Isabelle Marie Kramer, Markus Pfenninger, Barbara Feldmeyer, Meghnath Dhimal, Ishan Gautam, Pramod Shreshta, Sunita Baral, Parbati Phuyal, Juliane Hartke, Axel Magdeburg, Jan David Alexander Groneberg, Bodo Ahrens, Ruth Müller, Ann-Marie Waldvogel
- Driven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion. By applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Aedes aegypti, sampled along an altitudinal gradient in Nepal (200–1300 m), we identify putatively adaptive traits and describe the species' genomic footprint of climate adaptation to colder ecoregions. We found two differentiated clusters with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300 m) and all other lowland populations (≤800 m). We revealed nonsynonymous mutations in 13 of the candidate genes associated to either altitude, precipitation or cold tolerance and identified an isolation-by-environment differentiation pattern. Other than the expected gradual differentiation along the altitudinal gradient, our results reveal a distinct genomic differentiation of the highland population. Local high-altitude adaptation could be one explanation of the population's phenotypic cold tolerance. Carrying alleles relevant for survival under colder climate increases the likelihood of this highland population to a worldwide expansion into other colder ecoregions.
MetadatenAuthor: | Isabelle Marie KramerORCiDGND, Markus PfenningerORCiDGND, Barbara FeldmeyerORCiDGND, Meghnath DhimalORCiDGND, Ishan Gautam, Pramod Shreshta, Sunita BaralORCiD, Parbati PhuyalORCiD, Juliane HartkeORCiDGND, Axel MagdeburgGND, Jan David Alexander GronebergORCiDGND, Bodo AhrensORCiDGND, Ruth MüllerORCiD, Ann-Marie WaldvogelORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-742159 |
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DOI: | https://doi.org/10.1111/mec.16752 |
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Parent Title (English): | Molecular ecology |
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Publisher: | Wiley-Blackwell |
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Place of publication: | Oxford [u.a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/10/28 |
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Date of first Publication: | 2022/10/28 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/11/27 |
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Tag: | climate change genomics; latent factor mixed model; range expansion; whole genome pooled sequencing; yellow fever mosquito |
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Volume: | 32 |
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Issue: | 2 |
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Page Number: | 19 |
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First Page: | 350 |
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Last Page: | 368 |
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HeBIS-PPN: | 515128112 |
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Institutes: | Medizin |
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| Geowissenschaften / Geographie / Geowissenschaften |
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| Angeschlossene und kooperierende Institutionen / Senckenbergische Naturforschende Gesellschaft |
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Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 59 Tiere (Zoologie) / 590 Tiere (Zoologie) |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International |
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