Rapid neuromodulation of ayer 1 interneurons in human neocortex

  • Inhibitory interneurons govern virtually all computations in neocortical circuits and are in turn controlled by neuromodulation. While a detailed understanding of the distinct marker expression, physiology, and neuromodulator responses of different interneuron types exists for rodents and recent studies have highlighted the role of specific interneurons in converting rapid neuromodulatory signals into altered sensory processing during locomotion, attention, and associative learning, it remains little understood whether similar mechanisms exist in human neocortex. Here, we use whole-cell recordings combined with agonist application, transgenic mouse lines, in situ hybridization, and unbiased clustering to directly determine these features in human layer 1 interneurons (L1-INs). Our results indicate pronounced nicotinic recruitment of all L1-INs, whereas only a small subset co-expresses the ionotropic HTR3 receptor. In addition to human specializations, we observe two comparable physiologically and genetically distinct L1-IN types in both species, together indicating conserved rapid neuromodulation of human neocortical circuits through layer 1.
Metadaten
Author:Rogier B. Poorthuis, Karzan Muhammad, Mantian Wang, Matthijs B. Verhoog, Stephan Junek, Anne Wrana, Huibert D. Mansvelder, Johannes J. Letzkus
URN:urn:nbn:de:hebis:30:3-511137
DOI:https://doi.org/10.1016/j.celrep.2018.03.111
ISSN:2211-1247
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29694902
Parent Title (English):Cell reports
Publisher:Cell Press ; Elsevier
Place of publication:Maryland Heights, MO ; [New York, NY]
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/04/25
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2019/10/16
Tag:cell types; evolution; genetic markers; human neocortex; interneuron types; layer 1 interneurons; mouse neocortex; neocortical circuits; neuromodulation; translation; whole-cell recordings
Volume:23
Issue:4
Page Number:9
First Page:951
Last Page:958
Note:
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
HeBIS-PPN:455330786
Institutes:Wirtschaftswissenschaften / Wirtschaftswissenschaften
Angeschlossene und kooperierende Institutionen / MPI f├╝r Hirnforschung
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0