Modeling the effects of neuronal morphology on dendritic chloride diffusion and GABAergic inhibition
- Poster presentation at the Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014. Gamma-aminobutyric acid receptors (GABAARs) are ligand-gated chloride (Cl−) channels which mediate the majority of inhibitory neurotransmission in the CNS. Spatiotemporal changes of intracellular Cl− concentration alter the concentration gradient for Cl− across the neuronal membrane and thus affect the current flow through GABAARs and the efficacy of GABAergic inhibition. However, the impact of complex neuronal morphology on Cl− diffusion and the redistribution of intracellular Cl− is not well understood. Recently, computational models for Cl− diffusion and GABAAR-mediated inhibition in realistic neuronal morphologies became available [1-3]. Here we have used computational models of morphologically complex dendrites to test the effects of spines on Cl− diffusion. In all dendritic morphologies tested, spines slowed down longitudinal Cl− diffusion along dendrites and decreased the amount and spatial spread of synaptically evoked Cl− changes. Spine densities of 2-10 spines/µm decreased the longitudinal diffusion coefficient of Cl− to 80-30% of its value in smooth dendrites, respectively. These results suggest that spines are able to limit short-term ionic plasticity [4] at dendritic GABAergic synapses.
Verfasserangaben: | Namrata Mohapatra, Fidel Santamaria, Peter JedličkaORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-347170 |
DOI: | https://doi.org/10.1186/1471-2202-15-S1-P138 |
ISSN: | 1471-2202 |
Titel des übergeordneten Werkes (Englisch): | BMC neuroscience |
Verlag: | BioMed Central |
Verlagsort: | London |
Dokumentart: | Konferenzveröffentlichung |
Sprache: | Englisch |
Datum der Veröffentlichung (online): | 21.07.2014 |
Datum der Erstveröffentlichung: | 21.07.2014 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 25.07.2014 |
Jahrgang: | 15(Suppl 1) |
Ausgabe / Heft: | P138 |
Seitenzahl: | 1 |
Bemerkung: | © 2014 Mohapatra et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
HeBIS-PPN: | 432883495 |
Institute: | Medizin / Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Lizenz (Deutsch): | ![]() |