In vivo functional diversity of midbrain dopamine neurons within identified axonal projections

  • Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement in behaving animals. Distinct in vitro biophysical features of DA neurons have been associated with different axonal projection targets. However, it is unknown how this translates to different firing patterns of projection-defined DA subpopulations in the intact brain. We combined retrograde tracing with single-unit recording and labelling in mouse brain to create an in vivo functional topography of the midbrain DA system. We identified differences in burst firing among DA neurons projecting to dorsolateral striatum. Bursting also differentiated DA neurons in the medial substantia nigra (SN) projecting either to dorsal or ventral striatum. We found differences in mean firing rates and pause durations among ventral tegmental area (VTA) DA neurons projecting to lateral or medial shell of nucleus accumbens. Our data establishes a high-resolution functional in vivo landscape of midbrain DA neurons.
Metadaten
Author:Navid FarassatORCiDGND, Kauê Machado CostaORCiDGND, Strahinja StojanovicORCiD, Stefan Albert, Lora KovachevaORCiD, Josef ShinORCiD, Richard Egger, Mahalakshmi Somayaji, Sevil Duvarci, Gaby SchneiderGND, Jochen Roeper
URN:urn:nbn:de:hebis:30:3-510974
DOI:https://doi.org/10.7554/eLife.48408
ISSN:2050-084X
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31580257
Parent Title (English):eLife
Publisher:eLife Sciences Publications
Place of publication:Cambridge
Contributor(s):Olivier J. Manzoni
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/10/03
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/10/16
Tag:Action potential; Axon; Burst; Dopamine; Mouse; Neuroscience; Pause; Research article; Striatum
Volume:8
Issue:e48408
Page Number:27
First Page:1
Last Page:27
Note:
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication
HeBIS-PPN:455688796
Institutes:Informatik und Mathematik / Mathematik
Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoGemeinfreies Werk / Public Domain