A guide to the regulation of selective autophagy receptors

  • Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign pathogens and other cellular components. Hence, autophagy can be nonselective, where bulky portions of the cytoplasm are degraded upon stress, or a highly selective process, where preselected cellular components are degraded. To distinguish between different cellular components, autophagy employs selective autophagy receptors, which will link the cargo to the autophagy machinery, thereby sequestering it in the autophagosome for its subsequent degradation in the lysosome. Autophagy receptors undergo post-translational and structural modifications to fulfil their role in autophagy, or upon executing their role, for their own degradation. We highlight the four most prominent protein modifications – phosphorylation, ubiquitination, acetylation and oligomerisation – that are essential for autophagy receptor recruitment, function and turnover. Understanding the regulation of selective autophagy receptors will provide deeper insights into the pathway and open up potential therapeutic avenues.
Author:Andrea Gubas, Ivan ĐikićORCiDGND
Parent Title (English):The FEBS journal
Place of publication:Oxford [u.a.]
Document Type:Article
Date of Publication (online):2021/03/17
Date of first Publication:2021/03/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/03/16
Tag:autophagy; oligomerisation; phosphorylation; receptor; ubiquitination
Issue:online version before inclusion in an issue
Page Number:15
First Page:1
Last Page:15
Early View: Online Version before inclusion in an issue
Our research is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project Number 259130777 – SFB 1177, the grants from Else Kroener Fresenius Stiftung and Dr. Rolf M. Schwiete Stiftung.
Version of Record: http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hebis:30:3-638632
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0