Increased risk of postoperative in-hospital complications after radical prostatectomy in patients with prior organ transplant

  • Background: To analyze postoperative, in-hospital, complication rates in patients with organ transplantation before radical prostatectomy (RP). Methods: From National Inpatient Sample (NIS) database (2000–2015) prostate cancer patients treated with RP were abstracted and stratified according to prior organ transplant versus nontransplant. Multivariable logistic regression models predicted in-hospital complications. Results: Of all eligible 202,419 RP patients, 216 (0.1%) underwent RP after prior organ transplantation. Transplant RP patients exhibited higher proportions of Charlson comorbidity index ≥2 (13.0% vs. 3.0%), obesity (9.3% vs. 5.6%, both p < 0.05), versus to nontransplant RP. Of transplant RP patients, 96 underwent kidney (44.4%), 44 heart (20.4%), 40 liver (18.5%), 30 (13.9%) bone marrow, <11 lung (<5%), and <11 pancreatic (<5%) transplantation before RP. Within transplant RP patients, rates of lymph node dissection ranged from 37.5% (kidney transplant) to 60.0% (bone marrow transplant, p < 0.01) versus 51% in nontransplant patients. Regarding in-hospital complications, transplant patients more frequently exhibited, diabetic (31.5% vs. 11.6%, p < 0.001), major (7.9% vs. 2.9%) cardiac complications (3.2% vs. 1.2%, p = 0.01), and acute kidney failure (5.1% vs. 0.9%, p < 0.001), versus nontransplant RP. In multivariable logistic regression models, transplant RP patients were at higher risk of acute kidney failure (odds ratio [OR]: 4.83), diabetic (OR: 2.81), major (OR: 2.39), intraoperative (OR: 2.38), cardiac (OR: 2.16), transfusion (OR: 1.37), and overall complications (1.36, all p < 0.001). No in-hospital mortalities were recorded in transplant patients after RP. Conclusions: Of all transplants before RP, kidney ranks first. RP patients with prior transplantation have an increased risk of in-hospital complications. The highest risk, relative to nontransplant RP patients appears to acute kidney failure.

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Author:Mike WenzelORCiDGND, Christoph WürnschimmelORCiD, Francesco Chierigo, Zhe Tian, Shahrokh F. Shariat, Carlo Terrone, Fred Saad, Derya TilkiORCiDGND, Markus Graefen, Séverine BanekGND, Luis KluthORCiDGND, Philipp Mandel, Felix ChunORCiDGND, Pierre I. Karakiewicz
URN:urn:nbn:de:hebis:30:3-644110
DOI:https://doi.org/10.1002/pros.24224
ISSN:1097-0045
Parent Title (English):The prostate
Publisher:Wiley-Liss
Place of publication:New York, NY
Document Type:Article
Language:English
Date of Publication (online):2021/09/13
Date of first Publication:2021/09/13
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/01/13
Tag:bone barrow; heart; kidney; liver; surgical complications
Volume:81
Issue:16
Page Number:9
First Page:1294
Last Page:1302
Note:
The research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Open Access funding enabled and organized by Projekt DEAL.
HeBIS-PPN:490811981
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0