Learning-related plasticity in dendrite-targeting layer 1 interneurons

  • A wealth of data has elucidated the mechanisms by which sensory inputs are encoded in the neocortex, but how these processes are regulated by the behavioral relevance of sensory information is less understood. Here, we focus on neocortical layer 1 (L1), a key location for processing of such top-down information. Using Neuron-Derived Neurotrophic Factor (NDNF) as a selective marker of L1 interneurons (INs) and in vivo 2-photon calcium imaging, electrophysiology, viral tracing, optogenetics, and associative memory, we find that L1 NDNF-INs mediate a prolonged form of inhibition in distal pyramidal neuron dendrites that correlates with the strength of the memory trace. Conversely, inhibition from Martinotti cells remains unchanged after conditioning but in turn tightly controls sensory responses in NDNF-INs. These results define a genetically addressable form of dendritic inhibition that is highly experience dependent and indicate that in addition to disinhibition, salient stimuli are encoded at elevated levels of distal dendritic inhibition.
Metadaten
Author:Elisabeth Abs, Rogier B. Poorthuis, Daniella Apelblat, Karzan Muhammad, M. Belen Pardi, Leona Enke, Dahlia Kushinsky, De-Lin Pu, Max Ferdinand Eizinger, Karl-Klaus Conzelmann, Ivo Spiegel, Johannes J. Letzkus
URN:urn:nbn:de:hebis:30:3-483569
DOI:https://doi.org/10.1016/j.neuron.2018.09.001
ISSN:1097-4199
ISSN:0896-6273
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30269988
Parent Title (English):Neuron
Publisher:Cell Press ; Elsevier
Place of publication:[Cambridge, Mass.] ; New York, NY
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/09/27
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2018/11/27
Tag:GABAergic interneurons; NDNF interneurons; connectivity; dendritic inhibition; fear learning; genetic markers; interneurons; layer 1; neocortical circuits; somatostatin interneurons; top-down processing
Volume:100
Issue:3
Page Number:23
First Page:684
Last Page:699.e6
Note:
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
HeBIS-PPN:440895383
Institutes:Medizin / Medizin
Wissenschaftliche Zentren und koordinierte Programme / Sonderforschungsbereiche / Forschungskollegs
Angeschlossene und kooperierende Institutionen / MPI f├╝r Hirnforschung
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0