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Schommers, Philipp Frederik ; Grüll, Henning ; Abernathy, Morgan E. ; Tran, My-Kim ; Dingens, Adam S. ; Gristick, Harry B. ; Barnes, Christopher O. ; Schoofs, Till ; Schlotz, Maike ; Vanshylla, Kanika ; Kreer, Christoph ; Weiland, Daniela ; Holtick, Udo ; Scheid, Christof ; Valter, Markus ; Gils, Marit J. van ; Sanders, Rogier W. ; Vehreschild, Jörg Janne ; Cornely, Oliver Andreas ; Lehmann, Clara ; Fätkenheuer, Gerd ; Seaman, Michael S. ; Bloom, Jesse D. ; Bjorkman, Pamela J. ; Klein, Florian
Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope glycoprotein (Env) limits clinical applications. Here we describe 1-18, a new VH1-46-encoded CD4 binding site (CD4bs) bNAb with outstanding breadth (97%) and potency (GeoMean IC50 = 0.048 μg/mL). Notably, 1-18 is not susceptible to typical CD4bs escape mutations and effectively overcomes HIV-1 resistance to other CD4bs bNAbs. Moreover, mutational antigenic profiling uncovered restricted pathways of HIV-1 escape. Of most promise for therapeutic use, even 1-18 alone fully suppressed viremia in HIV-1-infected humanized mice without selecting for resistant viral variants. A 2.5-Å cryo-EM structure of a 1-18-BG505SOSIP.664 Env complex revealed that these characteristics are likely facilitated by a heavy-chain insertion and increased inter-protomer contacts. The ability of 1-18 to effectively restrict HIV-1 escape pathways provides a new option to successfully prevent and treat HIV-1 infection.
Medema, Marnix H. ; Kottmann, Renzo ; Yilmaz, Pelin ; Cummings, Matthew ; Biggins, John B. ; Kai, Blin ; de Bruijn, Irene ; Chooi, Yit Heng ; Claesen, Jan ; Coates, R. Cameron ; Cruz-Morales, Pablo ; Duddela, Srikanth ; Düsterhus, Stephanie ; Edwards, Daniel J. ; Fewer, David P. ; Garg, Neha ; Geiger, Christoph ; Gomez-Escribano, Juan Pablo ; Greule, Anja ; Hadjithomas, Michalis ; Haines, Anthony S. ; Helfrich, Eric J. N. ; Hillwig, Matthew L. ; Ishida, Keishi ; Jones, Adam C. ; Jones, Carla S. ; Jungmann, Katrin ; Kegler, Carsten ; Kim, Hyun Uk ; Kötter, Peter ; Krug, Daniel ; Masschelein, Joleen ; Melnik, Alexey V. ; Mantovan, Simone M. ; Monroe, Emily A. ; Moore, Marcus ; Moss, Nathan ; Nützmann, Hans-Wilhelm ; Pan, Guohui ; Pati, Amrita ; Petras, Daniel ; Reen, F. Jerry ; Rosconi, Federico ; Rui, Zhe ; Tian, Zhenhua ; Tobias, Nicholas J. ; Tsunematsu, Yuta ; Wiemann, Philipp ; Wyckoff, Elizabeth ; Yan, Xiaohui ; Yim, Grace ; Yu, Fengan ; Xie, Yunchang ; Aigle, Bertrand ; Apel, Alexander K. ; Balibar, Carl J. ; Balskus, Emily P. ; Barona-Gómez, Francisco ; Bechthold, Andreas ; Bode, Helge Björn ; Borriss, Rainer ; Brady, Sean F. ; Brakhage, Axel A. ; Caffrey, Patrick ; Cheng, Yi-Qiang ; Clardy, Jon ; Cox, Russell J. ; De Mot, René ; Donadio, Stefano ; Donia, Mohamed S. ; van der Donk, Wilfred A. ; Dorrestein, Pieter C. ; Doyle, Sean ; Driessen, Arnold J. M. ; Ehling-Schulz, Monika ; Entian, Karl-Dieter ; Fischbach, Michael A. ; Gerwick, Lena ; Gerwick, William H. ; Gross, Harald ; Gust, Bertolt ; Hertweck, Christian ; Höfte, Monica ; Jensen, Susan E. ; Ju, Jianhua ; Katz, Leonard ; Kaysser, Leonard ; Klassen, Jonathan L. ; Keller, Nancy P. ; Kormanec, Jan ; Kuipers, Oscar P. ; Kuzuyama, Tomohisa ; Kyrpides, Nikos C. ; Kwon, Hyung-Jin ; Lautru, Sylvie ; Lavigne, Rob ; Lee, Chia Y. ; Linquan, Bai ; Liu, Xinyu ; Liu, Wen ; Luzhetskyy, Andriy ; Mahmud, Taifo ; Mast, Yvonne ; Méndez, Carmen ; Metsä-Ketelä, Mikko ; Micklefield, Jason ; Mitchell, Douglas A. ; Moore, Bradley S. ; Moreira, Leonilde M. ; Müller, Rolf ; Neilan, Brett A. ; Nett, Markus ; Nielsen, Jens ; O’Gara, Fergal ; Oikawa, Hideaki ; Osbourn, Anne ; Osburne, Marcia S. ; Ostash, Bohdan ; Payne, Shelley M. ; Pernodet, Jean-Luc ; Petricek, Miroslav ; Piel, Jörn ; Ploux, Olivier ; Raaijmakers, Jos M. ; Salas, José A. ; Schmitt, Esther K. ; Scott, Barry ; Seipke, Ryan F. ; Shen, Ben ; Sherman, David H. ; Sivonen, Kaarina ; Smanski, Michael J. ; Sosio, Margherita ; Stegmann, Evi ; Süssmuth, Roderich D. ; Tahlan, Kapil ; Thomas, Christopher M. ; Tang, Yi ; Truman, Andrew W. ; Viaud, Muriel ; Walton, Jonathan D. ; Walsh, Christopher T. ; Weber, Tilmann ; van Wezel, Gilles P. ; Wilkinson, Barrie ; Willey, Joanne M. ; Wohlleben, Wolfgang ; Wright, Gerard D. ; Ziemert, Nadine ; Zhang, Changsheng ; Zotchev, Sergey B. ; Breitling, Rainer ; Takano, Eriko ; Glöckner, Frank Oliver
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
Non-standard errors
(2021)
Menkveld, Albert J. ; Dreber, Anna ; Holzmeister, Felix ; Huber, Jürgen ; Johannesson, Magnus ; Kirchler, Michael ; Razen, Michael ; Weitzel, Utz ; Abad Díaz, David ; Abudy, Menachem ; Adrian, Tobias ; Ait-Sahalia, Yacine ; Akmansoy, Olivier ; Alcock, Jamie ; Alexeev, Vitali ; Aloosh, Arash ; Amato, Livia ; Amaya, Diego ; Angel, James ; Bach, Amadeus ; Baidoo, Edwin ; Bakalli, Gaetan ; Barbon, Andrea ; Bashchenko, Oksana ; Bindra, Parampreet Christopher ; Bjonnes, Geir Hoidal ; Black, Jeff ; Black, Bernard S. ; Bohorquez, Santiago ; Bondarenko, Oleg ; Bos, Charles S. ; Bosch-Rosa, Ciril ; Bouri, Elie ; Brownlees, Christian ; Calamia, Anna ; Cao, Viet Nga ; Capelle-Blancard, Gunther ; Capera, Laura ; Caporin, Massimiliano ; Carrion, Allen ; Caskurlu, Tolga ; Chakrabarty, Bidisha ; Chernov, Mikhail ; Cheung, William M. ; Chincarini, Ludwig Boris ; Chordia, Tarun ; Chow, Sheung Chi ; Clapham, Benjamin ; Colliard, Jean-Edouard ; Comerton-Forde, Carole ; Curran, Edward ; Dao, Thong ; Dare, Wale ; Davies, Ryan J. ; De Blasis, Riccardo ; De Nard, Gianluca ; Declerck, Fany ; Deev, Oleg ; Degryse, Hans ; Deku, Solomon ; Desagre, Christophe ; Dijk, Mathijs van ; Dim, Chukwuma ; Dimpfl, Thomas ; Dong, Yun Jiang ; Drummond, Philip ; Dudda, Tom ; Dumitrescu, Ariadna ; Dyakov, Teodor ; Haubo Dyhrberg, Anne ; Dzieliński, Michał ; Eksi, Asli ; El Kalak, Izidin ; Ellen, Saskia ter ; Eugster, Nicolas ; Evans, Martin D. D. ; Farrell, Michael ; Félez-Viñas, Ester ; Ferrara, Gerardo ; Ferrouhi, El Mehdi ; Flori, Andrea ; Fluharty-Jaidee, Jonathan ; Foley, Sean ; Fong, Kingsley Y. L. ; Foucault, Thierry ; Franus, Tatiana ; Franzoni, Francesco ; Frijns, Bart ; Frömmel, Michael ; Fu, Servanna ; Füllbrunn, Sascha ; Gan, Baoqing ; Gehrig, Thomas ; Gerritsen, Dirk ; Gil-Bazo, Javier ; Glosten, Lawrence R. ; Gomez, Thomas ; Gorbenko, Arseny ; Güçbilmez, Ufuk ; Grammig, Joachim ; Gregoire, Vincent ; Hagströmer, Björn ; Hambuckers, Julien ; Hapnes, Erik ; Harris, Jeffrey H. ; Harris, Lawrence ; Hartmann, Simon ; Hasse, Jean-Baptiste ; Hautsch, Nikolaus ; He, Xuezhong ; Heath, Davidson ; Hediger, Simon ; Hendershott, Terrence ; Hibbert, Ann Marie ; Hjalmarsson, Erik ; Hoelscher, Seth A. ; Hoffmann, Peter ; Holden, Craig W. ; Horenstein, Alex R. ; Huang, Wenqian ; Huang, Da ; Hurlin, Christophe ; Ivashchenko, Alexey ; Iyer, Subramanian Rama ; Jahanshahloo, Hossein ; Jalkh, Naji ; Jones, Charles M. ; Jurkatis, Simon ; Jylha, Petri ; Kaeck, Andreas ; Kaiser, Gabriel ; Karam, Arzé ; Karmaziene, Egle ; Kassner, Bernhard ; Kaustia, Markku ; Kazak, Ekaterina ; Kearney, Fearghal ; Kervel, Vincent van ; Khan, Saad ; Khomyn, Marta ; Klein, Tony ; Klein, Olga ; Klos, Alexander ; Koetter, Michael ; Krahnen, Jan Pieter ; Kolokolov, Aleksey ; Korajczyk, Robert A. ; Kozhan, Roman ; Kwan, Amy ; Lajaunie, Quentin ; Lam, FY Eric C ; Lambert, Marie ; Langlois, Hugues ; Lausen, Jens ; Lauter, Tobias ; Leippold, Markus ; Levin, Vladimir ; Li, Yijie ; Li, Hui ; Liew, Chee Yoong ; Lindner, Thomas ; Linton, Oliver B. ; Liu, Jiacheng ; Liu, Anqi ; Llorente, Guillermo ; Lof, Matthijs ; Lohr, Ariel ; Longstaff, Francis A. ; Lopez-Lira, Alejandro ; Mankad, Shawn ; Mano, Nicola ; Marchal, Alexis ; Martineau, Charles ; Mazzola, Francesco ; Meloso, Debrah ; Mihet, Roxana ; Mohan, Vijay ; Moinas, Sophie ; Moore, David ; Mu, Liangyi ; Muravyev, Dmitriy ; Murphy, Dermot ; Neszveda, Gabor ; Neumeier, Christian ; Nielsson, Ulf ; Nimalendran, Mahendrarajah ; Nolte, Sven ; Norden, Lars L. ; O'Neill, Peter ; Obaid, Khaled ; Ødegaard, Bernt Arne ; Östberg, Per ; Painter, Marcus ; Palan, Stefan ; Palit, Imon ; Park, Andreas ; Pascual, Roberto ; Pasquariello, Paolo ; Pastor, Lubos ; Patel, Vinay ; Patton, Andrew J. ; Pearson, Neil D. ; Pelizzon, Loriana ; Rzeźnik, Aleksandra ; Sanford, Anthony ; Sankaran, Harikumar ; Sarkar, Asani ; Sarno, Lucio ; Scaillet, O. ; Scharnowski, Stefan ; Schenk-Hoppé, Klaus Reiner ; Schertler, Andrea ; Schneider, Michael ; Schroeder, Florian ; Schürhoff, Norman ; Schuster, Philipp ; Schwarz, Marco A. ; Seasholes, Mark S. ; Seeger, Norman ; Shachar, Or ; Shkilko, Andriy ; Shui, Jessica ; Sikic, Mario ; Simion, Giorgia ; Smales, Lee A. ; Söderlind, Paul ; Sojli, Elvira ; Sokolov, Konstantin ; Spokeviciute, Laima ; Stefanova, Denitsa ; Subrahmanyam, Marti G. ; Neusüss, Sebastian ; Szaszi, Barnabas ; Talavera, Oleksandr ; Tang, Yuehua ; Taylor, Nicholas ; Tham, Wing Wah ; Theissen, Erik ; Thimme, Julian ; Tonks, Ian ; Tran, Hai ; Trapin, Luca ; Trolle, Anders B. ; Valente, Giorgio ; Van Ness, Robert A. ; Vasquez, Aurelio ; Verousis, Thanos ; Verwijmeren, Patrick ; Vilhelmsson, Anders ; Vilkov, Grigory ; Vladimirov, Vladimir ; Vogel, Sebastian ; Voigt, Stefan ; Wagner, Wolf ; Walther, Thomas ; Weiss, Patrick ; Wel, Michel van der ; Werner, Ingrid M. ; Westerholm, Joakim ; Westheide, Christian ; Wipplinger, Evert ; Wolf, Michael ; Wolff, Christiaan Cornelis Petrus ; Wolk, Leonard ; Wong, Wing Keung ; Wrampelmeyer, Jan ; Xia, Shuo ; Xiu, Dacheng ; Xu, Ke ; Xu, Caihong ; Yadav, Pradeep ; Yagüe, José ; Yan, Cheng ; Yang, Antti ; Yoo, Woongsun ; Yu, Wenjia ; Yu, Shihao ; Yueshen, Bart Zhou ; Yuferova, Darya ; Zamojski, Marcin ; Zareei, Abalfazl ; Zeisberger, Stefan ; Zhang, Sarah ; Zhang, Xiaoyu ; Zhong, Zhuo ; Zhou, Z. Ivy ; Zhou, Chen ; Zhu, Xingyu Sonya ; Zoican, Marius ; Zwinkels, Remco C. J. ; Chen, Jian ; Duevski, Teodor ; Gao, Ge ; Gemayel, Roland ; Gilder, Dudley ; Kuhle, Paul ; Pagnotta, Emiliano ; Pelli, Michele ; Sönksen, Jantje ; Zhang, Lu ; Ilczuk, Konrad ; Bogoev, Dimitar ; Qian, Ya ; Wika, Hans C. ; Yu, Yihe ; Zhao, Lu ; Mi, Michael ; Bao, Li ; Vaduva, Andreea ; Prokopczuk, Marcel ; Avetikian, Alejandro ; Wu, Zhen-Xing
In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in sample estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: non-standard errors. To study them, we let 164 teams test six hypotheses on the same sample. We find that non-standard errors are sizeable, on par with standard errors. Their size (i) co-varies only weakly with team merits, reproducibility, or peer rating, (ii) declines significantly after peer-feedback, and (iii) is underestimated by participants.
Oellerich, Thomas ; Schneider, Constanze ; Thomas, Dominique Jeanette ; Knecht, Kirsten M. ; Buzovetsky, Olga ; Kaderali, Lars ; Schliemann, Christoph ; Bohnenberger, Hanibal ; Angenendt, Linus ; Hartmann, Wolfgang ; Wardelmann, Eva ; Rothenburger, Tamara ; Mohr, Sebastian ; Scheich, Sebastian ; Comoglio, Federico ; Wilke, Anne ; Ströbel, Philipp ; Serve, Hubert ; Michaelis, Martin ; Ferreirós Bouzas, Nerea ; Geisslinger, Gerd ; Xiong, Yong ; Keppler, Oliver Till ; Cinatl, Jindrich
Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the treatment of acute myeloid leukemia (AML). However, their mechanisms of action remain incompletely understood, and predictive biomarkers for HMA efficacy are lacking. Here, we show that the bioactive metabolite decitabine triphosphate, but not azacytidine triphosphate, functions as activator and substrate of the triphosphohydrolase SAMHD1 and is subject to SAMHD1-mediated inactivation. Retrospective immunohistochemical analysis of bone marrow specimens from AML patients at diagnosis revealed that SAMHD1 expression in leukemic cells inversely correlates with clinical response to decitabine, but not to azacytidine. SAMHD1 ablation increases the antileukemic activity of decitabine in AML cell lines, primary leukemic blasts, and xenograft models. AML cells acquire resistance to decitabine partly by SAMHD1 up-regulation. Together, our data suggest that SAMHD1 is a biomarker for the stratified use of hypomethylating agents in AML patients and a potential target for the treatment of decitabine-resistant leukemia.
Borsch, Thomas ; Stevens, Albert-Dieter ; Häffner, Eva ; Güntsch, Anton ; Berendsohn, Walter G. ; Appelhans, Marc Sebastian ; Barilaro, Christina ; Beszteri, Bánk ; Blattner, Frank R. ; Bossdorf, Oliver ; Dalitz, Helmut ; Dressler, Stefan ; Duque-Thüs, Rhinaixa ; Esser, Hans-Joachim ; Franzke, Andreas ; Goetze, Dethardt ; Grein, Michaela ; Grünert, Uta ; Hellwig, Frank ; Hentschel, Jörn ; Hörandl, Elvira ; Janßen, Thomas ; Jürgens, Norbert ; Kadereit, Gudrun ; Karisch, Timm ; Koch, Marcus ; Müller, Frank ; Müller, Jochen ; Ober, Dietrich ; Porembski, Stefan ; Poschlod, Peter ; Printzen, Christian ; Röser, Martin ; Sack, Peter ; Schlüter, Philipp M. ; Schmidt, Marco ; Schnittler, Martin ; Scholler, Markus ; Schultz, Matthias ; Seeber, Elke ; Simmel, Josef ; Stiller, Michael ; Thiv, Mike ; Thüs, Holger ; Tkach, Natalia ; Triebel, Dagmar ; Warnke, Ursula ; Weibulat, Tanja ; Wesche, Karsten ; Yurkov, Andrey ; Zizka, Georg
Plants, fungi and algae are important components of global biodiversity and are fundamental to all ecosystems. They are the basis for human well-being, providing food, materials and medicines. Specimens of all three groups of organisms are accommodated in herbaria, where they are commonly referred to as botanical specimens.The large number of specimens in herbaria provides an ample, permanent and continuously improving knowledge base on these organisms and an indispensable source for the analysis of the distribution of species in space and time critical for current and future research relating to global biodiversity. In order to make full use of this resource, a research infrastructure has to be built that grants comprehensive and free access to the information in herbaria and botanical collections in general. This can be achieved through digitization of the botanical objects and associated data.The botanical research community can count on a long-standing tradition of collaboration among institutions and individuals. It agreed on data standards and standard services even before the advent of computerization and information networking, an example being the Index Herbariorum as a global registry of herbaria helping towards the unique identification of specimens cited in the literature.In the spirit of this collaborative history, 51 representatives from 30 institutions advocate to start the digitization of botanical collections with the overall wall-to-wall digitization of the flat objects stored in German herbaria. Germany has 70 herbaria holding almost 23 million specimens according to a national survey carried out in 2019. 87% of these specimens are not yet digitized. Experiences from other countries like France, the Netherlands, Finland, the US and Australia show that herbaria can be comprehensively and cost-efficiently digitized in a relatively short time due to established workflows and protocols for the high-throughput digitization of flat objects.Most of the herbaria are part of a university (34), fewer belong to municipal museums (10) or state museums (8), six herbaria belong to institutions also supported by federal funds such as Leibniz institutes, and four belong to non-governmental organizations. A common data infrastructure must therefore integrate different kinds of institutions.Making full use of the data gained by digitization requires the set-up of a digital infrastructure for storage, archiving, content indexing and networking as well as standardized access for the scientific use of digital objects. A standards-based portfolio of technical components has already been developed and successfully tested by the Biodiversity Informatics Community over the last two decades, comprising among others access protocols, collection databases, portals, tools for semantic enrichment and annotation, international networking, storage and archiving in accordance with international standards. This was achieved through the funding by national and international programs and initiatives, which also paved the road for the German contribution to the Global Biodiversity Information Facility (GBIF).Herbaria constitute a large part of the German botanical collections that also comprise living collections in botanical gardens and seed banks, DNA- and tissue samples, specimens preserved in fluids or on microscope slides and more. Once the herbaria are digitized, these resources can be integrated, adding to the value of the overall research infrastructure. The community has agreed on tasks that are shared between the herbaria, as the German GBIF model already successfully demonstrates.We have compiled nine scientific use cases of immediate societal relevance for an integrated infrastructure of botanical collections. They address accelerated biodiversity discovery and research, biomonitoring and conservation planning, biodiversity modelling, the generation of trait information, automated image recognition by artificial intelligence, automated pathogen detection, contextualization by interlinking objects, enabling provenance research, as well as education, outreach and citizen science.We propose to start this initiative now in order to valorize German botanical collections as a vital part of a worldwide biodiversity data pool.
Ellenrieder, Lars ; Opaliński, Łukasz ; Becker, Lars ; Krüger, Vivien ; Mirus, Oliver ; Straub, Sebastian Philipp ; Ebell, Katharina ; Flinner, Nadine ; Stiller, Sebastian ; Guiard, Bernard ; Meisinger, Chris ; Wiedemann, Nils ; Schleiff, Enrico ; Wagner, Richard ; Pfanner, Nikolaus ; Becker, Thomas
The endoplasmic reticulum–mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology protein Mdm10 is present in both ERMES and the mitochondrial sorting and assembly machinery (SAM), it is unknown how the ERMES functions are connected on a molecular level. Here we report that conserved surface areas on opposite sides of the Mdm10 β-barrel interact with SAM and ERMES, respectively. We generated point mutants to separate protein assembly (SAM) from morphology and phospholipid homeostasis (ERMES). Our study reveals that the β-barrel channel of Mdm10 serves different functions. Mdm10 promotes the biogenesis of α-helical and β-barrel proteins at SAM and functions as integral membrane anchor of ERMES, demonstrating that SAM-mediated protein assembly is distinct from ER-mitochondria contact sites.
Koch, Christine ; Göller, Markus ; Schott, Eckart ; Waidmann, Oliver ; Winkel, Mark op den ; Paprottka, Philipp Marius ; Zangos, Stephan ; Vogel, Thomas ; Bechstein, Wolf Otto ; Zeuzem, Stefan ; Kolligs, Frank Thomas ; Trojan, Jörg
Background and Aims. Systemic treatment with sorafenib has been the standard of care (SOC) in patients with advanced Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) for more than a decade. TACE has been reported to allow better local tumor control in selected patients with BCLC stage C HCC. Methods. A retrospective analysis of patients with BCLC stage C HCC that were treated with sorafenib and TACE was conducted; they were compared to BCLC stage C patients treated either with TACE or sorafenib in the same period of time outside a clinical trial. Results. A total of 201 patients with BCLC stage C were identified, who were treated with either sorafenib and TACE (group A; n = 54), sorafenib (group B; n = 82) or TACE (group C; n = 65). No significant difference in baseline characteristics was observed. Time to progression was 7.0 months (95% CI: 4.3–9.7), 4.1 months (95% CI: 3.6–4.7) and 5.0 months (95% CI: 2.9–7.1) in groups A, B and C, respectively, and overall survival was 16.5 months (95% CI: 15.0–18.1), 8.4 months (95% CI: 6.0–10.8) and 10.5 months (95% CI: 7.5–13.6), respectively (group A vs. group B: p < 0.001; group A vs. group C: p = 0.0023). Adverse events of grade 3/4 occurred in 34% of patients in group A. Conclusions. Although sorafenib is a SOC in patients with BCLC stage C HCC, TACE is frequently used as an additional locoregional treatment in selected patients. This combined approach resulted in a significant overall survival benefit in selected patients, although randomized trials have not yet proven this benefit.
Kröger, Felix Martin ; Weber, Günter ; Herdrich, Marc Oliver ; Glorius, Jan ; Langer, Christoph ; Slavkovská, Zuzana ; Bott, Lukas ; Brandau, Carsten ; Brückner, Benjamin ; Blaum, Klaus ; Chen, Xin ; Dababneh, Saed ; Davinson, Thomas ; Erbacher, Philipp ; Fiebiger, Stefan ; Gaßner, Tobias ; Göbel, Kathrin ; Groothuis, Mathias ; Gumberidze, Alexandre ; Gyürky, György ; Hagmann, Siegbert ; Hahn, Christoph ; Heil, Michael ; Heß, Regina ; Hensch, Roman ; Hillmann, Paula ; Hillenbrand, Pierre-Michel ; Hinrichs, Ole Djürko ; Jurado Apruzzese, Beatriz ; Kausch, Tanja ; Khodaparast, Anahita ; Kisselbach, Timo ; Klapper, Nadine ; Kozhuharov, Christopher ; Kurtulgil, Cem Deniz ; Lane, Gregory J. ; Lederer-Woods, Claudia ; Lestinsky, Michael ; Litvinov, Sergey A. ; Litvinov, Yuri A. ; Löher, Bastian ; Nolden, Fritz ; Petridis, Nikolaos ; Popp, Ulrich ; Reed, Matthew ; Reifarth, René ; Sanjari, Mohammad Shahab ; Simon, Haik ; Spillmann, Uwe ; Steck, Markus ; Stumm, Julia ; Szücs, Tamas ; Nguyen, Thien Tam ; Taremi Zadeh, Ashkan ; Thomas, Benedikt ; Torilov, Sergey Yu. ; Törnqvist, Hans Toshihide ; Trageser, Christian ; Trotsenko, Sergiy ; Volknandt, Meiko ; Weigand, Mario ; Wolf, Clemens ; Woods, Philip John ; Ševelʹko, Vjačeslav P. ; Stöhlker, Thomas
The electron-capture process was studied for Xe54+ colliding with H2 molecules at the internal gas target of the Experimental Storage Ring (ESR) at GSI, Darmstadt. Cross-section values for electron capture into excited projectile states were deduced from the observed emission cross section of Lyman radiation, being emitted by the hydrogenlike ions subsequent to the capture of a target electron. The ion beam energy range was varied between 5.5 and 30.9 MeV/u by applying the deceleration mode of the ESR. Thus, electron-capture data were recorded at the intermediate and, in particular, the low-collision-energy regime, well below the beam energy necessary to produce bare xenon ions. The obtained data are found to be in reasonable qualitative agreement with theoretical approaches, while a commonly applied empirical formula significantly overestimates the experimental findings.
Acharya, Shreyasi ; Adamová, Dagmar ; Agarwal, Apar ; Aglieri Rinella, Gianluca ; Aglietta, Luca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Shakeel ; Ahn, Sang Un ; Ahuja, Ishaan ; Akindinov, Alexander ; Akishina, Valentina ; Al-Turany, Mohammad ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfanda, Haidar Mas’ud ; Alfaro Molina, Jose Ruben ; Ali, Bushra ; Alici, Andrea ; Alizadehvandchali, Negin ; Alkin, Anton ; Alme, Johan ; Alocco, Giacomo ; Alt, Torsten ; Altamura, Anna Rita ; Altsybeev, Igor ; Alvarado Garcia, Jesús Ricardo ; Anaam, Mustafa Naji ; Andrei, Cristian ; Andreou, Nicodemos ; Andronic, Anton ; Andronov, Evgeny ; Anguelov, Venelin ; Antinori, Federico ; Antonioli, Pietro ; Apadula, Nicole ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arata, Carolina ; Arcelli, Silvia ; Aresti, Mauro ; Arnaldi, Roberta ; Arneiro, Jhoao Gabriel Martins Campos Almeida ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Azmi, Mohd Danish ; Baba, Hitoshi ; Badalà, Angela ; Bae, Joonsuk ; Baek, Yong Wook ; Bai, Xiaozhi ; Bailhache, Raphaëlle ; Bailung, Yoshini ; Bala, Renu ; Balbino, Alessandro ; Baldisseri, Alberto ; Balis, Bartosz ; Banerjee, Debjani ; Banoo, Zarina ; Barbasova, Veronika ; Barile, Francesco ; Barioglio, Luca ; Barlou, Maria ; Barman, Banajit ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Barreau, Emilie Martine ; Ramillien Barret, Valerie ; Barreto De Oliveira Campos, Leonardo ; Bartels, Clara ; Barth, Klaus ; Bartsch, Esther ; Bastid, Nicole ; Basu, Sumit ; Batigne, Guillaume ; Battistini, Daniel ; Batyunya, Boris ; Bauri, Dibakar ; Bazo Alba, José Luis ; Bearden, Ian Gardner ; Beattie, Caitlin ; Becht, Pascal ; Behera, Debadatta ; Belikov, Iouri ; Bell Hechavarria, Ailec de la Caridad ; Bellini, Francesca ; Bellwied, Rene ; Belokurova, Svetlana ; Espinoza Beltran, Lucina Gabriela ; Vasquez Beltran, Yael Antonio ; Bencédi, Gyula ; Bensaoula, Adel ; Beolè, Stefania ; Berdnikov, Yaroslav ; Berdnikova, Anastasia ; Bergmann, Luisa ; Besoiu, Mihaela Gabriela ; Betev, Latchezar ; Bhaduri, Partha Pratim ; Bhasin, Anju ; Bhat, Mohammad Asif ; Bhattacharjee, Buddhadeb ; Bianchi, Livio ; Bianchi, Nicola ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bigot, Alexandre Patrick ; Bilandzic, Ante ; Biro, Gabor ; Biswas, Saikat ; Bize, Nicolas Luc ; Blair, Justin Thomas ; Blau, Dmitry S. ; Blidaru, Mihail-Bogdan ; Bluhme, Nora ; Blume, Christoph ; Boca, Gianluigi ; Bock, Friederike ; Bodova, Tea ; Bok, Jeongsu ; Boldizsar, Laszlo ; Bombara, Marek ; Bond, Peter Matthew ; Bonomi, Germano ; Borel, Herve ; Borissov, Alexander ; Borquez Carcamo, Andres Gerardo ; Bossi, Hannah ; Botta, Elena ; El Mard Bouziani, Youssef ; Bratrud, Lars ; Braun-Munzinger, Peter ; Bregant, Marco ; Broz, Michal ; Bruno, Giuseppe Eugenio ; Buckland, Matthew Daniel ; Budnikov, Dmitry ; Büsching, Henner ; Bufalino, Stefania ; Bühler, Paul ; Burmasov, Nazar ; Buthelezi, Edith Zinhle ; Bylinkin, Alexander ; Bysiak, Sebastian Adam ; Cabanillas Noris, Juan Carlos ; Torres Cabrera, Maria Fernanda ; Cai, Mengke ; Caines, Helen Louise ; Caliva, Alberto ; Calvo Villar, Ernesto ; Mejia Camacho, Juan Manuel ; Camerini, Paolo ; Canedo, Fabio de Moraes Canedo ; Weyhmiller, Sierra Lisa ; Carabas, Mihai ; Amatriain Carballo, Aitor ; Carnesecchi, Francesca ; Caron, Robin Albert Andre ; Abranches De Carvalho, Leopoldo ; Castillo Castellanos, Javier Ernesto ; Castoldi, Matteo ; Catalano, Fabio ; Cattaruzzi, Samuele ; Ceballos Sanchez, Cesar ; Cerri, Rebecca ; Chakaberia, Irakli ; Chakraborty, Pritam ; Chandra, Sinjini ; Chapeland, Sylvain ; Chartier, Marielle ; Chattopadhay, Souvik ; Chattopadhyay, Subhasis ; Chattopadhyay, Sukalyan ; Cheng, Tiantian ; Cheshkov, Cvetan Valeriev ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chizzali, Emma Sophia ; Cho, Jaeyoon ; Cho, Soyeon ; Chochula, Peter ; Chochulska, Zuzanna Anna ; Choudhury, Dhrubajyoti ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Ciacco, Mario ; Cicalò, Corrado ; Ciupek, Michael Rudolf ; Clai, Giulia ; Colamaria, Fabio Filippo ; Colburn, Jonathan Samuel ; Colella, Domenico ; Colocci, Manuel ; Concas, Matteo ; Conesa Balbastre, Gustavo ; Conesa Del Valle, Zaida ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Coquet, Maurice ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Costanza, Susanna ; Cot, Corentin ; Crkovská, Jana ; Crochet, Philippe ; Cruz Torres, Reynier ; Cui, Pengyao ; Czarnynoga, Maciej Marek ; Dainese, Andrea ; Dange, Gautam ; Danisch, Meike Charlotte ; Danu, Andrea ; Das, Prottay ; Das, Prottoy ; Das, Supriya ; Dash, Archita Rani ; Dash, Sadhana ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Martin, Chiara ; De Pasquale, Salvatore ; Deb, Rohaan ; Del Grande, Raffaele ; Dello Stritto, Luigi ; Deng, Wenjing ; Devereaux, Kyle Christian ; Dhankher, Preeti ; Di Bari, Domenico ; Di Mauro, Antonio ; Diab, Batoul ; Arteche Diaz, Raul ; Dietel, Thomas ; Ding, Yanchun ; Ditzel, Janik ; Divià, Roberto ; Dixit, Dhruv Utpalkumar ; Djuvsland, Øystein ; Dmitrieva, Uliana ; Dobrin, Alexandru Florin ; Donigus, Benjamin ; Dubinski, Jan Michal ; Dubla, Andrea ; Dupieux, Pascal ; Dzalaiova, Natalia ; Eder, Tabea Maria ; Ehlers, Raymond James, III ; Eisenhut, Florian ; Ejima, Ren ; Elia, Domenico ; Erazmus, Barbara Ewa ; Ercolessi, Francesca ; Espagnon, Bruno ; Eulisse, Giulio ; Evans, David ; Evdokimov, Sergey ; Fabbietti, Laura ; Faggin, Mattia ; Faivre, Julien ; Fan, Feng ; Fan, Wenqing ; Fantoni, Alessandra ; Fasel, Markus ; Feliciello, Alessandro ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferrandi De Oliveira, Lucas ; Bertran Ferrer, Marta ; Ferrero, Andrea ; Ferrero, Chiara ; Ferretti, Alessandro ; Feuillard, Victor Jose Gaston ; Filova, Vendulka ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Flatland, Erlend ; Flor, Fernando Antonio ; Flores, Amanda Nicole ; Foertsch, Siegfried Valentin ; Fokin, Ilya ; Fokin, Sergey ; Follo, Umberto ; Fragiacomo, Enrico ; Frajna, Eszter ; Fuchs, Ulrich ; Funicello, Nicola ; Furget, Christophe ; Furs, Artur ; Fusayasu, Takahiro ; Gaardhoeje, Jens Joergen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Gahlaut, Tanu ; Duarte Galvan, Carlos ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Garabatos Cuadrado, Jose Maria ; Martinez Garcia, Josue ; García Chávez, Tonatiuh ; Garcia-Solis, Edmundo Javier ; Gargiulo, Corrado ; Gasik, Piotr ; Gaur, Hari Mohan ; Gautam, Amrit ; Ducati, Maria Beatriz de Leone Gay ; Germain, Marie ; Ghimouz, Abderrahmane ; Ghosh, Chandrasekhar ; Giacalone, Marco ; Gioachin, Giulia ; Giubellino, Paolo ; Giubilato, Piero ; Glaenzer, Aude Marie Camille ; Glässel, Peter ; Glimos, Ewa ; Goh, Daniel Jia Qin ; Gonzalez Sebastian, Victor Luis ; Gordeev, Pavel ; Gorgon, Marek Boguslaw ; Goswami, Kangkan ; Gotovac, Sven ; Grabski, Varlen ; Graczykowski, Łukasz Kamil ; Grecka, Ekaterina ; Grelli, Alessandro ; Grigoraș, Costin ; Grigoryev, Vladislav ; Grigoryan, Smbat ; Grosa, Fabrizio ; Große-Oetringhaus, Jan Fiete ; Grosso, Raffaele ; Grund, David ; Grünwald, Nadine Alice ; Garcia Guardiano, Gabriel ; Guernane, Rachid ; Guilbaud, Maxime Rene Joseph ; Gulbrandsen, Kristjan Herlache ; Gündem, Tuba ; Gunji, Taku ; Guo, Wenda ; Gupta, Anik ; Gupta, Ramni ; Gupta, Rashi ; Gwizdziel, Katarzyna ; Gyulai, Laszlo ; Hadjidakis, Cynthia Marie ; Haider, Fakhar Ul ; Haidlova, Sara ; Haldar, Mintu ; Hamagaki, Hideki ; Hamdi, Abdennacer ; Han, Younghoon ; Hanley, Brian Gerald ; Hannigan, Ryan ; Hansen, Joachim ; Haque, Md Rihan ; Harris, John William ; Harton, Austin Vincent ; Hartung, Michael Volker ; Hassan, Hadi ; Hatzifotiadou, Despina ; Hauer, Philip ; Havener, Laura Brittany ; Hellbär, Ernst ; Helstrup, Håvard ; Hemmer, Marvin ; Herman, Tomáš ; Hernandez, Sabrina Gabrielle ; Herrera Corral, Gerardo Antonio ; Herrmann, Florian ; Herrmann, Sarah Nina Edwige ; Hetland, Kristin Fanebust ; Heybeck, Benedict ; Hillemanns, Hartmut ; Hippolyte, Boris ; Hoffmann, Felix Willi ; Hofman, Bas ; Hong, Geunhee ; Horst, Maximilian ; Horzyk, Adrian ; Hou, Yongzhen ; Hristov, Peter ; Huhn, Patrick ; Huhta, Laura Maria ; Humanic, Thomas J. ; Hutson, Alek ; Hutter, Dirk ; Hwang, Minyoung Chris ; Ilkaev, Radiy ; Inaba, Motoi ; Innocenti, Gian Michele ; Ippolitov, Mikhail ; Isakov, Artem ; Isidori, Tommaso ; Islam, Md Samsul ; Iurchenko, Semen ; Ivanov, Marian ; Ivanov, Marian ; Ivanov, Vladimir ; Iversen, Kaare Endrup ; Jablonski, Miroslaw ; Jacak, Barbara ; Jacazio, Nicolò ; Jacobs, Peter Martin ; Jadlovska, Slavka ; Jadlovsky, Jan ; Jaelani, Syaefudin ; Jahnke, Cristiane ; Jakubowska, Monika Joanna ; Janik, Malgorzata Anna ; Janson, Thomas ; Ji, Su-jeong ; Jia, Shihai ; Paz Jimenez, Alom Antonio ; Jonas, Florian ; Jones, Daniel Matthew ; Jowett, John M. ; Jung, Jerome ; Jung, Michael ; Junique, Antoine Jean-Simon ; Jusko, Anton ; Kaewjai, Jetnipit ; Kalinak, Peter ; Kalweit, Alexander Philipp ; Karasu Uysal, Ayben ; Karatović, David ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Karwowska, Maja Jadwiga ; Kebschull, Udo ; Keidel, Ralf ; Keil, Markus ; Ketzer, Bernhard ; Khade, Swapnesh Santosh ; Khan, Ahsan Mehmood ; Khan, Shaista ; Khanzadeev, Alexei ; Kharlov, Yury ; Khatun, Anisa ; Khuntia, Arvind ; Khuranova, Zhanna ; Kileng, Bjarte ; Kim, Beomkyu ; Kim, Chong ; Kim, Dong Jo ; Kim, Eun Joo ; Kim, Jaehyun ; Kim, Jiyoung ; Kim, Junlee ; Kim, Minjung ; Kim, Se Yong ; Kim, Taejun ; Kimura, Kento ; Kirkova, Aleksandrina ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Kitowski, Jacek Pawel ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein, Spencer Robert ; Klein-Bösing, Christian ; Kleiner, Matthias ; Klemenz, Thomas ; Kluge, Alexander ; Kobdaj, Chinorat ; Kohara, Ryotaro ; Kollegger, Thorsten ; Kondratyev, Andrey ; Kondratyeva, Natalia ; König, Joshua Leon ; Königstorfer, Stephan Alexander ; Konopka, Piotr Jan ; Kornakov, Georgy ; Korwieser, Maximilian ; Koryciak, Sebastian Dominik ; 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Muhuri, Sanjib ; Mulligan, James Declan ; Mulliri, Alice ; Gameiro Munhoz, Marcelo ; Munzer, Robert Helmut ; Murakami, Hikari ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Myrcha, Julian Wojciech ; Naik, Bharati ; Nambrath, Anjali Ila ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nassirpour, Adrian Fereydon ; Nath, Abhishek ; Nattrass, Christine ; Naydenov, Momchil Nikolaev ; Neagu, Alexandra ; Negru, Adrian-eduard ; Nekrasova, Evgeniia ; Nellen, Lukas ; Nepeivoda, Roman ; Nese, Sigurd ; Nešković, Gvozden ; Nicassio, Nicola ; Nielsen, Borge Svane ; Nielsen, Emil Gorm ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Noferini, Francesco ; Noh, Seoyoung ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Oh, Saehanseul ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Otwinowski, Jacek Tomasz ; Oya, Motomi ; Oyama, Ken ; 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The intense photon fluxes from relativistic nuclei provide an opportunity to study photonuclear interactions in ultraperipheral collisions. The measurement of coherently photoproduced π+π−π+π− final states in ultraperipheral Pb-Pb collisions at sNN−−−√=5.02 TeV is presented for the first time. The cross section, dσ/dy, times the branching ratio (ρ→π+π+π−π−) is found to be 47.8±2.3 (stat.)±7.7 (syst.) mb in the rapidity interval |y|<0.5. The invariant mass distribution is not well described with a single Breit-Wigner resonance. The production of two interfering resonances, ρ(1450) and ρ(1700), provides a good description of the data. The values of the masses (m) and widths (Γ) of the resonances extracted from the fit are m1=1385±14 (stat.)±3 (syst.) MeV/c2, Γ1=431±36 (stat.)±82 (syst.) MeV/c2, m2=1663±13 (stat.)±22 (syst.) MeV/c2 and Γ2=357±31 (stat.)±49 (syst.) MeV/c2, respectively. The measured cross sections times the branching ratios are compared to recent theoretical predictions.
Acharya, Shreyasi ; Adamová, Dagmar ; Agarwal, Apar ; Aglieri Rinella, Gianluca ; Aglietta, Luca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmad, Shakeel ; Ahn, Sang Un ; Ahuja, Ishaan ; Akindinov, Alexander ; Akishina, Valentina ; Al-Turany, Mohammad ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfanda, Haidar Mas’ud ; Alfaro Molina, Jose Ruben ; Ali, Bushra ; Alici, Andrea ; Alizadehvandchali, Negin ; Alkin, Anton ; Alme, Johan ; Alocco, Giacomo ; Alt, Torsten ; Altamura, Anna Rita ; Altsybeev, Igor ; Alvarado Garcia, Jesús Ricardo ; Anaam, Mustafa Naji ; Andrei, Cristian ; Andreou, Nicodemos ; Andronic, Anton ; Andronov, Evgeny ; Anguelov, Venelin ; Antinori, Federico ; Antonioli, Pietro ; Apadula, Nicole ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arata, Carolina ; Arcelli, Silvia ; Aresti, Mauro ; Arnaldi, Roberta ; Arneiro, Jhoao Gabriel Martins Campos Almeida ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; 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Cabanillas Noris, Juan Carlos ; Torres Cabrera, Maria Fernanda ; Cai, Mengke ; Caines, Helen Louise ; Caliva, Alberto ; Calvo Villar, Ernesto ; Mejia Camacho, Juan Manuel ; Camerini, Paolo ; Canedo, Fabio de Moraes Canedo ; Weyhmiller, Sierra Lisa ; Carabas, Mihai ; Amatriain Carballo, Aitor ; Carnesecchi, Francesca ; Caron, Robin Albert Andre ; Abranches De Carvalho, Leopoldo ; Castillo Castellanos, Javier Ernesto ; Castoldi, Matteo ; Catalano, Fabio ; Cattaruzzi, Samuele ; Ceballos Sanchez, Cesar ; Cerri, Rebecca ; Chakaberia, Irakli ; Chakraborty, Pritam ; Chandra, Sinjini ; Chapeland, Sylvain ; Chartier, Marielle ; Chattopadhay, Souvik ; Chattopadhyay, Subhasis ; Chattopadhyay, Sukalyan ; Cheng, Tiantian ; Cheshkov, Cvetan Valeriev ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chizzali, Emma Sophia ; Cho, Jaeyoon ; Cho, Soyeon ; Chochula, Peter ; Chochulska, Zuzanna Anna ; Choudhury, Dhrubajyoti ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Ciacco, Mario ; Cicalò, Corrado ; Ciupek, Michael Rudolf ; Clai, Giulia ; Colamaria, Fabio Filippo ; Colburn, Jonathan Samuel ; Colella, Domenico ; Colocci, Manuel ; Concas, Matteo ; Conesa Balbastre, Gustavo ; Conesa Del Valle, Zaida ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Coquet, Maurice ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Costanza, Susanna ; Cot, Corentin ; Crkovská, Jana ; Crochet, Philippe ; Cruz Torres, Reynier ; Cui, Pengyao ; Dainese, Andrea ; Dange, Gautam ; Danisch, Meike Charlotte ; Danu, Andrea ; Das, Prottay ; Das, Prottoy ; Das, Supriya ; Dash, Archita Rani ; Dash, Sadhana ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Martin, Chiara ; De Pasquale, Salvatore ; Deb, Rohaan ; Del Grande, Raffaele ; Dello Stritto, Luigi ; Deng, Wenjing ; Devereaux, Kyle Christian ; Dhankher, Preeti ; Di Bari, Domenico ; Di Mauro, Antonio ; Diab, Batoul ; Arteche Diaz, Raul ; Dietel, Thomas ; Ding, Yanchun ; Ditzel, Janik ; Divià, Roberto ; Dixit, Dhruv Utpalkumar ; Djuvsland, Øystein ; Dmitrieva, Uliana ; Dobrin, Alexandru Florin ; Donigus, Benjamin ; Dubinski, Jan Michal ; Dubla, Andrea ; Dudi, Sandeep ; Dupieux, Pascal ; Dzalaiova, Natalia ; Eder, Tabea Maria ; Ehlers, Raymond James, III ; Eisenhut, Florian ; Ejima, Ren ; Elia, Domenico ; Erazmus, Barbara Ewa ; Ercolessi, Francesca ; Espagnon, Bruno ; Eulisse, Giulio ; Evans, David ; Evdokimov, Sergey ; Fabbietti, Laura ; Faggin, Mattia ; Faivre, Julien ; Fan, Feng ; Fan, Wenqing ; Fantoni, Alessandra ; Fasel, Markus ; Feliciello, Alessandro ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferrandi De Oliveira, Lucas ; Bertran Ferrer, Marta ; Ferrero, Andrea ; Ferrero, Chiara ; Ferretti, Alessandro ; Feuillard, Victor Jose Gaston ; Filova, Vendulka ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Flatland, Erlend ; Flor, Fernando Antonio ; Flores, Amanda Nicole ; Foertsch, Siegfried Valentin ; Fokin, Ilya ; Fokin, Sergey ; Follo, Umberto ; Fragiacomo, Enrico ; Frajna, Eszter ; Fuchs, Ulrich ; Funicello, Nicola ; Furget, Christophe ; Furs, Artur ; Fusayasu, Takahiro ; Gaardhoeje, Jens Joergen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Gahlaut, Tanu ; Duarte Galvan, Carlos ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Garabatos Cuadrado, Jose Maria ; Martinez Garcia, Josue ; García Chávez, Tonatiuh ; Garcia-Solis, Edmundo Javier ; Gargiulo, Corrado ; Gasik, Piotr ; Gaur, Hari Mohan ; Gautam, Amrit ; Ducati, Maria Beatriz de Leone Gay ; Germain, Marie ; Ghimouz, Abderrahmane ; Ghosh, Chandrasekhar ; Giacalone, Marco ; Gioachin, Giulia ; Giubellino, Paolo ; Giubilato, Piero ; Glaenzer, Aude Marie Camille ; Glässel, Peter ; Glimos, Ewa ; Goh, Daniel Jia Qin ; Gonzalez Sebastian, Victor Luis ; Gordeev, Pavel ; Gorgon, Marek Boguslaw ; Goswami, Kangkan ; Gotovac, Sven ; Grabski, Varlen ; Graczykowski, Łukasz Kamil ; Grecka, Ekaterina ; Grelli, Alessandro ; Grigoraș, Costin ; Grigoryev, Vladislav ; Grigoryan, Smbat ; Grosa, Fabrizio ; Große-Oetringhaus, Jan Fiete ; Grosso, Raffaele ; Grund, David ; Grünwald, Nadine Alice ; Garcia Guardiano, Gabriel ; Guernane, Rachid ; Guilbaud, Maxime Rene Joseph ; Gulbrandsen, Kristjan Herlache ; Gündem, Tuba ; Gunji, Taku ; Guo, Wenda ; Gupta, Anik ; Gupta, Ramni ; Gupta, Rashi ; Gwizdziel, Katarzyna ; Gyulai, Laszlo ; Hadjidakis, Cynthia Marie ; Haider, Fakhar Ul ; Haidlova, Sara ; Haldar, Mintu ; Hamagaki, Hideki ; Hamdi, Abdennacer ; Han, Younghoon ; Hanley, Brian Gerald ; Hannigan, Ryan ; Hansen, Joachim ; Haque, Md Rihan ; Harris, John William ; Harton, Austin Vincent ; Hartung, Michael Volker ; Hassan, Hadi ; Hatzifotiadou, Despina ; Hauer, Philip ; Havener, Laura Brittany ; Hellbär, Ernst ; Helstrup, Håvard ; Hemmer, Marvin ; Herman, Tomáš ; Hernandez, Sabrina Gabrielle ; Herrera Corral, Gerardo Antonio ; Herrmann, Florian ; Herrmann, Sarah Nina Edwige ; Hetland, Kristin Fanebust ; Heybeck, Benedict ; Hillemanns, Hartmut ; Hippolyte, Boris ; Hoffmann, Felix Willi ; Hofman, Bas ; Hong, Geunhee ; Horst, Maximilian ; Horzyk, Adrian ; Hou, Yongzhen ; Hristov, Peter ; Huhn, Patrick ; Huhta, Laura Maria ; Humanic, Thomas J. ; Hutson, Alek ; Hutter, Dirk ; Hwang, Minyoung Chris ; Ilkaev, Radiy ; Inaba, Motoi ; Innocenti, Gian Michele ; Ippolitov, Mikhail ; Isakov, Artem ; Isidori, Tommaso ; Islam, Md Samsul ; Iurchenko, Semen ; Ivanov, Marian ; Ivanov, Marian ; Ivanov, Vladimir ; Iversen, Kaare Endrup ; Jablonski, Miroslaw ; Jacak, Barbara ; Jacazio, Nicolò ; Jacobs, Peter Martin ; Jadlovska, Slavka ; Jadlovsky, Jan ; Jaelani, Syaefudin ; Jahnke, Cristiane ; Jakubowska, Monika Joanna ; Janik, Malgorzata Anna ; Janson, Thomas ; Ji, Su-jeong ; Jia, Shihai ; Paz Jimenez, Alom Antonio ; Jonas, Florian ; Jones, Daniel Matthew ; Jowett, John M. ; Jung, Jerome ; Jung, Michael ; Junique, Antoine Jean-Simon ; Jusko, Anton ; Kaewjai, Jetnipit ; Kalinak, Peter ; Kalweit, Alexander Philipp ; Karasu Uysal, Ayben ; Karatović, David ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Karwowska, Maja Jadwiga ; Kebschull, Udo ; Keidel, Ralf ; Keil, Markus ; Ketzer, Bernhard ; Khade, Swapnesh Santosh ; Khan, Ahsan Mehmood ; Khan, Shaista ; Khanzadeev, Alexei ; Kharlov, Yury ; Khatun, Anisa ; Khuntia, Arvind ; Khuranova, Zhanna ; Kileng, Bjarte ; Kim, Beomkyu ; Kim, Chong ; Kim, Dong Jo ; Kim, Eun Joo ; Kim, Jaehyun ; Kim, Jiyoung ; Kim, Junlee ; Kim, Minjung ; Kim, Se Yong ; Kim, Taejun ; Kimura, Kento ; Kirkova, Aleksandrina ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Kitowski, Jacek Pawel ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein, Spencer Robert ; Klein-Bösing, Christian ; Kleiner, Matthias ; Klemenz, Thomas ; Kluge, Alexander ; Kobdaj, Chinorat ; Kohara, Ryotaro ; Kollegger, Thorsten ; Kondratyev, Andrey ; Kondratyeva, Natalia ; König, Joshua Leon ; Königstorfer, Stephan Alexander ; Konopka, Piotr Jan ; Kornakov, Georgy ; Korwieser, Maximilian ; Koryciak, Sebastian Dominik ; Koster, Cornelia ; Kotliarov, Artem ; Kovacic, Nino ; Kovalenko, Vladimir ; Kowalski, Marek ; Kozhuharov, Venelin Valeriev ; Králik, Ivan ; Kravčáková, Adela ; Krcal, Lubos ; Krivda, Marian ; Krizek, Filip ; Krizkova Gajdosova, Katarina ; Krug, Cristiano ; Krüger, Mario ; Krupová, Diana Maria ; Kryshen, Evgeny ; Kucera, Vit ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kumaoka, Takuya ; Kumar, Deekshit ; Kumar, Lokesh ; Kumar, Navneet ; Kumar, Shyam ; Kundu, Sourav ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kuskov, Vladislav ; Kutyla, Monika ; Kweon, Min Jung ; Kwon, Youngil ; La Pointe, Sarah Louise ; La Rocca, Paola ; Lakrathok, Anantachai ; Lamanna, Massimo ; Landou, Aimeric Robin ; Langoy, Rune ; Larionov, Pavel ; Laudi, Elisa ; Lautner, Lukas ; Narcio Laveaga, Rafael Angel ; Lavicka, Roman ; Lea, Ramona ; Lee, Hyungjun ; Legrand, Iosif-charles ; Legras, Gauthier ; Lehrbach, Johannes ; Lelek, Tomasz Marcin ; Lemmon, Roy Crawford ; Leon Monzon, Ildefonso ; Lesch, Marcel Markus ; Lesser, Ezra Douglas ; Lévai, Peter ; Li, Mingze ; Li, Xiaomei ; Liang-gilman, Beatrice Eva ; Lien, Jørgen André ; Lietava, Roman ; Likmeta, Iris ; Lim, Bong-Hwi ; Lim, Sanghoon ; Lindenstruth, Volker ; Lindner, Amelia ; Lippmann, Christian ; Liu, Donghai ; Liu, Jian ; Setoue Liveraro, Gianni Shigeru ; Mckibben Lofnes, Ingrid ; Loizides, Constantinos ; Lokos, Sandor ; Lomker, Johanna ; Lopez, Xavier Bernard ; López Torres, Ernesto ; Lu, Pengzhong ; Lugo, Fabiola Viridiana ; Luhder, Jens Robert ; Lunardon, Marcello ; Luparello, Grazia ; Ma, Yu-Gang ; Mager, Magnus ; Maire, Antonin ; Majerz, Emilia Maria ; Makariev, Martin Vasilev ; Malaev, Mikhail ; Malfattore, Giovanni ; Malik, Nasir Mehdi ; Malik, Qasim Waheed ; Malik, Salman Khurshid ; Malinina, Liudmila ; Mallick, Dukhishyam ; Mallick, Neelkamal ; Mandaglio, Giuseppe ; Mandal, Sushobhan Kumar ; Manea, Alexandru ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Marcjan, Robert Waclaw ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marin, Ana Maria ; Markert, Christina ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; García Martínez, Ginés ; Martins Palhares, Maria Paula ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Massen, Olaf ; Mastroserio, Annalisa ; Matonoha, Oliver ; Mattiazzo, Serena ; Matyja, Adam Tomasz ; Lafuente Mazuecos, Antonio ; Mazzaschi, Francesco ; Mazzilli, Marianna ; Mdhluli, Joyful Elma ; Melikyan, Yury ; Menchaca-rocha, Arturo Alejandro ; Munoz Mendez, Jesus Eduardo ; Meninno, Elisa ; Sasikumar Menon, Anjaly ; Menzel, Marius Wilm ; Meres, Michal ; Miake, Yasuo ; Micheletti, Luca ; Mihaylov, Dimitar Lubomirov ; Mikhaylov, Konstantin ; Minafra, Nicola ; Czeslaw Miskowiec, Dariusz ; Modak, Abhi ; Mohanty, Bedangadas ; Khan, Mohammed Mohisin ; Molander, Mikael Andreas ; Monira, Shirajum ; Mordasini, Cindy ; Moreira De Godoy Willems, Denise Aparecida ; Morozov, Igor ; Morsch, Andreas ; Mrnjavac, Teo ; Muccifora, Valeria ; Muhuri, Sanjib ; Mulligan, James Declan ; Mulliri, Alice ; Gameiro Munhoz, Marcelo ; Munzer, Robert Helmut ; Murakami, Hikari ; Murray, Sean ; Musa, Luciano ; Musinsky, Jan ; Myrcha, Julian Wojciech ; Naik, Bharati ; Nambrath, Anjali Ila ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nassirpour, Adrian Fereydon ; Nath, Abhishek ; Nattrass, Christine ; Naydenov, Momchil Nikolaev ; Neagu, Alexandra ; Negru, Adrian-eduard ; Nekrasova, Evgeniia ; Nellen, Lukas ; Nepeivoda, Roman ; Nese, Sigurd ; Nešković, Gvozden ; Nicassio, Nicola ; Nielsen, Borge Svane ; Nielsen, Emil Gorm ; Nikolaev, Sergey ; Nikulin, Sergey ; Nikulin, Vladimir ; Noferini, Francesco ; Noh, Seoyoung ; Nomokonov, Petr V. ; Norman, Jaime ; Novitzky, Norbert ; Nowakowski, Piotr ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Oh, Saehanseul ; Ohlson, Alice ; Okorokov, Vitaly A. ; Oleniacz, Janusz ; Önnerstad, Anna ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Otwinowski, Jacek Tomasz ; Oya, Motomi ; Oyama, Ken ; Pachmayer, Yvonne C. ; Padhan, Sonali ; Pagano, Davide ; Paic, Guy ; Paisano Guzman, Sergio ; Palasciano, Antonio ; Panebianco, Stefano Matthias ; Park, Hanseo ; Park, Hyebin ; Parkkila, Jasper Elias ; Patley, Yash ; Paul, Biswarup ; De Melo Paulino, Maria Monalisa ; Pei, Hua ; Peitzmann, Thomas ; Peng, Xinye ; Pennisi, Michele ; Perciballi, Stefania ; Peresunko, Dmitry Yurevich ; Mesa Perez, Guillermo ; Pestov, Yury N. ; Petrov, Vitalii ; Petrovici, Mihai A. ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pinto, Chiara ; Pisano, Silvia ; Płoskoń, Mateusz ; Planinic, Mirko ; Pliquett, Fabian ; Poghosyan, Martin G. ; Polishchuk, Boris ; Politano, Stefano ; Poljak, Nikola ; Pop, Amalia ; Porteboeuf, Sarah Julie ; Pozdniakov, Valerii ; Yoval Pozos, Irandheny ; Pradhan, Kshitish Kumar ; Prasad, Sidharth Kumar ; Prasad, Suraj ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Pucillo, Sara ; Qiu, Shi ; Quaglia, Luca ; Ragoni, Simone ; Rai, Ananya ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Rami, Fouad ; Rasa, Marika ; Räsänen, Sami Sakari ; Rath, Rutuparna ; Rauch, Max Philip ; Ravasenga, Ivan ; Read, Kenneth Francis ; Reckziegel, Christian ; Redelbach, Andreas Ralph ; Redlich, Krzysztof ; Reetz, Carolina Anna ; Regules Medel, Hector David ; Rehman, Attiq ur ; Reidt, Felix ; Reme-Ness, Haakon André ; Jakubcinova, Zuzana ; Reygers, Klaus ; Riabov, Andrei ; Riabov, Viktor ; Ricci, Riccardo ; Richter, Matthias ; Riedel, Anton Albert ; Riegler, Werner ; Riffero, Andrea Giovanni ; Ripoli, Cristina ; Ristea, Cătălin-Lucian ; Viqueira Rodriguez, Manuel ; Rodrı́guez Cahuantzi, Mario ; Rodríguez Ramírez, Saúl Aníbal ; Røed, Ketil ; Rogalev, Roman ; Rogochaya, Elena ; Rogoschinski, Tim Sebastian ; Rohr, David ; Röhrich, Dieter ; Rojas Torres, Solangel ; Rokita, Przemyslaw Stefan ; Romanenko, Gleb ; Ronchetti, Federico ; Dominguez Rosas, Edgar ; Rosłon, Krystian ; Rossi, Andrea ; Roy, Ankhi ; Roy, Subhadeep ; Rubini, Nicola ; Ruggiano, Daniela ; Rui, Rinaldo ; Russek, Pawel Grzegorz ; Russo, Roberto ; Rustamov, Anar ; Ryabinkin, Evgeny ; Ryabov, Yury ; Rybicki, Andrzej Krzysztof ; Ryu, Jaehyeok ; Rzęsa, Wioleta ; Sadhu, Samrangy ; Sadovskiy, Sergey ; Sætre, Jon-are ; Šafařík, Karel ; Saha, Sumit Kumar ; Saha, Swati ; Sahoo, Bhagyarathi ; Sahoo, Raghunath ; Sahoo, Sarita ; Sahu, Dushmanta ; Sahu, Pradip Kumar ; Saini, Jogender ; Tropp, Klaudia ; Sakai, Shingo ; Panikkassery Salvan, Malavika ; Sambyal, Sanjeev Singh ; Samitz, Daniel ; Sanna, Isabella ; Saramela, Thiago Badaró ; Sarkar, Debojit ; Sarma, Pranjal ; Sarritzu, Valerio ; Mantovani Sarti, Valentina ; Sas, Mike Henry Petrus ; Sawan, Sawan ; Scapparone, Eugenio ; Schambach, Johann Joachim ; Scheid, Horst Sebastian ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schlepper, Felix ; Schmah, Alexander ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schmidt, Marten Ole ; Schmidt, Martin ; Schmidt, Nicolas ; 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Measurements of the pT-dependent flow vector fluctuations in Pb-Pb collisions at sNN−−−√=5.02 TeV using azimuthal correlations with the ALICE experiment at the LHC are presented. A four-particle correlation approach [1] is used to quantify the effects of flow angle and magnitude fluctuations separately. This paper extends previous studies to additional centrality intervals and provides measurements of the pT-dependent flow vector fluctuations at sNN−−−√=5.02 TeV with two-particle correlations. Significant pT-dependent fluctuations of the V⃗ 2 flow vector in Pb-Pb collisions are found across different centrality ranges, with the largest fluctuations of up to ∼15% being present in the 5% most central collisions. In parallel, no evidence of significant pT-dependent fluctuations of V⃗ 3 or V⃗ 4 is found. Additionally, evidence of flow angle and magnitude fluctuations is observed with more than 5σ significance in central collisions. These observations in Pb-Pb collisions indicate where the classical picture of hydrodynamic modeling with a common symmetry plane breaks down. This has implications for hard probes at high pT, which might be biased by pT-dependent flow angle fluctuations of at least 23% in central collisions. Given the presented results, existing theoretical models should be re-examined to improve our understanding of initial conditions, quark--gluon plasma (QGP) properties, and the dynamic evolution of the created system.