Synaptic plasticity and excitation-inhibition balance in the dentate gyrus : insights from in vivo recordings in neuroligin-1, neuroligin-2, and collybistin knockouts

  • The hippocampal dentate gyrus plays a role in spatial learning and memory and is thought to encode differences between similar environments. The integrity of excitatory and inhibitory transmission and a fine balance between them is essential for efficient processing of information. Therefore, identification and functional characterization of crucial molecular players at excitatory and inhibitory inputs is critical for understanding the dentate gyrus function. In this minireview, we discuss recent studies unraveling molecular mechanisms of excitatory/inhibitory synaptic transmission, long-term synaptic plasticity, and dentate granule cell excitability in the hippocampus of live animals. We focus on the role of three major postsynaptic proteins localized at excitatory (neuroligin-1) and inhibitory synapses (neuroligin-2 and collybistin). In vivo recordings of field potentials have the advantage of characterizing the effects of the loss of these proteins on the input-output function of granule cells embedded in a network with intact connectivity. The lack of neuroligin-1 leads to deficient synaptic plasticity and reduced excitation but normal granule cell output, suggesting unaltered excitation-inhibition ratio. In contrast, the lack of neuroligin-2 and collybistin reduces inhibition resulting in a shift towards excitation of the dentate circuitry.

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Author:Peter JedličkaORCiDGND, Julia MuellerleileGND, Stephan Schwarzacher
URN:urn:nbn:de:hebis:30:3-506470
DOI:https://doi.org/10.1155/2018/6015753
ISSN:2090-5904
ISSN:1687-5443
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29670649
Parent Title (English):Neural plasticity
Publisher:Hindawi
Place of publication:New York, NY
Contributor(s):Bruno Poucet
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/02/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/08/15
Volume:26
Issue:Art. 6015753
Page Number:12
First Page:1
Last Page:11
Note:
Copyright © 2018 Peter Jedlicka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS-PPN:453937195
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0