Longitudinal developmental trajectories do not follow cross-sectional age associations in hippocampal subfield and memory development

  • Cross-sectional findings suggest that volumes of specific hippocampal subfields increase in middle childhood and early adolescence. In contrast, a small number of available longitudinal studies reported decreased volumes in most subfields over this age range. Further, it remains unknown whether structural changes in development are associated with corresponding gains in children’s memory. Here we report cross-sectional age differences in children’s hippocampal subfield volumes together with longitudinal developmental trajectories and their relationships with memory performance. In two waves, 109 participants aged 6–10 years (wave 1: MAge=7.25, wave 2: MAge=9.27) underwent high-resolution magnetic resonance imaging to assess hippocampal subfield volumes (imaging data available at both waves for 65 participants) and completed tasks assessing hippocampus dependent memory processes. We found that cross-sectional age-associations and longitudinal developmental trends in hippocampal subfield volumes were discrepant, both by subfields and in direction. Further, volumetric changes were largely unrelated to changes in memory, with the exception that increase in subiculum volume was associated with gains in spatial memory. Longitudinal and cross-sectional patterns of brain-cognition couplings were also discrepant. We discuss potential sources of these discrepancies. This study underscores that children’s structural brain development and its relationship to cognition cannot be inferred from cross-sectional age comparisons.
Metadaten
Author:Attila Keresztes, Laurel RaffingtonORCiDGND, Andrew R. Bender, Katharina Bögl, Christine HeimORCiDGND, Yee Lee ShingORCiDGND
URN:urn:nbn:de:hebis:30:3-630860
DOI:https://doi.org/10.1016/j.dcn.2022.101085
ISSN:1878-9307
Parent Title (English):Developmental cognitive neuroscience
Publisher:Elsevier
Place of publication:Amsterdam [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2022/02/19
Date of first Publication:2022/02/19
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/05/23
Tag:Associative memory; Hippocampus; Mnemonic discrimination; Pattern separation; Spatial memory; Subiculum
Volume:54
Issue:art. 101085
Page Number:14
First Page:1
Last Page:14
Note:
This study was supported by the Jacobs Foundation [grant 2014-1151 to YLS and CH] and conducted at the Center for Lifespan Psychology, Max Planck Institute for Human Development. The work of YLS was funded by a Minerva Research Group from the Max Planck Society, as well as from the European Union [ERC-2018-StG-PIVOTAL-758898], Jacobs Foundation [JRF 2018-2020], and Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, [Project-ID 327654276, SFB 1315], ”Mechanisms and Disturbances in Memory Consolidation: From Synapses to Systems”). A.K. was supported by the Hungarian National Research, Development and Innovation Office – NKFIH [FK 128648], and a Max Planck Partner Group from the Max Planck Society. K.B. was supported by the DFG (Project-ID 337619223/RTG 2386).
HeBIS-PPN:495855936
Institutes:Psychologie und Sportwissenschaften
Dewey Decimal Classification:1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0