Role of POC INR in the early stage of diagnosis of coagulopathy

  • Background: Acute bleeding requires fast and targeted therapy. Therefore, knowledge of the patient's potential to form a clot is crucial. Point-of-care testing (POCT) provides fast and reliable information on coagulation. Structural circumstances, such as person-bound sample transport, can prolong the reporting of the results. The aim of the present study was to investigate the diagnostic quality and accuracy between POCT INR diagnostics and standard laboratory analysis (SLA) as well as the time advantage between a pneumatic tube and a personal-based transport system. Methods: Two groups of haemorrhagic patients (EG: emergency department; OG: delivery room; each n = 12) were examined in the context of bleeding emergencies using POCT and SLA. Samples were transported via a pneumatic tube system or by a personal transport service. Results: INR results between POCT and SLA showed a high and significant correlation (EG: p < 0.001; OG: p < 0.001). POCT results were reported significantly more quickly (EG: 1.1 vs. 39.6 min; OG: 2.0 vs. 75.0 min; p < 0.001) and required less time for analysis (EG: 0.3 vs. 24.0 min; OG: 0.5 vs. 45.0 min; p < 0.001) compared to SLA. The time for transportation with the pneumatic tube was significantly shorter (8.0 vs. 18.5 min; p < 0.001) than with the personal-based transport system. Conclusion: The results of the present study suggest that POCT may be a suitable method for the emergency diagnosis and may be used as prognostic diagnostic elements in haemotherapy algorithms to initiate targeted haemotherapy at an early point in time.

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Author:Florian Jürgen RaimannORCiDGND, Gesche Marie-Louise LindnerGND, Christoph Martin, Lukas JenneweinORCiDGND, Thomas LustenbergerORCiDGND, Florian PiekarskiORCiDGND, Kai ZacharowskiORCiDGND, Christian Friedrich WeberORCiDGND
URN:urn:nbn:de:hebis:30:3-630887
DOI:https://doi.org/10.1016/j.plabm.2021.e00238
ISSN:2352-5517
Parent Title (English):Practical laboratory medicine
Publisher:Elsevier
Place of publication:Amsterdam [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2021/05/23
Date of first Publication:2021/05/23
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/07/04
Tag:Bleeding; INR; International normalized ratio; Point-of-care testing
Volume:26.2021
Issue:art. e00238
Article Number:e00238
Page Number:8
First Page:1
Last Page:8
HeBIS-PPN:502341130
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0