Mike Wenzel, Christoph Würnschimmel, Claudia Collà Ruvolo, Luigi Nocera, Zhe Tian, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis Kluth, Philipp Mandel, Felix Chun, Pierre I. Karakiewicz
- Background: Recently, an increase in the rates of high-risk prostate cancer (PCa) was reported. We tested whether the rates of and low, intermediate, high and very high-risk PCa changed over time. We also tested whether the number of prostate biopsy cores contributed to changes rates over time. Methods: Within the Surveillance, Epidemiology and End Results (SEER) database (2010–2015), annual rates of low, intermediate, high-risk according to traditional National Comprehensive Cancer Network (NCCN) and high versus very high-risk PCa according to Johns Hopkins classification were tabulated without and with adjustment for the number of prostate biopsy cores. Results: In 119,574 eligible prostate cancer patients, the rates of NCCN low, intermediate, and high-risk PCa were, respectively, 29.7%, 47.8%, and 22.5%. Of high-risk patients, 39.6% and 60.4% fulfilled high and very high-risk criteria. Without adjustment for number of prostate biopsy cores, the estimated annual percentage changes (EAPC) for low, intermediate, high and very high-risk were respectively −5.5% (32.4%–24.9%, p < .01), +0.5% (47.6%–48.4%, p = .09), +4.1% (8.2%–9.9%, p < .01), and +8.9% (11.8%–16.9%, p < .01), between 2010 and 2015. After adjustment for number of prostate biopsy cores, differences in rates over time disappeared and ranged from 29.8%–29.7% for low risk, 47.9%–47.9% for intermediate risk, 8.9%–9.0% for high-risk, and 13.6%–13.6% for very high-risk PCa (all p > .05). Conclusions: The rates of high and very high-risk PCa are strongly associated with the number of prostate biopsy cores, that in turn may be driven by broader use magnetic resonance imaging (MRI).
MetadatenAuthor: | Mike WenzelORCiDGND, Christoph WürnschimmelORCiDGND, Claudia Collà RuvoloORCiD, Luigi NoceraORCiD, Zhe Tian, Fred SaadORCiDGND, Alberto BrigantiORCiD, Derya TilkiORCiDGND, Markus GraefenORCiDGND, Luis KluthORCiDGND, Philipp MandelORCiDGND, Felix ChunORCiDGND, Pierre I. Karakiewicz |
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URN: | urn:nbn:de:hebis:30:3-639269 |
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DOI: | https://doi.org/10.1002/pros.24184 |
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ISSN: | 1097-0045 |
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Parent Title (English): | The prostate |
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Publisher: | Wiley-Liss |
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Place of publication: | New York, NY |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/06/29 |
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Date of first Publication: | 2021/06/29 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2022/04/05 |
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Tag: | Gleason grade group; NCCN; intermediate risk; low risk; stage; very high risk |
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Volume: | 81 |
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Issue: | 12 |
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Page Number: | 8 |
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First Page: | 874 |
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Last Page: | 881 |
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Note: | Open Access funding enabled and organized by Projekt DEAL. |
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HeBIS-PPN: | 493745785 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (English): | Creative Commons - Namensnennung-Nicht kommerziell 4.0 |
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