Biological complexity facilitates tuning of the neuronal parameter space

  • The electrical and computational properties of neurons in our brains are determined by a rich repertoire of membrane-spanning ion channels and elaborate dendritic trees. However, the precise reason for this inherent complexity remains unknown. Here, we generated large stochastic populations of biophysically realistic hippocampal granule cell models comparing those with all 15 ion channels to their reduced but functional counterparts containing only 5 ion channels. Strikingly, valid parameter combinations in the full models were more frequent and more stable in the face of perturbations to channel expression levels. Scaling up the numbers of ion channels artificially in the reduced models recovered these advantages confirming the key contribution of the actual number of ion channel types. We conclude that the diversity of ion channels gives a neuron greater flexibility and robustness to achieve target excitability.

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Author:Marius SchneiderORCiD, Alexander D BirdORCiD, Albert GidonORCiD, Jochen TrieschORCiD, Peter JedličkaORCiDGND, Hermann CuntzORCiDGND
Parent Title (English):bioRxiv
Document Type:Preprint
Date of Publication (online):2022/07/21
Date of first Publication:2022/07/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/03/23
Page Number:52
Institutes:Informatik und Mathematik
Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International