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The purpose of this paper is to describe recent developments in the morphological, syntactic, and semantic annotation of the TüBa-D/Z treebank of German. The TüBa-D/Z annotation scheme is derived from the Verbmobil treebank of spoken German [4, 10], but has been extended along various dimensions to accommodate the characteristics of written texts. TüBa-D/Z uses as its data source the "die tageszeitung" (taz) newspaper corpus. The Verbmobil treebank annotation scheme distinguishes four levels of syntactic constituency: the lexical level, the phrasal level, the level of topological fields, and the clausal level. The primary ordering principle of a clause is the inventory of topological fields, which characterize the word order regularities among different clause types of German, and which are widely accepted among descriptive linguists of German [3, 6]. The TüBa-D/Z annotation relies on a context-free backbone (i.e. proper trees without crossing branches) of phrase structure combined with edge labels that specify the grammatical function of the phrase in question. The syntactic annotation scheme of the TüBa-D/Z is described in more detail in [12, 11]. TüBa-D/Z currently comprises approximately 15 000 sentences, with approximately 7 000 sentences being in the correction phase. The latter will be released along with an updated version of the existing treebank before the end of this year. The treebank is available in an XML format, in the NEGRA export format [1] and in the Penn treebank bracketing format. The XML format contains all types of information as described above, the NEGRA export format contains all sentenceinternal information while the Penn treebank format includes only those layers of information that can be expressed as pure tree structures. Over the course of the last year, more fine grained linguistic annotations have been added along the following dimensions: 1. the basic Stuttgart-Tübingen tagset, STTS, [9] labels have been enriched by relevant features of inflectional morphology, 2. named entity information has been encoded as part of the syntactic annotation, and 3. a set of anaphoric and coreference relations has been added to link referentially dependent noun phrases. In the following sections, we will describe each of these innovations in turn and will demonstrate how the additional annotations can be incorporated into one comprehensive annotation scheme.
The energy dependence of hadron production in central Pb+Pb collisions is presented and discussed. In particular, midrapidity m_T-spectra for pi-, K-, K+, p, bar p, d, phi, Lambda and bar Lambda at 40, 80 and 158 AGeV are shown. In addition Xi and Omega spectra are available at 158 AGeV. The spectra allow to determine the thermal freeze-out temperature T and the transverse flow velocity beta_T at the three energies. We do not observe a significant energy dependence of these parameters; furthermore there is no indication of early thermal freeze-out of Xi and Omega at 158 AGeV. Rapidity spectra for pi-, K-, K+ and phi at 40, 80 and 158 AGeV are shown, as well as first results on Omega rapidity distributions at 158 AGeV. The chemical freeze-out parameters T and mu_B at the three energies are determined from the total yields. The parameters are close to the expected phase boundary in the SPS energy range and above. Using the total yields of kaons and lambdas, the energy dependence of the strangeness to pion ratio is discussed. A maximum in this ratio is found at 40 AGeV. This maximum could indicate the formation of deconfined matter at energies above 40 AGeV. A search for open charm in a large sample of 158 AGeV events is presented. No signal is observed. This result is compared to several model predictions.
We predict transverse and longitudinal momentum spectra and yields of rho 0 and omega mesons reconstructed from hadron correlations in C+C reactions at 2~AGeV. The rapidity and pT distributions for reconstructable rho 0 mesons differs strongly from the primary distribution, while the omega's distributions are only weakly modified. We discuss the temporal and spatial distributions of the particles emitted in the hadron channel. Finally, we report on the mass shift of the rho 0 due to its coupling to the N*(1520), which is observable in both the di-lepton and pi pi channel. Our calculations can be tested with the Hades experiment at GSI, Darmstadt.
Mounting evidence suggests that perception depends on a largely-feedforward brain network. However, the discrepancy between (i) the latency of the corresponding feedforward responses (150-200 ms) and (ii) the time it takes human subjects to recognize brief images (often >500 ms) suggests that recurrent neuronal activity is critical to visual processing. Here, we use magneto-encephalography to localize, track and decode the feedforward and recurrent responses elicited by brief presentations of variably-ambiguous letters and digits. We first confirm that these stimuli trigger, within the first 200 ms, a feedforward response in the ventral and dorsal cortical pathways. The subsequent activity is distributed across temporal, parietal and prefrontal cortices and leads to a slow and incremental cascade of representations culminating in action-specific motor signals. We introduce an analytical framework to show that these brain responses are best accounted for by a hierarchy of recurrent neural assemblies. An accumulation of computational delays across specific processing stages explains subjects’ reaction times. Finally, the slow convergence of neural representations towards perceptual categories is quickly followed by all-or-none motor decision signals. Together, these results show how recurrent processes generate, over extended time periods, a cascade of hierarchical decisions that ultimately predicts subjects’ perceptual reports.
The SARS-CoV-2 Omicron variant is currently causing a large number of infections in many countries. A number of antiviral agents are approved or in clinical testing for the treatment of COVID-19. Despite the high number of mutations in the Omicron variant, we here show that Omicron isolates display similar sensitivity to eight of the most important anti-SARS-CoV-2 drugs and drug candidates (including remdesivir, molnupiravir, and PF-07321332, the active compound in paxlovid), which is of timely relevance for the treatment of the increasing number of Omicron patients. Most importantly, we also found that the Omicron variant displays a reduced capability of antagonising the host cell interferon response. This provides a potential mechanistic explanation for the clinically observed reduced pathogenicity of Omicron variant viruses compared to Delta variant viruses.
Reduced neutralization of SARS-CoV-2 Omicron variant by vaccine sera and monoclonal antibodies
(2021)
Due to numerous mutations in the spike protein, the SARS-CoV-2 variant of concern Omicron (B.1.1.529) raises serious concerns since it may significantly limit the antibody-mediated neutralization and increase the risk of reinfections. While a rapid increase in the number of cases is being reported worldwide, until now there has been uncertainty about the efficacy of vaccinations and monoclonal antibodies. Our in vitro findings using authentic SARS-CoV-2 variants indicate that in contrast to the currently circulating Delta variant, the neutralization efficacy of vaccine-elicited sera against Omicron was severely reduced highlighting T-cell mediated immunity as essential barrier to prevent severe COVID-19. Since SARS-CoV-2 Omicron was resistant to casirivimab and imdevimab, genotyping of SARS-CoV-2 may be needed before initiating mAb treatment. Variant-specific vaccines and mAb agents may be required to treat COVID-19 due to Omicron and other emerging variants of concern.
Reduced neutralization of SARS-CoV-2 Omicron variant by vaccine sera and monoclonal antibodies
(2021)
Due to numerous mutations in the spike protein, the SARS-CoV-2 variant of concern Omicron (B.1.1.529) raises serious concerns since it may significantly limit the antibody-mediated neutralization and increase the risk of reinfections. While a rapid increase in the number of cases is being reported worldwide, until now there has been uncertainty about the efficacy of vaccinations and monoclonal antibodies. Our in vitro findings using authentic SARS-CoV-2 variants indicate that in contrast to the currently circulating Delta variant, the neutralization efficacy of vaccine-elicited sera against Omicron was severely reduced highlighting T-cell mediated immunity as essential barrier to prevent severe COVID-19. Since SARS-CoV-2 Omicron was resistant to casirivimab and imdevimab, genotyping of SARS-CoV-2 may be needed before initiating mAb treatment. Variant-specific vaccines and mAb agents may be required to treat COVID-19 due to Omicron and other emerging variants of concern.
Cannabis is the most commonly used illicit drug in the world. However due to a changing legal landscape, and rising interest in therapeutic utility, there is an increasing trend in (long-term) use and possibly, cannabis impairment. Importantly, a growing body of evidence suggests regular cannabis users develop tolerance to the impairing, as well as the rewarding, effects of the drug. However, the neuroadaptations that may underlie cannabis tolerance remain unclear. Therefore, this double-blind, randomized, placebo controlled, cross-over study assessed the acute influence of cannabis on brain and behavioral outcomes in two distinct cannabis user groups. Twelve occasional (OUs) and 12 chronic (CUs) cannabis users received acute doses of cannabis (300 μg/kg THC) and placebo, and underwent ultra-high field functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS). In OUs, cannabis induced significant neurometabolic alterations in reward circuitry, namely decrements in functional connectivity and increments in striatal glutamate concentrations, which were associated with increases in subjective high and decreases in performance on a sustained attention task. Such changes were absent in CUs. The finding that cannabis altered circuitry and distorted behavior in OUs, but not CUs, suggests reduced responsiveness of the reward circuitry to cannabis intoxication in chronic users Taken together, the results suggest a pharmacodynamic mechanism for the development of tolerance to cannabis impairment.
This paper presents an LTAG analysis of reflexives like himself and reciprocals like each other. These items need to find a c-commanding antecedent from which they retrieve (part of) their own denotation and with which they syntactically agree. The relation between anaphoric item and antecendent must satisfy the following important locality conditions (Chomsky (1981)).
Wenn Deutsch geschrieben wird, wird im Allgemeinen die standardsprachliche Form gewählt. King: nei nei nöd eso Häx ..... verschtasch mi wieder falsch :-( *sniff (bluewin.ch, #flirt60plus, 1.10.2004) Elle: HeinEr: öhm jez versteh ich gar nix mehr (Antenne Bayern #flirten40, 16.9.2005) Big: Mu auch niemand verstehen (IRCnet, #mannheim,9.2.2003) Tezo: verstehe (IRCnet, #linux, 7.1.2003) In Büchern, Zeitungen, Zeitschriften und auch im Internet ist die deutsche Standardsprache Standard. Sie ist die für die Schriftlichkeit normierte Varietät, die überregional verständlich sein soll. Diese Standardsprache ist zwar überall ähnlich, aber nicht gleich. So zeigen sich Besonderheiten im Lexikon, in der Wortbildung und vereinzelt in der Grammatik, welche in einer Region üblich sind, in der anderen jedoch nicht, oder die da eine andere Bedeutung tragen. Diese Besonderheiten sind aber nicht an einem Ort einfach falsch, sondern sie stellen regionale Ausprägungen des Standards dar (vgl. dazu das Variantenwörterbuch; Ammon u. a. 2004). ...
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular mechanisms of this homeoviscous adaptation remain poorly understood. Here, we have reconstituted the core machinery for sensing and regulating lipid saturation in baker’s yeast to directly characterize its response to defined membrane environments. Using spectroscopic techniques and in vitro ubiquitylation, we uncover a unique sensitivity of the transcriptional regulator Mga2 to the abundance, position, and configuration of double bonds in lipid acyl chains and provide unprecedented insight into the molecular rules of membrane adaptivity. Our data challenge the prevailing hypothesis that membrane viscosity serves as the measured variable for regulating lipid saturation. Rather, we show that the signaling output of Mga2 correlates with the size of a single sensor residue in the transmembrane helix, which senses the lateral pressure and/or compressibility profile in a defined region of the membrane. Our findings suggest that membrane property sensors have evolved remarkable sensitivities to highly specific aspects of membrane structure and dynamics, thus paving the way toward the development of genetically encoded reporters for such membrane properties in the future.
Relationship between regional white matter hyperintensities and alpha oscillations in older adults
(2020)
Objective: To investigate whether regional white matter hyperintensities (WMHs) relate to alpha oscillations (AO) in a large population-based sample of elderly individuals.
Methods: We associated voxel-wise WMHs from high-resolution 3-Tesla MRI with neuronal alpha oscillations (AO) from resting-state multichannel EEG at sensor (N=907) and source space (N=855) in older participants of the LIFE-Adult study (60–80 years). In EEG, we computed relative alpha power (AP), individual alpha peak frequency (IAPF), as well as long-range temporal correlations (LRTC) that represent dynamic properties of the signal. We implemented whole-brain voxel-wise regression models to identify regions where parameters of AO were linked to probability of WMH occurrence. We further used mediation analyses to examine whether WMH volume mediated the relationship between age and AO.
Results: Higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. The age-related increase of relative AP in the right temporal brain region was shown to be mediated by total WMH volume.
Conclusion: A high relative AP corresponding to increased regional WMHs was not associated with age per se, in fact, this relationship was mediated by WMHs. We argue that the WMH-associated increase of AP reflects a generalized and likely compensatory spread of AO leading to a larger number of synchronously recruited neurons. Our findings thus suggest that longitudinal EEG recordings might be sensitive to detect functional changes due to WMHs.
Relationship between regional white matter hyperintensities and alpha oscillations in older adults
(2020)
White matter hyperintensities (WMHs) in the cerebral white matter and attenuation of alpha oscillations (AO; 7–13 Hz) occur with the advancing age. However, a crucial question remains, whether changes in AO relate to aging per se or they rather reflect the impact of age-related neuropathology like WMHs. In this study, using a large cohort (N=907) of elderly participants (60-80 years), we assessed relative alpha power (AP), individual alpha peak frequency (IAPF) and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. In contrast, we observed no significant relation of probability of WMH occurrence with IAPF and LRTC. We argue that the WMH-associated increase of AP reflects generalized and likely compensatory changes of AO leading to a larger number of synchronously recruited neurons.
Relationship between regional white matter hyperintensities and alpha oscillations in older adults
(2021)
Aging is associated with increased white matter hyperintensities (WMHs) and with the alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N=907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and LRTC. Finally, higher age was associated with elevated alpha power via total WMH volume. Although an increase in alpha oscillations due to WMH can have a compensatory nature, we rather suggest that an elevated alpha power is a consequence of WMH affecting a spatial organization of alpha sources.
First results on K/π, p/π and K/p fluctuations are obtained with the ALICE detector at the CERN LHC as a function of centrality in Pb-Pb collisions at sNN−−−√=2.76 TeV. The observable νdyn, which is defined in terms of the moments of particle multiplicity distributions, is used to quantify the magnitude of dynamical fluctuations of relative particle yields and also provides insight into the correlation between particle pairs. This study is based on a novel experimental technique, called the Identity Method, which allows one to measure the moments of multiplicity distributions in case of incomplete particle identification. The results for p/π show a change of sign in νdyn from positive to negative towards more peripheral collisions. For central collisions, the results follow the smooth trend of the data at lower energies and νdyn exhibits a change in sign for p/π and K/p.
First results on K/π, p/π and K/p fluctuations are obtained with the ALICE detector at the CERN LHC as a function of centrality in Pb-Pb collisions at sNN−−−√=2.76 TeV. The observable νdyn, which is defined in terms of the moments of particle multiplicity distributions, is used to quantify the magnitude of dynamical fluctuations of relative particle yields and also provides insight into the correlation between particle pairs. This study is based on a novel experimental technique, called the Identity Method, which allows one to measure the moments of multiplicity distributions in case of incomplete particle identification. The results for p/π show a change of sign in νdyn from positive to negative towards more peripheral collisions. For central collisions, the results follow the smooth trend of the data at lower energies and νdyn exhibits a change in sign for p/π and K/p.
Relativistic hadron-hadron collisions in the ultra-relativistic quantum molecular dynamics model
(1999)
Hadron-hadron collisions at high energies are investigated in the Ultra- relativistic-Quantum-Molecular-Dynamics approach. This microscopic trans- port model describes the phenomenology of hadronic interactions at low and intermediate energies ( s < 5 GeV) in terms of interactions between known hadrons and their resonances. At higher energies, s > 5 GeV, the excitation of color strings and their subsequent fragmentation into hadrons dominates the multiple production of particles in the UrQMD model. The model shows a fair overall agreement with a large body of experimental h-h data over a wide range of h-h center-of-mass energies. Hadronic reaction data with higher precision would be useful to support the use of the UrQMD model for relativistic heavy ion collisions.
We develop a relativistic model to describe the bound states of positive energy and negative energy in finite nuclei at the same time. Instead of searching for the negative-energy solution of the nucleon's Dirac equation, we solve the Dirac equations for the nucleon and the anti-nucleon simultaneously. The single-particle energies of negative-energy nucleons are obtained through changing the sign of the single-particle energies of positive-energy anti-nucleons. The contributions of the Dirac sea to the source terms of the meson fields are evaluated by means of the derivative expansion up to the leading derivative order for the one-meson loop and one-nucleon loop. After refitting the parameters of the model to the properties of spherical nuclei, the results of positive-energy sector are similar to that calculated within the commonly used relativistic mean field theory under the no-sea approximation. However, the bound levels of negative-energy nucleons vary drastically when the vacuum contributions are taken into account. It implies that the negative-energy spectra deserve a sensitive probe to the effective interactions in addition to the positive-energy spectra.
We develop a relativistic model to describe the bound states of positive energy and negative energy in finite nuclei at the same time. Instead of searching for the negative-energy solution of the nucleon s Dirac equation, we solve the Dirac equations for the nucleon and the anti-nucleon simultaneously. The single-particle energies of negative-energy nucleons are obtained through changing the sign of the single-particle energies of positive-energy anti-nucleons. The contributions of the Dirac sea to the source terms of the meson fields are evaluated by means of the derivative expansion up to the leading derivative order for the one-meson loop and one-nucleon loop. After refitting the parameters of the model to the properties of spherical nuclei, the results of positive-energy sector are similar to that calculated within the commonly used relativistic mean field theory under the no-sea approximation. However, the bound levels of negative-energy nucleons vary drastically when the vacuum contributions are taken into account. It implies that the negative-energy spectra deserve a sensitive probe to the e ective interactions in addition to the positive-energy spectra.
A steep maximum occurs in the Wroblewski ratio between strange and non-strange quarks created in central nucleus-nucleus collisions, of about A=200, at the lower SPS energy square root s approximately equal to 7 GeV. By analyzing hadronic multiplicities within the grand canonical statistical hadronization model this maximum is shown to occur at a baryochemical potential of about 450 MeV. In comparison, recent QCD lattice calculations at finite baryochemical potential suggest a steep maximum of the light quark susceptibility, to occur at similar mu B, indicative of "critical fluctuation" expected to occur at or near the QCD critical endpoint. This endpoint hat not been firmly pinned down but should occur in the 300 MeV < mu c B < 700 MeV interval. It is argued that central collisions within the low SPS energy range should exhibit a turning point between compression/heating, and expansion/cooling at energy density, temperature and mu B close to the suspected critical point. Whereas from top SPS to RHIC energy the primordial dynamics create a turning point far above in epsilon and T, and far below in mu B. And at lower AGS energies the dynamical trajectory stays below the phase boundary. Thus, the observed sharp strangeness maximum might coincide with the critical square root s at which the dynamics settles at, or near the QCD endpoint.