Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

  • Background: Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated. Methods: Therefore, we used pro-thrombotic venous milieu generation by bare metal stent transjugular intrahepatic portosystemic shunt insertion, to study the role of prostanoids in decompensated liver cirrhosis. Here, 89 patients receiving transjugular intrahepatic portosystemic shunt insertion were included in the study, and baseline levels of thromboxane B2, prostaglandin D2 and prostaglandin E2 were measured in the portal and the hepatic vein. Results: While the hepatic vein contained higher levels of thromboxane B2 than the portal vein, levels of prostaglandin E2 and D2 were higher in the portal vein (all P<0.0001). Baseline concentrations of thromboxane B2 in the portal vein were independently associated with an increase of portal hepatic venous pressure gradient during short term follow-up, as an indirect sign of thrombogenic potential (multivariable P = 0.004). Moreover, severity of liver disease was inversely correlated with portal as well as hepatic vein levels of prostaglandin D2 and E2 (all P<0.0001). Conclusions: Elevated portal venous thromboxane B2 concentrations are possibly associated with the extent of thrombogenic potential in patients with decompensated liver cirrhosis. Trial registration: identifier: NCT03584204.
Author:Alexander Queck, Dominique Jeanette ThomasORCiDGND, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Schwarzkopf, Marcus Maximilian MückeORCiDGND, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan ZeuzemORCiDGND, Gerd GeisslingerORCiDGND, Jonel TrebickaORCiDGND, Christian Lange
Pubmed Id:
Parent Title (English):PLoS one
Place of publication:Lawrence, Kan.
Contributor(s):Matias A. Avila
Document Type:Article
Year of Completion:2019
Date of first Publication:2019/10/23
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/10/28
Tag:Cirrhosis; Liver diseases; Platelets; Portal veins; Prostaglandin; Thrombosis; Thromboxane; Veins
Issue:(10): e0222840
Page Number:12
First Page:1
Last Page:12
Copyright: © 2019 Queck et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0