Christiane Ziegler, Jan Richter, Marina Mahr, Agnes Gajewska, Miriam A. Schiele, Andrea Gehrmann, Brad Schmidt, Klaus-Peter J. Lesch, Thomas Lang, Sylvia Helbig-Lang, Paul Pauli, Tilo Kircher, Andreas Reif, Winfried Rief, Anna Nicola Voßbeck-Elsebusch, Volker Arolt, Hans-Ulrich Wittchen, Alfons Hamm, Jürgen Deckert, Katharina Domschke
- Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of successful fear extinction, the present psychotherapy-epigenetic study for we believe the first time investigated MAOA methylation changes during the course of exposure-based cognitive behavioral therapy (CBT) in PD. MAOA methylation was compared between N=28 female Caucasian PD patients (discovery sample) and N=28 age- and sex-matched healthy controls via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells. MAOA methylation was furthermore analyzed at baseline (T0) and after a 6-week CBT (T1) in the discovery sample parallelized by a waiting time in healthy controls, as well as in an independent sample of female PD patients (N=20). Patients exhibited lower MAOA methylation than healthy controls (P<0.001), and baseline PD severity correlated negatively with MAOA methylation (P=0.01). In the discovery sample, MAOA methylation increased up to the level of healthy controls along with CBT response (number of panic attacks; T0–T1: +3.37±2.17%), while non-responders further decreased in methylation (−2.00±1.28%; P=0.001). In the replication sample, increases in MAOA methylation correlated with agoraphobic symptom reduction after CBT (P=0.02–0.03). The present results support previous evidence for MAOA hypomethylation as a PD risk marker and suggest reversibility of MAOA hypomethylation as a potential epigenetic correlate of response to CBT. The emerging notion of epigenetic signatures as a mechanism of action of psychotherapeutic interventions may promote epigenetic patterns as biomarkers of lasting extinction effects.
MetadatenAuthor: | Christiane Ziegler, Jan Richter, Marina Mahr, Agnes Gajewska, Miriam A. Schiele, Andrea Gehrmann, Brad Schmidt, Klaus-Peter J. LeschORCiDGND, Thomas Lang, Sylvia Helbig-Lang, Paul PauliORCiDGND, Tilo KircherORCiDGND, Andreas ReifORCiDGND, Winfried Rief, Anna Nicola Voßbeck-Elsebusch, Volker AroltORCiDGND, Hans-Ulrich WittchenORCiDGND, Alfons Hamm, Jürgen DeckertORCiDGND, Katharina Domschke |
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URN: | urn:nbn:de:hebis:30:3-440239 |
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DOI: | https://doi.org/10.1038/tp.2016.41 |
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ISSN: | 2158-3188 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27045843 |
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Parent Title (English): | Translational Psychiatry |
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Publisher: | Nature Publishing Group |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2017/05/15 |
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Year of first Publication: | 2016 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2017/05/15 |
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Volume: | 6 |
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Issue: | 4, e773 |
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Page Number: | 8 |
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First Page: | 1 |
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Last Page: | 8 |
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Note: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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HeBIS-PPN: | 432463364 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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