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Relativistic Hartree approach including negative energy-bound states (1999)

Guangjun Mao Horst Stöcker Walter Greiner

We develop a relativistic model to describe the bound states of positive energy and negative energy in finite nuclei at the same time. Instead of searching for the negative-energy solution of the nucleon s Dirac equation, we solve the Dirac equations for the nucleon and the anti-nucleon simultaneously. The single-particle energies of negative-energy nucleons are obtained through changing the sign of the single-particle energies of positive-energy anti-nucleons. The contributions of the Dirac sea to the source terms of the meson fields are evaluated by means of the derivative expansion up to the leading derivative order for the one-meson loop and one-nucleon loop. After refitting the parameters of the model to the properties of spherical nuclei, the results of positive-energy sector are similar to that calculated within the commonly used relativistic mean field theory under the no-sea approximation. However, the bound levels of negative-energy nucleons vary drastically when the vacuum contributions are taken into account. It implies that the negative-energy spectra deserve a sensitive probe to the e ective interactions in addition to the positive-energy spectra.

Kinetic freeze out models (1999)

Volodymyr K. Magas Csaba Anderlik László Pal Csernai Frederique Grassi Walter Greiner Yogiro Hama Takeshi Kodama Zsolt Iosif Lazar Horst Stöcker

Freeze out of particles across a space-time hypersurface is discussed in kinetic models. The calculation of final momentum distribution of emitted particles is described for freeze out surfaces, with spacelike normals. The resulting non-equilibrium distribution does not resemble, the previously proposed, cut Jüttner distribution, and shows non-exponential pt-spectra similar to the ones observed in experiments. PACS: 24.10.Nz, 25.75.-q

Untersuchungen zur Bedeutung des Kern-Zytoplasma Transports für die biologische Funktion zellulärer Proteine (2005)

Shirley Knauer

The thesis entitled „Investigations on the significance of nucleo-cytoplasmic transport for the biological function of cellular proteins" aimed to unreveal molecular mechanisms in order to improve our understanding of the impact of nucleo-cytoplasmic transport on cellular functions. Within the scope of this work, it could be shown that regulated nucleo-cytoplasmic transport of a subfamily of homeobox transcription factors controlled their intra- and intercellular transport, and thereby influencing also their transcriptional activity. This study describes a novel regulatory mechanism, which could in general play an important role for the ordered differentiation of complex organisms. Besides cis-active transport Signals, also post-translational modifications can influence the localization and biological activity of proteins in trans. In addition to the known impact of phosphorylation on the transport and activity of STAT1, experimental evidence was provided demonstrating that acetylation affected the interaction of STAT1 with NF-kB p65, and subsequently modulated the expression of apoptosis-inducing NF-kB target genes. The impact of nucleo-cytoplasmic transport on the regulation of apoptosis was underlined by showing that the evolutionary conservation of a NES within the anti-apoptotic protein survivin plays an essential role for its dual function in the inhibition of apoptosis and ordered cell division. Since survivin is considered a bona fide cancer therapy target, these results strongly encourage future work to identify molecular decoys that specifically inhibit the nuclear export of survivin as novel therapeutics. In order to further dissect the regulation of nuclear transport and to efficiently identify transport inhibitors, cell-based assays are urgently required. Therefore, the cellular assay Systems developed in this work may not only serve to identify synthetic nuclear export and Import inhibitors but may also be applied in systematic RNAi-screening approaches to identify novel components of the transport machinery. In addition, the translocation based protease- and protein-interaction biosensors can be applied in various biological Systems, in particular to identify protein-protein interaction inhibitors of cancer relevant proteins. In summary, this work does not only underline the general significance of nucleo-cytoplasmic transport for cell biology, but also demonstrates its potential for the development of novel therapies against diseases like cancer and viral infections.

Moments of event observable distributions and many-body correlations (1999)

Mohamed Belkacem Zoheir Aouissat Marcus Bleicher Horst Stöcker Walter Greiner

We investigate event-by-event fluctuations for ensembles with non-fixed multiplicity. Moments of event observable distributions, like total energy distribution, total transverse momentum distribution, etc, are shown to be related to the multi-body correlations present in the system. For classical systems, these moments reduce in the absence of any correlations to the mo- ments of particle inclusive momentum distribution. As a consequence, a zero value for the recently introduced Phi-variable is shown to indicate the van- ishing of two-body correlations from one part, and of correlations between multiplicity and momentum distributions from the other part. It is often misunderstood as a measure of the degree of equilibration in the system.

Nonequilibrium dynamics of a hadronizing quark gluon plasma (1999)

Markus Hofmann Judah M. Eisenberg Stefan Scherer Marcus Bleicher Ludwig Neise Horst Stöcker Walter Greiner

We investigate the hadronic cooling of a quark droplet within a microscopic model. The color flux tube approach is used to describe the hadronization of the quark phase. The model reproduces experimental particle ratios equally well compared to a static thermal hadronic source. Furthermore, the dynamics of the decomposition of a quark-gluon plasma is investigated and time dependent particle ratios are found.

Die Abenteuer des Don Sylvio von Rosalva (1853)

Christoph Martin Wieland

Deuterons and space-momentum correlations in high energy nuclear collisions (1999)

B. Monreal Steffen A. Bass Marcus Bleicher S. Esumi Walter Greiner Qingfeng Li H. Liu W.J. Llope Raffaele Mattiello Sergey Y. Panitkin I. Sakrejda Raimond Snellings Heinz Sorge Christian Spieles Horst Stöcker J. Thomas S. Voloshin F. Wang Nu Xu

Using a microscopic transport model together with a coalescence after-burner, we study the formation of deuterons in Au + Au central collisions at s = 200 AGeV . It is found that the deuteron transverse momentum distributions are strongly a ected by the nucleon space-momentum correlations, at the moment of freeze-out, which are mostly determined by the number of rescatterings. This feature is useful for studying collision dynamics at ultrarelativistic energies.

Freeze-out in hydrodynamical models in relativistic heavy ion collisions (1999)

Volodymyr K. Magas Csaba Anderlik László Pal Csernai Frederique Grassi Walter Greiner Yogiro Hama Takeshi Kodama Zsolt Iosif Lazar Horst Stöcker

In continuum and fluid dynamical models, particles, which leave the system and reach the detectors, can be taken into account via freeze-out (FO) or final break-up schemes, where the frozen out particles are formed on a 3-dimensional hypersurface in space-time. Such FO descriptions are important ingredients of evaluations of two-particle correlation data, transverse-, longitudinal-, radial- and cylindrical- flow analyses, transverse momentum and transverse mass spectra and many other observables. The FO on a hypersurface is a discontinuity, where the pre FO equilibrated and interacting matter abruptly changes to non-interacting particles, showing an ideal gas type of behavior.

Rho meson broadening and dilepton production in heavy ion collisions (1999)

Song Gao Charles Gale Christoph Ernst Horst Stöcker Walter Greiner

The modification of the width of the rho meson due to in-medium decays and collisions is evaluated. In high temperature and/or high density hadronic matter, the collision width is much larger than the one-loop decay width. The large width of the meson in matter seems to be consistent with some current interpretations of the e+e mass spectra measured at the CERN/SPS.

Plural semantics for natural language understanding : a computational proof-theoretic approach (2005)

Uta Schwertel

The semantics of natural language plurals poses a number of intricate problems – both from a formal and a computational perspective. In this thesis I investigate problems of representing, disambiguating and reasoning with plurals from a computational perspective. The work defines a computationally suitable representation for important plural constructions, proposes a tractable resolution algorithm for semantic plural ambiguities, and integrates an automatic reasoning component for plurals. My solution combines insights from formal semantics, computational linguistics and automated theorem proving and is based on the following main ideas. Whereas many existing approaches to plural semantics work on a model-theoretic basis using higher-order representation languages I propose a proof-theoretic approach to plural semantics based on a flat firstorder semantic representation language thus showing that a trade-off between expressive power and logical tractability can be found. The problem of automatic disambiguation of plurals is tackled by a deliberate decision to drastically reduce recourse to contextual knowledge for disambiguation but rely instead on structurally available and thus computationally manageable information. A further central aspect of the solution lies in carefully drawing the borderline between real ambiguity and mere indeterminacy in the interpretation of plural noun phrases. As a practical result of my computational proof-theoretic approach to plural semantics I can use my methods to perform automated reasoning with plurals by applying advanced firstorder theorem provers and model-generators available off-the shelf. The results are prototypically implemented within the two logic-oriented natural language understanding applications DRoPs and Attempto. DRoPs provides an automatic plural disambiguation component for uncontrolled natural language whereas Attempto works with a constructive disambiguation strategy for controlled natural language. Both systems provide tools for the automated analysis of technical texts allowing users for example to automatically detect inconsistencies, to perform question answering, to check whether a conjecture follows from a text or to find equivalences and redundancies.

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