Can neurophysiological markers of anticipation and attention predict ADHD severity and neurofeedback outcomes?

  • Abstract: Neurophysiological measures of preparation and attention are often atypical in ADHD. Still, replicated findings that these measures predict which patients improve after Neurofeedback (NF), reveal neurophysiological specificity, and reflect ADHD-severity are limited. Methods: We analyzed children’s preparatory (CNV) and attentional (Cue-P3) brain activity and behavioral performance during a cued Continuous Performance Task (CPT) before and after slow cortical potential (SCP)-NF or semi-active control treatment (electromyogram biofeedback). Mixed-effects models were performed with 103 participants at baseline and 77 were assessed for pre-post comparisons focusing on clinical outcome prediction, specific neurophysiological effects of NF, and associations with ADHD-severity. Results: Attentional and preparatory brain activity and performance were non-specifically reduced after treatment. Preparatory activity in the SCP-NF group increased with clinical improvement. Several performance and brain activity measures predicted non-specific treatment outcome. Conclusion: Specific neurophysiological effects after SCP-NF were limited to increased neural preparation associated with improvement on ADHD-subscales, but several performance and neurophysiological measures of attention predicted treatment outcome and reflected symptom severity in ADHD. The results may help to optimize treatment.

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Author:Pascal Aggensteiner, Björn Albrecht, Ute Strehl, Sonja Wörz, Christian Rainer Ruckes, Christine M. FreitagORCiDGND, Aribert Rothenberger, Holger Gevensleben, Sabina Millenet, Sarah Hohmann, Tobias BanaschewskiORCiDGND, Tanja Legenbauer, Martin Holtmann, Daniel Brandeis
URN:urn:nbn:de:hebis:30:3-644263
DOI:https://doi.org/10.1016/j.biopsycho.2021.108169
ISSN:1873-6246
Parent Title (English):Biological psychology 165.2021, art. 108169, doi:10.1016/j.biopsycho.2021.108169, ISSN 1873-6246
Publisher:Elsevier Science
Place of publication:Amsterdam [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2021/08/18
Date of first Publication:2021/08/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/01/21
Tag:Attention-Deficit/Hyperactivity Disorder (ADHD); Contingent Negative Variation, CNV; Continuous Performance Test, CPT; Cue-P3; Event related potentials; Neurofeedback; Randomized Controlled Trial; Response control; Slow Cortical Potentials, SCP; Sustained attention
Volume:165
Issue:art. 108169
Page Number:12
First Page:1
Last Page:12
Note:
This study was funded by the German Research Foundation DFG HO 2503/4-1 and 2503/4-2. The funding body had no influence on the study design, collection, analysis and interpretation of data, the writing of the report, or the decision to submit the paper for publication.
HeBIS-PPN:491292090
Institutes:Medizin
Dewey Decimal Classification:1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0