Issue: | 9 |
| Page Number: | 3 |
| First Page: | 1683 |
| Last Page: | 1684 |
| Note: | © 2016 Tihana Bionda and Christian Behrends. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| HeBIS-PPN: | 425191753 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell 3.0 |
