Testosterone is not associated with traits of optimism or pessimism : observational evidence from the prospective DETECT study

  • Background: Previous experimental research on testosterone (T) and psychological traits is inconclusive. Thus, we performed the first large-scale observational study of the association between T and dispositional optimism / pessimism. Methods: We used prospective data from 6,493 primary-care patients (3,840 women) of the DETECT study (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment), including repeated immunoassay-based measurement of serum T and optimism / pessimism assessed by the revised Life-Orientation Test (LOT-R). Cross-sectional and longitudinal associations of baseline T and one-year change in T with optimism and pessimism were investigated using age- and multivariable-adjusted regression models. Results: Cross-sectional analyses showed no association of T with optimism or pessimism in both sexes. Longitudinal analyses also showed no association of baseline T with optimism or pessimism at four-year follow-up. Multivariable analyses of total LOT-R score yielded similarly non-significant results (β-coefficient per unit change in T for men: -0.01 (95% CI: -0.24–0.22), women: 0.08 (-0.03–0.20)). Furthermore, change in T was not related to optimism or pessimism at four-year follow-up. Conclusions: The present observational study of a large-scale prospective sample showed no association of T with optimism or pessimism. Integrating further experimental and interventional evidence from alternative methodological approaches would strengthen this conclusion and establish stronger evidence about the potential hormonal basis of psychological traits.

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Author:Hanna Kische, Jürgen Hoyer, Lars Pieper, John Venz, Jens Klotsche, Winfried März, Uwe Koch-Gromus, David Pittrow, Hendrik Lehnert, Sigmund Silber, Günter K. Stalla, Andreas M. ZeiherORCiDGND, Hans-Ulrich Wittchen, Robin Haring
URN:urn:nbn:de:hebis:30:3-484266
DOI:https://doi.org/10.1371/journal.pone.0207870
ISSN:1932-6203
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30496216
Parent Title (English):PLoS one
Publisher:PLoS
Place of publication:Lawrence, Kan.
Contributor(s):Peter Karl Jonason
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/11/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/12/04
Tag:Alcohol consumption; Blood pressure; Decision making; Depression; Emotions; Mental health and psychiatry; Observational studies; Testosterone
Volume:13
Issue:(11): e0207870
Page Number:8
First Page:1
Last Page:8
Note:
Copyright: © 2018 Kische et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HeBIS-PPN:439902541
Institutes:Medizin / Medizin
Exzellenzcluster / Exzellenzcluster Herz-Lungen-System
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0