Frieder Haenisch, Jason D. Cooper, Andreas Reif, Sarah Kittel-Schneider, Johann Steiner, F. Markus Leweke, Matthias Rothermundt, Nico J. M. van Beveren, Benedicto Crespo-Facorro, David W. Niebuhr, David N. Cowan, Natalya S. Weber, Robert H. Yolken, Brenda W. J. H. Penninx, Sabine Bahn
- Highlights
• A panel of 20 biomarkers was identified capable of differentiating BD patients from controls.
• Excellent discrimination between established BD patients and controls.
• Good to excellent discrimination between misdiagnosed BD patients and first onset MDD patients.
• Fair to good discrimination between pre-diagnostic BD patients and controls.
• Study demonstrates the potential utility of a protein biomarker panel as a diagnostic test for BD.
Abstract
Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD.
Methods and findings: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients. We analysed 249 BD, 122 pre-diagnostic BD, 75 pre-diagnostic schizophrenia and 90 first onset major depression disorder (MDD) patients and 371 controls. The biomarker panel was identified using ten-fold cross-validation with lasso regression applied to the 87 analytes available across the meta-analysis studies.
We identified 20 protein analytes with excellent predictive performance [area under the curve (AUC) ⩾ 0.90]. Importantly, the panel had a good predictive performance (AUC 0.84) to differentiate 12 misdiagnosed BD patients from 90 first onset MDD patients, and a fair to good predictive performance (AUC 0.79) to differentiate between 110 pre-diagnostic BD patients and 184 controls. We also demonstrated the disease specificity of the panel.
Conclusions: An early and accurate diagnosis has the potential to delay or even prevent the onset of BD. This study demonstrates the potential utility of a biomarker panel as a diagnostic test for BD.
MetadatenAuthor: | Frieder HaenischORCiDGND, Jason D. Cooper, Andreas ReifORCiDGND, Sarah Kittel-SchneiderORCiDGND, Johann SteinerORCiDGND, F. Markus LewekeORCiDGND, Matthias Rothermundt, Nico J. M. van BeverenORCiD, Benedicto Crespo-FacorroORCiD, David W. NiebuhrORCiD, David N. Cowan, Natalya S. Weber, Robert H. YolkenORCiDGND, Brenda W. J. H. PenninxORCiD, Sabine BahnORCiD |
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URN: | urn:nbn:de:hebis:30:3-773033 |
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DOI: | https://doi.org/10.1016/j.bbi.2015.10.001 |
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ISSN: | 0889-1591 |
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Parent Title (English): | Brain, behavior and immunity |
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Publisher: | Elsevier |
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Place of publication: | Amsterdam |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2016/01/07 |
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Date of first Publication: | 2015/10/13 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/04/05 |
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Tag: | Biomarker; Bipolar disorder; Diagnostic test; Differential diagnosis; Multiplex immunoassay |
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Volume: | 52.2016 |
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Page Number: | 9 |
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First Page: | 49 |
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Last Page: | 57 |
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HeBIS-PPN: | 517871688 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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