Can neurophysiological markers of anticipation and attention predict ADHD severity and neurofeedback outcomes?

  • Abstract: Neurophysiological measures of preparation and attention are often atypical in ADHD. Still, replicated findings that these measures predict which patients improve after Neurofeedback (NF), reveal neurophysiological specificity, and reflect ADHD-severity are limited. Methods: We analyzed children’s preparatory (CNV) and attentional (Cue-P3) brain activity and behavioral performance during a cued Continuous Performance Task (CPT) before and after slow cortical potential (SCP)-NF or semi-active control treatment (electromyogram biofeedback). Mixed-effects models were performed with 103 participants at baseline and 77 were assessed for pre-post comparisons focusing on clinical outcome prediction, specific neurophysiological effects of NF, and associations with ADHD-severity. Results: Attentional and preparatory brain activity and performance were non-specifically reduced after treatment. Preparatory activity in the SCP-NF group increased with clinical improvement. Several performance and brain activity measures predicted non-specific treatment outcome. Conclusion: Specific neurophysiological effects after SCP-NF were limited to increased neural preparation associated with improvement on ADHD-subscales, but several performance and neurophysiological measures of attention predicted treatment outcome and reflected symptom severity in ADHD. The results may help to optimize treatment.

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Author:Pascal AggensteinerORCiDGND, Björn AlbrechtORCiDGND, Ute StrehlORCiDGND, Sonja WörzGND, Christian Rainer RuckesGND, Christine M. FreitagORCiDGND, Aribert RothenbergerORCiDGND, Holger Gevensleben, Sabina MillenetORCiDGND, Sarah HohmannORCiDGND, Tobias BanaschewskiORCiDGND, Tanja LegenbauerORCiDGND, Martin HoltmannORCiDGND, Daniel BrandeisGND
Parent Title (English):Biological psychology
Publisher:Elsevier Science
Place of publication:Amsterdam [u.a.]
Document Type:Article
Date of Publication (online):2021/08/18
Date of first Publication:2021/08/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/01/21
Tag:Attention-Deficit/Hyperactivity Disorder (ADHD); Contingent Negative Variation, CNV; Continuous Performance Test, CPT; Cue-P3; Event related potentials; Neurofeedback; Randomized Controlled Trial; Response control; Slow Cortical Potentials, SCP; Sustained attention
Issue:art. 108169
Page Number:12
First Page:1
Last Page:12
This study was funded by the German Research Foundation DFG HO 2503/4-1 and 2503/4-2. The funding body had no influence on the study design, collection, analysis and interpretation of data, the writing of the report, or the decision to submit the paper for publication.
Dewey Decimal Classification:1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0