Claus Meyer, J Hofmann, Thomas Burmeister, D Gröger, TS Park, M Emerenciano, M Pombo de Oliveira, A Renneville, E Macintyre, H Cavé, E Clappier, K Mass-Malo, Jan Zuna, J Trka, E De Braekeleer, M De Braekeleer, SH Oh, Grigory A. Tsaur, L Fechina, VH van der Velden, JJ van Dongen, E Delabesse, R Binato, ML Silva, A Kustanovich, O Aleinikova, MH Harris, T Lund-Aho, V Juvonen, Olaf Torben Heidenreich, J Vormoor, WW Choi, M Jarosova, A Kolenova, C Bueno, P Menendez, S Wehner, Cornelia Eckert, P Talmant, S Tondeur, E Lippert, E Launay, C Henry, P Ballerini, H Lapillone, MB Callanan, JM Cayuela, C Herbaux, G Cazzaniga, PM Kakadiya, Stefan Klaus Bohlander, M Ahlmann, JR Choi, P Gameiro, DS Lee, J Krauter, P Cornillet-Lefebvre, G Te Kronnie, BW Schäfer, S Kubetzko, CN Alonso, U zur Stadt, R Sutton, NC Venn, S Izraeli, L Trakhtenbrot, HO Madsen, P Archer, J Hancock, N Cerveira, MR Teixeira, L Lo Nigro, A Möricke, M Stanulla, M Schrappe, L Sedék, T Szczepański, CM Zwaan, EA Coenen, MM van den Heuvel-Eibrink, S Strehl, Michael N. Dworzak, Renate Panzer-Grümayer, Theodor Dingermann, Thomas Klingebiel, Rolf Marschalek
- Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize the chromosomal rearrangement of individual acute leukemia patients. We present data of the molecular characterization of 1590 MLL-rearranged biopsy samples obtained from acute leukemia patients. The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and novel TPGs identified. All patients were classified according to their gender (852 females and 745 males), age at diagnosis (558 infant, 416 pediatric and 616 adult leukemia patients) and other clinical criteria. Combined data of our study and recently published data revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level. However, only seven rearrangements seem to be predominantly associated with illegitimate recombinations of the MLL gene (~ 90%): AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, ELL, partial tandem duplications (MLL PTDs) and MLLT4/AF6, respectively. The MLL breakpoint distributions for all clinical relevant subtypes (gender, disease type, age at diagnosis, reciprocal, complex and therapy-induced translocations) are presented. Finally, we present the extending network of reciprocal MLL fusions deriving from complex rearrangements.
MetadatenAuthor: | Claus MeyerORCiDGND, J Hofmann, Thomas BurmeisterORCiDGND, D Gröger, TS Park, M Emerenciano, M Pombo de Oliveira, A Renneville, E Macintyre, H Cavé, E Clappier, K Mass-Malo, Jan ZunaORCiDGND, J Trka, E De Braekeleer, M De Braekeleer, SH Oh, Grigory A. TsaurORCiD, L Fechina, VH van der Velden, JJ van Dongen, E Delabesse, R Binato, ML Silva, A Kustanovich, O Aleinikova, MH Harris, T Lund-Aho, V Juvonen, Olaf Torben HeidenreichORCiDGND, J Vormoor, WW Choi, M Jarosova, A Kolenova, C Bueno, P Menendez, S Wehner, Cornelia EckertORCiDGND, P Talmant, S Tondeur, E Lippert, E Launay, C Henry, P Ballerini, H Lapillone, MB Callanan, JM Cayuela, C Herbaux, G Cazzaniga, PM Kakadiya, Stefan Klaus Bohlander, M Ahlmann, JR Choi, P Gameiro, DS Lee, J Krauter, P Cornillet-Lefebvre, G Te Kronnie, BW Schäfer, S Kubetzko, CN Alonso, U zur Stadt, R Sutton, NC Venn, S Izraeli, L Trakhtenbrot, HO Madsen, P Archer, J Hancock, N Cerveira, MR Teixeira, L Lo Nigro, A Möricke, M Stanulla, M Schrappe, L Sedék, T Szczepański, CM Zwaan, EA Coenen, MM van den Heuvel-Eibrink, S Strehl, Michael N. Dworzak, Renate Panzer-Grümayer, Theodor DingermannORCiDGND, Thomas KlingebielORCiDGND, Rolf MarschalekORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-355505 |
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DOI: | https://doi.org/10.1038/leu.2013.135 |
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ISSN: | 1476-5551 |
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ISSN: | 0887-6924 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/23628958 |
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Parent Title (English): | Leukemia |
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Publisher: | Nature Publ. Group |
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Place of publication: | Basingstoke |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2013/05/17 |
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Date of first Publication: | 2013/05/17 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2014/11/22 |
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Tag: | ALL; AML; MLL; acute leukemia; chromosomal translocations; translocation partner genes |
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Volume: | 27 |
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Issue: | 11 |
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Page Number: | 12 |
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First Page: | 2165 |
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Last Page: | 2176 |
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Note: | Copyright © 2013 Macmillan Publishers Limited This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
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HeBIS-PPN: | 36686288X |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
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