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In this paper we propose a way forward towards increased financial resilience in times of growing disagreement concerning open borders, free trade and global regulatory standards. In light of these concerns, financial resilience remains a highly valued policy objective. We wish to contribute by suggesting an agenda of concrete, do-able steps supporting an enhanced level of resilience, combined with a deeper understanding of its relevance in the public domain.
First, remove inconsistencies across regulatory rules and territorial regimes, and ensure their credibility concerning implementation. Second, discourage the use of financial regulatory standards as means of international competition. Third, give more weight to pedagogically explaining the established regulatory standards in public, to strengthen their societal backing.
Trata de uma investigação teórica que problematiza os contornos de uma pedagogia crítica na atualidade. Adota a perspectiva do filósofo Axel Honneth como fio condutor da análise, especificamente os textos em que ele discute as características contemporâneas de uma teoria adjetivada de crítica. Após descrever seu posicionamento, extrai alguns sentidos para o empreendimento crítico no âmbito de uma pedagogia da educação física.
Die Frage ist, ob und in welcher Weise säkulare Texte auf religiöse Auslegungspraktiken und Deutungsmuster rekurrieren, und welche Verschiebungen dabei zwischen ihnen stattfinden. Die Autoren gehen dabei erstens davon aus, dass der Kommentar eine paradoxe Textpraxis ist, und zweitens davon, dass diese Paradoxie in der Moderne besonders dort manifest wird, wo sie sich mit denjenigen Paradoxien berührt oder überschneidet, die im Prozess der Säkularisierung entstehen.
Panmixia and dispersal from the Mediterranean Basin to Macaronesian Islands of a macrolichen species
(2017)
The Mediterranean region, comprising the Mediterranean Basin and the Macaronesian Islands, represents a center of diversification for many organisms. The genetic structure and connectivity of mainland and island microbial populations has been poorly explored, in particular in the case of symbiotic fungi. Here we investigated genetic diversity and spatial structure of the obligate outcrossing lichen-forming fungus Parmelina carporrhizans in the Mediterranean region. Using eight microsatellite and mating-type markers we showed that fungal populations are highly diverse but lack spatial structure. This is likely due to high connectivity and long distance dispersal of fungal spores. Consistent with low levels of linkage disequilibrium and lack of clonality, we detected both mating-type idiomorphs in all populations. Furthermore we showed that the Macaronesian Islands are the result of colonization from the Mediterranean Basin. The unidirectional gene flow, though, seemed not to be sufficient to counterbalance the effects of drift, resulting in comparatively allelic poor peripheral populations. Our study is the first to shed light on the high connectivity and lack of population structure in natural populations of a strictly sexual lichen fungus. Our data further support the view of the Macaronesian Islands as the end of the colonization road for this symbiotic ascomycete.
In order to achieve the goals of social commentary and moral judgement pursued in her novels, Jane Austen describes and evaluates different aspects of her characters’ personalities: social attitude, intellectual qualities and moral traits (Lodge 1966). Mansfield Park (1814) is one of her novels in which this moral awareness is most acute. In order to construct a community of shared values with her readers, Austen skilfully alternates different points of view as sources of evaluation. We propose an analysis of the first chapter of Mansfield Park that addresses this dialogic dimension by focusing on the resources of engagement, the subsystem of Appraisal Theory with which speakers/writers express their commitment to the truth of a proposition and their willingness to open the negotiation space to other voices (Martin & White 2005: 97).
The linguistic subtlety and complexity of Jane Austen’s writing is a challenge to translators, who must try to identify all the concurrent interpretation possibilities and reproduce them in the target language. In this article we compare the English source text with various translations into Spanish, Catalan and German. Our analysis focuses on the lexicogrammatical realisations of engagement such as verba dicendi, epistemic expressions, lexical choices with a distinct attitudinal load, and also on the development of narration – as far as that is possible in a study centering on the first chapter –, since it is often the case that narrator stance is modified as the text unfolds.
We discuss fragments of narrator discourse, direct speech and indirect/free indirect speech and consider the advantages of the framework to uncover changes in the evaluative dimension of meaning that affect the readings the translations will afford in their target society, from character building to the articulation of points of view.
The ALICE High-Level-Trigger (HLT) is a large scale computing farm designed and constructed for the purpose of the realtime reconstruction of particle interactions (events) inside the ALICE detector. The reconstruction of such events is based on the raw data produced in collisions inside the ALICE at the Large Hadron Collider. The online reconstruction in the HLT allows the triggering on certain event topologies and a significant data reduction by applying compression algorithms. Moreover, it enables a real-time verification of the quality of the data.
To receive the raw data from the various sub-detectors of ALICE, the HLT is equipped with 226 custom built FPGA-based PCI-X cards, the H-RORCs. The H-RORC interfaces the detector readout electronics to the nodes of the HLT farm. In addition to the transfer of raw data, 108 H-RORCs host 216 Fast-Cluster-Finder (FCF) processors for the Time-Projection-Chamber (TPC). The TPC is the main tracking detector of ALICE and contributes with up to 16 GB/s to over 90% of the overall data volume. The FCF processor implements the first of two steps in the data reconstruction of the TPC. It calculates the space points and their properties from charge clouds (clusters) created by charged particles traversing the TPCs gas volume. Those space points are not only the base for the tracking algorithm, but also allow for a Huffman-based data compression, which reduces the data volume by a factor of 4 to 6.
The FCF processor is designed to cope with any incoming data rate up to the maximum bandwidth of the incoming optical link (160 MB/s) without creating back-pressure to the detectors readout electronics. A performance comparison with the software implementation of the algorithm shows a speedup factor of about 20 compared with one AMD Opteron 6172 Core @ 2.1 GHz, the CPU type used in the HLT during the LHC Run1 campaign. Comparison with an Intel E5-2690 Core @ 3.0 GHz, the CPU type used by the HLT for the LHC Run2 campaign, results in a speedup factor of 8.5. In total numbers, the 216 FCF processors provide the computing performance of 4255 AMD Opteron cores or 2203 Intel cores of the previously mentioned type. The performance of the reconstruction with respect to the physics analysis is equivalent or better than the official ALICE Offline clusterizer. Therefore, ALICE data taking was switched in 2011 to FCF cluster recording and compression only, discarding the raw data from the TPC. Due to the capability to compress the clusters, the recorded data volume could be increased by a factor of 4 to 6.
For the LHC Run3 campaign, starting in 2020, the FCF builds the foundation of the ALICE data taking and processing strategy. The raw data volume (before processing) of the upgraded TPC will exceed 3 TB/s. As a consequence, online processing of the raw data and compression of the results before it enters the online computing farms is an essential and crucial part of the computing model.
Within the scope of this thesis, the H-RORC card and the FCF processor were developed and built from scratch. It covers the conceptual design, the optimisation and implementation, as well as the verification. It is completed by performance benchmarks and experiences from real data taking.
Seit Jahrzehnten steht eine Gestalt an oberster Stelle des Kanons historisch bedeutsamer Figuren in der Ukraine: der Dichter und Maler Taras Ševčenko (1814−1861). Im Land besteht Einigkeit über seine identitätsstiftende Funktion für die imaginierte Gemeinschaft Ukraine. Er wird über die Regionen hinweg als verbindende Gestalt wahrgenommen - besonders in Zeiten, in denen ein mögliches "Auseinanderbrechen" des Landes intensiv diskutiert beziehungsweise befürchtet wird. Ein Grund dafür ist, dass Ševčenko für die historisch unterschiedlich geprägten Regionen einen gleichermaßen festen Bezugspunkt darstellt: Er lebte im Russischen Reich und stammte aus einem Gebiet, das heute zur Zentralukraine gehört; gleichzeitig konnte und kann man sich in der Westukraine mit der Idee von Ševčenko als einem der wichtigsten Träger ukrainischer Identität identifizieren. In Ševčenko laufen zentrale gesellschaftliche und erinnerungskulturelle Diskussionen und Projektionen über Vergangenheit, den gegenwärtigen Zustand und mögliche zukünftige Entwicklungen des Landes zusammen, und die spannungsreichen Veränderungen und erinnerungskulturellen Widersprüche in der Geschichte der Ukraine drücken sich ganz besonders in der Auseinandersetzung mit Ševčenko aus. Ševčenko ist also auch nach der Unabhängigkeit des Landes im Jahr 1991 der Kulturheros schlechthin. Diese Umwertung der Ševčenko-Gestalt wird heute vor allem bei renommierten Wissenschaftlern und Ševčenko-Forschern, aber auch in Reden von Politikern deutlich. Demgegenüber bestehen in der Gegenwartskultur jedoch zahlreiche andere Entwürfe, die die Gleichsetzung Ševčenkos mit der Nation in Frage stellen. Dabei führen die Um- und Neudeutungen zu einer Pluralisierung des Ševčenko-Bildes; und auch wenn Gegenentwürfe als Bedrohung empfunden werden - gerade durch sie wird Ševčenkos Bedeutung aktualisiert und seine Gestalt auch für jüngere Generationen zugänglich und interessant gemacht. Der Kulturheros Ševčenko, der in der Sowjetzeit etabliert und in Folge hoch verehrt wurde, ist weiterhin äußerst populär und ein beliebtes Objekt kultureller, wissenschaftlicher und medialer Auseinandersetzungen in der Ukraine.
The Middle East biting midges of the tribes Palpomyiini (20 species in three genera) and Sphaeromiini s. lat. (six species in five genera) are reviewed. Three new species are described and illustrated: Bezzia libanensis Alwin & Szadziewski sp. nov., B. sharjahi Alwin & Szadziewski sp. nov. and Palpomyia freidbergi Alwin & Szadziewski sp. nov. Bezzia aegyptia Kieffer, 1925 is recognized as a new junior synonym of B. albicornis (Meigen, 1818) (syn. nov.) and B. omanensis Boorman & van Harten, 2002, is recognized as a junior synonym of B. (Sivabezzia) pachypyga Remm, 1974 (syn. nov.). Keys to the genera and species of the tribes Palpomyiini and Sphaeromiini of the Middle East are also provided.
A política de identidade e o conceito de reconhecimento têm se transformado em questões dominantes da teoria política contemporânea. Como conceito, o reconhecimento significa que um indivíduo ou grupo social reivindica o direito a ter sua identidade reconhecida, de forma direta ou através da mediação de um conjunto de instituições. As teorias que tem problematizado estas questões abordam tanto temas teóricos importantes como questões políticas centrais do nosso tempo, como a definição de direitos das minorias, reivindicações de autodeterminação nacional ou os desafios colocados por nossas sociedades cada dia mais multiculturais. Dessa forma, o objetivo central do presente artigo é apresentar e discutir os argumentos centrais de Charles Taylor, Axel Honneth e Nancy Fraser que têm se transformando em essenciais para esta discussão, enfatizando o debate em torno da relação entre reconhecimento e redistribuição, e mais especificamente entre o problema da injustiça baseada na questão da identidade e o problema da injustiça econômica. Por último, tentaremos entender algumas das implicações teóricas e políticas do discurso da diferença e das teorias do reconhecimento dentro de uma perspectiva conceptual mais ampla.
International mediation has traditionally been understood as an instrument aimed at getting political representatives to agree on a negotiated settlement. However, in cases where referendums were required for ratification, peace agreements have been rejected bythe people. This paper uncovers how mediators can help political leaders reach agreementsthat are supported by the people they represent by comparing the Annan Plan and Good Friday Agreement (GFA) mediations and referendums in Cyprus and Northern Ireland, respectively...
Die Dritte Option: Für wen?
(2017)
Sollte der Gesetzgeber eine Dritte Option im Personenstandsrecht einführen, so wird er sich damit auseinandersetzen müssen, wer Zugang zu dieser Dritten Option erhalten soll. Dieser Beitrag geht der Frage nach, was sich aus der Entscheidung vom 10. Oktober 2017 dazu entnehmen lässt: Muss die dritte Option neben inter*geschlechtlichen Menschen auch allen anderen offen stehen, die sich weder als Mann noch als Frau verstehen?
What processes transform (im)mobile individuals into ‘migrants’ and geographic movements across political-territorial borders into ‘migration’? To address this question, the article develops the doing migration approach, which combines perspectives from social constructivism, praxeology and the sociologies of knowledge and culture. ‘Doing migration’ starts with the processes of social attribution that differentiate between ‘migrants’ and ‘non-migrants’. Embedded in institutional, organizational and interactional routines these attributions generate unique social orders of migration. By illustrating these conceptual ideas, the article provides insights into the elements of the contemporary European order of ‘migration’. Its institutional routines contribute to the emergence of a European migration regime that involves narratives of economization, securitization and humanitarization. The organizational routines of the European migration order involve surveillance and diversity management, which have disciplining effects on those defined as ‘migrants’. The routines of everyday face-to-face interactions produce various micro-forms of doing ‘migration’ through stigmatization and othering, but they also provide opportunities to resist a social attribution as ‘migrant’.
Forensic entomology
(2017)
For many members of the forensic community, insects still have an exotic status. This may be one reason why forensic entomology, the analysis of insect evidence for forensic and legal purposes, has not yet achieved the significance it deserves in forensic sciences. The present special issue may help to change that. ...
TO INCREASE THE INFORMATION SECURITY AWARENESS AMONG THEIR WORKFORCE AND TO ACHIEVE SECURE INFORMATION SYSTEMS, DECISION-MAKERS EMPLOY MEASURES OF INFORMATION SECURITY, SUCH AS SECURITY POLICIES OR ASSOCIATED TRAINING AND EDUCATIONAL PROGRAMS. HOWEVER, THESE MEASURES MIGHT STRESS EMPLOYEES. THIS IS TRUE IF, FOR INSTANCE, INFORMATION SECURITY MEASURES ARE PERCEIVED AS DIFFICULT TO UNDERSTAND, AS AN INVASION OF PRIVACY, OR IF THEY GIVE RISE TO CONFLICTS OF INTEREST. CONSEQUENTLY, A MULTI-FACETED PERSPECTIVE ON EMPLOYEES' STRUGGLE WITH INFORMATION SECURITY IS DISCUSSED.
Background: Previous magnetic resonance imaging (MRI) research suggests that, prior to the onset of psychosis, high risk youths already exhibit brain abnormalities similar to those present in patients with schizophrenia.
Objectives: The goal of the present study was to describe the functional organization of endogenous activation in young adolescents who report auditory verbal hallucinations (AVH) in view of the “distributed network” hypothesis of psychosis. We recruited 20 young people aged 13–16 years who reported AVHs and 20 healthy controls matched for age, gender and handedness from local schools.
Methods: Each participant underwent a semi-structured clinical interview and a resting state (RS) neuroimaging protocol. We explored functional connectivity (FC) involving three different networks: 1) default mode network (DMN) 2) salience network (SN) and 3) central executive network (CEN). In line with previous findings on the role of the auditory cortex in AVHs as reported by young adolescents, we also investigated FC anomalies involving both the primary and secondary auditory cortices (A1 and A2, respectively).
Further, we explored between-group inter-hemispheric FC differences (laterality) for both A1 and A2. Compared to the healthy control group, the AVH group exhibited FC differences in all three networks investigated. Moreover, FC anomalies were found in a neural network including both A1 and A2. The laterality analysis revealed no between-group, inter-hemispheric differences.
Conclusions: The present study suggests that young adolescents with subclinical psychotic symptoms exhibit functional connectivity anomalies directly and indirectly involving the DMN, SN, CEN and also a neural network including both primary and secondary auditory cortical regions.
Dysfunction of the NO/sGC/cGMP signaling pathway has been implicated in the pathogenesis of pulmonary hypertension (PH). Therefore, agents stimulating cGMP synthesis via sGC are important therapeutic options for treatment of PH patients. An unwanted effect of this novel class of drugs is their systemic hypotensive effect. We tested the hypothesis that aerosolized intra-tracheal delivery of the sGC stimulator BAY41-8543 could diminish its systemic vasodilating effect.
Pharmacodynamics and -kinetics of BAY41-8543 after single intra-tracheal delivery was tested in healthy rats. Four weeks after a single injection of monocrotaline (MCT, 60 mg/kg s.c.), rats were randomized to a two-week treatment with either placebo, BAY 41-8543 (10 mg/kg per os (PO)) or intra-tracheal (IT) instillation (3 mg/kg or 1 mg/kg).
Circulating concentrations of the drug 10 mg/kg PO and 3 mg/kg IT were comparable. BAY 41-8543 was detected in the lung tissue and broncho-alveolar fluid after IT delivery at higher concentrations than after PO administration. Systemic arterial pressure transiently decreased after oral BAY 41-8543 and was unaffected by intratracheal instillation of the drug. PO 10 mg/kg and IT 3 mg/kg regimens partially reversed pulmonary hypertension and improved heart function in MCT-injected rats. Minor efficacy was noted in rats treated IT with 1 mg/kg. The degree of pulmonary vascular remodeling was largely reversed in all treatment groups.
Intratracheal administration of BAY 41-8543 reverses PAH and vascular structural remodeling in MCT-treated rats. Local lung delivery is not associated with systemic blood pressure lowering and represents thus a further development of PH treatment with sGC stimulators.
Background: Signal transduction pathways are important cellular processes to maintain the cell’s integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they form intertwined networks. Mathematical models aim to capture their regulatory logic and allow an unbiased analysis of robustness and vulnerability of the signaling network. Pathway detection is yet a challenge for the analysis of signaling networks in the field of systems biology. A rigorous mathematical formalism is lacking to identify all possible signal flows in a network model.
Results: In this paper, we introduce the concept of Manatee invariants for the analysis of signal transduction networks. We present an algorithm for the characterization of the combinatorial diversity of signal flows, e.g., from signal reception to cellular response. We demonstrate the concept for a small model of the TNFR1-mediated NF- κB signaling pathway. Manatee invariants reveal all possible signal flows in the network. Further, we show the application of Manatee invariants for in silico knockout experiments. Here, we illustrate the biological relevance of the concept.
Conclusions: The proposed mathematical framework reveals the entire variety of signal flows in models of signaling systems, including cyclic regulations. Thereby, Manatee invariants allow for the analysis of robustness and vulnerability of signaling networks. The application to further analyses such as for in silico knockout was shown. The new framework of Manatee invariants contributes to an advanced examination of signaling systems.
We extend the classical ”martingale-plus-noise” model for high-frequency prices by an error correction mechanism originating from prevailing mispricing. The speed of price reversal is a natural measure for informational efficiency. The strength of the price reversal relative to the signal-to-noise ratio determines the signs of the return serial correlation and the bias in standard realized variance estimates. We derive the model’s properties and locally estimate it based on mid-quote returns of the NASDAQ 100 constituents. There is evidence of mildly persistent local regimes of positive and negative serial correlation, arising from lagged feedback effects and sluggish price adjustments. The model performance is decidedly superior to existing stylized microstructure models. Finally, we document intraday periodicities in the speed of price reversion and noise-to-signal ratios.
Im Folgenden werde ich die Rückkehr der Orthodoxie in drei Schritten am georgischen Beispiel erörtern. Im ersten Schritt werde ich die Rückkehr der Orthodoxie im Problemfeld des säkularisierten Staates verorten und einen Vergleich mit der Repolitisierung des Islam ziehen. Im zweiten Schritt werde ich die Rückkehr der Orthodoxie als nationalistische Ideologie beschreiben. Im dritten Schritt werde ich dieses Comeback aus der Erfahrung des Totalitarismus zu verstehen versuchen.
Im geographischen Areal der ehemaligen Sowjetunion existiert ein fast dreihundertjähriges Wechselverhältnis zwischen dem Feld der Macht und dem Feld der Literatur (und Kunst). Das "Denkmal" fungiert als Medium dieses Wechselverhältnisses, als ein Relais, das das Oszillieren des Heroischen zwischen dem Politischen und dem Künstlerischen, vom Staatslenker zum Künstler und zurück ermöglicht. Im Folgenden verfolgt Zaal Andronikashvili die Entstehung und Rezeption des Kulturheros aus und im Denkmal in fünf Schritten. Im ersten Schritt geht er auf die Aporien des Denkmals als eines absolutistischen Repräsentationsmediums ein. Der absolutistische Monarch ist zwischen dem Anspruch auf die ewige Präsenz und der nekrotischen Semantik des Denkmals hin- und hergerissen: er ist einerseits lebendig und immer präsent, andererseits erhebt er diesen Anspruch in und durch die Maske verstorbener Heroen. Im zweiten Schritt geht er den Konsequenzen nach, die die Einführung monarchischer Repräsentationsformen im Medium der Vollplastik im orthodoxen religionskulturellen Kontext hat: Sie setzt ikonoklastische Ressentiments frei und aktualisiert idolatrische Gefühle. Das Denkmal wird semantisch mit den Qualitäten des ambivalenten - sowohl heil- als auch unheilspendenden - Heros aufgeladen. Im dritten Teil untersucht Andronikashvili die künstlerische Kritik an solchen absolutistischen Repräsentationsformen sowie Fragen der Repräsentierbarkeit eines Künstlers am Beispiel der Denkmal-Gedichte von Aleksandr Puškin. Diese ist zugleich ikonoklastisch und ikonodul. Als ikonoklastische Kritik prangert sie das Gemachte, Künstliche, Tote der Repräsentation an. Der Künstler eignet sich aber auch monarchische Repräsentationsformen an, selbst wenn er sie sakral (freilich nicht im religiösen Sinne, sondern als Freiheitskampf) umdeutet. Dadurch begründet der Künstler einerseits einen vom Monarchischen unabhängigen politisch-poetischen Raum, andererseits übernimmt er sowohl die heilspendende als auch die nekrotische Semantik des Heros. Im vierten Teil verfolgt Andronikashvili die Transformation der künstlerischen Rezeption des Denkmals als Metapher zum tatsächlichen Denkmal des Künstlers im Russland des 19. Jahrhunderts. Im letzten Schritt wird gezeigt, wie die ikonoklastische Rezeption der Avantgarde den Künstler von seinem (metaphorischen) Denkmalpostament stürzt und das Künstlerische im Zuge der Oktoberrevolution wieder dem Politischen unterordnet. Die dadurch entstandene Leerstelle des Künstlerischen wird wiederum von der politischen Führer-Repräsentation gefüllt, die nicht nur die Erbschaft monarchischer Repräsentation, sondern auch die der kulturheroischen Repräsentation antritt.
Einleitung
(2017)
Das religionswissenschaftliche und ethnologische Kompositum Kulturheros bezeichnet Gestalten, die zwischen Göttern und Menschen stehen und die "für die Menschen überlebenswichtige[s] Kulturwissen zum ersten Mal einführen". Die Taten eines Kulturheros - etwa die Übergabe des Feuers an die Menschen - können in die Tradition der jeweiligen Gesellschaft eingehen, "zu bestimmten Anlässen feierlich erinnert" und "die Stiftungslegende eines Kults bilden". Die Enzyklopädie des Märchens definiert den Kulturheros als "mythische Figur meist früherer Überlieferungen, die für die jeweilige Gesellschaft Entscheidendes und Lebenswichtiges leistet". Donald Ward, der Verfasser dieses Eintrags, spricht zwar davon, dass neben Heiligen auch "Begründer, Reformer, Erfinder und politische Führer manchmal als echte Kulturheroen" (etwa Luther oder Kolumbus) gesehen werden können, seine Argumentation bleibt aber weitgehend auf Gestalten aus der Mythologie beschränkt. In unserem Band geht es hingegen nicht um mythische Figuren wie etwa Prometheus, sondern um ein neuzeitliches Phänomen: Mit Kulturheroen meinen wir Schriftsteller, Dichter, Wissenschaftler, Künstler oder Intellektuelle, denen ebenso wie den Kulturheroen der Religionswissenschaft bzw. Ethnologie in der Regel posthum eine herausragende kulturstiftende Rolle in der Gemeinschaft bzw. Gesellschaft zugeschrieben wird. Seit der Neuzeit werden Kulturheroen in dieser Weise medial konstruiert und durch Kultpraktiken geehrt, die früher eher militärischen oder politischen Helden vorbehalten waren.
Ein Dialog zwischen Sohn und Vater: "Wovon handeln Bücher eigentlich?" – "Alle wichtigen Bücher handeln von Gott." So beschreibt es Guus Kuijer in Das Buch von allen Dingen (2006). Mit dieser Geschichte beginnt der vorliegende Band über religiöse Spuren in aktueller Kinder- und Jugendliteratur, der die vier Vorlesungen des Kontaktstudiums der Theologischen Fakultät Fulda im Sommersemester 2015 unter dem Dictum versammelt: "Alle wichtigen Bücher handeln von Gott." (vgl. 7) Georg Langenhorst fundiert die religionspädagogische Auseinandersetzung mit Kinder- und Jugendliteratur in "Gestatten: Gott! Religion in der Kinder- und Jugendliteratur unserer Zeit. Befund, Deutung und Perspektiven für religiöses Lernen" (11–65) mit einer Analyse des aktuellen Jugendbuchmarktes. ...
The book examines the nexus between youth conflict and the occult drawing its insights from the oil-rich Niger Delta of Nigeria. It sees the occult represented by the Egbesu deity in this conflict as a form of religious belief imbued in this case with the powers of good. Thus, the religious occult is regenerated and re-energised as an idiom of justice and fairness within the Nigerian state by militant youth fighting the forces of the Nigerian state. Ingeniously, the young men simply dug into the cultural repertoire of the people for a hitherto popular expression of justice and perceived source of potency which they felt would not only provide spiritual protection but also pander to the popular imagination of justice. Even against the background prevalent Christianity, the Egbesu does not generate tension in beliefs but responds to the critical exigency of the immediate socio-political milieu of the people.
Due to the massive parallel operation modes at GSI accelerators, a lot of accelerator setup and re-adjustment has to be made by operators during a beam time. This is typically done manually using potentiometers and is very time-consuming. With the FAIR project the complexity of the accelerator facility increases further and for efficiency reasons it is recommended to establish a high level of automation for future operation. Modern Accelerator Control Systems allow a fast access to both, accelerator settings and beam diagnostics data. This provides the opportunity to implement algorithms for automated adjustment of e.g. magnet settings to maximize transmission and optimize required beam parameters. The fast-switching magnets in GSI-beamlines are an optimal basis for an automatic exploration of the parameter-space. The optimization of the parameters for the SIS18 multi-turn-injection using a genetic algorithm has already been simulated*. The first results of our automatized online parameter optimization at the CRYRING@ESR injector are presented here.
Para obter informações sobre os processos de pós-edição (PE) e tomada de decisão no par linguístico alemão/português, este trabalho apresenta os resultados de um estudo experimental de PE das partículas modais alemãs (PMs) doch e wohl para o português brasileiro. As PMs são elementos linguísticos que apresentam dificuldades de tradução e PE, pois são diretamente dependentes do contexto em que operam. Com a intenção de investigar o esforço cognitivo despendido no processamento das PMs em tarefas de PE, foram utilizados três instrumentos de pesquisa: o programa Translog-II; o rastreador ocular Tobii T60; relatos retrospectivos (livre e guiado). Para a realização do experimento, 20 participantes brasileiros pós-editaram cinco insumos de tradução automática para o português com as PMs doch e wohl. Os resultados corroboram a suposição de GUTT (1998) e os resultados da análise processual conduzida por ALVES (2007), que revelam que a relação entre esforço e efeito não acontece com base em uma associação de proporção direta. Portanto, a análise do processamento das PMs em tarefas de PE demonstra que, em ambientes cognitivos diferenciados, a capacidade de metarrepresentação tem implicações distintas na atribuição do mínimo esforço cognitivo necessário para se alcançar um determinado efeito contextual.
Este trabalho teve a intenção de investigar sobre o processo de tomada de decisão quanto às funções comunicativas das partículas modais (doravante PM), frente a diferentes contextos. Nesse sentido, aplicamos um questionário online em alemão. Para a coleta de dados foi solicitado a 62 participantes alemães nativos e não nativos que selecionassem dentre um conjunto de orações (contendo ou não PMs) as que proporcionariam interpretações adequadas para contextos pré-estabelecidos. Os resultados apontam que os participantes nativos tiveram maior facilidade em selecionar as opções esperadas nas tarefas apresentadas, porém as reflexões sobre as decisões tomadas foram desafiadoras para ambos os grupos. Portanto, a análise de dados indica deficiências na compreensão da função e complexidade modal das PMs. Assim, além de investigar as decisões tomadas pelos dois grupos, procuramos oferecer ferramentas para o ensino das PMs em aulas de alemão.
Southern African protected areas (PAs) harbour a great diversity of animals, which represent a large potential for wildlife tourism. In this region, global change is expected to result in vegetation changes, such as bush encroachment and increases in vegetation density. However, little is known on the influence of vegetation structure on wildlife tourists’ wildlife viewing experience and satisfaction. In this study, we collected data on vegetation structure and perceived mammal densities along 196 road transects (each 5 km long) and conducted a social survey with 651 questionnaires across four PAs in three Southern African countries. Our objectives were 1) to assess visitors’ attitude towards vegetation, 2) to test the influence of perceived mammal density and vegetation structure on the easiness to spot animals, and 3) on visitors’ satisfaction during their visit to PAs. Using a Boosted Regression Tree procedure, we found mostly negative non-linear relationships between vegetation density and wildlife tourists’ experience, and positive relationships between perceived mammal densities and wildlife tourists’ experience. In particular, wildlife tourists disliked road transects with high estimates of vegetation density. Similarly, the easiness to spot animals dropped at thresholds of high vegetation density and at perceived mammal densities lower than 46 individuals per road transect. Finally, tourists’ satisfaction declined linearly with vegetation density and dropped at mammal densities smaller than 26 individuals per transect. Our results suggest that vegetation density has important impacts on tourists’ wildlife viewing experience and satisfaction. Hence, the management of PAs in savannah landscapes should consider how tourists perceive these landscapes and their mammal diversity in order to maintain and develop a sustainable wildlife tourism.
Günümüzde, çevrilecek olan metnin sayfa düzeninin basıma hazır hale getirilmesinin çevirmenlerden sıkça istenmesi, çevirmenlik mesleğine olan bakış açısının değiştiğini açıkça göstermektedir. Kaynak kültürde var olan görsel bilgilerin alımlanması ve bunların erek kültüre uygun bir şekilde aktarılması gerekmektedir. Çeviri eğitiminde ‘başarılı’ bir çevirinin yalınızca sözcüklerin ve söz diziminin doğru aktarılmasıyla gerçekleşmeyeceği bilgisi edebi metinlere yönelik çözümleme yöntemini kullanarak verilebilir. Yan metinlerin değerlendirilmesi anlama sürecine katkı sağlar ve kültürel öğrenmeyi kolaylaştır. Bu bağlamda öğrencilere uyguladıkları çeviri stratejisini gerekçelendirme beceresi kazandırır. Edebi metinlerin çözümlenmesinde, yazar tarafından bilinçli kullanılan biçimsel özelliklerin ayırt edilmesi önemlidir. Bu doğrultudan yola çıkarak, bu çalışmada, çeviri sürecinde yan metinlerin önemini ortaya çıkarmaya çalışılacak ve bu bağlamda makro yapının çözümlenmesi yönteminden yararlanılacaktır. Bu nedenle "Wir Kinder vom Bahnhof Zoo,-Christiane F" adlı eserin Türkçe çevirisi "Eroin,-Christiane F'in Korkunç Anıları" [Die erschreckenden Erlebnisse der Christiane F.] kullanılacaktır. Ele alınan metnin çözümlenmesi, Koller tarafından ileri sürülen “alımlayıcının farklı beklentilerini saptayan ölçütler” (2004) göz önünde bulundurarak yapılacaktır.
The Republic of Panama currently has 21 recorded species of stoneflies, all in the genus Anacroneuria (Plecoptera: Perlidae). Herein, we record five species of this genus from the Mount Totumas Cloud Forest and Biological Reserve, in the upper reaches of the Río Chiriquí Viejo watershed. One of these species, A. plutonis (Banks), represents a new country record for Panama. These results are part of an ongoing effort to characterize the aquatic insect fauna of Panama, and to evaluate that country’s major watersheds.
Als Peter Härtling am 7.11.2014 mit dem Hessischen Kulturpreis ausgezeichnet wird, spielt er auf die reformpädagogischen "fromme[n] Wünsche" an, die mit dem von Ellen Key 1902 ausgerufenen "Jahrhundert des Kindes" für das 20. Jahrhundert postuliert worden waren, und die, wie er selbst als Kind während und nach dem Zweiten Weltkrieg erfahren musste, "unerfüllbar" gewesen seien. Sein Rückblick lässt ihn allerdings zu dem Schluss kommen, dass das 21. Jahrhundert noch "schlimmer" sei, denn es handele sich um das "Jahrhundert des Flüchtlingskindes". Es liegt folglich nahe, angesichts seines im Herbst 2016 erschienenen "Romans für Kinder", Djadi, Flüchtlingsjunge, auf den erinnernden Autor zu blicken, der mit 13 Jahren kurz nach Ende des Zweiten Weltkriegs zum Waisen wurde. ...
"Ich mache die Orte zu meinen Sehnsuchtsorten, an die es mich zufällig verschlägt. Und ich lade diese Orte mit dem auf, was ich mitbringe – ganz ohne Erwartungen. So erstaunt es mich auch immer wieder, wie viel man aus einem Ort "herausholen" kann." So beschreibt Felicitas Hoppe im Interview mit dem Journalisten und Geografen Jens Nommel ihr Vorgehen bei der Konstituierung von Räumen in der diegetischen Welt. Diese Aussage ließe sich paradigmatisch auf das Gesamtwerk der Autorin übertragen, so sind es weniger Beschreibungen von realen Orten und Topografien, die sich hier finden, als vielmehr im Schreibprozess entstehende Imaginationsorte, die durch das Zusammentreffen eines den Orten Bedeutung zuweisenden Bewusstseins und der äußeren Beschreibung derselben entstehen. Dies geschieht, so die These dieses Beitrags, mithilfe einer Destabilisierung der strukturbildenden Elemente von Raum, Zeit und Kausalität, die in der Folge einen Vorstellungsraum öffnen, in dem physikalische Grenzen überwunden und im Modus der Gleichzeitigkeit alternative Seinsweisen erprobt werden können. Hoppe schließt dabei an die Darstellungstechniken der Literarischen Moderne an, greift die Diskussionen der Postmoderne vom Ende der großen Metaerzählungen, dem Tod des Subjekts und allgemeiner Geschichtslosigkeit auf und entwirft im Sinne einer Transmoderne alternative Darstellungsformen. […] Ziel des vorliegenden Beitrags ist demnach zunächst das Aufzeigen der Destabilisierungsprozesse in Bezug auf die genannten Elemente mithilfe einer textimmanenten Analyse der zeitlichen und räumlichen Struktur. Dabei werden, erstens, die verschiedenen Spielarten des Zeitbegriffs sowie Raumsemantiken auf der intradiegetischen Ebene in den Blick genommen, zweitens, Möglichkeiten der Zeit- und Raumgestaltung auf der Ebene des discours untersucht und schließlich der Prozess der Refiguration beleuchtet. Im Anschluss wird der Frage nach dem Funktionspotenzial der erarbeiteten Destabilisierungsprozesse sowie der Entwicklung derselben als ästhetisches Programm nachgegangen. Da die angeführten Destabilisierungsprozesse je nach thematischer Schwerpunktsetzung unterschiedliche Funktionen einnehmen, werden Hoppes Romane 'Pigafetta', 'Paradiese, Übersee', 'Johanna' und 'Der beste Platz der Welt' chronologisch analysiert und im Anschluss einem synthetisierenden Vergleich unterzogen.
Der jüdische Intellektuelle Ludwig Börne (1786-1837), der einer breiten Öffentlichkeit als Journalist, Literatur- und Theaterkritiker sowie Vermittler zwischen Frankreich und Deutschland bis in die Gegenwart ein Begriff ist, soll 1821 geurteilt haben, dass Johannes Weitzel der beste deutsche politische Schriftsteller sei. Umso erstaunlicher bei einer solchen Eloge durch eine weithin bekannte und seine Zeit prägende Geistesgröße ist, dass der Name Johannes Weitzel und dessen Werk heute weitestgehend unbekannt sind. Wenn man weiterhin berücksichtigt, dass Weitzels schriftstellerisches Werk mit den Werken und den Lebenswegen von Johann Joseph von Görres (1776-1848), Karl August Fürst von Hardenberg (1750-1822) und Karl Wenzeslaus Rodeckher von Rotteck (1775-1840), Karl Theodor Georg Philipp Welcker (1790-1869) sowie Georg Christoph Lichtenberg (1742-1799) korrespondierte, mit allen denen er in einem direkten Austausch stand, wundert man sich umso mehr, dass ein solch wichtiger ideengeschichtlicher Impulsgeber - was sich übrigens auch daran zeigt, dass er als eher bürgerlicher politischer Autor selbst für das Demokratieverständnis der deutschen Frühsozialisten von großer Bedeutung war - dermaßen in Vergessenheit geraten konnte. Wolfgang Kötzlers 1961 aufgeworfene Frage "Und wem, außer wenigen Fachhistorikern, ist sein Name heute noch ein Begriff?" gilt jedenfalls auch heute noch.
This paper is a comparative imagological analysis of the novels Die Schrift des Freundes (1998) by Barbara Frischmuth and Über Land (2016) by Hannah Dübgen. It aims to examine the direct communication with the stranger because the discussion with the stranger includes the discussion with the Self. The encounter with other religions and cultures opens up new ways for the self, to understand one’s own self from different angles. In this context, this study is to analyze the two novels with respect to interpretive models of experiencing the strangeness by Ortfried Schäffter and tries to answer the question about the influence of the stranger on the Self and the complementarity between them.
In Deutschland nahezu unbekannt, gehört der Schriftsteller Laurent Tailhade (1854-1919) zu den interessantesten Persönlichkeiten des literarischpolitischen Anarchismus im Frankreich des späten 19. Jahrhunderts. Er verfasste zahlreiche Gedichte und Essays, trat aber auch als Autor polemischer Zeitungsartikel und als aggressiver Redner hervor, sodass sich an seiner Person exemplarisch das Zusammenspiel von literarisch-ästhetischer und politisch-provokativer Praxis darstellen lässt.
Berühmt wurde Tailhade durch seinen zynischen Ausspruch "Qu’importent les victimes si le geste est beau!" anlässlich des Attentats von Auguste Vaillant auf die Französische Nationalversammlung im Dezember 1893: Gegenüber der "Schönheit" des terroristischen Aktes spielten humanitäre Erwägungen für Tailhade scheinbar keine Rolle. Nur wenige Monate später, im April 1894, wurde er selbst Opfer eines Anschlags in dem Pariser Restaurant Foyot, wobei er ein Auge einbüßte, sich aber dennoch - dies ist neben der ‚Ironie des Schicksals‘ der eigentlich entscheidende Aspekt - weiterhin für anarchistische Ideen einsetzte. Im Folgenden soll versucht werden aufzuzeigen, wie sich die zur viel zitierten ästhetizistischen Provokationsformel geronnene Aussage Tailhades in dessen literarisch-intellektueller Entwicklung und im künstlerischen und politischen Kontext des 19. Jahrhunderts verorten lässt.
Die Berichterstattung über den Nahostkonflikt gehört seit Jahrzehnten zum Standardrepertoire der Nachrichten. Hierzulande hat fast jeder eine Meinung zum israelisch-arabischen Konflikt, doch wenige verstehen, um was es den Konfliktparteien eigentlich geht, was in bisherigen Verhandlungen erreicht worden ist und wo genau die Hürden für eine Konfliktregelung liegen. Dieses Buch liefert eine kompakte und zugleich anschauliche und detaillierte Analyse des Konflikts zwischen Israel und seinen arabischen Nachbarn. Dabei stehen die lokalen und regionalen Akteure im Mittelpunkt. Um die Konfliktdynamiken zu erklären, geht das Buch vor allem auf die konkurrierenden Interessen und Narrative der Konfliktparteien sowie ihre Wechselwirkungen ein.
Background: HCV GT4 accounts for up to 20% of HCV infections worldwide. Simeprevir, given for 12 weeks as part of a 24- or 48-week combination regimen with PR is approved for the treatment of chronic HCV GT4 infection. Primary study objectives were assessment of efficacy and safety of simeprevir plus PR in treatment-naïve patients with HCV GT4 treated for 12 weeks. Primary efficacy outcome was sustained virologic response 12 weeks post-treatment (SVR12). Additional objectives included investigation of potential associations of rapid virologic response and baseline factors with SVR12.
Methods: This multicentre, open-label, single-arm study (NCT01846832) evaluated efficacy and safety of simeprevir plus PR in 67 patients with HCV GT4 infection. Patients were treatment-naïve, aged 18–70 years with METAVIR F0–F2 fibrosis. Patients with early virologic response (HCV RNA <25 IU/mL [detectable/undetectable in IL28B CC patients or undetectable in IL28B CT/TT patients] at Week 2 and undetectable at Weeks 4 and 8) were eligible to stop all treatment at the end of Week 12, otherwise PR therapy was continued to Week 24.
Results: Of 67 patients treated, 34 (51%) qualified for 12-week treatment including all but one patient with IL28B CC genotype (14/15). All patients in the 12-week group had undetectable HCV RNA at end of treatment, and 97% (33/34) achieved SVR12. No new safety signals with simeprevir plus PR were identified. The proportion of patients experiencing Grade 3–4 adverse events was lower in the 12-week group than in the 24-week group.
Conclusions: Our findings on simeprevir plus PR therapy shortened to 12 weeks in patients with HCV GT4 infection with favourable baseline characteristics and displaying early on-treatment virologic response are encouraging. No new safety signals were associated with simeprevir plus PR in this study.
[Rezension zu: Lewe, Christiane; Othold, Tim und Nicolas Oxen (Hg.): Müll. Interdisziplinäre Perspektiven auf das Übrig-Gebliebene. Bielefeld: Transcript, 2016.]”.
Der von Christiane Lewe, Tim Othold und Nicolas Oxen herausgegebene Band Müll. Interdisziplinäre Perspektiven auf das Übrig-Gebliebene eröffnet in Schlaglichtern Zugänge zu ‚übrig-gebliebener‘ Materialität in kulturwissenschaftlicher Perspektive. Ausgehend von der Annahme, bei nicht mehr gebrauchten Dingen handele es sich um das Ergebnis sozio-kultureller Zuschreibungsprozesse, interessieren sich die Beiträge für so unterschiedliche Phänomene wie die Inszenierung von Müll im Fernsehen, Gender und Schmutz, Gebäuderecycling, Self-Storage oder künstlerische Auseinandersetzungen mit Müll. Als gemeinsamer Schnittpunkt der Fallstudien stellt sich dabei das Vorhaben heraus, den als konventionell unterstellten Abwertungen des Übrig-Gebliebenen entgegenzuarbeiten. Eine literaturwissenschaftliche Perspektive fehlt hingegen.
In Benin, people have a rich ethnobotanical knowledge of plant species, reflecting the cultural and ecological diversity of their environment. Several studies were focused on the question of how valuable are plant species for local communities. However, there has been very little research interest in the orchid species in spite of the importance of orchids in the livelihood of the local people. This study examined the use and differences in knowledge of local people of orchids in the Sudanian zone of Benin. An ethnobotanical study was conducted amongst the four main socio-economic and ethnic groups from six villages around the Pendjari Biosphere Reserve in Benin. One hundred and sixty people participated in this study. Data were gathered using semi-structured individual interviews and analysed using quantitative ethnobotanical methods. 29 different types of use were recorded and can be grouped into four main use categories: medicinal, veterinary, spiritual and food. There were differences in orchid utilization among the ethnic groups, gender and age. The knowledge of orchid uses was significantly affected by the ethnic group and the age of the respondent. Unlike young educated generations, most adults and elders, especially women, had a more comprehensive knowledge of orchid uses. Calyptrochilum christianum, the most used orchid, was mentioned in more than 50% of the types of orchid use. The Gourmantché and Waama tribe had more knowledge on orchid use whereas the Berba tribe had less knowledge. Three orchid species (Habenaria cirrhata, Eulophia horsfallii and Nervilia bicarinata) were reported as food. Orchids had low use value ranging from 0.01 (Eulophia spp) to 0.2 (C. christianum). The controlled access to the biosphere reserve and rural exodus can explain the lack of indigenous knowledge transfer of orchid use and value from elders to the young generation.
Die Mittelalterabteilung des Liebieghauses unter der Leitung von Stefan Roller, stellt seit dem 6. Dezember seine neueste, spektakuläre Erwerbung vor. Das spätgotische (um 1470/75), noch original polychrom gefasste Christuskind wurde schon 2011 bei der Ausstellung "Niclaus Gerhaert. Der Bildhauer des Mittelalters" im Liebieghaus gezeigt und stammt aus Privatbesitz. ...
This book is about transnational migration (familiarly called bushfalling) and remittance flows to Cameroon. With the current dire economic state, Cameroonians increasingly aspire to go abroad to make a living. Migrants achieve this through a collective (family) strategy and with the help of migration brokers. Relations between migrants and the family that stays in Cameroon can be characterized as follows: Families raise and educate their children to become adults. In return to giving their children the gift of life, families expect reciprocity, best secured through economic success abroad and the sending of remittances by migrants. As families in Cameroon heavily contribute to the funding of migration trajectories, often by selling properties such as land or houses or borrowing money, they also expect a return on their investments. All that constitutes this study explores under the notion of the moral economy of transnational remittances. In this study, remittances are understood to be a composite of financial, material, and cultural flowsmaintaining and transforming social and kinship ties. The book proposes also a large exploration of themes in relation to transnational migration: why and how Cameroonians migrate (the role of the operational family in terms of decision and funding; the role of migration brokers through the identification of lines and the provision of the necessary papers); the moral justification for migration; the ways social relations and customs are changed by status gained through migration; the ways people explain the failure of migration projects, the difficulties to stay abroad; the matrimonial strategies to go and stay abroad. This is an empirically rich and theoretically sophisticated study that takes thinking on transnational migration informed by African strategies and experiences a step further.
Polychelidan lobsters (Decapoda: Polychelida) are crustaceans with extant species which are restricted to deep water environments. Fossil species, however, used to live in more varied palaeoenvironments, from shallow water to deep water, and were more diverse morphologically. We redescribe two species of polychelidan lobsters, the Late Triassic Rosenfeldia triasica Garassino, Teruzzi & Dalla Vecchia, 1996 and the Late Jurassic Eryon oppeli Woodward, 1866, recently assigned to the same genus, Rosenfeldia, based upon only a few characters. Our investigation of all available material of both species leads us to distinguish these two species and to erect Rogeryon gen. nov. to accommodate Eryon oppeli. The palaeobiology of both species is interpreted for the first time. Rosenfeldia triasica with its stout first pereiopods and mandibles with both incisor and molar processes (documented for the first time in Polychelida) was benthic and probably fed either on slow-moving sedentary preys or was a scavenger. Rogeryon oppeli gen. et comb. nov. was benthic, visually adapted to shallow water palaeoenvironments, and possibly had a diet similar to that of slipper lobsters and horseshoe crabs. The redescription of these two species highlights the palaeobiological diversity of fossil polychelidans.
Ich spreche im Folgenden über ein Thema, das 'Hermeneutik nach Luther' heißen soll. Als Hermeneutik verstehe ich dabei im Anschluss an Friedrich Schleiermacher - also im Anschluss an einen protestantischen Theologen, der seine eigene Hermeneutikkonzeption vorwiegend mit Bezug auf die Auslegung des Neuen Testamentes entwickelt hat, das heißt in einem dezidiert christlichen und zugleich mehrfachen, noch näher zu klärenden nach-Luther'schen Sinn - die "Kunst des Verstehens". Die Bestimmung verdeutlicht, dass das Verstehen nichts Selbstverständliches ist. Verstehen versteht sich nicht von selbst. Es muss selbst verstanden werden. Hermeneutik bezeichnet nach diesem Verständnis eine Aufgabe, und zwar, wie Schleiermacher zu betonen nicht müde wird, eine niemals abgeschlossene, immer weiter fortzusetzende Aufgabe.
The concept of sound iconicity implies that phonemes are intrinsically associated with non-acoustic phenomena, such as emotional expression, object size or shape, or other perceptual features. In this respect, sound iconicity is related to other forms of cross-modal associations in which stimuli from different sensory modalities are associated with each other due to the implicitly perceived correspondence of their primal features. One prominent example is the association between vowels, categorized according to their place of articulation, and size, with back vowels being associated with bigness and front vowels with smallness. However, to date the relative influence of perceptual and conceptual cognitive processing on this association is not clear. To bridge this gap, three experiments were conducted in which associations between nonsense words and pictures of animals or emotional body postures were tested. In these experiments participants had to infer the relation between visual stimuli and the notion of size from the content of the pictures, while directly perceivable features did not support–or even contradicted–the predicted association. Results show that implicit associations between articulatory-acoustic characteristics of phonemes and pictures are mainly influenced by semantic features, i.e., the content of a picture, whereas the influence of perceivable features, i.e., size or shape, is overridden. This suggests that abstract semantic concepts can function as an interface between different sensory modalities, facilitating cross-modal associations.
Eirini Avramopoulou asks the following questions in her essay 'Claims of Existence between Biopolitics and Thanatopolitics': How is the desire for existence implicated in the experience of identity as wound? Under which conditions does the demand for desire appear to confront the repetition of trauma? Or else, what echoes in the last breath of someone dying? In Istanbul, a city built upon neoliberal structures of governance and cosmopolitan aesthetics, and defined by severe policing and local histories of ethnic and gender violence, these questions reflect upon a particular historical and political period through a personal story. The essay focuses on a transgender activist named Ali, his fight against transphobia, his illness and death, while reflecting on the 2013 public uprising in Istanbul following attempts by the Turkish government to demolish Gezi park. By exploring the notion of spectral survival as a political praxis, it argues that this notion, rather than acceding to claims over a fuller subjectivity, mobilizes an aporia of de-subjectivation. De-constituting the 'I' here attests to an attempt neither to reconfigure its parts nor to merely perceive life as dismantled, but rather to speak of a loss that no familiar language can yet describe. The spectrality of this 'I' troubles and repoliticizes, then, the very notion of haunting, as it lays claims to its own differing and deferral from the constitution of a proper name, or of a 'self'-acclaimed existence, especially when the fight for existence here is also a performative assertion of loss and death connected to processes of resisting sexist, neoliberal, heteronormative, and phallogocentric representations of possession and belonging.
Background: Hereditary angioedema (HAE) is a rare genetic disease causing unpredictable and potentially life-threatening subcutaneous and submucosal edematous attacks. Cinryze® (Shire ViroPharma Inc., Lexington, MA, USA), a nanofiltered C1 inhibitor (C1-INH), is approved in Europe for the treatment, preprocedure prevention, and routine prophylaxis of HAE attacks, and for the routine prophylaxis of attacks in the USA. This phase 3 study assessed the safety and efficacy of 2 C1-INH doses in preventing attacks in children aged 6-11 years. Methods: A randomized single-blind crossover study was initiated in March 2014. Results for the first 6 patients completing the study are reported here. After a 12-week qualifying observation period, patients were randomly assigned to 1 of 2 C1-INH doses, 500 or 1,000 U, every 3-4 days for 12 weeks and crossed over to the alternative dose for a second 12-week period. The primary efficacy endpoint was the number of angioedema attacks per month. Results: Six females with HAE type I and a median age of 10.5 years received 2 doses of C1-INH (500 and 1,000 U). The mean (SD) difference in the number of monthly angioedema attacks between the baseline observation period and the treatment period was -1.89 (1.31) with 500 U and -1.89 (1.11) with 1,000 U. During the treatment periods, cumulative attack severity, cumulative daily severity, and the number of attacks needing acute treatment were lower. No serious adverse events or study drug discontinuations occurred. Conclusions: Interim findings from this study indicate that routine prevention with intravenous administration of C1-INH is efficacious, safe, and well tolerated in children ≥6 years of age.
Background: Kyrgyzstan, where HIV is concentrated in prisons and driven by injection drug use, provides a prison-based methadone maintenance therapy program as well as abstinence-oriented therapeutic community based on the 12-step model called the “Clean Zone.” We aimed to qualitatively assess how prisoners navigate between these treatment options to understand the persistence of the Clean Zone despite a lack of evidence to support its effectiveness in treating opioid use disorders.
Methods: We conducted an analysis of policy documents and over 60 h of participant observation in February 2016, which included focus groups with a convenience sample of 20 therapeutic community staff members, 110 prisoners across three male and one female prisons, and qualitative interviews with two former Clean Zone participants. Field notes containing verbatim quotes from participants were analyzed through iterative reading and discussion to understand how participants generally perceive the program, barriers to entry and retention, and implications for future treatment within prisons.
Results: Our analyses discerned three themes: pride in the mission of the Clean Zone, idealism regarding addiction treatment outcomes against all odds, and the demonization of methadone.
Conclusion: Despite low enrollment and lack of an evidence base, the therapeutic community is buttressed by the strong support of the prison administration and its clients as an “ordered” alternative to what is seen as chaotic life outside of the Clean Zone. The lack of services for Clean Zone patients after release likely contributes to high rates of relapse to drug use. The Clean Zone would benefit from integration of stabilized methadone patients combined with a post-release program.
We have reported previously that Short Interspersed Degenerate Retroposons of the SIDER2 subfamily, largely located within 3'UTRs of Leishmania transcripts, promote rapid turnover of mRNAs through endonucleolytic cleavage within the highly conserved second tandem 79-nt hallmark sequence (79-nt SII). Here, we used site-directed mutagenesis and in silico RNA structural studies to delineate the cis-acting requirements within 79-nt SII for cleavage and mRNA degradation. The putative cleavage site(s) and other nucleotides predicted to alter the RNA secondary structure of 79-nt SII were either deleted or mutated and their effect on mRNA turnover was monitored using a gene reporter system. We found that short deletions of 8-nt spanning the two predicted cleavage sites block degradation of SIDER2-containing transcripts, leading to mRNA accumulation. Furthermore, single or double substitutions of the dinucleotides targeted for cleavage as well as mutations altering the predicted RNA secondary structure encompassing both cleavage sites also prevent mRNA degradation, confirming that these dinucleotides are the bona fide cleavage sites. In line with these results, we show that stage-regulated SIDER2 inactivation correlates with the absence of endonucleolytic cleavage. Overall, these data demonstrate that both cleavage sites within the conserved 79-nt SII as well as RNA folding in this region are essential for SIDER2-mediated mRNA decay, and further support that SIDER2-harboring transcripts are targeted for degradation by endonucleolytic cleavage.
We describe a new vanilla species growing in sympatry with Vanilla planifolia Jacks. ex Andrews (Orchidaceae) in the province of Limón, Caribbean coast of Costa Rica. The morphology of the reproductive and vegetative organs observed on vines cultivated under shade-house, the nuclear (Internal Transcribed Spacer) and plastid (matK) nucleotide sequences, as well as the contents of aromatic compounds measured in ripe fruits, show that this species is close to but distinct from V. planifolia. The name V. sotoarenasii M.Pignal, Azofeifa-Bolaños & Grisoni sp. nov. is proposed for this new Vanilla species endemic in Costa Rica. It is especially distinguished from V. planifolia by a reduction of about 30% of the size of the fruits and flowers, by a divergence of ITS sequences for at least two species-conserved nucleotides compared to seven other species of the V. planifolia group, and by the presence of anisic compounds and low content of phenolic compounds (including vanillin) in the fruits. These results confirmed the extension of the area of distribution of V. planifolia southward to Costa Rica, where a recent speciation process occurred. Because of its particular agronomic and aromatic properties, V. sotoarenasii sp. nov. could represent a valuable biological resource for the vanilla industry.
Cytokine regulation of high-output nitric oxide (NO) derived from inducible NO synthase (iNOS) is critically involved in inflammation biology and host defense. Herein, we set out to characterize the role of type I interferon (IFN) as potential regulator of hepatic iNOS in vitro and in vivo. In this regard, we identified in murine Hepa1-6 hepatoma cells a potent synergism between pro-inflammatory interleukin-β/tumor necrosis factor-α and immunoregulatory IFNβ as detected by analysis of iNOS expression and nitrite release. Upregulation of iNOS by IFNβ coincided with enhanced binding of signal transducer and activator of transcription-1 to a regulatory region at the murine iNOS promoter known to support target gene expression in response to this signaling pathway. Synergistic iNOS induction under the influence of IFNβ was confirmed in alternate murine Hepa56.1D hepatoma cells and primary hepatocytes. To assess iNOS regulation by type I IFN in vivo, murine acetaminophen (APAP)-induced sterile liver inflammation was investigated. In this model of acute liver injury, excessive necroinflammation drives iNOS expression in diverse liver cell types, among others hepatocytes. Herein, we demonstrate impaired iNOS expression in type I IFN receptor-deficient mice which associated with diminished APAP-induced liver damage. Data presented indicate a vital role of type I IFN within the inflamed liver for fine-tuning pathological processes such as overt iNOS expression.
Michael Bachmann untersucht die spezifische Situation von Theater und Performancekunst als "privilegierte Orte der (künstlerischen) Zeugenschaft". Nachdem er die grundsätzliche Ambivalenz der Beziehung zwischen dem Theatralen und der Rechtspraxis, zwischen Theater und Prozess, herausgestellt hat, analysiert Bachmann das südafrikanische Stück "Ubu and the Truth Commission" (1997), in dem eine Puppe das bezeugende Opfer verkörpert. Die Übertragung des Zeugenstatus auf eine explizit künstliche Figur erlaubt eine Reflexion, die auf "die ethische Frage der Stellvertretung zwischen verschiedenen Akteuren der Zeugenschaft und deren jeweilige Handlungsmacht sowie auf die Frage der Autorisierung" hinausläuft: "Wer gewinnt in welchem Rahmen auf welche Weise die Autorität, als Zeuge zu fungieren?" Bachmann zeigt, wie die Puppe als ästhetisches Objekt eine testimoniale Überzeugungskraft gewinnt und das Verhältnis von Handlungsmacht ('agency') und testimonialer Autorität veranschaulicht. Die ethisch-epistemische Frage der Autorität und Autorisierung des Zeugen wird letztlich auf das ästhetische Verfahren des Puppenspiels zurückgeführt, in dem die Differenz zwischen Bühnenfigur und Opferzeuge "einen Raum eröffnet, durch den das Zeugnis vermeintlich selbst zur Sprache kommt". Dieses "zur Sprache kommen" ereignet sich allerdings unterschiedlich, wenn es tatsächlich durch Sprache geschieht (wie etwa in Peter Weiss' "Ermittlung") oder eher durch einen körperlich-performativen Ausdruck (wie in William Kentridges Inszenierung von "Ubu").
In this thesis we study strongly correlated electron systems within the Density Functional Theory (DFT) in combination with the Dynamical Mean-Field Theory (DMFT).
First, we give an introduction into the theoretical methods and then apply them to study realistic materials. We present results on the hole-doped 122-family of the iron-based superconductors and the transition-metal oxide SrVO3. Our investigations show that a proper treatment of strong electronic correlations is necessary to describe the experimental observations.
In Volume 5, Number 2, of Zoologia Caboverdiana, Richard Porter and Tony Prater reassessed the two existing records of Baird’s sandpiper Calidris bairdii for Cabo Verde, concluding that both were misidentified, based on the respective photographs in the 6th and 8th Cabo Verde Bird Reports (Hazevoet 2010, 2014).
Beim Gebrauch einer Fremdsprache durch Anfänger handelt es sich offensichtlich um "Spielarten interkultureller Kommunikation" (FÖLDES 2007: 614). Eine bezüglich der arabischen Auslandsgermanistik ergiebige Auseinandersetzung mit der Schreibfertigkeit gelingt erst, wenn interkulturelle und handlungsorientierte Aspekte zusammen und sprachkomparatistisch berücksichtigt werden. Davon ausgehend lässt sich dann erklären, inwieweit mögliche differente Verhaltens- und Handlungsmuster in der deutschen und der arabischen Sprach- bzw. Kulturgemeinschaft das Schreiben in der deutschen Sprache beeinflussen. Neben Faktoren im sprachsystematischen und lexikalisch-semantischen Bereich lässt sich dies im pragmatischen Bereich an zwei Parametern des kommunikativen Verhaltenstyps (Grad der Expressivität sowie der der Ritualisierung) untersuchen. Mögliche differente Verhaltens- bzw. Handlungsweisen werden hier anhand von arabischen Germanistikstudierenden geschriebener Aufsätze bzw. E-Mails diskutiert.
Autophagy is a physiological process for the recycling and degradation of cellular materials. Forming the autophagosome from the phagophore, a cup-shaped double-membrane vesicle, is a critical step in autophagy. The origin of the cup shape of the phagophore is poorly understood. In yeast, fusion of a small number of Atg9-containing vesicles is considered a key step in autophagosome biogenesis, aided by Atg1 complexes (ULK1 in mammals) localized at the preautophagosomal structure (PAS). In particular, the S-shaped Atg17-Atg31-Atg29 subcomplex of Atg1 is critical for phagophore nucleation at the PAS. To study this process, we simulated membrane remodeling processes in the presence and absence of membrane associated Atg17. We show that at least three vesicles need to fuse to induce the phagophore shape, consistent with experimental observations. However, fusion alone is not sufficient. Interactions with 34-nm long, S-shaped Atg17 complexes are required to overcome a substantial kinetic barrier in the transition to the cup-shaped phagophore. Our finding rationalizes the recruitment of Atg17 complexes to the yeast PAS, and their unusual shape. In control simulations without Atg17, with weakly binding Atg17, or with straight instead of S-shaped Atg17, the membrane shape transition did not occur. We confirm the critical role of Atg17-membrane interactions experimentally by showing that mutations of putative membrane interaction sites result in reduction or loss of autophagic activity in yeast. Fusion of a small number of vesicles followed by Atg17-guided membrane shape-remodeling thus emerges as a viable route to phagophore formation.
Development of the timing system for the Bunch-to-Bucket transfer between the FAIR accelerators
(2017)
The FAIR project is aiming at providing high-energy beams of ions of all elements from hydrogen to uranium, antiprotons and rare isotopes with high intensities. The existing accelerator facility of GSI and the future FAIR facility employ a variety of circular accelerators like heavy ion synchrotrons (SIS18 and SIS100) and storage rings (ESR, CRYRING, CR and HESR) for the preparation of secondary beams and experiments. Bunches are required to be transferred into rf buckets among GSI and FAIR ring accelerators for different purposes. Without the proper transfer, the beam will be subject to various beam quality deterioration and even to beam losses. Hence, the proper bunch-to-bucket (B2B) transfer between two rings is of great importance for FAIR and is the topic, which has been investigated in this thesis.
These circular accelerators of GSI and FAIR have different ratios in their circumference. For example, the circumference ratio between SIS100 and SIS18 is an integer and between SIS18 and ESR is close to an integer and between CR and HESR is far away from an integer. The ring accelerators are connected via a complicated system of beam transfer lines, targets for the secondary particle production and the high energy separators mentioned above. For FAIR, not only the primary beams are required to be transferred from one ring to another, but also the secondary beams, e.g. the antiproton or rare isotope beams produced by the antiproton (pbar) target, the fragment separator (FRS) or the superconducting fragment separator (Super-FRS). An important topic for this system of accelerators is the proper transfer of beam between the different circular accelerators. Bunches of one ring must be transferred into buckets of another ring within an upper bound time constraint (e.g. 10 ms for most FAIR use cases) and with an acceptable B2B injection center mismatch +-1 degree for most FAIR use cases). Hence, a flexible FAIR B2B transfer system is required to realize the different complex B2B transfers between the FAIR rings in the future. In the focus of the system development and of this thesis is the transfer from SIS18 to SIS100, which can be tested at GSI on the transfer from SIS18 to ESR and from ESR to CRYRING. The system is based on the existing technical basis at GSI, the low-level radio frequency (LLRF) system and the FAIR control system. It coordinates with the Machine Protection System (MPS), which protects SIS100 and subsequent accelerators and experiments from damage caused by high intensity primary beams in case of malfunctioning. Besides, it indicates the beam status and the actual beam injection time for the beam instrumentation and diagnostics.
The conceptual realization of the FAIR B2B transfer system was introduced in this thesis for the first time. It achieves the most FAIR B2B transfers with a tolerable B2B injection center mismatch (e.g. +-1 degree) and within an upper bound time (e.g. 10 ms). It supports two synchronization methods, the phase shift and frequency beating methods. It is flexible to support the beam transfer between two rings with different ratios in their circumference and several B2B transfers running at the same time, e.g. the B2B transfer from SIS18 to SIS100 and at the same time the B2B transfer from ESR to CRYRING. It is capable to transfer beam of different ion species from one machine cycle to another and to transfer beams between two rings via the FRS, the pbar target and the Super-FRS. It allows various complex bucket filling pattern. In addition, it coordinates with the MPS system, which protects the SIS100 and subsequent accelerators or experiments from beam induced damage.
A list of criteria for the preservation of beam qualities during the rf frequency modulation of the phase shift method was analyzed. As an example the beam reaction on three different rf frequency modulation examples were analyzed for SIS18 beams. According to the beam dynamic analysis, there is a maximum value for the rf frequency modulation. The first derivative of the rf frequency modulation must be continuous and small enough and the second derivative must be small enough.
In addition to the analysis from the viewpoint of beam dynamics, two test setups were built. The first test setup was used to characterize the FAIR timing network – white rabbit network for the B2B transfer. In the second test setup, the firmware of the FAIR B2B transfer system was evaluated, which was running on the soft CPU, LatticeMico32, of the Scalable Control Unit - the FAIR standard Front End Controller. Besides, the boundary conditions of the different trigger scenarios of the SIS18 extraction and SIS100 injection kicker magnets were investigated. Finally, the application of the FAIR B2B transfer system for all FAIR use cases was demonstrated.
The dissertation plays a significant important role for the realization of the FAIR B2B transfer system and the further practical application of the system to all FAIR use cases.
This paper analyzes serpentine figures in Eichendorff's novella 'Das Marmorbild', which are inscribed in the body of Venus in the mannerist style. These figurae serpentinatae gradually gain dynamism, move into the foreground of attention, and then condense into repulsive snake figures which evoke associations of the cunning snake of the Garden of Eden, the serpents on the back of the Frau Welt figure, and the fearsome Echidna of Greek mythology. These allusions also characterize the art which Venus represents as something abysmal and threatening. The multiple contextualization of the snake also reveals that 'Das Marmorbild' offers a double reading: in the narrower sense, Venus can be viewed as a representation of Romantic art, while in the wider sense she personifies art in general.
Rezension zu: Zengin, Dursun (2016): Her Yönüyle Almanca İlgeçler. Ankara: Nika Yayınevi. 409 S. ISBN: 9786059386050
Edebi Çevirinin Özellikleri
(2017)
Rezension zu: Zengin, Dursun (2016): Edebi Çevirinin Özellikleri. Kayseri: Tiydem Yayıncılık. 176 S. ISBN: 9786054510979
The accuracy on neutron capture cross section of fissile isotopes must be improved for the design of future nuclear systems such as Gen-IV reactors and Accelerator Driven Systems. The High Priority Request List of the Nuclear Energy Agency, which lists the most important nuclear data requirements, includes also the neutron capture cross sections of fissile isotopes such as 233,235U and 239,241Pu. A specific experimental setup has been used at the CERN n_TOF facility for the measurement of the neutron capture cross section of 235U by a set of micromegas fission detectors placed inside a segmented BaF2 Total Absorption Calorimeter.
Die humane 5-LO ist das Schlüsselenzym in der LT-Biosynthese. LTs sind wichtige Entzündungsmediatoren und sind in einer Vielzahl von Krankheiten involviert, u. a. Asthma, Atherosklerose, rheumatische Arthritis, Sepsis, allergischen Reaktionen und in vielen Krebsarten. Die Struktur der 5-LO besteht aus 673 Aminosäuren und besitzt ein Molekulargewicht von 78 kDa. Sie ist in zwei Domänen unterteilt: die kleinere C2-ähnliche regulatorische Domäne (C2ld) und der größeren katalytischen Domäne. Die 5-LO besitzt NIS und NES, die für die zelluläre Lokalisation der 5-LO verantwortlich sind. Außerdem wird die Lokalisation noch von Phosphorylierungsstellen reguliert, die auf der katalytischen Domäne identifiziert werden konnten. 2011 konnten Häfner et al. zeigen, dass die 5-LO in der Lage ist Homodimere zu bilden.
Wie für die meisten anderen humanen Gene konnten auch bei der 5-LO alternative Spleißvarianten identifiziert werden. Schon 1992 konnten die ersten unterschiedlich gesüleißten Transkripte in Hirntumoren und differenzierten HL-60-Zellen gefunden werden. Später konnten weitere Isoformen in verschiedenen Zelllinien entdeckt werden.
In der vorliegenden Arbeit wurden die alternativen Spleißvarianten 5-LO∆13, 5-LO∆4 und 5-LOp12 untersucht und charakterisiert. Auf mRNA-Ebene wurde die Expression des 5-LO-WT und deren Isoformen sowohl in B- und T-Zelllinien als auch primären B- und T-Zellen, monozytären Zelllinien und primäre Monozyten aus Patientenproben (RA und Sepsis) untersucht. Es wurde festgestellt, dass das Expressionsprofil der 5-LO-Varianten zellspezifisch ist. Im Vergleich zu den T-Zellen konnte in B-Zelllinien ein höheres Expressionslevel detektiert werden. Des Weiteren zeigte sich interessanterweise ein stark erhöhtes Expressionslevel in primären Monozyten von RA- und Sepsis-Patienten.
Untersuchungen der 5-LO-Aktivität ergaben unterschiedliche Ergebnisse, abhängig von der Transfektionsmethode. Als transiente Transfektion diente die Calciumphosphat-Methode. Für die stabile Integration der HEK293T-Zellen wurde die Sleeping Beauty-Methode gewählt. Hierfür wurden Proteine mit einem GFP bzw. mCherry-Tag (GFP-5-LO-WT, mCherry∆13, mCherry∆4, mCherryp12) verwendet, um diese mittels Konfokalmikroskop visualisieren zu können. Nach transienter Transfektion konnte eine Inhibition der 5-LO-Aktivität nach Kotransfektion mit jeweils einer Isoform gemessen werden. Nach stabiler Integration jedoch zeigte sich eine Steigerung der 5-LO-Produktbildung. Mit Hilfe von Western Blots wurden Expressionskontrollen angefertigt und die Menge des 5-LO-WT quantifiziert. In transient transfizierten Zellen wurde eine Erniedrigung der Expression des 5-LO-WT bestimmt, wohingegen in stabil integrierten Zellen ein Anstieg des 5-LO-WT als auch der Isoformen beobachtet werden konnte. Einerseits könnte dies einem Artefakt der Transfektionmethode zugrunde liegen, andererseits könnte es ein Hinweis darauf sein, dass sich die Proteine gegenseitig in ihrer Expression beeinflussen.
Ebenso wurde die Lokalisation der 5-LO und deren Isoformen untersucht. Es konnte gezeigt werden, dass die 5-LO überwiegend im Zellkern lokalisiert ist, während alle alternativen Protein-Isoformen im Zytosol zu finden waren. Durch Ionophor-Behandlung wurde eine Translokation des 5-LO-WT an die Kernmembran detektiert, die Isoformen verblieben im Zytosol. Überraschenderweise konnte beobachtet werden, dass die Spleißvariante 5-LO∆13 mit höherer Ionophor-Konzentration ebenso in der Lage ist an die Kernmembran zu translozieren. Um eine mögliche Interaktion der 5-LO mit den Isoformen zu untersuchen, sollten alle Proteine im selben Zellkompartiment lokalisiert sein. Dafür wurden verschiedene Stimuli und Mutationen getestet. Mit der Mutante GFP-5-LO-S271A und dem Stressstimulus Sorbitol und den CaMKII/p38-Inhibotoren KN-93/SB203580 konnte eine Translokation in das Zytosol erreicht werden. Die Ergebnisse der anschließenden Aktivitätsassays zeigten, dass die Isoformen keinen Einfluss auf die Aktivität der 5-LO ausüben.
Des Weiteren wurden die Phosphorylierungen an S523 und S271 von 5-LO-WT, 5-LO∆13, 5-LO∆4 und 5-LOp12 untersucht. Es wurde herausgefunden, dass die 5-LO-Proteine unterschiedliche Phosphorylierungsmuster aufweisen. Während 5-LO-WT und 5-LO∆4 eine schwache Phosphorylierung an S271 aufzeigen, konnte eine starke Phosphorylierung der 5-LO∆13 und 5-LOp12 detektiert werden. Im Vergleich dazu zeigte lediglich die Isoform 5-LOp12 eine sehr starke Bande an der Phosphorylierungsstelle S523. Bei beiden Phosphorylierungen konnten deutlich stärkere Signale nach Kotransfektion gemessen werden. Durch Klonierung eines P2A-Linkers zwischen 5-LO und des GFP-Tags, konnten die Isoformen vom 5-LO-WT in Western Blots voneinander getrennt werden. Dies zeigte, dass es zu einer Hochregulation der Expression der alternativen 5-LO-Varianten nach Kotransfektion mit dem WT führte, aber auch, dass die stärkere Phosphorylierung nach Kotransfektion unabhängig von der Proteinmenge ist.
nvestor-state-dispute-settlement (ISDS) is an arbitration mechanism to settle disputes between foreign investors and host-states. Seemingly a technical issue in private international law, ISDS procedures have recently become a matter of public concern and the target of political resistance, due to the power they grant to foreign investors in matters of public policies in the countries they invest in. This article examines the practice of ISDS through the lenses of liberal-statist theories of international justice, which value self-determination. It argues that the investor-state arbitration system illustrates how liberal-statist theories of international distributive justice ought to care about relative socioeconomic disadvantage, contra the sufficiency principle that they typically defend. The sufficiency principle draws on a questionable conception of the freedom that self-determination consists in.
Labour migration from Malawi to South Africa is a 'century-old phenomenon'. It dates as far back as the 1880s following the establishment of diamond and gold mines. In the period up to the 1980s, this migration took either formal or informal nature whereas in the post-1990 period it became exclusively informal, popularly known as selufu in Malawi. This book is an attempt to shed light on both forms of migration over time. By using the case of Mzimba, one of the major labour migration districts in Malawi, Perspectives of Labour Migration shows that migration, especially in the post-1990 period, remains a preoccupation of the different categories of both men and women in selected areas in the country. A cross-section of Malawians continue to regard emigration to South Africa as a means to an end: a way of fulfilling their heart-felt and life-time goals at household and societal levels. Because of their distinguished and unparalleled determination, these labour migrants continue to flock to South Africa in the midst of such challenges as xenophobia, crime, arrests and deportations. The book advances the argument that Malawian labour migrants are purposive and rational human beings who are ready to overcome these challenges, at times using the most improbable means, for example, through the use of mankhwala gha mwabi (luck medicine).
Migration from Malawi to South Africa : A Historical and Cultural Novel ; Real-life Experiences
(2017)
Since the discovery and exploitation of minerals like gold, diamond and copper in South Africa, Zimbabwe and Zambia in the late nineteenth and early twentieth centuries, Malawi has played the role of a labour supplier. Malawians were attracted by the relatively higher wages obtaining in the South African mines up to the period of the decline in mine migrancy at the end of the 1980s. Following this decline, a cross-section of Malawians continued to emigrate to South Africa to seek various jobs in the burgeoning informal sector and also for trade purposes. Migration from Malawi to South Africa sheds light on the problems that labour migrants and traders encounter as they are 'toing' and 'froing' between Malawi and South Africa in pursuit of their respective goals. It shows that migration, which initially was exclusively done for wage employment, is becoming more complex by the day. This is a result of the infusion of elements of commercial migration, smuggling and human trafficking. The book advances the argument that the numbers of migrants to South Africa increased in the post-1994 period partly as a result of mal-administration by the successive democratically-elected governments in Malawi. This development weakened Malawi's otherwise promising economy and impoverished the rural masses. The book 'sees' forlorn hope in the future of labour migrants and traders, unless the Malawi Government starts to genuinely have the welfare of the populace at heart! The book is relevant and accessible to policy-makers, university and college students interested in migration studies, general readers and migrants, themselves.
We analyze the market reaction to the sentiment of the CEO speech at the Annual General Meeting (AGM). As the AGM is typically preceded by several information disclosures, the CEO speech may be expected to contribute only marginally to investors’ decision-making. Surprisingly, however, we observe from the transcripts of 338 CEO speeches of German corporates between 2008 and 2016 that their sentiment is significantly related to abnormal stock returns and trading volumes following the AGM. Using a novel business-specific German dictionary based on Loughran and McDonald (2011), we find a negative association of the post-AGM returns with the speeches’ negativity and a positive association with the speeches’ relative positivity (i.e. positivity relative to negativity). Relative positivity moreover corresponds with a lower trading volume in a short time window surrounding the AGM. Investors hence seem to perceive the sentiment of CEO speeches at AGMs as a valuable indicator of future firm performance.
We analyze the market reaction to the sentiment of the CEO speech at the Annual General Meeting (AGM). As the AGM is typically preceded by several information disclosures, the CEO speech may be expected to contribute only marginally to investors’ decision making. Surprisingly, however, we observe from the transcripts of 338 CEO speeches of German corporates between 2008 and 2016 that their sentiment is significantly related to abnormal stock returns and trading volume around the AGM. By adapting a finance-specific German dictionary based on Loughran and McDonald (2011), we find a negative association of the post-AGM returns with the speeches’ negativity and a positive association with the speeches’ relative positivity (i.e. positivity relative to negativity). Relative positivity moreover corresponds with a lower trading volume around the AGM. Investors hence seem to perceive the sentiment of CEO speeches at AGMs as a valuable indicator of future firm performance. Our results are robust against different weighting schemes and our dictionary appears to be better suited to grasp the sentiment of German business documents compared to general dictionaries.
The training of morphological decomposition in word processing and its effects on literacy skills
(2017)
This study set out to examine the effects of a morpheme-based training on reading and spelling in fifth and sixth graders (N = 47), who present poor literacy skills and speak German as a second language. A computerized training, consisting of a visual lexical decision task (comprising 2,880 items, presented in 12 sessions), was designed to encourage fast morphological analysis in word processing. The children were divided between two groups: the one underwent a morpheme-based training, in which word-stems of inflections and derivations were presented for a limited duration, while their pre- and suffixes remained on screen until response. Another group received a control training consisting of the same task, except that the duration of presentation of a non-morphological unit was restricted. In a Word Disruption Task, participants read words under three conditions: morphological separation (with symbols separating between the words’ morphemes), non-morphological separation (with symbols separating between non-morphological units of words), and no-separation (with symbols presented at the beginning and end of each word). The group receiving the morpheme-based program improved more than the control group in terms of word reading fluency in the morphological condition. The former group also presented similar word reading fluency after training in the morphological condition and in the no-separation condition, thereby suggesting that the morpheme-based training contributed to the integration of morphological decomposition into the process of word recognition. At the same time, both groups similarly improved in other measures of word reading fluency. With regard to spelling, the morpheme-based training group showed a larger improvement than the control group in spelling of trained items, and a unique improvement in spelling of untrained items (untrained word-stems integrated into trained pre- and suffixes). The results further suggest some contribution of the morpheme-based training to performance in a standardized spelling task. The morpheme-based training did not, however, show any unique effect on comprehension. These results suggest that the morpheme-based training is effective in enhancing some basic literacy skill in the population examined, i.e., morphological analysis in word processing and the access to orthographic representations in spelling, with no specific effects on reading fluency and comprehension.
The Cosmological Lithium Problem refers to the large discrepancy between the abundance of primordial 7Li predicted by the standard theory of Big Bang Nucleosynthesis and the value inferred from the so-called “Spite plateau” in halo stars. A possible explanation for this longstanding puzzle in Nuclear Astrophysics is related to the incorrect estimation of the destruction rate of 7Be, which is responsible for the production of 95% of primordial Lithium. While charged-particle induced reactions have mostly been ruled out, data on the 7Be(n,α) and 7Be(n,p) reactions are scarce or completely missing, so that a large uncertainty still affects the abundance of 7Li predicted by the standard theory of Big Bang Nucleosynthesis. Both reactions have been measured at the n_TOF facility at CERN, providing for the first time data in a wide neutron energy range.
"Im Grunde ist der ästhetische Anarchismus viel gefährlicher als der politische", warnte Hans Sedlmayr, österreichischer Kunsthistoriker mit NS-Vergangenheit und höchst umstrittener Kritiker der modernen Kunst, in einem Beitrag für die Zeitschrift Scheidewege von 1978. Während die Aktionen der politischen Anarchisten historisch weitgehend folgenlos geblieben seien, habe die anarchische Ästhetik der künstlerischen Avantgarden in einer viel umfassenderen, permanenten Revolution alle Bereiche des menschlichen Lebens im 20. Jahrhundert erfasst.
Die Absage an die Kunst, die Logik, die Ethik, die Scham; an die Kirche, den Staat, die Familie; an die klassische Tradition Europas wie an jede Religion - ist in die Tages- und Bildzeitungen, in Film- und Fernsehen, auf das Theater und in die Happenings, in die Praxis des Lebens eingedrungen. Die Ursprünge dieser Entwicklung verortet Sedlmayr in der Frühromantik, genauer: den Texten von Friedrich Schlegel und Novalis - "ohne sie ist das anarchische 20. Jahrhundert in der Tiefe nicht zu begreifen."
In Schlegels frühem, Ende 1795 fertiggestelltem Aufsatz 'Über das Studium der griechischen Poesie' allerdings, der noch weitgehend den Maßstäben einer klassizistischen Ästhetik verpflichtet ist und vom Verfasser des Verlusts der Mitte bei seinen Überlegungen daher zustimmend angeführt wird, erscheint das Wort 'Anarchie' überwiegend negativ konnotiert. Es fungiert hier als Metapher für Charakter-, Gesetz- und Formlosigkeit, für moralischen Verfall und ästhetische Desorientierung auf dem Gebiet der modernen Dichtkunst.
Neste artigo se investiga a linguagem do poema satírico "Atta Troll - ein Sommernachtstraum" (Atta Troll - sonho de uma noite de verão), escrito em 1841 por Heinrich Heine. A investigação se volta a dois aspectos profundamente entrelaçados preponderantes no poema, que suscitam este estudo literário: primeiramente a exigência do poeta, a qual percorre o longo poema como Leitmotiv, de uma arte sem fins, sem influências de motivações morais, religiosas ou políticas, fundamentada em leis próprias, emergente da noção do belo, e cujos fins estejam inerentes na arte mesma. O segundo viés que se releva no poema é a relação metafórica da poesia com a dança, arte essa que em suas diversas manifestações formais e informais é observada por um crivo rigoroso ao longo do poema. A partir desses dois aspectos se indicia através de trechos traduzidos ao português afinidades importantes dessa literatura, que tanto se inclina ao romantismo, quanto à passagem para a modernidade, a cujas transformações ela aponta quando aborda questões sobre estética e sobre o papel do poeta.
Sie treten einzeln auf, zu zweit, in der Regel durchfenstert, oft in Begleitung von Backstein, meistens mit einem Vordach und immer: in Farbe. Doch nicht nur den Türen verpasste Bruno Taut einen Anstrich – ganze Siedlungen wurden vielfarbig gestaltet, außen wie innen. Auf dem Ersten Deutschen Farbentag 1925 in Hamburg stellte Taut in seinem Vortrag kategorisch fest: "Da alles seine Farbe hat, so muss auch alles, was Menschen tun, farbig gestaltet sein." ...
Cnestus mutilatus (Blandford) (Coleoptera: Curculionidae: Scolytinae) is reported from Pennsylvania for the fi rst time, new state record. Specimens were collected using baited Lindgren funnels as early as 2013. Within Pennsylvania, C. mutilatus is now reported from Berks, Bucks, Lehigh, Montgomery, and York Counties.
Cixidia fusca and Synecdoche impunctata (Hemiptera: Achilidae) are reported from Missouri for the first time, new state records. Ecological and trapping information is also provided.
Auf den ersten Blick wirkt der zur Besprechung vorliegende Sammelband uneinheitlich, weil eine große Zahl von unterschiedlichen Themen angesprochen wird, denen scheinbar nur gemeinsam ist, dass sie sich mit der unmittelbaren Vorgeschichte des Ersten Weltkrieges und mit dem Jahr 1914 befassen. Dies ist bei näherer Betrachtung aber kein Manko: Gerade diese Diversität zeigt, wie uneinheitlich und widersprüchlich sich Europa im Sommer 1914 präsentiert hat. Aus vielen Beiträgen wird deutlich, dass es die eine Vorkriegszeit nicht gegeben hat, sondern dass sehr unterschiedliche Erfahrungen und Wahrnehmungen, die sich zum Teil widersprachen, direkt nebeneinander existierten. Diese Pluralität stellt einen untrennbaren Bestandteil der unmittelbaren Vorkriegszeit dar. Der Band ist in die drei Hauptsektionen Kriegserwartungen, Friedenshoffnungen und Mobilisierungen unterteilt. Abgerundet werden diese durch einen abschließenden Ausblick von Christoph Cornelissen, in dem knapp aber präzise auf die neuen Kontroversen um die Kriegsursachen, auf die Globalgeschichte des Weltkrieges und auf das erhebliche Medienecho im Epochenjahr 2014 eingegangen wird. ...
Recently the Universal Linear Accelerator (UNILAC) serves as a powerful high duty factor (25%) heavy ion beam accelerator for the ambitious experiment program at GSI. Beam time availability for SHE (Super Heavy Element)-research will be decreased due to the limitation of the UNILAC providing Uranium beams with an extremely high peak current for FAIR simultaneously. To keep the GSI-SHE program competitive on a high level and even beyond, a standalone superconducting continuous wave (100% duty factor) LINAC in combination with the upgraded GSI High Charge State injector is envisaged. In preparation for this, the first LINAC section (financed by HIM and GSI) will be tested with beam in 2017, demonstrating the future experimental capabilities. Further on the construction of an extended cryo module comprising two shorter Crossbar-H cavities is foreseen to test until end of 2017. As a final R&D step towards an entire LINAC three advanced cryo modules, each comprising two CH cavities, should be built until 2019, serving for first user experiments at the Coulomb barrier.
"Bibliotheken in [die] Zukunft führen" (Bibliothekartag 2016) bleibt das bestimmende Motto für die Managementkommission, da es angesichts zahlreicher Umweltveränderungen weiterhin seine Relevanz behalten wird. Daher wurde beim Round Table am 12. September 2016 in Stuttgart der Frage nachgegangen, welche organisationalen Strukturen gut geeignet sind, um erforderliche Prozesse zu unterstützen: „Beschränkt durch Linie, Stab und Matrix – Relevanz von Organisationsstrukturen und alternative Instrumente zur Organisationsentwicklung“. Zu dieser erweiterten Kommissionssitzung wurden Expert/inn/en aus öffentlichen und wissenschaftlichen Bibliotheken eingeladen, die sich aktuell mit der organisatorischen Gestaltung ihrer Häuser auseinandersetzen. Organisationsmodelle und Veränderungsprozesse wurden von Christine Brunner (Stadtbibliothek Stuttgart), Karl-Wilhelm Horstmann (Kommunikations-, Informations- und Medienzentrum Hohenheim) und Salina Lotz (Universitätsbibliothek Kassel – Landesbibliothek und Murhardsche Bibliothek der Stadt Kassel) präsentiert. Der Einblick in die Organisationsstrukturen und ihre Anpassungen dokumentierte, dass organisationale Veränderungen aus konkreten Problemlagen heraus entwickelt werden, also unmittelbar Bestandteil eines Veränderungsprozesses sind, weniger Mittel der Veränderung als ergänzende Maßnahme. Für die Kommission war eine wesentliche Erkenntnis aus dieser Diskussion, dass auch in Bibliotheken das Denken in hierarchisch organisierten Organisationsmodellen und Arbeitsprozessen immer ungeeigneter wird, um die erforderliche Anpassung zu wettbewerbsfähigen Betrieben zu gestalten. ...
Public employees in many developing economies earn much higher wages than similar privatesector workers. These wage premia may reflect an efficient return to effort or unobserved skills, or an inefficient rent causing labor misallocation. To distinguish these explanations, we exploit the Kenyan government’s algorithm for hiring eighteen-thousand new teachers in 2010 in a regression discontinuity design. Fuzzy regression discontinuity estimates yield a civil-service wage premium of over 100 percent (not attributable to observed or unobserved skills), but no effect on motivation, suggesting rent-sharing as the most plausible explanation for the wage premium.
Stefan Barton behandelt die Bedeutung des Zeugenbeweises im Strafverfahren. Im Zentrum steht die für den juridischen Kontext so wichtige Regelhaftigkeit zur Autorisierung des Zeugnisses, sowohl im Sinne eines Szenariums als auch bezüglich seiner Choreographie. Es gibt nicht nur einen festen Korpus an möglichen Beweisen ("Urkunden-, Augenscheins-, Sachverständigen- oder eben Zeugenbeweis"); vielmehr unterliegt jede Beweisart einem Regelwerk, so auch das Zeugnis. Dort, wo an anderen Stellen ein Faktor wie ein 'Zeugenhelfer' hinzutreten muss, um aus dem Zeugnis Gewissheit entstehen zu lassen, kann es eine Glaubwürdigkeitsprüfung sein, beispielsweise in einer psychologischen Glaubhaftigkeitsbeurteilung: Auch vor Gericht wird das Zeugnis evaluiert. Und auch hier gilt, dass ein schwer fassbarer Überzeugungsfaktor am Ende Ausschlag gibt für die Evaluierung bzw. Relevanz des Zeugnisses: Für das Urteil entscheidend ist die Überzeugung des Richters bezüglich des verhandelten Sachverhalts.
The fouling serpulids (Polychaeta: Serpulidae) from United States coastal waters: an overview
(2017)
Serpulids are an important component of fouling communities. This paper provides an overview of the serpulid species found in North America, as part of a broader study of fouling invertebrates focused on NIS (non-indigenous species) in United States coastal ecosystems. Almost 4400 serpulid specimens were examined from selected fouling plates. Fouling plates were deployed in 26 bays and coastal lagoons along the continental coasts of the United States and Hawaiian islands, primarily in bays and lagoons with salinities averaging 20‰ or greater. Twenty-five serpulid species were identified, including four new records for the United States (Ficopomatus uschakovi, Hydroides cf. brachyacantha, H. longispinosa and Protula longiseta), three known NIS, two presumed NIS, three cryptogenic serpulids, and several range extensions. Crucigera websteri extends its northward range from Santa Barbara Island to Humboldt Bay, California; Ficopomatus enigmaticus, first recorded in North America from San Francisco, California in 1920, Rockport, Texas in 1952 and Barnegat Bay, New Jersey in 1980, is now recorded at additional localities on the east coast (Chesapeake Bay, Virginia, Charleston, South Carolina and Indian River, Florida) and the northern Gulf of Mexico (Galveston Bay, Texas); F. miamiensis extends its westward range from Louisiana to Texas; F. uschakovi, an Indo-Pacific and Western African species, was recorded formally for the first time from the northern Gulf of Mexico ((Galveston Bay and Corpus Christi, Texas) and the east coast of Florida (Jacksonville). Hydroides cf. brachyacantha extends its northward range from Curaҫao to Pensacola Bay, Florida; H. dirampha from Veracruz, Mexico to Corpus Christi, Texas; H. floridana extends its westward range from Louisiana to Texas; H. gracilis extends its northward range from Pacific Grove to San Francisco, California; Salmacina huxleyi from Cape Hatteras, North Carolina to Rhode Island; and Spirobranchus minutus from Veracruz, Mexico to Pensacola Bay, Florida. The following additional species range extensions are provisional in that they represent only one record or were not found in the most recent surveys (e.g., Hydroides elegans - east coast): H. longispinosa from Marshall Islands to Oahu, Hawaii; Protula balboensis from Florida to Texas; P. longiseta from the Mexican Caribbean to the Indian River, Florida; H. elegans from San Francisco to Humboldt Bay, northern California and on the east coast from the Indian River, Florida, to Cape Cod, Massachusetts. Among surveyed bays, Biscayne Bay, Florida and Corpus Christi, Texas (northern Gulf of Mexico) had the greatest number of species (14 and 8, respectively); in contrast, almost all sites in Alaska, Washington, Oregon (northwest Pacific), Rhode Island, Virginia and South Carolina (Atlantic) had only one or two species each. Hydroides dianthus was, by far, the most abundant serpulid species on fouling plates in the northern Gulf of Mexico and the east coast, while Pseudochitinopoma occidentalis was the most abundant serpulid detected on the west coast. For each species recorded herein, we include the synonyms and some key references, a material studied section, a diagnosis, and updated distributional information. A checklist and identification key to the known shallow-water serpulids sensu stricto of the United States are included.
Literatur- und Fremdsprachendidaktik : zur Rolle des Theaters im Deutschunterricht in Burkina Faso
(2017)
Die Verwendung der Belletristik im Fremdsprachenunterricht trägt dazu bei, sprachliche und kulturelle Kompetenzen zu erwerben. Da die Sprechfertigkeit eine der sechs Grundkompetenzen im DaF-Unterricht ist, ist ihr Erlernen eine grundlegende und unverzichtbare Aufgabe im Fach "Deutsch als Fremdsprache" in und außerhalb Deutschlands. Deshalb versucht dieser Aufsatz, die Potenziale des Theaters auszuloten, um diese Grundkompetenz bei den Deutschlernenden in Burkina Faso zu entwickeln. Es geht also darum, die Möglichkeiten des Theaters als literarische fiktionale Gattung beim Spracherwerb der burkinischen Deutschlernenden zu bestimmen. Darüber hinaus wird dargestellt, inwiefern ein Theaterstück in einer "classe de première" bzw. einer 11. Klasse Unterrichtsgegenstand sein sollte und literaturdidaktisch aufbereitet werden kann. Dafür werden Theorien und Methoden der Theaterdidaktik sowie der rezeptionsästhetischen Literaturdidaktik verwendet und an einem Beispiel illustriert.
Serine/arginine-protein kinase 1 (SRPK1) regulates alternative splicing of VEGF-A to pro-angiogenic isoforms and SRPK1 inhibition can restore the balance of pro/antiangiogenic isoforms to normal physiological levels. The lack of potency and selectivity of available compounds has limited development of SRPK1 inhibitors, with the control of alternative splicing by splicing factor-specific kinases yet to be translated. We present here compounds that occupy a binding pocket created by the unique helical insert of SRPK1, and trigger a backbone flip in the hinge region, that results in potent (<10 nM) and selective inhibition of SRPK1 kinase activity. Treatment with these inhibitors inhibited SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), resulting in alternative splicing of VEGF-A from pro-angiogenic to antiangiogenic isoforms. This property resulted in potent inhibition of blood vessel growth in models of choroidal angiogenesis in vivo. This work identifies tool compounds for splice isoform selective targeting of pro-angiogenic VEGF, which may lead to new therapeutic strategies for a diversity of diseases where dysfunctional splicing drives disease development.
Unter der Leitung der Ege Universität und der Beteiligung der Universität Paderborn, Istanbul und Hamburg fand vom 14. bis zum 16. November 2017 die erste internationale/kooperative Vierer-Tagung im Rahmen der Germanistischen Institutspartnerschaft an der Ege Universität in Izmir statt. Wissenschaftler und Interessierte reisten aus verschiedenen Städten wie Istanbul, Ankara, Eskişehir, Berlin, Paderborn, Hildesheim und Hamburg für die vom Deutschen Akademischen Austauschdienst (DAAD) geförderte GIP Tagung an und leisteten mit gebiets- und themenbezogenen Vorträgen einen besonderen Beitrag dazu, eine international sehr vielschichtige Plattform entstehen zu lassen, die mehr als nur den literaturwissenschaftlichen Austausch ermöglichte
Dort, wo der Weg der Geschichte sich gegabelt hat zwischen der Hinnahme des Gewohnten und dem Ausstieg aus ihm, so sanft wie tunlich oder so revolutionär wie nötig, da stoßen wir auf eine Reihe von Neuerern: Kritiker der gesellschaftlichen Verhältnisse oder der überkommenen Denkbahnen, z.T. auch Sprachkritiker, Sprachneuerer. Die "Linkshegelianer" bilden den Grundstock: Strauß, Feuerbach, Bruno Bauer, Stirner, Hess, in ihren Anfängen müssen wir auch Marx und Engels dazu zählen. Sie haben an schon etablierten politischen Lehren weitergearbeitet, aber sie haben, vor allem, neue Lehren und eine Kritik an allem Überkommenen in die Welt gesetzt. Zu einem beträchtlichen Teil haben sie sie nicht selbst erdacht. Bei französischen Revolutionären (oder auch Reformern) von Babeuf und Fourier bis zu Proudhon sind sie in die Lehre gegangen, Marx auch bei Ricardo und den Größen der britischen Nationalökonomie. Auf die Nachzeichnung jener Lehren soll es hier ankommen. Dazu greife ich einen heraus, der interessant ist, weil er von den Anfängen seiner Reflexion an, erst mit der Verarbeitung seines Judentums beschäftigt, sich zu einem Mitkämpfer der führenden kommunistischen Führerpersönlichkeiten entwickelt hat, aber auf anarchistische Weise; danach ist er auch noch bei den frühen Sozialdemokraten gelandet, eben Moses Hess.
Background: Health care accessibility is known to differ geographically. With this study we focused on analysing accessibility of general and specialized obstetric units in England and Germany with regard to urbanity, area deprivation and neonatal outcome using routine data.
Methods: We used a floating catchment area method to measure obstetric care accessibility, the degree of urbanization (DEGURBA) to measure urbanity and the index of multiple deprivation to measure area deprivation.
Results: Accessibility of general obstetric units was significantly higher in Germany compared to England (accessibility index of 16.2 vs. 11.6; p < 0.001), whereas accessibility of specialized obstetric units was higher in England (accessibility index for highest level of care of 0.235 vs. 0.002; p < 0.001). We further demonstrated higher obstetric accessibility for people living in less deprived areas in Germany (r = − 0.31; p < 0.001) whereas no correlation was present in England. There were also urban–rural disparities present, with higher accessibility in urban areas in both countries (r = 0.37–0.39; p < 0.001). The analysis did not show that accessibility affected neonatal outcomes. Finally, our computer generated model for obstetric care provider demand in terms of birth counts showed a very strong correlation with actual birth counts at obstetric units (r = 0.91–0.95; p < 0.001).
Conclusion: In Germany the focus of obstetric care seemed to be put on general obstetric units leading to higher accessibility compared to England. Regarding specialized obstetric care the focus in Germany was put on high level units whereas in England obstetric care seems to be more balanced between the different levels of care with larger units on average leading to higher accessibility.
In Germany, orthopedic workforce planning relies on population-to-provider-ratios represented by the "official degree of care provision". However, with geographic information systems (GIS), more sophisticated measurements are available. By utilizing GIS-based technologies we analyzed the current state of demand and supply of the orthopedic workforce in Germany (orthopedic accessibility) with the integrated Floating Catchment Area method. The analysis of n = 153,352,220 distances revealed significant geographical variations on national scale: 5,617,595 people (6.9% of total population) lived in an area with significant low orthopedic accessibility (average z-score = -4.0), whereas 31,748,161 people (39.0% of total population) lived in an area with significant high orthopedic accessibility (average z-score = 8.0). Accessibility was positively correlated with the degree of urbanization (r = 0.49; p<0.001) and the official degree of care provision (r = 0.33; p<0.001) and negatively correlated with regional social deprivation (r = -0.47; p<0.001). Despite advantages of simpler measures regarding implementation and acceptance in health policy, more sophisticated measures of accessibility have the potential to reduce costs as well as improve health care. With this study, significant geographical variations were revealed that show the need to reduce oversupply in less deprived urban areas in order to enable adequate care in more deprived rural areas.
Terahertz (THz) physics are an emerging field of research dealing with electromagnetic radiation in the far-infrared to microwave region. The development of innovative technologies for the generation and detection of THz radiation has only in the recent past led to a tremendous rise of both fundamental research as well as investigation of possible fields of application for THz radiation. The most prominent reason has long been the scarce accessibility of the THz region of the electromagnetic spectrum - commonly loosely located between 0.1 and 30 THz - to broad research, and it was mostly limited to astronomy and high energy physics facilities. Over the recent years, numerous novel concepts on both the source and detector side have been proposed and successfully implemented to overcome this so-called THz gap. New technology has become available and paved the way for wide-spread experimental laboratory work and accompanying theoretical investigations. First application studies have emerged and in some cases even commercial development of the field of THz physics is on the rise. Despite these enormous progresses, a continuing demand for more efficient THz detectors still impels current technological research. Relatively low source powers are often a major limiting factor and the request for new detection concepts, their understanding and implementation, as well as the optimization on a device basis has been and still remains in place. One of these concepts is the use of field-effect transistors (FETs) high above their conventional cut-off frequencies as electronic THz detectors. The concept has been proposed in a number of theoretical publications by M. Dyakonov and M. Shur in the early 1990's, who pioneered to show that under certain boundary conditions, non-linear collective excitations of the charge carrier system of a two-dimensional electron gas (2DEG) by incident THz radiation can exhibit rectifying behaviour - a detection principle, which has become known as plasma wave or plasmonic mixing. Up until this day, the concept has been successfully implemented in many device realizations - most advanced in established silicon CMOS technology - and stands on the edge of becoming commercially available on a large scale. The main direction of the work presented in this thesis was the modeling and experimental characterization of antenna-coupled FETs for THz detection - termed TeraFETs in this and the author's previous works - which have been implemented in different material systems. The materials presented in this thesis are AlGaN/GaN HEMTs and graphene FETs. In a number of scientific collaborations, TeraFETs were designed based on a hydrodynamic transport model, fabricated in the respective materials, and characterized mainly in the lower THz frequency region from 0.2 to 1.2 THz. The theoretical description of the plasma wave mixing mechanism in TeraFETs, as initiated by Dyakonov and Shur, was based on a fluid-dynamic transport model for charge carriers in the transistor channel. The THz radiation induces propagating charge density oscillations (plasma waves) in the 2DEG, which via non-linear self-mixing cause rectification of the incident THz signals. Over the course of this work, it became evident in the on-going detector characterization experiments that this original theoretical model of the detection process widely applied in the respective literature does not suffice to describe some of the experimental findings in TeraFET detection signals. Thorough measurements showed signal contributions, which are identified in this work to be of thermoelectric origin arising from an inherent asymmetric local heating of charge carriers in the devices. Depending on the material, these contributions constituted a mere side effect to plasmonic detection (AlGaN/GaN) or even reached a comparable magnitude (graphene FETs). To include these effects in the detector model, the original reduced fluid-dynamic description was extended to a hydrodynamic transport model. The model yields at the current stage a reasonable qualitative agreement to the measured THz detection signals. This thesis presents the formulation of a hydrodynamic charge carrier transport model and its specific implementation in a circuit simulation tool. A second modeling aspect is that the transport equations cover only the intrinsic plasmonic detection process in the active gated part of the TeraFET's transistor channel. In order to model and simulate the behavior of real devices, extrinsic detector parts such as ungated channel regions, parasitic resistances and capacitances, integrated antenna impedance, and others must be considered. The implemented detector model allows to simulate THz detection in real devices with the above influences included. Besides presentation of the detector model, experimental THz characterization of the fabricated TeraFETs is presented in this work. Careful device design yielded record detection performance for detectors in both investigated materials. The respective results are shown and the experimental observations of the thermoelectric effect in TeraFETs are compared to modeling results. It is the goal of this work to provide a framework for further theoretical and experimental studies of the plasmonic and thermoelectric effect in TeraFETs, which could eventually lead to a new type of THz detectors particularly exploiting the thermoelectric effect to enhance the sensitivity of today's plasmonic TeraFETs.
'Die Literatur der Roma Frankreichs' von Julia Blandfort, vorgelegt 2013 als Dissertation an der Universität Regensburg, ausgezeichnet mit dem Prix Germaine de Staël 2014, erschienen 2015 bei de Gruyter, legt den Grundstein für die Beschäftigung, innerhalb der romanischen Literaturen, aber darüber hinausgehend auch allgemein komparatistisch, mit den Roma-Literaturen der Romania.
Der Zwerg-Rohrkolben (Typha minima Funck ex Hoppe) ist eine charakteristische Pionierpflanze von alpinen Wildflusslandschaften. Seit den siebziger Jahren ist diese Kennart jedoch in Deutschland vollständig und in Österreich nahezu ausgestorben. Die anhaltenden Populationsrückgänge der Art sind wahrscheinlich das Ergebnis der weitverbreiteten Flussregulierung und des Kraftwerksbaus in Kombination mit den sehr speziellen Standortsansprüchen der Art. Dank den Anstrengungen von Wiederansiedlungsprogrammen befindet sich T. minima wieder an der Oberen Drau in Österreich. In dieser Publikation wird über die Keimung, das Wachstum, die Reproduktion und die Umweltpräferenzen von T. minima berichtet.
Die Keimungsexperimente von 2014 zeigten eine sehr niedrige mittlere Keimungsrate von 15,6% bei einem Schwankungsbereich von 0–90 %. Die Keimungsraten stiegen mit höheren Temperaturen, erhöhter Saatgutreife und kürzeren Saatgutlagerungszeiten. Nach der Saatgutlagerung von 480 Stunden wurde keine Keimung mehr beobachtet.
Beim FFH-Monitoring 2014 an der Oberen Drau wurden Zwerg-Rohrkolben-Keimlinge (Höhe < 5 cm) generell nur selten gefunden. Die vegetative Jungphase (Höhe > 15 cm, ausschließlich sterile Triebe) wies zumeist den höchsten Flächenanteil im Mittel von 62% auf. Typha minima bildete bis zu einem Alter von ca. 3 Jahren ausschließlich sterile Triebe aus. Ab einem Alter von ca. 9 Jahren wurden auch fertile Triebe mit Blütenständen ausgebildet, wobei deren Anzahl mit zunehmendem Alter sich tendenziell erhöhte. Die Analyse der Standortsfaktoren zeigte, dass T. minima auf eine hohe Bodenfeuchte im Mittel von 39 Vol-% angewiesen ist. Darüber hinaus war der Faktor Beschattung entscheidend. Erst ab einem Beschattungsgrad von 50% durch Weidengebüsche war eine Abnahme der Triebdichte von T. minima zu verzeichnen. Wir schließen daraus, dass T. minima-Populationen während der Keimungsphase extrem empfindlich sind und dass massive Habitatverluste überwiegend das Ergebnis der Flussregulation und der reduzierten Morphodynamik sind, die normalerweise geeignete offene Siedlungsräume für die Keimung des Zwerg-Rohrkolbens schaffen würde.
Scharlatane waren für die Gelehrtendiskurse der Frühen Neuzeit von kaum zu überschätzender Bedeutung, da sich anhand ihres Negativbeispiels Verhaltensideale formulieren ließen, die für die Wissenschaft maßgeblich waren. Das Interesse an dieser Figur reichte auch in die Literatur hinein, wo sie in vielfältiger Weise aufgegriffen wurde und um 1800 verstärkt in Erscheinung trat. Christoph Martin Wieland war einer der Autoren, die sich besonders intensiv mit ihr befassten. In seinem Roman Geschichte der Abderiten (1773-1779) inszeniert er den geistigen Gegensatz, der zwischen dem Protagonisten Demokrit, einem beispielhaften Gelehrten, und seinen Mitbürgern, den törichten Abderiten, besteht. Die These des vorliegenden Beitrags lautet, dass Wieland damit auf eine poetische Reflexion von Wissen abzielt, wobei er mit Hilfe des Scharlatanmotivs die wissenschaftlichen Ausschlussmechanismen seiner Zeit ironisiert. Mithin sind es die Bedingungen der Produktion von Wissen, die im Text aufs Korn genommen werden. Dabei spielt Wieland die komischen Konflikte durch, die auftreten können, wenn das der Aufklärung nahestehende Wissenschaftsethos eines Demokrit auf den Eigendünkel einer unaufgeklärten Gesellschaft trifft.
Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, distinct pulmonary vascular disease, and therefore, there is a lack of data regarding its clinical presentation, diagnosis, and management at a national basis. We aimed to describe the demographics and management of patients with CTEPH in Northern Greece. Methods: We conducted a retrospective, observational study by a joint collaboration between two pulmonary hypertension expert centers in Greece, and the study included patients diagnosed with CTEPH. The patient population was divided into two groups depending on their operability. Results: Overall, 27 consecutive patients were included (59% female, mean age 59.3±15.1 years). Dyspnea and fatigue were the most common presenting symptoms. History of pulmonary embolism was present in 82%. Of patients, 18 (67%) were assessed as operable, of whom 10 (55%) finally underwent pulmonary endarterectomy (PEA). There were no differences in symptoms, WHO functional class, 6-min walking test distance, and hemodynamics between the operable and nonoperable groups. At the end of follow-up, all non-operable and operable patients who did not receive surgical treatment were treated with at least one pulmonary hypertension-specific drug. Conclusion: This is the first report that presents data of patients diagnosed with CTEPH in Greece. The percentage of patients who underwent surgical treatment is lower but approaches the reported rates in large registries. Considering that PEA is a relatively safe and potentially curative surgical procedure, we emphasize the need for establishing a designated PEA center in Greece. Keywords: Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, registry, riociguat.
The study of lattice gauge theories with Monte Carlo simulations is hindered by the infamous sign problem that appears under certain circumstances, in particular at non-zero chemical potential. So far, there is no universal method to overcome this problem. However, recent years brought a new class of non-perturbative Hamiltonian techniques named tensor networks, where the sign problem is absent. In previous work, we have demonstrated that this approach, in particular matrix product states in 1+1 dimensions, can be used to perform precise calculations in a lattice gauge theory, the massless and massive Schwinger model. We have computed the mass spectrum of this theory, its thermal properties and real-time dynamics. In this work, we review these results and we extend our calculations to the case of two flavours and non-zero chemical potential. We are able to reliably reproduce known analytical results for this model, thus demonstrating that tensor networks can tackle the sign problem of a lattice gauge theory at finite density